Comparison of risk factors for bilateral and unilateral eye involvement in normal-tension glaucoma.

abstract：PURPOSE:Trabecular meshwork (TM) cells appear to sense changes in intraocular pressure (IOP) as mechanical stretching. In response, they make homeostatic corrections in the aqueous humor outflow resistance, partially by increasing extracellular matrix (ECM) turnover initiated by the matrix metalloproteinases. To unders...

journal_title：Investigative ophthalmology & visual science

authors： Vittal V,Rose A,Gregory KE,Kelley MJ,Acott TS

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:To define rod and cone function further in terms of visual cycle mechanism, the retinal phenotype resulting from Rpe65 (retinoid isomerase I) deficiency in Nrl(-)(/)(-) mice having a single class of photoreceptors resembling wild-type cones was characterized and outcomes of retinoid supplementation evaluated. ...

journal_title：Investigative ophthalmology & visual science

authors： Feathers KL,Lyubarsky AL,Khan NW,Teofilo K,Swaroop A,Williams DS,Pugh EN Jr,Thompson DA

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:We evaluated the roles of tumor necrosis factor (TNF)-α in alkali-induced corneal neovascularization (CNV). METHODS:CNV was induced by alkali injury and compared in wild-type (WT) BALB/c mice, and TNF receptor 1-deficient (TNF-Rp55 KO) counterparts, or in mice treated with TNF-α antagonist and recombinant TNF-...

journal_title：Investigative ophthalmology & visual science

authors： Lu P,Li L,Liu G,Baba T,Ishida Y,Nosaka M,Kondo T,Zhang X,Mukaida N

更新日期：2012-06-14 00:00:00

abstract：PURPOSE:To assess cross-sectional and longitudinal associations between exposure to Chlamydia pneumoniae infection and age-related macular degeneration (AMD) in the nested case-control sample drawn from the Blue Mountains Eye Study (BMES) cohort. METHODS:The BMES examined 3654 persons aged 49 to 97 years during 1992 t...

journal_title：Investigative ophthalmology & visual science

authors： Robman L,Mahdi OS,Wang JJ,Burlutsky G,Mitchell P,Byrne G,Guymer R,Taylor H

更新日期：2007-09-01 00:00:00

abstract：Purpose:To develop and use a custom virtual fields method (VFM) to assess the biomechanical properties of human prelamina and lamina cribrosa (LC) in vivo. Methods:Clinical data of 20 healthy, 20 ocular hypertensive (OHT), 20 primary open-angle glaucoma, and 16 primary angle-closure glaucoma eyes were analyzed. For ea...

journal_title：Investigative ophthalmology & visual science

authors： Zhang L,Beotra MR,Baskaran M,Tun TA,Wang X,Perera SA,Strouthidis NG,Aung T,Boote C,Girard MJA

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:To examine whether Na(+)-K(+)-2Cl(-) cotransport has the potential to contribute to corneal endothelial ion and fluid transport in cultured and fresh bovine corneal endothelial cells. METHODS:Cl- and Na+ sensitive fluorescent dyes were used to measure furosemide-dependent ion fluxes in cultured and fresh endot...

journal_title：Investigative ophthalmology & visual science

authors： Jelamskii S,Sun XC,Herse P,Bonanno JA

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:The iron carrier transferrin is expressed at remarkably high levels in normal retinas and is upregulated during retinal degeneration. The authors characterized the consequences of genetically reduced retinal transferrin production on retinal structure and function. METHODS:Hypotransferrinemic (HPX⁻/⁻) mice tre...

journal_title：Investigative ophthalmology & visual science

authors： Lederman M,Obolensky A,Grunin M,Banin E,Chowers I

更新日期：2012-02-02 00:00:00

abstract：:Substance P (SP)--like immunoreactivity has been localized to distinct retinal cell populations in the primate Macaca nemestrina by means of immunohistochemical techniques with a well-characterized monoclonal antiserum directed to SP. The specificity of the immunoreactive staining was established by absorption of the ...

journal_title：Investigative ophthalmology & visual science

authors： Brecha N,Hendrickson A,Florén I,Karten HJ

更新日期：1982-08-01 00:00:00

abstract：:We present results from 64 glaucoma patients and glaucoma suspects followed up for a median period of 7.4 yr who had a median of seven examinations using Program 31 on the Octopus perimeter. The patients also had manual visual fields recorded on either the Tübinger or Goldmann perimeter during the same period. By exam...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Drance SM,Douglas GR

更新日期：1990-03-01 00:00:00

abstract：PURPOSE:To determine, with the use of optical coherence tomography (OCT), the peripapillary retinal nerve fiber layer (RNFL) thickness among patients with retinitis pigmentosa (RP) of different degrees of disease severity. METHODS:One eye in each of 25 RP patients was included. All patients underwent complete ocular e...

journal_title：Investigative ophthalmology & visual science

authors： Walia S,Fishman GA,Edward DP,Lindeman M

更新日期：2007-10-01 00:00:00

abstract：Purpose:To model the sensitivity of the optic nerve head (ONH) biomechanical environment to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery blood pressure (BP). Methods:We extended a previously published numerical model of the ONH to include 24 factors representing tissue anato...

journal_title：Investigative ophthalmology & visual science

authors： Hua Y,Voorhees AP,Sigal IA

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To investigate the foveal changes after repair of macula-off rhegmatogenous retinal detachment (RRD). METHODS:Prospective comparative case series. Twenty-four eyes of 24 patients with macula-off/fovea-on detachment (n = 9) and fovea-off detachment (n = 15) were studied. Serial optical coherence tomography (OCT...

journal_title：Investigative ophthalmology & visual science

authors： dell'Omo R,Viggiano D,Giorgio D,Filippelli M,Di Iorio R,Calo' R,Cardone M,Rinaldi M,dell'Omo E,Costagliola C

更新日期：2015-01-22 00:00:00

abstract：PURPOSE:Peripheral and limbal corneal stromal cells (PLCSCs), which contain keratocytes, have a complex phenotype. Knowledge of keratocyte cell properties, function, and origin is limited. Evidence available thus far has suggested both mesenchymal stromal and hematopoietic characteristics. Multipotent mesenchymal strom...

journal_title：Investigative ophthalmology & visual science

authors： Branch MJ,Hashmani K,Dhillon P,Jones DR,Dua HS,Hopkinson A

更新日期：2012-08-03 00:00:00

abstract：:The corneas of 12 eye donors with maturity-onset diabetes were obtained, and the corneal epithelial basement membranes were studied by transmission electron microscopy. Similar tissue was obtained from 12 nondiabetic eye donors who were matched for age (within 2 years) and race. The mean thickness of the corneal epith...

journal_title：Investigative ophthalmology & visual science

authors： Taylor HR,Kimsey RA

更新日期：1981-04-01 00:00:00

abstract：:The effect of prostaglandin (PG) F2 alpha-isopropyl ester (IE), PGA2, or PGA2-IE on intraocular pressure (IOP) was tested in eight cynomolgus monkey eyes with argon laser-induced glaucoma. Dose-response testing and baseline IOP measurements were done. For multiple dose testing, 5 micrograms in 25 microliters (0.02%) o...

journal_title：Investigative ophthalmology & visual science

authors： Wang RF,Camras CB,Lee PY,Podos SM,Bito LZ

更新日期：1990-11-01 00:00:00

abstract：:The ocular toxicity of liposome-intercalated amphotericin B and commercial amphotericin B were compared after intravitreal injection in healthy pigmented rabbits. Ophthalmoscopic observations over 5 weeks following a single intravitreal injection showed vitreal band formation and focal retinal damage after doses of co...

journal_title：Investigative ophthalmology & visual science

authors： Tremblay C,Barza M,Szoka F,Lahav M,Baum J

更新日期：1985-05-01 00:00:00

abstract：PURPOSE:Interphotoreceptor retinoid-binding protein (IRBP) binds and transports retinoids and fatty acids in the interphotoreceptor space (IPS). To understand the relationship between the protein structure and its functions requires bulk quantities of human IRBP. The authors sought to produce recombinant human IRBP (rh...

journal_title：Investigative ophthalmology & visual science

authors： Lin ZY,Si JS,Nickerson JM

更新日期：1994-09-01 00:00:00

abstract：PURPOSE:To compare accommodative facility in eyes with myopia to that in eyes with emmetropia or hyperopia and to determine whether accommodative facility can be used to predict an association with myopia. METHODS:In the Sydney Myopia Study, year-1 school children (6.7 +/- 0.4 years) were assessed for accommodative fa...

journal_title：Investigative ophthalmology & visual science

authors： Pandian A,Sankaridurg PR,Naduvilath T,O'Leary D,Sweeney DF,Rose K,Mitchell P

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:To assess the variability in choroidal laser Doppler flowmetry (LDF). METHODS:Five measurements of choroidal blood flow were obtained on 5 days in both eyes of 10 subjects. Reliability, sensitivity, and sample size calculations were performed. Yield, the intensity of the returning light (direct current [DC]) d...

journal_title：Investigative ophthalmology & visual science

authors： Gugleta K,Orgül S,Flammer I,Gherghel D,Flammer J

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:To identify proteinases and growth factors abnormally expressed in human corneas of donors with diabetic retinopathy (DR), additional to previously described matrix metalloproteinase (MMP)-10 and -3 and insulin-like growth factor (IGF)-I. METHODS:RNA was isolated from 35 normal, diabetic, and DR autopsy human ...

journal_title：Investigative ophthalmology & visual science

authors： Saghizadeh M,Kramerov AA,Tajbakhsh J,Aoki AM,Wang C,Chai NN,Ljubimova JY,Sasaki T,Sosne G,Carlson MR,Nelson SF,Ljubimov AV

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To determine whether a novel peroxynitrite-based photosensitizer S-nitrosoglutathione (GSNO) can produce specific in vitro light-induced cell death of both standard animal lung and human Tenon's capsule (TC) fibroblasts and to compare this effect with that produced by the established photodynamic porphyrin prec...

journal_title：Investigative ophthalmology & visual science

authors： Tannous M,Hutnik CM,Tingey DP,Mutus B

更新日期：2000-03-01 00:00:00

abstract：:Cataracts in cultured rabbit lenses were produced by elevation of internal calcium. Experimental procedures were successful in increasing levels of total and bound Ca++, often without significant changes in sodium, potassium, or water content. Although the excess in calcium was predominantly associated with water-solu...

journal_title：Investigative ophthalmology & visual science

authors： Hightower KR,Reddy VN

更新日期：1982-02-01 00:00:00

abstract：PURPOSE:To compare the diagnostic ability of the new spectral-domain optical coherence tomography (SD-OCT) algorithm for measuring circumpapillary retinal nerve fiber layer (RNFL) thickness centered on Bruch's membrane opening (BMO), with the conventional circumpapillary RNFL thickness measurement centered on the optic...

journal_title：Investigative ophthalmology & visual science

authors： Lee EJ,Lee KM,Kim H,Kim TW

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To test the hypothesis that subnormal retinal oxygenation response (DeltaPo2) found at 3 months of experimental diabetes is associated with cellular swelling and increased retinal thickness. METHODS:Two groups of animals were studied: control rats injected intraperitoneally with either 15% body weight of salin...

journal_title：Investigative ophthalmology & visual science

authors： Luan H,Roberts R,Sniegowski M,Goebel DJ,Berkowitz BA

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Environmental tobacco smoke (ETS) is widely regarded as a major modifiable risk factor for age-related macular degeneration (AMD). Yet, precisely how it exerts its pathologic effects is poorly understood. Since early-stage AMD is characterized by choroidal capillary loss, this study examined the effect of sides...

journal_title：Investigative ophthalmology & visual science

authors： Yang X,Scott HA,Ardekani S,Williams M,Talbot P,Ghosh K

更新日期：2014-04-08 00:00:00

abstract：PURPOSE:Autophagy is a lysosomal machinery-dependent process that catabolizes cellular components/organelles and proteins in an autophagic vacuole (AV)-dependent and -independent manner, respectively. Short-term exposure of the retina to bright light results in shortening of the outer segments, concomitant with AV form...

journal_title：Investigative ophthalmology & visual science

authors： Kunchithapautham K,Coughlin B,Lemasters JJ,Rohrer B

更新日期：2011-05-05 00:00:00

abstract：PURPOSE:To study the spatial distribution of posterior pole choroidal thickness (CT) in healthy eyes using spectral domain optical coherence tomography (SD-OCT). METHODS:Fifty-nine eyes from 30 subjects with no retinal or choroidal disease were examined with high-definition (HD) OCT using macular volume cube scanning ...

journal_title：Investigative ophthalmology & visual science

authors： Ouyang Y,Heussen FM,Mokwa N,Walsh AC,Durbin MK,Keane PA,Sanchez PJ,Ruiz-Garcia H,Sadda SR

更新日期：2011-09-01 00:00:00

abstract：:The autofluorescence of reduced pyridine nucleotides (NADH and NADPH) and oxidized flavoproteins within the rabbit cornea were noninvasively measured as a function of depth. This was accomplished by combining a corneal specular microscope with a time-shared spectrofluorometer. When either 8 mM sodium pentobarbital or ...

journal_title：Investigative ophthalmology & visual science

authors： Laing RA,Fischbarg J,Chance B

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:To evaluate quantitatively the relationship between the displacement of anterior visual pathway structures by pituitary tumors and visual field damage with the goal of improving diagnosis and management. METHODS:Subjects had pituitary macroadenomas and both magnetic resonance imaging (MRI) and static perimetry...

journal_title：Investigative ophthalmology & visual science

authors： Boland MV,Lee IH,Zan E,Yousem DM,Miller NR

更新日期：2016-07-01 00:00:00

abstract：Purpose:The lysozyme 2 (Lyz2 or LysM) cre mouse is extensively used to achieve genetic manipulation in myeloid cells and it has been widely employed in retinal research. However, LysM has been recently described to be expressed in brain neurons and there is a debate on whether it is also expressed by resident microglia...

journal_title：Investigative ophthalmology & visual science

authors： Fouda AY,Xu Z,Narayanan SP,Caldwell RW,Caldwell RB

更新日期：2020-03-09 00:00:00