Fibroblast growth factor receptor-1, interleukin-1 receptor, and glucocorticoid receptor messenger RNA production in the human lacrimal gland.

abstract：PURPOSE:To unravel the molecular genetic background in families with congenital cataract in association with microcornea (CCMC, OMIM 116150). METHODS:CCMC families were recruited from a national database on hereditary eye diseases; DNA was procured from a national gene bank on hereditary eye diseases and by blood samp...

journal_title：Investigative ophthalmology & visual science

authors： Hansen L,Yao W,Eiberg H,Kjaer KW,Baggesen K,Hejtmancik JF,Rosenberg T

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To determine the role of polyphosphate kinase 1 (PPK1) in the ocular virulence of Pseudomonas aeruginosa. METHODS:Using a mouse model of infection, P. aeruginosa strains PAO1, PAOM5 (an isogenic mutant of PAO1 deficient in PPK1), and PAOM5+PPK1 (the mutant complemented with PPK1 on plasmid pHEPAK11) were compa...

journal_title：Investigative ophthalmology & visual science

authors： Parks QM,Hobden JA

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To determine quantitatively forward light scattering in the human lens as a function of depth. To use this to explain the psychophysical result, verified earlier in vitro, showing total light scattering in the human lens to decrease with scattering angle according to an approximate power law (power -2). METHOD...

journal_title：Investigative ophthalmology & visual science

authors： van den Berg TJ

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:National programs for trachoma control are implementing mass treatment programs in which azithromycin is used as part of the control strategy. Dose is determined by weight, which can be difficult to determine in field conditions. The purposes of this study were to determine whether an accurate dose could be det...

journal_title：Investigative ophthalmology & visual science

authors： Muñoz B,Solomon AW,Zingeser J,Barwick R,Burton M,Bailey R,Mabey D,Foster A,West SK

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:We assessed the association between complement pathway genes and age-related macular degeneration (AMD) in a Chinese population. METHODS:In a case-control study, 165 AMD patients and 216 unrelated controls were recruited from two hospitals in central China. We selected and genotyped six single nucleotide poly...

journal_title：Investigative ophthalmology & visual science

authors： Wu L,Tao Q,Chen W,Wang Z,Song Y,Sheng S,Li P,Zhou J

更新日期：2013-01-07 00:00:00

abstract：Purpose:Pituitary adenylate cyclase activating polypeptide (PACAP) is neuroprotective in neuronal injuries. Bilateral common carotid artery occlusion (BCCAO) causes chronic hypoperfusion-induced degeneration in the rat retina, where we proved the retinoprotective effect of intravitreal PACAP. Although this route of adm...

journal_title：Investigative ophthalmology & visual science

authors： Werling D,Reglodi D,Banks WA,Salameh TS,Kovacs K,Kvarik T,Vaczy A,Kovacs L,Mayer F,Danyadi B,Lokos E,Tamas A,Toth G,Biro Z,Atlasz T

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:To determine whether integrin-linked kinase (ILK) controls the organization of the actin cytoskeleton in the trabecular meshwork (TM) by regulating integrin co-signaling. METHODS:The cell binding domain and the Heparin II (Hep II) domain of fibronectin were used to activate α5β1 and α4β1 integrin signaling, re...

journal_title：Investigative ophthalmology & visual science

authors： Faralli JA,Newman JR,Sheibani N,Dedhar S,Peters DM

更新日期：2011-03-25 00:00:00

abstract：PURPOSE:To assess the repeatability and reproducibility of central corneal thickness (CCT) measurements obtained by combined scanning-slit/Placido-disc topography (Orbscan II; Bausch & Lomb, Rochester, NY) after laser in situ keratomileusis (LASIK) and to compare the results with another noncontact method, specular mic...

journal_title：Investigative ophthalmology & visual science

authors： Maldonado MJ,López-Miguel A,Nieto JC,Cano-Parra J,Calvo B,Alió JL

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:To determine whether gene expression changes occur in the trabecular meshwork (TM) of cow eyes with steroid-induced intraocular pressure (IOP) elevation. METHODS:Adult female Braford cows (n = 4) were subjected to uniocular prednisolone acetate treatment for 6 weeks. IOP was monitored with an applanation tonom...

journal_title：Investigative ophthalmology & visual science

authors： Danias J,Gerometta R,Ge Y,Ren L,Panagis L,Mittag TW,Candia OA,Podos SM

更新日期：2011-11-07 00:00:00

abstract：:The impact of aging on cell loss in the human retina was examined in foveal and temporal equatorial regions in eyes from 35 donors with ages spanning a 78-yr period from the second to the ninth decade of life. Equatorial cones and retinal pigment epithelial cells (RPE) decreased at uniform rates from the second to the...

journal_title：Investigative ophthalmology & visual science

authors： Gao H,Hollyfield JG

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Videokeratography is a powerful tool for the diagnosis of corneal shape abnormalities. However, interpretation of the topographic map is sometimes difficult, especially when pathologies with similar topographic patterns are suspected. The neural networks model, an artificial intelligence approach, was applied f...

journal_title：Investigative ophthalmology & visual science

authors： Maeda N,Klyce SD,Smolek MK

更新日期：1995-06-01 00:00:00

abstract：PURPOSE:Pterygia are common, frequently recurring ocular surface lesions characterized by tissue remodeling, cellular proliferation, angiogenesis, and inflammation. The increased incidence of pterygia in persons exposed to excessive solar radiation suggests that ultraviolet (UV) light may play a critical role in the pa...

journal_title：Investigative ophthalmology & visual science

authors： Di Girolamo N,Coroneo MT,Wakefield D

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:It is known that the pattern electroretinogram (PERG) of normal subjects is reduced temporarily after short-term elevation of intraocular pressure (IOP). The authors evaluated PERG changes in ocular hypertension during and after transient IOP elevation. METHODS:Steady state (8 Hz) PERGs to sinusoidal gratings ...

journal_title：Investigative ophthalmology & visual science

authors： Colotto A,Falsini B,Salgarello T,Buzzonetti L,Cermola S,Porrello G

更新日期：1996-12-01 00:00:00

abstract：:Light and electron microscopic studies were done on 11 cynomolgus monkey eyes which had undergone total iris removal followed by surgical disinsertion of the ciliary muscle from the scleral spur 4.7 to 14.4 months earlier. Anterior chamber perfusion to measure gross outflow facility had been performed one to nine time...

journal_title：Investigative ophthalmology & visual science

authors： Lütjen-Drecoll E,Kaufman PL,Bárány EH

更新日期：1977-03-01 00:00:00

abstract：PURPOSE:Transgenic mice were developed that express tetracycline-controlled transactivator 1 (tTA1) specifically in photoreceptor cells. In these mice the transcription of the gene of interest can be easily inactivated in the retina in a short time frame. METHODS:A construct was prepared containing tTA1 under control ...

journal_title：Investigative ophthalmology & visual science

authors： Angeletti B,Löster J,Auricchio A,Gekeler F,Shinoda K,Ballabio A,Graw J,Marigo V

更新日期：2003-02-01 00:00:00

abstract：Purpose:To identify the role of the BBSome protein Bardet-Biedl syndrome 5 (BBS5) in photoreceptor function, protein trafficking, and structure using a congenital mutant mouse model. Methods:Bbs5-/- mice (2 and 9 months old) were used to assess retinal function and morphology. Hematoxylin and eosin staining of retinal...

journal_title：Investigative ophthalmology & visual science

authors： Bales KL,Bentley MR,Croyle MJ,Kesterson RA,Yoder BK,Gross AK

更新日期：2020-08-03 00:00:00

abstract：PURPOSE:The purpose of this study was to examine the relationship between objectively measured ambient light exposure and longitudinal changes in axial eye growth in childhood. METHODS:A total of 101 children (41 myopes and 60 nonmyopes), 10 to 15 years of age participated in this prospective longitudinal observationa...

journal_title：Investigative ophthalmology & visual science

authors： Read SA,Collins MJ,Vincent SJ

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Lectin studies have shown that in the rabbit corneal epithelium, alpha-2,3 sialylation of O-linked glycans differentiates limbal and corneal epithelial cell phenotypes. Because sialic acid can be regulated at the level of the expression of sialyltransferases (STs), the purpose of the present study was to analyz...

journal_title：Investigative ophthalmology & visual science

authors： Matic M,Petrov I,Stegman Z,Buku A,Wolosin JM

更新日期：1998-05-01 00:00:00

abstract：:Gamma-interferon (G-IFN) exhibits antiproliferative effects, inhibits collagen synthesis by fibroblasts, and may help to regulate the turnover of fibrous tissue. Fibroblasts from Tenon's capsule are cellular components that contribute to unsuccessful glaucoma filtration surgery. Therefore, the authors studied the effe...

journal_title：Investigative ophthalmology & visual science

authors： Latina MA,Belmonte SJ,Park C,Crean E

更新日期：1991-09-01 00:00:00

abstract：PURPOSE:To study pathologic changes in the photoreceptors in eyes with idiopathic macular telangiectasia (MacTel) type 2 using adaptive optics scanning laser ophthalmoscopy (AO-SLO). METHODS:Thirteen eyes with nonproliferative MacTel type 2 and 10 normal eyes underwent a full ophthalmologic examination, spectral-domai...

journal_title：Investigative ophthalmology & visual science

authors： Ooto S,Hangai M,Takayama K,Arakawa N,Tsujikawa A,Koizumi H,Oshima S,Yoshimura N

更新日期：2011-07-25 00:00:00

abstract：PURPOSE:Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the PAR1 receptor. The authors recently showed that parstatin is a potent inhibitor of angiogenesis. The purpose of the present study was to evaluate the therapeutic effect of parstatin on ocular neovascularization. METHODS:Choroidal...

journal_title：Investigative ophthalmology & visual science

authors： Huang H,Vasilakis P,Zhong X,Shen JK,Geronatsiou K,Papadaki H,Maragoudakis ME,Gartaganis SP,Vinores SA,Tsopanoglou NE

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:Lens epithelial cells transdifferentiate to myofibroblasts during the formation of anterior subcapsular cataracts and secondary cataracts. One of the defining characteristics of myofibroblasts is the expression of alpha-smooth muscle actin (alpha-SMA). This study investigated some of the factors that influence ...

journal_title：Investigative ophthalmology & visual science

authors： Nagamoto T,Eguchi G,Beebe DC

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:Recoverin has been identified as a target autoantigen for antirecoverin antibodies found in the sera of some patients with cancer-associated retinopathy. The aim of this study was to investigate the role of antirecoverin antibodies in cancer-associated retinopathy. METHODS:Human, rat, and rabbit antirecoverin ...

journal_title：Investigative ophthalmology & visual science

authors： Adamus G,Machnicki M,Seigel GM

更新日期：1997-02-01 00:00:00

abstract：PURPOSE:To determine the influence of specific regions within Lp82 calpain on protein stability, enzymatic activity, and localization within lens and to test the influence of an Lp82 knockout mouse on normal maturational proteolysis in lens. METHODS:DNA constructs for Lp82 and Lp82-related proteins were subcloned into...

journal_title：Investigative ophthalmology & visual science

authors： Ma H,Shih M,Fukiage C,Azuma M,Duncan MK,Reed NA,Richard I,Beckmann JS,Shearer TR

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to characterize a Krt12-Cre knock-in mouse line for corneal epithelium-specific gene ablation and to analyze the allelic selection of the keratin 12 (Krt12) gene during corneal type-epithelium differentiation. METHODS:Knock-in mice were generated by gene targeting. The authors exa...

journal_title：Investigative ophthalmology & visual science

authors： Hayashi Y,Call MK,Liu CY,Hayashi M,Babcock G,Ohashi Y,Kao WW

更新日期：2010-09-01 00:00:00

abstract：Purpose:To compare static rod function obtained with and without photobleach in control and intermediate age-related macular degeneration (iAMD) participants with and without subretinal drusenoid deposits (SDD). Methods:In this cross-sectional study, retinal sensitivities within the central 24° retina were obtained tw...

journal_title：Investigative ophthalmology & visual science

authors： Tan R,Guymer RH,Luu CD

更新日期：2018-08-01 00:00:00

abstract：:Gross correlation coefficient between light-scattering intensity and the optical parameters obtained for 48 sections of eight lenses with nuclear cataracts were evaluated. On the basis of these and other data in the literature, the structural elements, within the lens fiber are identified. These give rise to the optic...

journal_title：Investigative ophthalmology & visual science

authors： Bettelheim FA,Siew EL,Chylack LT Jr

更新日期：1981-03-01 00:00:00

abstract：PURPOSE:Strabismic amblyopia is typically associated with several visual deficits, including loss of contrast sensitivity in the amblyopic eye and abnormal binocular vision. Binocular summation ratios (BSRs) are usually assessed by comparing contrast sensitivity for binocular stimuli (sens(BIN)) with that measured in t...

journal_title：Investigative ophthalmology & visual science

authors： Baker DH,Meese TS,Mansouri B,Hess RF

更新日期：2007-11-01 00:00:00

abstract：Purpose:Melanopsin expressing intrinsically photosensitive retinal ganglion cells (ipRGC) input to multiple brain regions including those for pupil control, circadian rhythms, sleep and mood regulation. Here we measured ipRGC function and its relationship to sleep quality and depression in patients with advanced AMD. ...

journal_title：Investigative ophthalmology & visual science

authors： Maynard ML,Zele AJ,Kwan AS,Feigl B

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:Clonidine and brimonidine, two alpha-2 agonists, have been shown to reduce intraocular pressure (IOP) in patients with glaucoma. Little is known, however, about the exact role of alpha receptors in the control of ocular blood flow in the posterior pole of the eye. Hence, the study was conducted to investigate t...

journal_title：Investigative ophthalmology & visual science

authors： Weigert G,Resch H,Garhofer G,Fuchsjäger-Mayrl G,Schmetterer L

更新日期：2007-09-01 00:00:00