当前位置： SCI文献检索 > INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE期刊下所有文献 > Functional changes in the retina during and after acute intraocular pressure elevation in mice.

Functional changes in the retina during and after acute intraocular pressure elevation in mice.

Abstract：

PURPOSE:To examine retinal function using the full-field electroretinogram (ERG) during and after acute intraocular pressure (IOP) elevation in wild-type mice. METHODS:IOP was elevated by anterior chamber cannulation in wild-type C57/BL6 mice. The pressure-function relationship was determined by IOP elevation in steps from baseline to 80 mm Hg. The rate of functional recovery was assessed for 60 minutes after an IOP spike of 50 mm Hg for 30 minutes. During and immediately after IOP elevation, scotopic ERG signals were recorded in response to dim and bright flashes (-4.54, -2.23, and 0.34 log cd x s x m(-2)) and analyzed for photoreceptoral (a-wave), ON-bipolar (b-wave), oscillatory potentials (OPs), and scotopic threshold responses (positive [p]STR/negative [n] STR). A full ERG protocol was collected 2 days before and 7 days after the single 50-mm Hg IOP spike. RESULTS:The pSTR was most sensitive to IOP elevation with 50% amplitude loss (mu) at 41 mm Hg (mu, 95% confidence limits (CL): 37.7, 45.6) followed by nSTR at 45 mm Hg (95% CL: 41.0, 49.1). pSTR was significantly more sensitive than the b-wave (95% CL: 41.4, 49.1), a-wave (95% CL: 47.6, 55.3), and OPs (95% CL: 49.6, 59.2). pSTR showed slower recovery immediately after the 50 mm Hg spike compared with the b-wave (P = 0.02). One week after the 50-mm Hg spike, pSTR (-30% +/- 6%, P < 0.001) and OP (-27% +/- 2%, P < 0.001) amplitudes were reduced, whereas other components were unaffected. CONCLUSIONS:The STR in mice is more sensitive to acute IOP elevation and recovers slower than other ERG components. Reduction in pSTR and OP amplitude at 1 week suggests persistent impairment of inner retinal function can occur after a single IOP spike.

journal_name

Invest Ophthalmol Vis Sci

journal_title

Investigative ophthalmology & visual science

authors

Kong YX,Crowston JG,Vingrys AJ,Trounce IA,Bui VB

doi

10.1167/iovs.09-3814

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

5732-40

issue

12

eissn

0146-0404

issn

1552-5783

pii

iovs.09-3814

journal_volume

50

pub_type

杂志文章

相关文献

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE文献大全
  • Effect of intravitreal injection of high-dose bevacizumab in monkey eyes.

    abstract：PURPOSE:To evaluate the ocular complications of intravitreal injection of high dose bevacizumab in monkey eyes. METHODS:Four healthy monkeys (Macaca fuscata) received an intravitreal injection of either 6.25 or 12.5 mg bevacizumab in the right eye; the left control eye received an intravitreal injection of the same vo...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.07-1542

    authors： Sakurai K,Akiyama H,Shimoda Y,Yoshida I,Kurabayashi M,Kishi S

    更新日期：2009-10-01 00:00:00

  • Effect of aniseikonia on binocular function.

    abstract：:The pattern reversal visual evoked response (VER) was recorded under conditions of artificially unbalanced visual input between two eyes, an aniseikonia induced by size lenses that alter the perceived retinal image size without changing refraction. At 3.0% aniseikonia binocular summation started to decrease, and at 5....

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Katsumi O,Tanino T,Hirose T

    更新日期：1986-04-01 00:00:00

  • In vitro and in vivo susceptibility of Candida keratitis to topical polyenes.

    abstract：:The susceptibility of Candida albicans to topical amphotericin B and natamycin was evaluated in a model of stromal keratitis in Dutch-belted rabbits and compared with minimal inhibitory concentrations in vitro. Treatment was delayed 24 hr to allow invasive disease to occur and was then continued for 5 days. Ten strain...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： O'Day DM,Ray WA,Robinson RD,Head WS,Savage AM

    更新日期：1987-05-01 00:00:00

  • IOP-Lowering Effect of ONO-9054, A Novel Dual Agonist of Prostanoid EP3 and FP Receptors, in Monkeys.

    abstract：PURPOSE:The purpose of this study was to determine whether a better IOP reduction can be observed in conscious, normotensive monkeys treated with ONO-9054, a novel dual EP3 and FP receptor agonist, compared with prostaglandin F2α analogs. METHODS:The binding affinities and agonistic activities of ONO-AG-367, a carboxy...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.14-16181

    authors： Yamane S,Karakawa T,Nakayama S,Nagai K,Moriyuki K,Neki S,Suto F,Kambe T,Hirota Y,Kawabata K

    更新日期：2015-04-01 00:00:00

  • Choroidal blood flow and progression of age-related macular degeneration in the fellow eye in patients with unilateral choroidal neovascularization.

    abstract：PURPOSE:Cardiovascular risk factors such as smoking, hypertension, and atherosclerosis seem to play an important role in the development of choroidal neovascularization (CNV). Recent studies have also provided evidence suggesting that choroidal and retinal blood flow is decreased in patients with AMD. On the basis of t...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.09-4968

    authors： Boltz A,Luksch A,Wimpissinger B,Maar N,Weigert G,Frantal S,Brannath W,Garhöfer G,Ergun E,Stur M,Schmetterer L

    更新日期：2010-08-01 00:00:00

  • Influences of chorion type on saccadic eye movements in twins.

    abstract：PURPOSE:The influence of genetic and prenatal environmental factors on characteristics of saccadic performance were evaluated in young monozygotic (MZ) twins (8-19 years old) of known chorion type. METHODS:Saccadic eye movements were recorded using an infrared system. Saccadic latency, accuracy, and parameters of ampl...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Blekher T,Christian JC,Abel LA,Yee RD

    更新日期：1998-10-01 00:00:00

  • Survey of common eye diseases in laboratory mouse strains.

    abstract：PURPOSE:As in human populations, in which founder mutations have been identified in groups of families, a number of founder mutations have been observed across strains in mice. In this report, we provide a phenotype and genotype survey of three common eye diseases in the collection of JAX mice strains at The Jackson La...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.13-12289

    authors： Chang B,Hurd R,Wang J,Nishina P

    更新日期：2013-07-24 00:00:00

  • How useful is population data for informing visual field progression rate estimation?

    abstract：PURPOSE:Bayesian estimators allow the frequency of visual field progression rates in the population (the prior distribution) to constrain rate estimates for individuals. We examined the benefits of a prior distribution accounting for one of progression's major risk factors--whether intraocular pressure is treated--to g...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.13-11668

    authors： Anderson AJ,Johnson CA

    更新日期：2013-03-01 00:00:00

  • Inhibition of RAP1 enhances corneal recovery following alkali injury.

    abstract：PURPOSE:Recently, RAP1 (Telomeric Repeat Binding Factor 2, Interacting Protein [TERF2IP]) was discovered as a modulator that selectively regulates nuclear factor light chain kappa enhancer of activated B cells (NFκB) signaling. The roles of RAP1 in regulation of inflammation and angiogenesis for corneal recovery follow...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.14-15268

    authors： Poon MW,Yan L,Jiang D,Qin P,Tse HF,Wong IY,Wong DS,Tergaonkar V,Lian Q

    更新日期：2015-01-08 00:00:00

  • Dysregulated Tear Fluid Nociception-Associated Factors, Corneal Dendritic Cell Density, and Vitamin D Levels in Evaporative Dry Eye.

    abstract：Purpose:The purpose of this study was to study the status and association among tear-soluble factors, corneal dendritic cell density, vitamin D, and signs and symptoms in dry eye disease (DED). Methods:A total of 33 control subjects and 47 evaporative dry eye patients were included in the study. DED diagnosis and clas...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.19-26914

    authors： Khamar P,Nair AP,Shetty R,Vaidya T,Subramani M,Ponnalagu M,Dhamodaran K,D'souza S,Ghosh A,Pahuja N,Deshmukh R,Ahuja P,Sainani K,Nuijts RMMA,Das D,Ghosh A,Sethu S

    更新日期：2019-06-03 00:00:00

  • Feasibility of microelectrode array (MEA) based on silicone-polyimide hybrid for retina prosthesis.

    abstract：PURPOSE:To adopt micropatterning technology in manufacturing silicone elastomer-based microelectrode arrays for retinal stimulation, a silicone-polyimide hybrid microelectrode array was proposed and tested in vivo. METHODS:Gold microelectrodes were created by semiconductor manufacturing technology based on polyimide a...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.08-2500

    authors： Kim ET,Kim C,Lee SW,Seo JM,Chung H,Kim SJ

    更新日期：2009-09-01 00:00:00

  • Lenses of diabetic patients "yellow" at an accelerated rate similar to older normals.

    abstract：:The authors used a psychophysical method to measure lens transmission of young, type I diabetic patients and normal controls. The results from normal controls agreed with previously published reports of decreasing lens transmission with age, and those from diabetic subjects suggested that lenses of young, type I diabe...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Lutze M,Bresnick GH

    更新日期：1991-01-01 00:00:00

  • Lactoferrin Concentration in Human Tears and Ocular Diseases: A Meta-Analysis.

    abstract：Purpose:To evaluate the potential of lactoferrin (Lf) as a diagnostic biomarker for ocular diseases using a meta-analytic approach. Methods:All original studies reporting an estimate of the average Lf concentration in healthy subjects and those affected by ocular diseases were searched up to March 2020. The DerSimonia...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.61.12.9

    authors： Ponzini E,Scotti L,Grandori R,Tavazzi S,Zambon A

    更新日期：2020-10-01 00:00:00

  • Integrin alphavbeta5 participates in the binding of photoreceptor rod outer segments during phagocytosis by cultured human retinal pigment epithelium.

    abstract：PURPOSE:To examine the expression of integrin vitronectin receptors (integrins alphavbeta3 and alphavbeta5) in native human fetal retinal pigment epithelium (RPE) and cultured hunman fetal RPE and to examine the role of RPE VnRs in the phagocytosis of photoreceptor rod outer segments (ROS). METHODS:Monoclonal antibodi...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Lin H,Clegg DO

    更新日期：1998-08-01 00:00:00

  • Detection of glaucoma progression by assessment of segmented macular thickness data obtained using spectral domain optical coherence tomography.

    abstract：PURPOSE:We evaluated the clinical use of segmented macular layer thickness measurement in terms of glaucoma diagnosis and the ability to detect progression, and to compare such outcomes to those by circumpapillary retinal nerve fiber layer (cRNFLT) and total macular thickness (TMT) measurements. METHODS:The study incl...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-9369

    authors： Na JH,Sung KR,Baek S,Kim YJ,Durbin MK,Lee HJ,Kim HK,Sohn YH

    更新日期：2012-06-20 00:00:00

  • Enzymatic degradation identifies components responsible for the structural properties of the vitreous body.

    abstract：PURPOSE:Vitreous degeneration contributes to several age-related eye diseases, including retinal detachment, macular hole, macular traction syndrome, and nuclear cataracts. Remarkably little is understood about the molecular interactions responsible for maintaining vitreous structure. The purpose of this study was to m...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.13-13026

    authors： Filas BA,Zhang Q,Okamoto RJ,Shui YB,Beebe DC

    更新日期：2014-01-03 00:00:00

  • Relative axial myopia in Egr-1 (ZENK) knockout mice.

    abstract：PURPOSE:Experiments in chickens have implicated the transcription factor ZENK (also known as Egr-1, NGFI-A, zif268, tis8, cef5, and Krox24) in the feedback mechanisms for visual control of axial eye growth and myopia development. ZENK is upregulated in retinal glucagon amacrine cells when axial eye growth is inhibited ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.06-0851

    authors： Schippert R,Burkhardt E,Feldkaemper M,Schaeffel F

    更新日期：2007-01-01 00:00:00

  • The decline in attentional visual fields over time among older participants in the Salisbury Eye Evaluation Driving Study.

    abstract：PURPOSE:The loss of attentional visual field (AVF) has been linked to poor mobility and car crashes. We investigated the risk factors associated with a decrease in AVF over time among participants in the Salisbury Eye Evaluation Driving Study (SEEDS). METHODS:In a longitudinal cohort of 968 individuals ages 67 to 87, ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-8874

    authors： Rao P,Munoz B,Turano K,Munro C,West SK

    更新日期：2013-03-13 00:00:00

  • Direct injection of liposome-encapsulated doxorubicin optimizes chemomyectomy in rabbit eyelid.

    abstract：PURPOSE:Doxorubicin chemomyectomy presently represents the only permanent, nonsurgical treatment for blepharospasm and hemifacial spasm. The major deterrent to an otherwise extremely effective treatment protocol is the development in patients of localized inflammation, discomfort, and skin injury over the injection sit...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： McLoon LK,Wirtschafter JD

    更新日期：1999-10-01 00:00:00

  • Fundus autofluorescence in patients with leber congenital amaurosis.

    abstract：PURPOSE:Fundus autofluorescence (FAF), as an index of lipofuscin accumulation in the retinal pigment epithelium (RPE), provides indirect information on the level of metabolic activity of the RPE and thus the integrity of the RPE/photoreceptor complex. To investigate whether the photoreceptor/RPE complex is still viable...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.03-1208

    authors： Scholl HP,Chong NH,Robson AG,Holder GE,Moore AT,Bird AC

    更新日期：2004-08-01 00:00:00

  • Estimation of the relative amount of hemoglobin in the cup and neuroretinal rim using stereoscopic color fundus images.

    abstract：PURPOSE:To calculate the relative amount of hemoglobin (Hb) in sectors of the optic nerve head (ONH) from stereoscopic color fundus images using the Laguna ONhE method and compare the results with the visual field evaluation and optical coherence tomography (OCT). METHODS:Healthy eyes (n = 87) and glaucoma eyes (n = 7...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.14-15592

    authors： Pena-Betancor C,Gonzalez-Hernandez M,Fumero-Batista F,Sigut J,Medina-Mesa E,Alayon S,Gonzalez de la Rosa M

    更新日期：2015-02-10 00:00:00

  • Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16.

    abstract：PURPOSE:How vitamin A contributes to the maintenance of the wet-surfaced phenotype at the ocular surface is not well understood. This study sought to identify vitamin A-responsive genes in ocular surface epithelia using gene microarray analysis of cultures of a human conjunctival epithelial (HCjE) cell line grown with ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.05-0627

    authors： Hori Y,Spurr-Michaud SJ,Russo CL,Argüeso P,Gipson IK

    更新日期：2005-11-01 00:00:00

  • Gene expression profiling of purified rat retinal ganglion cells.

    abstract：PURPOSE:The phenotype of specialized cells arises, in part, from their characteristic gene expression patterns. Retinal ganglion cells (RGCs) are of wide interest in neuroscience and die in glaucoma and other optic neuropathies. In this study the genes expressed by RGCs were profiled by expressed sequence tag (EST) ana...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.03-1391

    authors： Farkas RH,Qian J,Goldberg JL,Quigley HA,Zack DJ

    更新日期：2004-08-01 00:00:00

  • Characterization of retinoblastoma immune complexes.

    abstract：:Immune complexes from retinoblastoma sera were characterized with molecular sieve chromatography, affinity chromatography, and polyacrylamide gel electrophoresis (PAGE). Retinoblastoma patients' sera had two well-defined peaks of immune complex activity after molecular sieve chromatography. These protein fractions had...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Stein PC,Christensen M,Char DH

    更新日期：1980-03-01 00:00:00

  • The benign concentric annular macular dystrophy locus maps to 6p12.3-q16.

    abstract：PURPOSE:To describe the clinical findings and to identify the genetic locus in a Dutch family with autosomal dominant benign concentric annular macular dystrophy (BCAMD). METHODS:All family members underwent ophthalmic examination. Linkage analysis of candidate retinal dystrophy loci and a whole genome scan were perfo...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.03-0392

    authors： van Lith-Verhoeven JJ,Hoyng CB,van den Helm B,Deutman AF,Brink HM,Kemperman MH,de Jong WH,Kremer H,Cremers FP

    更新日期：2004-01-01 00:00:00

  • Noninvasive Assessment of Corneal Crosslinking With Phase-Decorrelation Optical Coherence Tomography.

    abstract：Purpose:There is strong evidence that abnormalities in corneal biomechanical play a causal role in corneal ectasias, such as keratoconus. Additionally, corneal crosslinking (CXL) treatment, which halts progression of keratoconus, directly appeals to corneal biomechanics. However, existing methods of corneal biomechanic...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.18-25535

    authors： Blackburn BJ,Gu S,Ford MR,de Stefano V,Jenkins MW,Dupps WJ Jr,Rollins AM

    更新日期：2019-01-02 00:00:00

  • Objective signs of photoreceptor displacement by binocular correspondence perimetry: a study of epiretinal membranes.

    abstract：PURPOSE:To describe a method for quantitative mapping of metamorphopsia and abnormalities of oculocentric direction in subjects with epiretinal membranes. METHODS:Binocular correspondence perimetry was performed using red and green dichoptic stimuli applied in a rectangular grid pattern. The study included 9 healthy s...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.04-0952

    authors： Krøyer K,Jensen OM,Larsen M

    更新日期：2005-03-01 00:00:00

  • TSHR Signaling Stimulates Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid Eye Disease Orbital Fibroblasts.

    abstract：Purpose:To investigate the molecular pathways that drive thyroid stimulating hormone receptor (TSHR)-induced cellular proliferation in orbital fibroblasts (OFs) from thyroid eye disease (TED) patients. Methods:Orbital fibroblasts from TED and non-TED patients were treated with TSH and changes in gene expression and pr...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.19-27865

    authors： Woeller CF,Roztocil E,Hammond C,Feldon SE

    更新日期：2019-10-01 00:00:00

  • Cone degeneration following rod ablation in a reversible model of retinal degeneration.

    abstract：PURPOSE:Amphibian retinas regenerate after injury, making them ideal for studying the mechanisms of retinal regeneration, but this leaves their value as models of retinal degeneration in question. The authors asked whether the initial cellular changes after rod loss in the regenerative model Xenopus laevis mimic those ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.10-5347

    authors： Choi RY,Engbretson GA,Solessio EC,Jones GA,Coughlin A,Aleksic I,Zuber ME

    更新日期：2011-01-21 00:00:00

  • Discovery of a Cynomolgus Monkey Family With Retinitis Pigmentosa.

    abstract：Purpose:To accelerate the development of new therapies, an inherited retinal degeneration model in a nonhuman primate would be useful to confirm the efficacy in preclinical studies. In this study, we describe the discovery of retinitis pigmentosa in a cynomolgus monkey (Macaca fascicularis) pedigree. Methods:First, sc...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.17-22958

    authors： Ikeda Y,Nishiguchi KM,Miya F,Shimozawa N,Funatsu J,Nakatake S,Fujiwara K,Tachibana T,Murakami Y,Hisatomi T,Yoshida S,Yasutomi Y,Tsunoda T,Nakazawa T,Ishibashi T,Sonoda KH

    更新日期：2018-02-01 00:00:00