Reliability of noncontact pachymetry after laser in situ keratomileusis.

abstract：:Attempts to describe normal corneal shape and to represent corneal topography by an array of discrete points have limited usefulness. A quantitative photogrammetric method that produces indices to describe corneal shape was developed. Four indices depict the departure of keratographic rings from circularity, and two i...

journal_title：Investigative ophthalmology & visual science

authors： Cohen KL,Tripoli NK,Pellom AC,Kupper LL,Fryczkowski AW

更新日期：1984-03-01 00:00:00

abstract：PURPOSE:The angiopoietin (Ang) system plays an important role in vascular stabilization and pathologic neovascularization. The hypothesis for the study was that, in addition to modulating endothelial cell behavior, the angiopoietin/Tie-2 system also regulates the pericyte apoptosis and/or the vessel maturation associat...

journal_title：Investigative ophthalmology & visual science

authors： Cai J,Kehoe O,Smith GM,Hykin P,Boulton ME

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:To demonstrate the conjunctival alterations in patients with Sjögren's (SSDE) and non-Sjögren's syndrome dry eye (NSSDE) using a new generation confocal microscope (HRTII/ RCM; Heidelberg Engineering, Heidelberg, Germany), in a prospective controlled study. METHODS:Twenty-eight right eyes of 28 patients with S...

journal_title：Investigative ophthalmology & visual science

authors： Wakamatsu TH,Sato EA,Matsumoto Y,Ibrahim OM,Dogru M,Kaido M,Ishida R,Tsubota K

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To identify stem cells in the chamber angle of the monkey eye by detection of 5-bromo-2'-deoxyuridine (BrdU) long-term retention. METHODS:Four cynomolgus monkeys were treated with BrdU via subcutaneous pumps for 4 weeks. The eyes of two animals were processed immediately thereafter (group 1) while in the other...

journal_title：Investigative ophthalmology & visual science

authors： Braunger BM,Ademoglu B,Koschade SE,Fuchshofer R,Gabelt BT,Kiland JA,Hennes-Beann EA,Brunner KG,Kaufman PL,Tamm ER

更新日期：2014-10-16 00:00:00

abstract：:Advanced macular degeneration is an important cause of vision loss in the United States with over 2 million people affected by the disease. Despite substantial progress in the development of new therapies for wet AMD, the severe visual impairment associated with geographic atrophy in dry AMD or Stargardt disease remai...

journal_title：Investigative ophthalmology & visual science

authors： Schwartz SD,Tan G,Hosseini H,Nagiel A

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To assess the strength of the association between retinal nerve fiber layer (RNFL) thickness and optic disc topography measured with confocal retinal tomography (HRT II; Heidelberg Engineering, Dossenheim, Germany), optical coherence tomography (StratusOCT; Carl Zeiss Meditec, Inc., Dublin, CA), and scanning la...

journal_title：Investigative ophthalmology & visual science

authors： Bowd C,Zangwill LM,Medeiros FA,Tavares IM,Hoffmann EM,Bourne RR,Sample PA,Weinreb RN

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess qualitatively the expression of adhesion molecules by human retinal pigment epithelium (RPE) and to study their regulation by inflammatory cytokines. These molecular events and the role played by inflammatory cytokines are important for selective lymphocyte trafficking in...

journal_title：Investigative ophthalmology & visual science

authors： Platts KE,Benson MT,Rennie IG,Sharrard RM,Rees RC

更新日期：1995-10-01 00:00:00

abstract：:Although aqueous outflow is most likely a passive, nonenergy-dependent process, alterations in cellular function in the trabecular meshwork presumably are involved in the development of some types of glaucoma. Accordingly, it seems important to define both the normal and abnormal biochemistry of this tissue. The autho...

journal_title：Investigative ophthalmology & visual science

authors： Anderson PJ,Karageuzian LN,Cheng HM,Epstein DL

更新日期：1984-11-01 00:00:00

abstract：PURPOSE:The influence of genetic and prenatal environmental factors on characteristics of saccadic performance were evaluated in young monozygotic (MZ) twins (8-19 years old) of known chorion type. METHODS:Saccadic eye movements were recorded using an infrared system. Saccadic latency, accuracy, and parameters of ampl...

journal_title：Investigative ophthalmology & visual science

authors： Blekher T,Christian JC,Abel LA,Yee RD

更新日期：1998-10-01 00:00:00

abstract：PURPOSE:To define the retinal phenotype in patients with the Bardet-Biedl syndrome and mutations in the BBS1 gene. METHODS:Ten patients (age range, 16-48 years), representing eight pedigrees, with BBS1 gene mutations were studied clinically and with kinetic perimetry, chromatic static perimetry, electroretinography (E...

journal_title：Investigative ophthalmology & visual science

authors： Azari AA,Aleman TS,Cideciyan AV,Schwartz SB,Windsor EA,Sumaroka A,Cheung AY,Steinberg JD,Roman AJ,Stone EM,Sheffield VC,Jacobson SG

更新日期：2006-11-01 00:00:00

abstract：:The authors have examined the fate of intravitreally injected liposomes in the aphakic, vitrectomized eye of the rabbit. Liposomes labelled with 125[I]-p-hydroxybenzimidylphosphatidylethanolamine were eliminated rapidly from the intraocular fluid. Nonetheless, a significant fraction of these liposomes were found to bi...

journal_title：Investigative ophthalmology & visual science

authors： Stern WH,Heath TD,Lewis GP,Guerin CJ,Erickson PA,Lopez NG,Hong KL

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:The purpose of the present study was to investigate metabolic changes in different compartments of the rat lens (anterior, nuclear, posterior, and equatorial) after exposure to an acute double threshold dose of ultraviolet-B radiation (UVR-B) by using high-resolution magic angle spinning (HR-MAS) (1)H nuclear m...

journal_title：Investigative ophthalmology & visual science

authors： Tessem MB,Bathen TF,Löfgren S,Saether O,Mody V,Meyer L,Dong X,Söderberg PG,Midelfart A

更新日期：2006-12-01 00:00:00

abstract：:The mitotic rate and goblet cell content of conjunctival epithelium following total or central corneal epithelial removal using n-heptanol was measured to determine how the conjunctival epithelium responds to injury and whether conjuctiva responds to central corneal epithelial loss. One day following a wound that remo...

journal_title：Investigative ophthalmology & visual science

authors： Danjo S,Friend J,Thoft RA

更新日期：1987-09-01 00:00:00

abstract：PURPOSE:Adipogenesis contributes to the pathogenesis of thyroid eye disease (TED). Thyrotropin receptor (TSHR) transcripts are present in orbital fat. This study was conducted to determine whether they are expressed as functional protein, and if so, whether this is restricted to TED orbits or to a particular stage in a...

journal_title：Investigative ophthalmology & visual science

authors： Crisp M,Starkey KJ,Lane C,Ham J,Ludgate M

更新日期：2000-10-01 00:00:00

abstract：:One eye of each of eight subjects was exposed to gases containing oxygen concentrations of 1.0%, 2.5%, 4.9%, 7.5%, 10.1%, and 21.4% (oxygen partial pressures ranging from 8 to 158 mmHg) for 8 hr. The precorneal oxygen concentration required to avoid corneal edema for the group as a whole was 10.1% (an oxygen tension o...

journal_title：Investigative ophthalmology & visual science

authors： Holden BA,Sweeney DF,Sanderson G

更新日期：1984-04-01 00:00:00

abstract：PURPOSE:To determine if limited proteolysis of beta-crystallins is associated with insolubilization of proteins in rats lens during maturation and to test if the protease, calpain II, is involved. METHODS:Soluble and insoluble lens proteins from 4-day-old to 4-month-old rat lens cortexes and nuclei were separated by t...

journal_title：Investigative ophthalmology & visual science

authors： David LL,Azuma M,Shearer TR

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:Visual field defects after vitrectomy can be seen after any surgery involving fluid-air exchange. To elucidate the effect during surgery of the infused air on the retina, the present study investigated the changes in the morphology of the rabbit retina induced by air infusion and the changes resulting from vary...

journal_title：Investigative ophthalmology & visual science

authors： Hasumura T,Yonemura N,Hirata A,Murata Y,Negi A

更新日期：2000-12-01 00:00:00

abstract：Purpose:Synucleinopathies such as multiple system atrophy (MSA) and Parkinson's disease are associated with a variety of visual symptoms. Functional and morphological retinal aberrations are therefore supposed to be valuable biomarkers for these neurodegenerative diseases. This study examined the retinal morphology and...

journal_title：Investigative ophthalmology & visual science

authors： Kaehler K,Seitter H,Sandbichler AM,Tschugg B,Obermair GJ,Stefanova N,Koschak A

更新日期：2020-06-03 00:00:00

abstract：PURPOSE:α-Crystallins are small heat shock proteins that regulate cellular damage and cell survival. Expression of the proteins of the crystallin superfamily in the retina and their role in neuronal cell survival were investigated in two animal models of diabetes and retinal neurons in culture. METHODS:Crystallin expr...

journal_title：Investigative ophthalmology & visual science

authors： Losiewicz MK,Fort PE

更新日期：2011-08-24 00:00:00

abstract：PURPOSE:To characterize the chemokines and chemokine receptors that mediate the effect of proinflammatory cytokines, interleukin (IL)-1 and tumor necrosis factor (TNF)-alpha, on the recruitment of MHC class II(+) Langerhans cells (LCs) in the corneal epithelium. METHODS:A standard model for corneal LC recruitment, app...

journal_title：Investigative ophthalmology & visual science

authors： Yamagami S,Hamrah P,Miyamoto K,Miyazaki D,Dekaris I,Dawson T,Lu B,Gerard C,Dana MR

更新日期：2005-04-01 00:00:00

abstract：:Male albino rats, injected intravenously or intracerebroventricularly with delta 1-tetrahydrocannabinol (THC), develop mudriasis. The median effective dose of the intravenous administration group was 5 mg/kg THC, whereas that for the intracerebroventricular route was 150 microgram/kg THC. Sympathectomy significantly d...

journal_title：Investigative ophthalmology & visual science

authors： Korczyn AD,Eshel Y

更新日期：1982-03-01 00:00:00

abstract：PURPOSE:To determine factors affecting the disc-fovea angle (DFA), and to test the hypotheses that adjusting for DFA improves limits of retinal nerve fiber layer (RNFL) variability in normal subjects or enhances performance of RNFL measures for glaucoma detection. METHODS:Disc-fovea angle was measured on scanning lase...

journal_title：Investigative ophthalmology & visual science

authors： Amini N,Nowroozizadeh S,Cirineo N,Henry S,Chang T,Chou T,Coleman AL,Caprioli J,Nouri-Mahdavi K

更新日期：2014-10-09 00:00:00

abstract：PURPOSE:Müller glia play crucial roles in retinal homeostasis and function. Genetic modification of Müller cells by viral gene delivery would be valuable for studies of their normal physiology and roles in retinal disease states. However, stable and efficient transgene expression in Müller cells after delivery of gene ...

journal_title：Investigative ophthalmology & visual science

authors： Greenberg KP,Geller SF,Schaffer DV,Flannery JG

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:Neural ectopic rewiring in retinal degeneration such as retinitis pigmentosa (RP) may form functional synapses between cones and rod bipolar cells that cause atypical signal processing. In this study, the multifocal electroretinograms (mfERGs) of a large animal model of RP, the rhodopsin P347L transgenic (Tg) p...

journal_title：Investigative ophthalmology & visual science

authors： Ng YF,Chan HH,Chu PH,To CH,Gilger BC,Petters RM,Wong F

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:Strabismic amblyopia is typically associated with several visual deficits, including loss of contrast sensitivity in the amblyopic eye and abnormal binocular vision. Binocular summation ratios (BSRs) are usually assessed by comparing contrast sensitivity for binocular stimuli (sens(BIN)) with that measured in t...

journal_title：Investigative ophthalmology & visual science

authors： Baker DH,Meese TS,Mansouri B,Hess RF

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:We compared the anti-fibrotic effects of single versus multiple postoperative injections of saratin following glaucoma filtration surgery (GFS) in the rabbit model. METHODS:The experiment was in two parts. To determine the optimal frequency for postoperative therapy, seven New Zealand White (NZW) rabbits recei...

journal_title：Investigative ophthalmology & visual science

authors： Min J,Lukowski ZL,Levine MA,Meyers CA,Beattie AR,Schultz GS,Samuelson DA,Sherwood MB

更新日期：2012-11-19 00:00:00

abstract：PURPOSE:Since central corneal thickness may inversely influence the amount and rate of progression of glaucomatous optic nerve damage and because lamina cribrosa thickness may be of importance in susceptibility to glaucoma, it was the purpose of the present study to evaluate whether central corneal thickness is related...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Holbach L

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:To investigate spatial anisotropies in the peripheral visual field of axially myopic eyes, in an attempt to distinguish between models of isotropic and anisotropic ocular stretching. METHODS:Stimuli consisted of two high-contrast Gaussian patches presented in one of four orientations (90 degrees, 180 degrees, ...

journal_title：Investigative ophthalmology & visual science

authors： Vera-Diaz FA,McGraw PV,Strang NC,Whitaker D

更新日期：2005-02-01 00:00:00

abstract：:The predominant risk factor for the progression of glaucoma is an increase in IOP, mediated via a reduction in aqueous outflow through the conventional (trabecular meshwork and Schlemm's canal) outflow pathway. Current IOP lowering pharmacological strategies target the uveoscleral (nonconventional) outflow pathway or ...

journal_title：Investigative ophthalmology & visual science

authors： Cavet ME,Vittitow JL,Impagnatiello F,Ongini E,Bastia E

更新日期：2014-08-14 00:00:00

abstract：PURPOSE:To use a theoretical model of the observer on the Farnsworth-Munsell 100-hue test to estimate the magnitude of random variation in 100-Hue test error scores. METHODS:The model was based upon classical signal detection theory. Results from the model were obtained by computer simulation. RESULTS:There is a fair...

journal_title：Investigative ophthalmology & visual science

authors： Craven BJ

更新日期：1993-03-01 00:00:00