Expression of nitrotyrosine and oxidative consequences in the trabecular meshwork of patients with primary open-angle glaucoma.

abstract：PURPOSE:To characterize the pharmacology of the carbachol-induced changes of phospholipase C (PLC) activity and intracellular calcium concentration ([Ca2+]i) in cultured human ciliary muscle cells. METHODS:Changes in PLC activity of cultured human ciliary muscle cells were determined by production of inositol phosphat...

journal_title：Investigative ophthalmology & visual science

authors： Matsumoto S,Yorio T,DeSantis L,Pang IH

更新日期：1994-09-01 00:00:00

abstract：PURPOSE:To determine new referents, or cutoff levels for tear film hyperosmolarity in the diagnosis of keratoconjunctivitis sicca (KCS) and to assess their effectiveness in independent patient groups. METHOD:A meta-analysis was performed on published data for tear osmolarity in samples of normal eyes and various subty...

journal_title：Investigative ophthalmology & visual science

authors： Tomlinson A,Khanal S,Ramaesh K,Diaper C,McFadyen A

更新日期：2006-10-01 00:00:00

abstract：:Failure of corneal grafts is thought to involve the development and activation of specifically sensitized T-cells. One method which might be used to circumvent the development of such cells is the phenomenon of anterior chamber-associated immune deviation (ACAID). Injection of antigen into the anterior chamber of the ...

journal_title：Investigative ophthalmology & visual science

authors： She SC,Steahly LP,Moticka EJ

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:To study the distribution and predominant orientations of fibrillar collagen at different depths throughout the entire thickness of the human cornea. This information will form the basis of a full three-dimensional reconstruction of the preferred orientations of corneal lamellae. METHODS:Femtosecond laser tech...

journal_title：Investigative ophthalmology & visual science

authors： Abahussin M,Hayes S,Knox Cartwright NE,Kamma-Lorger CS,Khan Y,Marshall J,Meek KM

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To examine the extent to which the two major determinants of refractive error, corneal curvature and axial length, are scaled relative to one another by shared genetic variants, along with their relationship to the genetic scaling of height. METHODS:Corneal curvature, axial length, and height were measured in ...

journal_title：Investigative ophthalmology & visual science

authors： Guggenheim JA,Zhou X,Evans DM,Timpson NJ,McMahon G,Kemp JP,St Pourcain B,Northstone K,Ring SM,Fan Q,Wong TY,Cheng CY,Khor CC,Aung T,Saw SM,Williams C

更新日期：2013-03-07 00:00:00

abstract：PURPOSE:To investigate the mechanism of σ receptor 1 (σR1) neuroprotection in retinal neurons. METHODS:Oxidative stress, which is implicated in diabetic retinopathy, was induced in mouse primary ganglion cells (GCs) and RGC-5 cells, and the effect of the σR1 ligand (+)-pentazocine on pro- and anti-apoptotic and endopl...

journal_title：Investigative ophthalmology & visual science

authors： Ha Y,Dun Y,Thangaraju M,Duplantier J,Dong Z,Liu K,Ganapathy V,Smith SB

更新日期：2011-01-25 00:00:00

abstract：PURPOSE:To ascertain whether the corneal endothelium exhibits specific receptors for atrial natriuretic peptide (ANP) and to characterize partially any binding activity. METHODS:Most experiments employed radioligand-binding techniques to characterize 125I-ANP binding activity. Guanylate cyclase and corneal deturgescen...

journal_title：Investigative ophthalmology & visual science

authors： Walkenbach RJ,Ye GS,Korenfeld MS,Boney F

更新日期：1993-07-01 00:00:00

abstract：Purpose:To compare the visual field (VF) progression among high tension glaucoma (HTG), primary angle closure glaucoma (PACG), and normal tension glaucoma (NTG) subjects in routine clinical care. Methods:All patients had ≥5 VF tests using HFA, 24-2, SITA-standard strategy. We compared the progression between glaucoma ...

journal_title：Investigative ophthalmology & visual science

authors： Ballae Ganeshrao S,Senthil S,Choudhari N,Sri Durgam S,Garudadri CS

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:BM88 is a cell-cycle exit and neuronal differentiation protein that has been used as a marker of surviving retinal ganglion cells (RGCs) after optic nerve injury. Thy1.1 has also been used as a marker for RGC loss, but after optic nerve crush (ONC) a decrease in Thy1.1 expression precedes the loss of RGCs. The ...

journal_title：Investigative ophthalmology & visual science

authors： Siddiqui AM,Sabljic TF,Koeberle PD,Ball AK

更新日期：2014-03-28 00:00:00

abstract：PURPOSE:To study pathologic changes in the photoreceptors in eyes with idiopathic macular telangiectasia (MacTel) type 2 using adaptive optics scanning laser ophthalmoscopy (AO-SLO). METHODS:Thirteen eyes with nonproliferative MacTel type 2 and 10 normal eyes underwent a full ophthalmologic examination, spectral-domai...

journal_title：Investigative ophthalmology & visual science

authors： Ooto S,Hangai M,Takayama K,Arakawa N,Tsujikawa A,Koizumi H,Oshima S,Yoshimura N

更新日期：2011-07-25 00:00:00

abstract：PURPOSE:To assess the neuroprotective effects of different glutamate modulation strategies, with a nonselective (MK801) and a selective (ifenprodil) NMDA receptor antagonist and a metabotropic glutamate receptor agonist (mGluR Group II, LY354740), in glaucoma-related in vivo rat models of retinal ganglion cell (RGC) ap...

journal_title：Investigative ophthalmology & visual science

authors： Guo L,Salt TE,Maass A,Luong V,Moss SE,Fitzke FW,Cordeiro MF

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To identify pathogenic mutations in the guanylate cyclase-activating protein 1 (GCAP1) and GCAP2 genes and to characterize the biochemical effect of mutation on guanylate cyclase (GC) stimulation. METHODS:The GCAP1 and GCAP2 genes were screened by direct sequencing for mutations in 216 patients and 421 patient...

journal_title：Investigative ophthalmology & visual science

authors： Nishiguchi KM,Sokal I,Yang L,Roychowdhury N,Palczewski K,Berson EL,Dryja TP,Baehr W

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:Recent evidence suggests that platelets play a major role in ischemia-reperfusion injury, not only through thrombus formation but also through participation in inflammatory reactions with leukocytes. This study was designed to investigate the contribution of platelets in leukocyte recruitment to inflamed region...

journal_title：Investigative ophthalmology & visual science

authors： Nishijima K,Kiryu J,Tsujikawa A,Miyamoto K,Honjo M,Tanihara H,Nonaka A,Yamashiro K,Katsuta H,Miyahara S,Honda Y,Ogura Y

更新日期：2004-03-01 00:00:00

abstract：Purpose:Dense deposit disease (DDD) is caused by dysregulation of the alternative pathway of the complement cascade and characterized by electron-dense deposits in the kidney glomerular basement membrane (GBM) and drusen in Bruch's membrane (BrM). Complement factor H (fH) and factor properdin (fP) regulate complement a...

journal_title：Investigative ophthalmology & visual science

authors： Song D,Mohammed I,Bhuyan R,Miwa T,Williams AL,Gullipalli D,Sato S,Song Y,Dunaief JL,Song WC

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:To investigate whether myopia is present in a breed of domestic dog, the Labrador retriever, and how the ocular components are related to refractive error in this breed. METHODS:Cycloplegic refractive error was measured in 75 Labrador retrievers by retinoscopy. Corneal and crystalline lens radii of curvature w...

journal_title：Investigative ophthalmology & visual science

authors： Mutti DO,Zadnik K,Murphy CJ

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:To investigate the effects of retinoic acid, retinol, and 11-cis retinaldehyde on proliferation, differentiation, and survival of cultured embryonic chick neural retina cells; to describe the metabolic transformations of these retinoids by the cultured cells. METHODS:Retinoids were added to glia-free, low-dens...

journal_title：Investigative ophthalmology & visual science

authors： Stenkamp DL,Gregory JK,Adler R

更新日期：1993-07-01 00:00:00

abstract：:Previous investigations have shown that corneal epithelium, migrating to cover a wound, synthesizes protein and glycoprotein at a faster rate than does normal stratified epithelium. The authors have found that the maximal rate of synthesis, as indicated by the incorporation of leucine and glucosamine, occurs 16 hr aft...

journal_title：Investigative ophthalmology & visual science

authors： Zieske JD,Gipson IK

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:BetaIG-H3 is a TGF-beta-induced cell adhesion molecule, the mutations of which are responsible for a group of 5q31-linked corneal dystrophies. The characteristic findings in these diseases are accumulation of protein deposits of different ultrastructures. To understand the mechanisms of protein deposits in 5q31...

journal_title：Investigative ophthalmology & visual science

authors： Kim JE,Park RW,Choi JY,Bae YC,Kim KS,Joo CK,Kim IS

更新日期：2002-03-01 00:00:00

abstract：Purpose:To investigate the underlying mechanisms for how the mouse Cx50-R205G point mutation, a homologue of the human Cx50-R198W mutation that is linked to cataract-microcornea syndrome, affects proper lens growth and fiber cell differentiation to lead to severe lens phenotypes. Methods:EdU labeling, immunostaining, ...

journal_title：Investigative ophthalmology & visual science

authors： Tjahjono N,Xia CH,Li R,Chu S,Wang J,Gong X

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:To assess alterations in allergic ocular responses to nonparasite antigens in an experimental system in which mice were skewed toward a Th2 cytokine profile by helminth infection. METHODS:Mice were inoculated with Ascaris suum (A. suum) eggs concurrent with ragweed (RW) sensitization (RW/acute) or by repeated ...

journal_title：Investigative ophthalmology & visual science

authors： Schopf L,Luccioli S,Bundoc V,Justice P,Chan CC,Wetzel BJ,Norris HH,Urban JF Jr,Keane-Myers A

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:To isolate tissue-specific gene products that contribute to corneal integrity. METHODS:A cDNA library was constructed and differentially hybridized. Cornea-specific clones were purified and further characterized. RESULTS:In this study cornea-specific gene products were isolated by differential cDNA hybridizat...

journal_title：Investigative ophthalmology & visual science

authors： Peek R,van Gelderen BE,Bruinenberg M,Kijlstra A

更新日期：1998-09-01 00:00:00

abstract：:Determination of intraocular antibody synthesis against certain microorganisms is a diagnostic aid in identifying the causative agent in clinical uveitis. Little is known, however, concerning the kinetics and specificity of antibodies produced during intraocular inflammation. To investigate this subject we induced uve...

journal_title：Investigative ophthalmology & visual science

authors： van der Voet JC,Liem A,Otto AJ,Kijlstra A

更新日期：1989-02-01 00:00:00

abstract：PURPOSE:This retrospective observational study was designed to evaluate the frequency of, and the factors associated with, optic disc swelling in Vogt-Koyanagi-Harada disease (VKH). METHODS:A retrospective observational study was conducted. We analyzed 116 eyes of 58 patients with VKH. Demographic and clinical differe...

journal_title：Investigative ophthalmology & visual science

authors： Nakao K,Abematsu N,Mizushima Y,Sakamoto T

更新日期：2012-04-18 00:00:00

abstract：PURPOSE:To investigate the neural basis of contraction anisocoria and any implications for assessments using pupillary responses, through analysis of topographic variation in amplitudes of direct and consensual pupil responses. METHODS:Direct and consensual pupillary contraction amplitudes were analyzed from six studi...

journal_title：Investigative ophthalmology & visual science

authors： Carle CF,Maddess T,James AC

更新日期：2011-04-12 00:00:00

abstract：PURPOSE:To compare the ability of several machine learning classifiers to predict development of abnormal fields at follow-up in ocular hypertensive (OHT) eyes that had normal visual fields in baseline examination. METHODS:The visual fields of 114 eyes of 114 patients with OHT with four or more visual field tests with...

journal_title：Investigative ophthalmology & visual science

authors： Sample PA,Goldbaum MH,Chan K,Boden C,Lee TW,Vasile C,Boehm AG,Sejnowski T,Johnson CA,Weinreb RN

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:Intramuscular innervation of horizontal rectus extraocular muscles (EOMs) is segregated into superior and inferior (transverse) compartments, while all EOMs are also divided into global (GL) and orbital (OL) layers with scleral and pulley insertions, respectively. We sought evidence of potential independent act...

journal_title：Investigative ophthalmology & visual science

authors： Shin A,Yoo L,Chaudhuri Z,Demer JL

更新日期：2012-12-19 00:00:00

abstract：PURPOSE:The purposes of the present study were to assess the effect of a sympathetic inhibitory pharmacologic agent, timolol maleate, on the magnitude of nearwork-induced transient myopia (NITM) and its decay in different refractive groups for an extended near task duration and to determine the proportion of the young ...

journal_title：Investigative ophthalmology & visual science

authors： Vasudevan B,Ciuffreda KJ,Gilmartin B

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:The RAS association domain family 1 (RASSF1) gene is a tumor-suppressor gene located on chromosome 3p21.3. The alternative transcript (RASSF1a) has been shown to be inactivated by hypermethylation in several human malignancies, including breast, prostate, and lung cancer, and in cutaneous melanoma. The purpose ...

journal_title：Investigative ophthalmology & visual science

authors： Maat W,van der Velden PA,Out-Luiting C,Plug M,Dirks-Mulder A,Jager MJ,Gruis NA

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:To study heterogeneity for chromosome 3 copy number in mixed choroidal melanoma with discrete populations of spindle and epithelioid cells using chromosome in situ hybridization (CISH) and to correlate chromosomal loss with cell type. METHODS:Twenty-two archival cases of choroidal melanoma with discrete popula...

journal_title：Investigative ophthalmology & visual science

authors： Sandinha T,Farquharson M,McKay I,Roberts F

更新日期：2006-12-01 00:00:00

abstract：Purpose:To compare cross-sectional choroidal morphology in rhesus macaque and human eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) and histologic analysis. Methods:Enhanced-depth imaging-OCT images from 25 rhesus macaque and 30 human eyes were evaluated for choriocapillaris and choroidal-scle...

journal_title：Investigative ophthalmology & visual science

authors： Yiu G,Vuong VS,Oltjen S,Cunefare D,Farsiu S,Garzel L,Roberts J,Thomasy SM

更新日期：2016-10-01 00:00:00