Localization of substance P-like immunoreactivity within the monkey retina.

abstract：PURPOSE:To determine the influence of specific regions within Lp82 calpain on protein stability, enzymatic activity, and localization within lens and to test the influence of an Lp82 knockout mouse on normal maturational proteolysis in lens. METHODS:DNA constructs for Lp82 and Lp82-related proteins were subcloned into...

journal_title：Investigative ophthalmology & visual science

authors： Ma H,Shih M,Fukiage C,Azuma M,Duncan MK,Reed NA,Richard I,Beckmann JS,Shearer TR

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:To evaluate the effects of 5-fluorouracil (5-FU) on ocular cells in vitro and the effects of degradable 5-FU-loaded poly(DL-lactide-co-glycolide; PDLGA) 50:50 implant in the rabbit eye in vivo. METHODS:Cytotoxicity was assessed with a tetrazolium salt WST-1 cell proliferation/viability test and a lactate dehyd...

journal_title：Investigative ophthalmology & visual science

authors： Huhtala A,Rönkkö S,Teräsvirta M,Puustjärvi T,Sihvola R,Vehanen K,Laukkanen A,Anttila J,Urtti A,Pohjonen T,Uusitalo H

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Levels of some cytokines are significantly higher in the vitreous fluid of patients with acute uveitis than in normal vitreous fluid. The authors sought to determine which proinflammatory cytokines were upregulated in the vitreous fluid of patients with ocular sarcoidosis. METHODS:Samples of vitreous fluid wer...

journal_title：Investigative ophthalmology & visual science

authors： Nagata K,Maruyama K,Uno K,Shinomiya K,Yoneda K,Hamuro J,Sugita S,Yoshimura T,Sonoda KH,Mochizuki M,Kinoshita S

更新日期：2012-06-20 00:00:00

abstract：PURPOSE:Patients with sickle cell disease have elevated circulating levels of cytokines including tumor necrosis factor (TNF) alpha. TNF-alpha stimulates expression by endothelial cells of adhesion molecules, including vascular cell adhesion molecule (VCAM) 1. Others have demonstrated that VLA-4 (alpha(4)beta(1)), a li...

journal_title：Investigative ophthalmology & visual science

authors： Lutty GA,Taomoto M,Cao J,McLeod DS,Vanderslice P,McIntyre BW,Fabry ME,Nagel RL

更新日期：2001-05-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the impact of stanniocalcin-1 (STC-1), a photoreceptor-protective glycoprotein, on the development of choroidal neovascularization (CNV) in relation to VEGF and its main receptor (VEGFR2) expression after laser injury. Methods:In rats, CNV was induced by laser photo...

journal_title：Investigative ophthalmology & visual science

authors： Zhao M,Xie W,Tsai SH,Hein TW,Rocke BA,Kuo L,Rosa RH Jr

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To explore the effect of dominance and laterality on refractive error and axial length. METHODS:Ocular dominance was assessed with the hole-in-the-card test in 543 children during their 2006 follow-up visits for the Singapore Cohort study Of the Risk factors for Myopia (SCORM). Data were compared to cycloplegi...

journal_title：Investigative ophthalmology & visual science

authors： Chia A,Jaurigue A,Gazzard G,Wang Y,Tan D,Stone RA,Saw SM

更新日期：2007-08-01 00:00:00

abstract：:Experimental detachments were made in Dutch rabbit eyes by injecting autologous serum or Hanks' solution into the subretinal space through a glass micropipette. The serum was resorbed at a rate of 0.064 +/- 0.023 microliter/mm2/hr, which is approximately half as fast as Hanks' solution. Both cyclic GMP and dibutyryl c...

journal_title：Investigative ophthalmology & visual science

authors： Kawano S,Marmor MF

更新日期：1988-08-01 00:00:00

abstract：:Contrast sensitivity functions for sinusoidal gratings of different spatial frequencies and stimulus durations have been determined for both eyes of amblyopic subjects. For both long and short stimulus durations, the entire contrast sensitivity function of the amblyopic eyes is lower than that of the nonamblyopic eyes...

journal_title：Investigative ophthalmology & visual science

authors： Levi DM,Harwerth RS

更新日期：1977-01-01 00:00:00

abstract：PURPOSE:CD4(+)CD25(+)FoxP3(+) naturally occurring regulatory T cells (Tregs) maintain self-tolerance and function to suppress overly exuberant immune responses. However, it is unclear whether innate immune cells modulate Treg function. Here the authors examined the role of innate immunity in lymphomyeloid homeostasis. ...

journal_title：Investigative ophthalmology & visual science

authors： Mott KR,Gate D,Zandian M,Allen SJ,Rajasagi NK,van Rooijen N,Chen S,Arditi M,Rouse BT,Flavell RA,Town T,Ghiasi H

更新日期：2011-04-08 00:00:00

abstract：PURPOSE:To assess the mutation spectrum in the ABCR gene and clinical phenotypes in Italian families with autosomal recessive Stargardt disease (STGD1) and fundus flavimaculatus (FFM). METHODS:Eleven families from southern Italy, including 18 patients with diagnoses of STGD1, were clinically examined. Ophthalmologic e...

journal_title：Investigative ophthalmology & visual science

authors： Simonelli F,Testa F,de Crecchio G,Rinaldi E,Hutchinson A,Atkinson A,Dean M,D'Urso M,Allikmets R

更新日期：2000-03-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and d-ala2-methionine enkephalinamide (DALA, a long-lasting enkephalin analogue) were used to investigate the peptidergic control of lacrimal gland function. To characterize the mechanism by which VIP stimulates and DALA inhibits lacrimal peroxidase secretion, the effect of these pe...

journal_title：Investigative ophthalmology & visual science

authors： Cripps MM,Bennett DJ

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:To determine quantitatively forward light scattering in the human lens as a function of depth. To use this to explain the psychophysical result, verified earlier in vitro, showing total light scattering in the human lens to decrease with scattering angle according to an approximate power law (power -2). METHOD...

journal_title：Investigative ophthalmology & visual science

authors： van den Berg TJ

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:To compare different methods of glycerol-preserved corneas intended for deep anterior lamellar keratoplasty (DALK). METHODS:We analyzed transparency, transmittance, thickness, biomechanics, morphology, and antigenicity of donor corneas preserved by four different glycerol-based methods (n = 6 per group) for 3 ...

journal_title：Investigative ophthalmology & visual science

authors： Li J,Shi S,Zhang X,Ni S,Wang Y,Curcio CA,Chen W

更新日期：2012-08-17 00:00:00

abstract：PURPOSE:To assess the neuroprotective effects of different glutamate modulation strategies, with a nonselective (MK801) and a selective (ifenprodil) NMDA receptor antagonist and a metabotropic glutamate receptor agonist (mGluR Group II, LY354740), in glaucoma-related in vivo rat models of retinal ganglion cell (RGC) ap...

journal_title：Investigative ophthalmology & visual science

authors： Guo L,Salt TE,Maass A,Luong V,Moss SE,Fitzke FW,Cordeiro MF

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To study factors associated with choroidal thickness (CT) and to compare CT in angle closure (AC), open angle (OA), and normal eyes. METHODS:Forty controls, 106 OA, and 79 AC subjects underwent measurements of posterior CT by spectral domain-optical coherence tomography, and of intraocular pressure (IOP), bloo...

journal_title：Investigative ophthalmology & visual science

authors： Arora KS,Jefferys JL,Maul EA,Quigley HA

更新日期：2012-11-27 00:00:00

abstract：PURPOSE:The role of macular pigment (MP) in age-related maculopathy (ARM) is still not clearly understood. Recent studies have reported on variations in the spatial distribution of MP optical density (MPOD) including a secondary peak ("ring") in the slope of the MPOD profile. The authors investigated in a cross-section...

journal_title：Investigative ophthalmology & visual science

authors： Dietzel M,Zeimer M,Heimes B,Pauleikhoff D,Hense HW

更新日期：2011-10-11 00:00:00

abstract：PURPOSE:The purpose of this study was to examine the test-retest repeatability of microperimetric sensitivity at the border of deep scotomas. METHODS:Thirty normal participants underwent two examinations, each on the Macular Integrity Assessment (MAIA) microperimeter and on the MP-1 microperimeter (four examinations i...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Jung CJ,Ayton LN,Luu CD,Guymer RH

更新日期：2015-04-01 00:00:00

abstract：:PURPOSE. Mitochondrial function and the presence of somatic mitochondrial DNA (mtDNA) defects were investigated in extraocular muscles (EOMs) collected from individuals covering a wide age range, to document the changes seen with normal aging. METHODS. Cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histo...

journal_title：Investigative ophthalmology & visual science

authors： Yu-Wai-Man P,Lai-Cheong J,Borthwick GM,He L,Taylor GA,Greaves LC,Taylor RW,Griffiths PG,Turnbull DM

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To study the diameter response of retinal arterioles as a function of the arteriolar diameter. METHODS:Ten healthy young volunteers aged 22 to 33 years were subjected to diameter measurement of four successive segments of a retinal arteriole with a retinal vessel analyzer (RVA). At each of the segments, the di...

journal_title：Investigative ophthalmology & visual science

authors： Jeppesen P,Sanye-Hajari J,Bek T

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Evidence suggests that altered metabolism of amyloid precursor protein (APP) may play a role in the pathophysiology of retinal ganglion cell (RGC) death in the etiology of glaucoma. The authors sought to determine the distribution of APP and amyloid-beta (Abeta) in DBA/2J glaucomatous mouse retinas. METHODS:Th...

journal_title：Investigative ophthalmology & visual science

authors： Goldblum D,Kipfer-Kauer A,Sarra GM,Wolf S,Frueh BE

更新日期：2007-11-01 00:00:00

abstract：Purpose:Aging is a risk factor for dry eye disease. The aim of this study was to investigate if aging is associated with a range of signs of dry eye disease, including tear hyperosmolarity, reduced nerve density, and increased dendritic cell number, in mice. Method:Healthy C57BL/6 female mice, aged 2 months (young, n ...

journal_title：Investigative ophthalmology & visual science

authors： De Silva MEH,Hill LJ,Downie LE,Chinnery HR

更新日期：2019-06-03 00:00:00

abstract：Purpose:To determine if there is structural and functional recovery of the retina from light induced retinal degeneration, and to evaluate the role of the oxidative stress response elements Nrf2, SOD1, DJ-1, and Parkin in such a recovery process. Methods:Eyes from C57BL/6J (B6J) mice and from oxidative stress response...

journal_title：Investigative ophthalmology & visual science

authors： Chen B,Aredo B,Zhu Y,Ding Y,Xin-Zhao C,Ufret-Vincenty RL

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To determine whether tonometric readings of increases in intraocular pressure (IOP) during the water-drinking test (WDT) are affected by variations in central corneal thickness (CCT) induced by photorefractive keratectomy (PRK). METHODS:Data from 30 randomly selected eyes of 30 patients (18 men and 12 women; m...

journal_title：Investigative ophthalmology & visual science

authors： Tamburrelli C,Giudiceandrea A,Vaiano AS,Caputo CG,Gullà F,Salgarello T

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To determine the prevalence and incidence of epiretinal membranes (ERM) in eyes with inactive extramacular cytomegalovirus (CMV) retinitis in patients with acquired immune deficiency syndrome (AIDS). METHODS:A case-control report from a longitudinal multicenter observational study by the Studies of the Ocular ...

journal_title：Investigative ophthalmology & visual science

authors： Kozak I,Vaidya V,Van Natta ML,Pak JW,May KP,Thorne JE,Studies of the Ocular Complications of AIDS Research Group.

更新日期：2014-06-12 00:00:00

abstract：:We investigated the possibility that the spatial imprecision of amblyopic eyes can be accounted for by the relative insensitivity to contrast that has been documented for these eyes. Thresholds for the discrimination of spatial misalignment, a measure of spatial uncertainty, were determined for three amblyopes and one...

journal_title：Investigative ophthalmology & visual science

authors： Barbeito R,Bedell HE,Flom MC

更新日期：1988-02-01 00:00:00

abstract：Purpose:Evidence from animals and blind humans suggests that early visual experience influences the developmental calibration of auditory localization. Hypothesizing that unilateral amblyopia may involve cross-modal deficits in spatial hearing, we measured the precision and accuracy of sound localization in humans with...

journal_title：Investigative ophthalmology & visual science

authors： Richards MD,Goltz HC,Wong AMF

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To explore the role in the eye of tenomodulin (TeM), a chondromodulin (ChM)-I-related glycoprotein, the expression, localization, and antiangiogenic potential of TeM were investigated. METHODS:Gene expression and protein localization of TeM in mouse eyes were examined by Northern blot analysis, in situ hybridi...

journal_title：Investigative ophthalmology & visual science

authors： Oshima Y,Shukunami C,Honda J,Nishida K,Tashiro F,Miyazaki J,Hiraki Y,Tano Y

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:Orbital eye position and vestibular sensitivity have both been postulated to influence vestibulo-ocular reflex (VOR) axis direction. The interaction of these factors in unilateral vestibular deafferentation (UVD) was examined. METHODS:Initial VOR direction and magnitude were examined in six normal human subjec...

journal_title：Investigative ophthalmology & visual science

authors： Crane BT,Tian J,Ishiyama A,Demer JL

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:To examine changes in spherical equivalent over a 5-year period in persons 43 to 84 years of age. METHODS:All people 43 to 84 years of age and living in Beaver Dam, Wisconsin, in 1988 were invited for a baseline examination (1988-1990) and a 5-year follow-up examination (1993-1995). Refractions were determined...

journal_title：Investigative ophthalmology & visual science

authors： Lee KE,Klein BE,Klein R

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Retinal basement membranes (BMs) serve as attachment sites for retinal pigment epithelial cells on Bruch's membrane and Müller cells (MCs) on the inner limiting membrane (ILM), providing polarity cues to adherent cells. The beta2 and gamma3 chains of laminin are key components of retinal BMs throughout developm...

journal_title：Investigative ophthalmology & visual science

authors： Pinzón-Duarte G,Daly G,Li YN,Koch M,Brunken WJ

更新日期：2010-03-01 00:00:00