Reduced toxicity of liposome-associated amphotericin B injected intravitreally in rabbits.

abstract：PURPOSE:To assess the safety of a possible substitute treatment for intraocular steroid injections, intraocular injections of ketorolac tromethamine, one of the nonsteroidal anti-inflammatory drugs, were performed in rabbits. METHODS:Either 0.5% or 0.25% preservative-free ketorolac tromethamine ophthalmic solution (0....

journal_title：Investigative ophthalmology & visual science

authors： Margalit E,Kugler LJ,Brumm MV,Meza JL,Kompella UB,Escobar ER,Christensen GR

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:To assess the postural stability and gait characteristics of adults with age-related maculopathy (ARM) and to identify the visual factors associated with postural stability and gait in this clinical population. METHODS:Participants included 80 individuals with a range of severity of ARM (mean age, 77.2 years)....

journal_title：Investigative ophthalmology & visual science

authors： Wood JM,Lacherez PF,Black AA,Cole MH,Boon MY,Kerr GK

更新日期：2009-01-01 00:00:00

abstract：:Lymphocyte cultures were employed to assess the degree of spontaneous and induced chromosomal fragility in retinoblastoma. Sister chromatid exchange (SCEs) were scored in metaphases. Three unilateral, three bilateral, eleven family members and controls were studied. Retinoblastoma (RB) lymphocytes did not exhibit incr...

journal_title：Investigative ophthalmology & visual science

authors： Abramovsky-Kaplan I,Jones IS

更新日期：1984-06-01 00:00:00

abstract：PURPOSE:Submucosal fibrosis due to excessive accumulation of collagens is an important histologic feature in the pathogenesis of ocular cicatricial pemphigoid (OCP). Heat shock protein 47 (HSP47), a collagen-binding protein, plays an important role in the biosynthesis of procollagens. In the present study, we examined ...

journal_title：Investigative ophthalmology & visual science

authors： Razzaque MS,Foster CS,Ahmed AR

更新日期：2003-04-01 00:00:00

abstract：:We have investigated alterations of the metabolic state in vitamin A-deficient (A-) corneas using phosphorus-31 (31P) nuclear magnetic resonance (NMR) spectroscopy. Comparing to the control, A- corneas showed a prominent rise of phosphocreatine (PCr) as well as a total loss of glycerophosphorylcholine (GPC). Further, ...

journal_title：Investigative ophthalmology & visual science

authors： Hayashi K,Cheng HM,Xiong J,Xiong H,Kenyon KR

更新日期：1989-04-01 00:00:00

abstract：:We describe a new technique for the separation and isolation of nonpigmented ciliary body epithelial cells from rabbit. Excised ciliary body is incubated in a medium buffered with EGTA to a free-Ca2+ concentration of 10(-8) M, and the nonpigmented cell layer is separated from the pigmented layer by microdissection und...

journal_title：Investigative ophthalmology & visual science

authors： Fain GL,Cilluffo MC,Fain MJ,Lee DA

更新日期：1988-05-01 00:00:00

abstract：PURPOSE:To determine the interaction of M3 muscarinic receptors (M3AChR) and P2X(7) receptors to increase intracellular [Ca2+] ([Ca2+]i) and stimulate protein secretion in rat lacrimal gland cells. METHODS:Exorbital lacrimal glands from male Sprague-Dawley rats were divided into pieces or digested with collagenase to ...

journal_title：Investigative ophthalmology & visual science

authors： Dartt DA,Hodges RR

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To understand the involvement of the CYP1B1 gene in cases of primary open-angle (POAG) and primary angle-closure (PACG) glaucomas and obtain the haplotype background of these mutations. METHODS:The entire coding region of CYP1B1 was screened by resequencing in 224 unrelated cases of POAG (n = 134) and PACG (n ...

journal_title：Investigative ophthalmology & visual science

authors： Chakrabarti S,Devi KR,Komatireddy S,Kaur K,Parikh RS,Mandal AK,Chandrasekhar G,Thomas R

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:To determine whether messenger RNA coding for fibroblast growth factor receptor-1, interleukin-1 receptor, and glucocorticoid receptor messenger RNA are produced in human lacrimal tissue. METHODS:Total cellular RNA was isolated from three specimens of normal human lacrimal tissue and complementary DNA was synt...

journal_title：Investigative ophthalmology & visual science

authors： Wilson SE,Lloyd SA,Kennedy RH

更新日期：1993-05-01 00:00:00

abstract：PURPOSE:To determine whether the size and configuration of the optic chiasm in humans with albinism is different from that in normal control subjects. METHODS:Seventeen patients and 15 control subjects underwent magnetic resonance imaging of the entire head. Images were reformatted to the chiasm region and analyzed wi...

journal_title：Investigative ophthalmology & visual science

authors： Schmitz B,Schaefer T,Krick CM,Reith W,Backens M,Käsmann-Kellner B

更新日期：2003-01-01 00:00:00

abstract：:The profound visual deficits associated with early monocular form deprivation (MD) are caused largely by competitive binocular interactions in the visual cortex. We tested the hypothesis that disrupting normal cortical binocularity prior to the onset of MD would reduce the degree of form deprivation amblyopia compared...

journal_title：Investigative ophthalmology & visual science

authors： Smith EL 3rd,Harwerth RS,Siderov J,Wingard M,Crawford ML,von Noorden GK

更新日期：1992-04-01 00:00:00

abstract：PURPOSE:To investigate the pharmacologic effect of tetramethylpyrazine (TMP) on human Tenon's fibroblasts (HTFs), the cells implicated in scarring after filtration surgery. METHODS:Transforming growth factor-β2 (TGF-β2) was used to stimulate a fibrotic phenotype in primary HTFs, and the influence of TMP on the fibroti...

journal_title：Investigative ophthalmology & visual science

authors： Cai X,Yang Y,Chen P,Ye Y,Liu X,Wu K,Yu M

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:A subset of patients with anterior uveitis express the marker, perinuclear anti-neutrophil cytoplasmic antibody (pANCA). In this study, recombinantly isolated pANCA monoclonal antibodies were used to search for ocular cells expressing the pANCA antigen. METHODS:Paraffin sections of human ocular tissues obtaine...

journal_title：Investigative ophthalmology & visual science

authors： Gordon LK,Eggena M,Targan SR,Braun J

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:To improve the 30-year-old "trypsin digestion" procedure for isolation of the complete retinal vasculature, which, in its time, was a revolutionary advance that allowed important discoveries about diabetic retinopathy; to provide a method that will yield more consistent results when applied to retinas represent...

journal_title：Investigative ophthalmology & visual science

authors： Laver NM,Robison WG Jr,Pfeffer BA

更新日期：1993-05-01 00:00:00

abstract：Purpose:To evaluate the relationship between retinal vascular caliber and AMD in patients with AIDS. Methods:Participants enrolled in the Longitudinal Study of the Ocular Complications of AIDS had retinal photographs taken at enrollment. Retinal vascular caliber (central retinal artery equivalent [CRAE] and central re...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Van Natta ML,Pak JW,Danis RP,Hunt PW

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To determine the usefulness of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing dexamethasone in delayed adjustable strabismus surgery. METHODS:A prospective, masked-observer, controlled study was performed in rabbits. Fifty-two rabbit eyes were divided into three groups. After ...

journal_title：Investigative ophthalmology & visual science

authors： Jee JP,Choung HK,Kim CK,Hwang JM

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:This study evaluated the level of histamine in the interaction between the environment and the visual system during lifespan development, exploring potential sex differences. METHODS:Male and female Wistar rats, reared in standard laboratory or enriched-environment cages from birth to prepuberty or adulthood, ...

journal_title：Investigative ophthalmology & visual science

authors： Bessinis DP,Dalla C,Daifoti ZP,Tiligada E

更新日期：2012-11-01 00:00:00

abstract：:To compare the effects on the postnatal development of the eye of both total and partial form deprivation in diurnally reared chicks and of dark-rearing, chicks were reared with occluders covering one eye from hatching for up to 6 weeks. In diurnally reared birds, both total and partial form deprivation resulted in se...

journal_title：Investigative ophthalmology & visual science

authors： Gottlieb MD,Fugate-Wentzek LA,Wallman J

更新日期：1987-08-01 00:00:00

abstract：:Overall corneal hydration control expressed as the percent recovery per hour (PRPH) can be assessed with an exponential model that uses data derived from two kinds of corneal thickness measurements; one from monitoring recovery after inducing corneal swelling, and the other from measurements made after the eye has bee...

journal_title：Investigative ophthalmology & visual science

authors： Cohen SR,Polse KA,Brand RJ,Mandell RB

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:In ischemic proliferative retinopathies, Müller glial cells (MGCs) acquire migratory abilities. However, the mechanisms that regulate this migration remain poorly understood. In addition, proliferative disorders associated with enhanced activities of matrix metalloproteinases (MMPs) also involve insulin-like gr...

journal_title：Investigative ophthalmology & visual science

authors： Lorenc VE,Jaldín-Fincati JR,Luna JD,Chiabrando GA,Sánchez MC

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Lens epithelial tissue does not normally express major histocompatibility complex (MHC) class I molecules. In addition, the mechanism of self-tolerance to intraocular antigens is unknown. To study the effect of class I expression in the lens, transgenic mice were produced that express an allo-MHC class I molecu...

journal_title：Investigative ophthalmology & visual science

authors： Martin WD,Egan RM,Stevens JL,Woodward JG

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:To investigate the effect of corneal trauma on gene expression in the lacrimal gland and to assess how many genes and what specific genes are regulated in response to corneal trauma. METHODS:A mouse model with acute corneal trauma was created with a chemical burn to the cornea with silver nitrate. Sixty-four f...

journal_title：Investigative ophthalmology & visual science

authors： Fang Y,Choi D,Searles RP,Mathers WD

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:The structure of collagen lamellae in the anterior stroma of the human cornea is thought to be an important determinant of corneal rigidity. The three-dimensional structure of such collagen lamellae in normal human corneas was examined. METHODS:The anterior portion of 27 normal human corneas was obtained from ...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Takagi Y,Chikama T,Takahara A,Nishida T

更新日期：2011-02-16 00:00:00

abstract：PURPOSE:To assess the repeatability and reproducibility of central corneal thickness (CCT) measurements obtained by combined scanning-slit/Placido-disc topography (Orbscan II; Bausch & Lomb, Rochester, NY) after laser in situ keratomileusis (LASIK) and to compare the results with another noncontact method, specular mic...

journal_title：Investigative ophthalmology & visual science

authors： Maldonado MJ,López-Miguel A,Nieto JC,Cano-Parra J,Calvo B,Alió JL

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:To develop a novel in vitro model to study the formation of Staphylococcus epidermidis biofilm on intraocular lenses (IOLs) from the primary-attachment phase to the biofilm-accumulation phase. The model was designed to replicate intraocular conditions especially by taking into account intraocular hydrodynamics....

journal_title：Investigative ophthalmology & visual science

authors： Baillif S,Casoli E,Marion K,Roques C,Pellon G,Hartmann DJ,Freney J,Burillon C,Kodjikian L

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:To investigate the neural basis of contraction anisocoria and any implications for assessments using pupillary responses, through analysis of topographic variation in amplitudes of direct and consensual pupil responses. METHODS:Direct and consensual pupillary contraction amplitudes were analyzed from six studi...

journal_title：Investigative ophthalmology & visual science

authors： Carle CF,Maddess T,James AC

更新日期：2011-04-12 00:00:00

abstract：PURPOSE:To present a new method of performing scanning laser ophthalmoscope perimetry that compensates for eye movements so that the correct retinal location is tested even if fixation changes. This allows for accurate testing of patients with central scotomas and for repeating testing longitudinally at the same retina...

journal_title：Investigative ophthalmology & visual science

authors： Sunness JS,Schuchard RA,Shen N,Rubin GS,Dagnelie G,Haselwood DM

更新日期：1995-08-01 00:00:00

abstract：:Ocular adenoviral infections occur worldwide, and currently, there is no ocular animal model for evaluating new antivirals or studying pathogenesis. With a paired-eye design, an ocular model was developed in 32 New Zealand rabbits following topical and intrastromal inoculation with a clinical isolate of adenovirus typ...

journal_title：Investigative ophthalmology & visual science

authors： Gordon YJ,Romanowski E,Araullo-Cruz T

更新日期：1992-03-01 00:00:00

abstract：Purpose:The purpose of this study was to study the effect of minocycline and several neurotrophic factors, alone or in combination, on photoreceptor survival and macro/microglial reactivity in two rat models of retinal degeneration. Methods:P23H-1 (rhodopsin mutation), Royal College of Surgeon (RCS, pigment epithelium...

journal_title：Investigative ophthalmology & visual science

authors： Di Pierdomenico J,Scholz R,Valiente-Soriano FJ,Sánchez-Migallón MC,Vidal-Sanz M,Langmann T,Agudo-Barriuso M,García-Ayuso D,Villegas-Pérez MP

更新日期：2018-09-04 00:00:00

abstract：PURPOSE:To test the effect of valacyclovir alone and with aspirin on the asymptomatic shedding of HSV-1 DNA in tears and saliva of healthy individuals. METHOD. The subjects (n = 45) were randomized into three groups without regard to age, sex, or race. Group 1 (n = 14) received the placebo, group 2 (n = 15) received a ...

journal_title：Investigative ophthalmology & visual science

authors： Kumar M,Hill JM,Clement C,Varnell ED,Thompson HW,Kaufman HE

更新日期：2009-12-01 00:00:00