Effect of leukocytes on corneal cellular proliferation and wound healing.

abstract：PURPOSE:Angiotensin II (AII) has been shown to play a role in many vascular diseases. In the study described, the effect of AII on vascular endothelial growth factor (VEGF) expression and related intracellular signaling mechanism was investigated in bovine retinal microcapillary pericytes. METHODS:Cultured bovine reti...

journal_title：Investigative ophthalmology & visual science

authors： Otani A,Takagi H,Oh H,Suzuma K,Matsumura M,Ikeda E,Honda Y

更新日期：2000-04-01 00:00:00

abstract：:Visual fixation of a small, stationary target was measured in 12 young observers (mean age = 22 yr) and in 12 older observers (mean age = 70 yr). The two groups' fixation behavior did not differ on various dimensions of fixation stability: mean fixation area, intra-subject variability, or changes in fixation over succ...

journal_title：Investigative ophthalmology & visual science

authors： Kosnik W,Fikre J,Sekuler R

更新日期：1986-12-01 00:00:00

abstract：:An objective visual field can be mapped in terms of stimulus-induced eye movement. The authors used the scleral coil technique to record vergence and conjugate eye movements while stimulating different visual field locations with a 3 X 3 deg target whose image vergence was oscillated. For each of three subjects tested...

journal_title：Investigative ophthalmology & visual science

authors： Regan D,Erkelens CJ,Collewijn H

更新日期：1986-05-01 00:00:00

abstract：:Glaucoma has been known to be associated with a loss of retinal ganglion cells and their axons throughout the fundus and a decreased count of photoreceptors and retinal pigment epithelial (RPE) cells in the parapapillary region. This study investigated whether glaucomatous changes of the deep retinal layer occur outsi...

journal_title：Investigative ophthalmology & visual science

authors： Panda S,Jonas JB

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:Research to restore some degree of vision to patients suffering from retinal degeneration is becoming increasingly more promising. Several groups have chosen electrical stimulation of the remaining network of a degenerate retina as a means to generate discrete light percepts (phosphenes). Approaches vary signif...

journal_title：Investigative ophthalmology & visual science

authors： Matteucci PB,Chen SC,Tsai D,Dodds CW,Dokos S,Morley JW,Lovell NH,Suaning GJ

更新日期：2013-06-21 00:00:00

abstract：:Recent work demonstrated that a mannose receptor is involved in the phagocytosis of rod outer segments by the rat retinal pigment epithelium (RPE). In this study the binding of soluble mannose-containing ligands by human RPE explants is described. In addition, the authors report the isolation of a mannose receptor fro...

journal_title：Investigative ophthalmology & visual science

authors： Shepherd VL,Tarnowski BI,McLaughlin BJ

更新日期：1991-05-01 00:00:00

abstract：PURPOSE:To assess the repeatability and reproducibility of central corneal thickness (CCT) measurements obtained by combined scanning-slit/Placido-disc topography (Orbscan II; Bausch & Lomb, Rochester, NY) after laser in situ keratomileusis (LASIK) and to compare the results with another noncontact method, specular mic...

journal_title：Investigative ophthalmology & visual science

authors： Maldonado MJ,López-Miguel A,Nieto JC,Cano-Parra J,Calvo B,Alió JL

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Mice rendered hypoglycemic by a null mutation in the glucagon receptor gene Gcgr display late-onset retinal degeneration and loss of retinal sensitivity. Acute hyperglycemia induced by dextrose ingestion does not restore their retinal function, which is consistent with irreversible loss of vision. The goal of t...

journal_title：Investigative ophthalmology & visual science

authors： Umino Y,Cuenca N,Everhart D,Fernandez-Sanchez L,Barlow RB,Solessio E

更新日期：2012-02-21 00:00:00

abstract：Purpose:Tissue transglutaminase (TGM2) is elevated in glaucomatous trabecular meshwork (TM) tissues. We investigated whether increased expression of TGM2 increases extracellular matrix crosslinking in the TM, thereby increasing aqueous humor outflow resistance and elevating intraocular pressure (IOP) in mouse eyes. Me...

journal_title：Investigative ophthalmology & visual science

authors： Raychaudhuri U,Millar JC,Clark AF

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To determine whether the size and configuration of the optic chiasm in humans with albinism is different from that in normal control subjects. METHODS:Seventeen patients and 15 control subjects underwent magnetic resonance imaging of the entire head. Images were reformatted to the chiasm region and analyzed wi...

journal_title：Investigative ophthalmology & visual science

authors： Schmitz B,Schaefer T,Krick CM,Reith W,Backens M,Käsmann-Kellner B

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:This study investigated, using high-resolution magnetic resonance imaging (MRI), inferior oblique muscle (IO) position relative to the adnexa in normal controls, subjects with and without vertical strabismus following lower lid blepharoplasty, and subjects with other hypertropia. METHODS:Sagittal plane MRI was...

journal_title：Investigative ophthalmology & visual science

authors： Shin SY,Demer JL

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:By their control of membrane potential and intracellular free Ca(2+) ([Ca(2+)](i)), K(+) currents are pivotal in the regulation of arterial smooth muscle tone. The goal of the present study was to identify and characterize the A-type K(+) current in retinal microvascular smooth muscle (MVSM) and to examine its ...

journal_title：Investigative ophthalmology & visual science

authors： McGahon MK,Dawicki JM,Scholfield CN,McGeown JG,Curtis TM

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:StarGen is an equine infectious anemia virus (EIAV)-based lentiviral vector that expresses the photoreceptor-specific adenosine triphosphate (ATP)-binding cassette transporter (ABCA4) protein that is mutated in Stargardt disease (STGD1), a juvenile macular dystrophy. EIAV vectors are able to efficiently transdu...

journal_title：Investigative ophthalmology & visual science

authors： Binley K,Widdowson P,Loader J,Kelleher M,Iqball S,Ferrige G,de Belin J,Carlucci M,Angell-Manning D,Hurst F,Ellis S,Miskin J,Fernandes A,Wong P,Allikmets R,Bergstrom C,Aaberg T,Yan J,Kong J,Gouras P,Prefontaine A,

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:To determine the role of polyphosphate kinase 1 (PPK1) in the ocular virulence of Pseudomonas aeruginosa. METHODS:Using a mouse model of infection, P. aeruginosa strains PAO1, PAOM5 (an isogenic mutant of PAO1 deficient in PPK1), and PAOM5+PPK1 (the mutant complemented with PPK1 on plasmid pHEPAK11) were compa...

journal_title：Investigative ophthalmology & visual science

authors： Parks QM,Hobden JA

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To describe and analyze developmental change from birth through maturity of human electroretinogram (ERG) response, especially in terms of rod phototransduction as represented in the ERG a-wave. METHODS:Electroretinograms were recorded from 16 human infants from 5 to 270 days of age, two children 1.9 and 3.4 y...

journal_title：Investigative ophthalmology & visual science

authors： Breton ME,Quinn GE,Schueller AW

更新日期：1995-07-01 00:00:00

abstract：PURPOSE:Late infantile neuronal ceroid lipofuscinosis (NCL) is an inherited disorder characterized by progressive vision loss. The disease results from mutations in the TPP1 (CLN2) gene. Studies were undertaken to characterize the effects of a TPP1 frameshift mutation on the retina in Dachshunds. METHODS:A litter of f...

journal_title：Investigative ophthalmology & visual science

authors： Katz ML,Coates JR,Cooper JJ,O'Brien DP,Jeong M,Narfström K

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Invasion of tumor cells into blood vessels is essential for metastasis of uveal melanoma. The occurrence of ingrowth of tumor cells in blood vessels in uveal melanoma was analyzed, and this parameter was compared with the survival of the patients. METHODS:Between 1972 and 2007, 643 eyes primarily enucleated fo...

journal_title：Investigative ophthalmology & visual science

authors： Ly LV,Odish OF,Wolff-Rouendaal Dd,Missotten GS,Luyten GP,Jager MJ

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To demonstrate the conjunctival alterations in patients with Sjögren's (SSDE) and non-Sjögren's syndrome dry eye (NSSDE) using a new generation confocal microscope (HRTII/ RCM; Heidelberg Engineering, Heidelberg, Germany), in a prospective controlled study. METHODS:Twenty-eight right eyes of 28 patients with S...

journal_title：Investigative ophthalmology & visual science

authors： Wakamatsu TH,Sato EA,Matsumoto Y,Ibrahim OM,Dogru M,Kaido M,Ishida R,Tsubota K

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To evaluate the feasibility of near-infrared (NIR) imaging acquisition in a large sample of consecutive pediatric patients with neurofibromatosis type 1 (NF1), to evaluate the diagnostic performance of NF1-related choroidal abnormalities as a diagnostic criterion of the disease, and to compare this criterion wi...

journal_title：Investigative ophthalmology & visual science

authors： Parrozzani R,Clementi M,Frizziero L,Miglionico G,Perrini P,Cavarzeran F,Kotsafti O,Comacchio F,Trevisson E,Convento E,Fusetti S,Midena E

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To test whether retinal pigment epithelial (RPE) cells are able to induce myeloid-derived suppressor cell (MDSC) differentiation from bone marrow (BM) progenitors. METHODS:BM cells were cocultured with or without RPE cells in the presence of GM-CSF and IL-4. Numbers of resultant MDSCs were assessed by flow cyt...

journal_title：Investigative ophthalmology & visual science

authors： Tu Z,Li Y,Smith D,Doller C,Sugita S,Chan CC,Qian S,Fung J,Caspi RR,Lu L,Lin F

更新日期：2012-02-23 00:00:00

abstract：Purpose:To determine whether combining quantitative optical coherence tomography angiography (OCTA) parameters can achieve high sensitivity and specificity to distinguish eyes with nonproliferative diabetic retinopathy (NPDR) from those with proliferative diabetic retinopathy (PDR) as well as eyes with diabetes and no ...

journal_title：Investigative ophthalmology & visual science

authors： Ashraf M,Nesper PL,Jampol LM,Yu F,Fawzi AA

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:To determine the effects of overexpression of mutated BIGH3 in HeLa and human corneal epithelial (HCE) cells. METHODS:Six mutations known to be responsible for autosomal dominant corneal dystrophies linked to chromosome 5 were generated in a BIGH3 expression vector and transfected in HeLa and HCE cells. The ex...

journal_title：Investigative ophthalmology & visual science

authors： Morand S,Buchillier V,Maurer F,Bonny C,Arsenijevic Y,Munier FL,Schorderet DF

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:To compare a multisampling suprathreshold strategy with conventional suprathreshold and full-threshold strategies in detecting localized visual field defects and in quantifying the area of loss. METHODS:Probability theory was applied to examine various suprathreshold pass criteria (i.e., the number of stimuli ...

journal_title：Investigative ophthalmology & visual science

authors： Artes PH,Henson DB,Harper R,McLeod D

更新日期：2003-06-01 00:00:00

abstract：:The integrity of the RPE barrier function in retinal detachment was studied in vitro. The retinal pigment epithelium (RPE)-choroid tissue was isolated from cynomolgus monkey eyes with acute (less than 1 hr), subacute (1-2 weeks), and chronic (8-20 months) retinal detachments, and clamped between Ussing-type chambers. ...

journal_title：Investigative ophthalmology & visual science

authors： Tsuboi S,Pederson JE,Toris CB

更新日期：1987-11-01 00:00:00

abstract：PURPOSE:During mammalian embryonic eyelid closure ADAM17 has been proposed to play a role as a transactivator of epidermal growth factor receptor (EGFR) signaling by shedding membrane bound EGFR ligands. However, ADAM17 also sheds numerous other ligands, thus implicating ADAM17 in additional molecular pathways. The goa...

journal_title：Investigative ophthalmology & visual science

authors： Hassemer EL,Endres B,Toonen JA,Ronchetti A,Dubielzig R,Sidjanin DJ

更新日期：2013-01-07 00:00:00

abstract：PURPOSE:Human leukocyte antigen (HLA) polymorphisms have been associated with the development of autoimmune diseases. In uveal melanoma, a high expression of HLA classes I and II, and infiltration with lymphocytes and macrophages are associated with a bad prognosis. Inflammation has an important role in this malignancy...

journal_title：Investigative ophthalmology & visual science

authors： van Essen TH,Bronkhorst IH,Maat W,Verduyn W,Roelen DL,Luyten GP,Jager MJ

更新日期：2012-05-04 00:00:00

abstract：:To evaluate the penetration of ciprofloxacin, a new wide-spectrum oral antibiotic, into the vitreous, ciprofloxacin was administered orally to 21 patients who were scheduled to undergo vitreal surgery. Seven patients received 750 mg ciprofloxacin 4 hr before surgery (group I), seven patients received this dose 8 hr be...

journal_title：Investigative ophthalmology & visual science

authors： Keren G,Alhalel A,Bartov E,Kitzes-Cohen R,Rubinstein E,Segev S,Treister G

更新日期：1991-07-01 00:00:00

abstract：:A method to quantify different glaucomatous visual field defects is presented. Three visual field indices are calculated: the short-term fluctuation, the mean defect, and the corrected loss variation. The method was applied to visual fields tested with program JO on the Octopus automated perimeter. The indices of 130 ...

journal_title：Investigative ophthalmology & visual science

authors： Flammer J,Drance SM,Augustiny L,Funkhouser A

更新日期：1985-02-01 00:00:00

abstract：PURPOSE:Pterygia are common, frequently recurring ocular surface lesions characterized by tissue remodeling, cellular proliferation, angiogenesis, and inflammation. The increased incidence of pterygia in persons exposed to excessive solar radiation suggests that ultraviolet (UV) light may play a critical role in the pa...

journal_title：Investigative ophthalmology & visual science

authors： Di Girolamo N,Coroneo MT,Wakefield D

更新日期：2003-11-01 00:00:00

abstract：:Three congenic Royal College of Surgeons (RCS) strains of rats have been developed: the RCS-p+ strain, which is a black-eyed dystrophic strain; the pink-eyed RCS-rdy+ strain, which is wild-type (+/+) at the retinal dystrophy (rdy) genetic locus and serves as the control for the inbred, pink-eyed RCS strain; and the bl...

journal_title：Investigative ophthalmology & visual science

authors： LaVail MM

更新日期：1981-05-01 00:00:00