Individualized compensation of anterior segment birefringence during scanning laser polarimetry.

abstract：PURPOSE:To determine whether blur adaptation influences blur sensitivity and blur discrimination thresholds in young adult myopes and emmetropes. In addition, to determine whether there is a differential effect of blur adaptation on blur sensitivity and discrimination between refractive error groups. METHODS:Proximal ...

journal_title：Investigative ophthalmology & visual science

authors： Cufflin MP,Mankowska A,Mallen EA

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:Endothelin (ET)-1 is known to inhibit active NaK transport by as much as 50% in kidney tubule and other tissues. The presence of low levels of ET-1 in aqueous humor combined with the potential for release of ET-1 from ciliary processes suggests that the lens could be exposed to ET-1 in vivo. In this study, expe...

journal_title：Investigative ophthalmology & visual science

authors： Okafor MC,Delamere NA

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:The ultrastructure of tight junctions in the corneal endothelium has been studied extensively, yet little is known about their molecular composition. Junctional adhesion molecule-A (JAM-A) is a tight junction-associated adhesion protein previously implicated in tight junction assembly and regulation of barrier ...

journal_title：Investigative ophthalmology & visual science

authors： Mandell KJ,Holley GP,Parkos CA,Edelhauser HF

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:The exact pathophysiological processes underlying keratoconus remain an enigma. In this study, laser scanning in vivo confocal microscopy (IVCM) was used to define further the microstructural abnormalities in the keratoconic cornea and to establish the relationship with disease severity. METHODS:This was a pro...

journal_title：Investigative ophthalmology & visual science

authors： Niederer RL,Perumal D,Sherwin T,McGhee CN

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:Retinal nerve fiber (RNFL) thickness and visual field loss data from patients with glaucoma were analyzed in the context of a model, to better understand individual variation in structure versus function. METHODS:Optical coherence tomography (OCT) RNFL thickness and standard automated perimetry (SAP) visual fi...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Anderson SC,Wall M,Raza AS,Kardon RH

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:As efforts to noninvasively measure intracranial pressure (ICP) increase, we thought it important to investigate the timing of retinal venous pulsation in relation to the intraocular and intracranial pressure pulses. METHODS:Neurosurgical patients undergoing continuous direct ICP monitoring had video recording...

journal_title：Investigative ophthalmology & visual science

authors： Morgan WH,Lind CR,Kain S,Fatehee N,Bala A,Yu DY

更新日期：2012-07-10 00:00:00

abstract：:Normal adult rabbit corneas were digested with 5% pepsin and their collagens extracted with acetic acid. Collagen extracts were fractionated by differential salt precipitation. The 2.5 M NaCl fraction was then redissolved with tris buffer and precipitated with sodium acetate. The precipitate contained a high-molecular...

journal_title：Investigative ophthalmology & visual science

authors： Cintron C,Hong BS

更新日期：1988-05-01 00:00:00

abstract：PURPOSE:The authors took advantage of the Oa1 mutant mouse in combination with other albinism mouse models (i.e., Tyrosinase and membrane-associated transporter protein [Matp]) to study the function of Oa1, the gene mutated in ocular albinism type 1, in the RPE during development and after birth. METHODS:Enzyme activi...

journal_title：Investigative ophthalmology & visual science

authors： Cortese K,Giordano F,Surace EM,Venturi C,Ballabio A,Tacchetti C,Marigo V

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:People with limited literacy are at increased risks of chronic systemic conditions. The authors therefore investigated the independent contribution of limited literacy on visual impairment and visual function in a large eye survey in Singapore. METHODS:The authors undertook a population-based, cross-sectional ...

journal_title：Investigative ophthalmology & visual science

authors： Zheng Y,Lamoureux EL,Chiang PP,Cheng CY,Anuar AR,Saw SM,Aung T,Wong TY

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:Oxidative stress and metabolic dysregulation of the RPE have been implicated in AMD; however, the molecular regulation of RPE metabolism remains unclear. The transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) is a powerful mediator of mitochondrial function. Th...

journal_title：Investigative ophthalmology & visual science

authors： Iacovelli J,Rowe GC,Khadka A,Diaz-Aguilar D,Spencer C,Arany Z,Saint-Geniez M

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Persistent hyperplastic primary vitreous (PHPV) is an idiopathic developmental eye disease associated with failed involution of the hyaloid vasculature. The present work addressed the pathogenesis of PHPV in a mouse model that replicates many aspects of the human disease. METHODS:Ophthalmoscopic and histologic...

journal_title：Investigative ophthalmology & visual science

authors： Martin AC,Thornton JD,Liu J,Wang X,Zuo J,Jablonski MM,Chaum E,Zindy F,Skapek SX

更新日期：2004-10-01 00:00:00

abstract：Purpose:To assess interocular delays in amblyopes with stereopsis and to evaluate the relationship between interocular delays and the clinical characteristics. Methods:Twenty amblyopes with stereopsis (median, 400 arcseconds) and 20 controls with normal or corrected to normal visual acuity (≤0 logMAR) and normal stere...

journal_title：Investigative ophthalmology & visual science

authors： Wu Y,Reynaud A,Tao C,Mao Y,He Z,Zhou J,Hess RF

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:Many types of chronic blepharitis have been believed to be primarily microbial in origin; however, it was proposed that differences and changes in lipid composition of meibomian secretion may be the initiating factor in some of these. It was recently reported that there are two subgroups of normals, those whose...

journal_title：Investigative ophthalmology & visual science

authors： Shine WE,Silvany R,McCulley JP

更新日期：1993-06-01 00:00:00

abstract：:The extracellular matrix of retinal pigment epithelial (RPE) cells is an important component of the fibroelastic membranes formed in proliferative vitreoretinopathy (PVR). These membranes consist of cells intermingled with fibrillar proteins, such as elastin and collagen. Because RPE cells may be exposed to vitreous a...

journal_title：Investigative ophthalmology & visual science

authors： Martini B,Pandey R,Ogden TE,Ryan SJ

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:The influence of the inner wall of Schlemm's canal on aqueous outflow facility remains poorly understood. We examined the relationship between inner wall pore characteristics and outflow facility in living primate eyes in which facility had been pharmacologically increased by ethacrynic acid (ECA) infusion and ...

journal_title：Investigative ophthalmology & visual science

authors： Ethier CR,Croft MA,Coloma FM,Gangnon RE,Ladd W,Kaufman PL

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:To validate velocity measurements produced by spectral domain optical coherence tomography (SD-OCT) in an in vitro laminar flow model. METHODS:A 30-mL syringe filled with skim milk was inserted into a syringe pump. Intravenous (i.v.) tubing connected the syringe within the pump to a glass capillary tube (inter...

journal_title：Investigative ophthalmology & visual science

authors： Kagemann L,Wollstein G,Ishikawa H,Townsend KA,Schuman JS

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:Diabetes reduces retinal and visual sensitivity to dim light flashes. However, the impact of diabetes on contrast sensitivity in dim light is unknown. Based on the lowered visual sensitivity previously observed, we hypothesized that contrast sensitivity would similarly be reduced. We therefore examined scotopic...

journal_title：Investigative ophthalmology & visual science

authors： Umino Y,Solessio E

更新日期：2013-02-28 00:00:00

abstract：:In order to determine whether a possible barrier exists to diffusion of tracer into the optic nerve during development and to provide a basis for later studies of retrograde axonal transport in embryonic nerves, we studied the diffusion of horseradish peroxidase (HRP) into the nerve after vitreal injections in chicks ...

journal_title：Investigative ophthalmology & visual science

authors： Kistler HB Jr,LaVail JH

更新日期：1981-06-01 00:00:00

abstract：PURPOSE:We measured the aqueous humor levels of matrix metalloproteinases (MMP) MMP-1, MMP-2, MMP-3, and tissue inhibitors of matrix metalloproteinases (TIMP) TIMP-1, TIMP-2, and TIMP-3 in patients with myopia or cataract, and investigated the relationship between their levels and axial length (AL). METHODS:We measure...

journal_title：Investigative ophthalmology & visual science

authors： Jia Y,Hu DN,Zhu D,Zhang L,Gu P,Fan X,Zhou J

更新日期：2014-05-29 00:00:00

abstract：PURPOSE:Beta-adrenergic receptor (AR) antagonists are frequently prescribed ophthalmic drugs, yet previous investigations into how catecholamines affect corneal wound healing have yielded conflicting RESULTS:With the use of an integrated pharmacologic and genetic approach, the authors investigated how the beta-AR impa...

journal_title：Investigative ophthalmology & visual science

authors： Ghoghawala SY,Mannis MJ,Pullar CE,Rosenblatt MI,Isseroff RR

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:Leukocytes play a critical role in ocular diseases such as uveitis, diabetic retinopathy, and choroidal neovascularization. Intercellular adhesion molecule (ICAM)-1 is essential for the migration of leukocytes. Control of ICAM-1 expression may lead to therapies for these diseases. Small-interfering ribonucleic ...

journal_title：Investigative ophthalmology & visual science

authors： Hirano Y,Sakurai E,Matsubara A,Ogura Y

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To establish, using adaptive optics scanning laser ophthalmoscopy (AOSLO), that the retinal parafoveal capillary network is altered before the onset of diabetic retinopathy in adult patients with type 2 diabetes. METHODS:AOSLO videos were acquired in the parafoveal region of one eye from control subjects and f...

journal_title：Investigative ophthalmology & visual science

authors： Tam J,Dhamdhere KP,Tiruveedhula P,Manzanera S,Barez S,Bearse MA Jr,Adams AJ,Roorda A

更新日期：2011-11-29 00:00:00

abstract：PURPOSE:Fibroblast growth factor-binding proteins (FGF-BPs) have been identified recently in blood and other biologic fluids and have been shown to be identical to a truncated form of the high-affinity cell surface FGF receptor. The authors examined the hypothesis that FGF-BPs also are present in human vitreous fluid. ...

journal_title：Investigative ophthalmology & visual science

authors： Hanneken A,Baird A

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:Environmental tobacco smoke (ETS) is widely regarded as a major modifiable risk factor for age-related macular degeneration (AMD). Yet, precisely how it exerts its pathologic effects is poorly understood. Since early-stage AMD is characterized by choroidal capillary loss, this study examined the effect of sides...

journal_title：Investigative ophthalmology & visual science

authors： Yang X,Scott HA,Ardekani S,Williams M,Talbot P,Ghosh K

更新日期：2014-04-08 00:00:00

abstract：PURPOSE:Strabismus is a common eye disorder with a prevalence of 1% to 4%. Comitant strabismus accounts for approximately 75% of all strabismus, yet more is known about the less common incomitant disorders. Comitant strabismus is at least partly inherited, but only one recessive genetic susceptibility locus, on chromos...

journal_title：Investigative ophthalmology & visual science

authors： Rice A,Nsengimana J,Simmons IG,Toomes C,Hoole J,Willoughby CE,Cassidy F,Williams GA,George ND,Sheridan E,Young TL,Hunter TI,Barrett BT,Elliott DB,Bishop DT,Inglehearn CF

更新日期：2009-07-01 00:00:00

abstract：:A disruption of the blood-aqueous barrier in rabbit eyes was elicited by use of topical prostaglandin E2(PGE2), infrared irradiation of the iris, or by subcutaneous alpha-melanocyte-stimulating hormone (alpha-MSH). The aqueous flare provoked was measured quantitatively with a photoelectric instrument. The effect of th...

journal_title：Investigative ophthalmology & visual science

authors： Holmdahl G,Bengtsson E

更新日期：1981-06-01 00:00:00

abstract：PURPOSE:To describe and evaluate a new experimental reference plane for measuring rim area in scanning laser tomography. METHODS:The experimental reference plane was positioned so that (1) it always lay entirely below the margin of the optic nerve head (ONH), (2) it remained at a set z-axis distance below the ONH in i...

journal_title：Investigative ophthalmology & visual science

authors： Tan JC,Hitchings RA

更新日期：2003-03-01 00:00:00

abstract：Purpose:To compare the hemifield asymmetry of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) across all severity levels. Methods:A total of 522 eyes of 327 patients with POAG (mean age ± SD, 54.1 ± 12.4 years) and 375 eyes of 204 patients with PACG (67.3 ± 8.9 ye...

journal_title：Investigative ophthalmology & visual science

authors： Yousefi S,Sakai H,Murata H,Fujino Y,Garway-Heath D,Weinreb R,Asaoka R

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Changes in gene expression were investigated after treatment of cultured human retinal pigment epithelial (RPE) cells with vitreous. This may have implications for proliferative diseases such as proliferative vitreoretinopathy. METHODS:Cells were cultured in the presence or absence of human vitreous, and gene ...

journal_title：Investigative ophthalmology & visual science

authors： Hunt DM,Chen WH,Hunt RC

更新日期：1998-10-01 00:00:00

abstract：Purpose:To use laser speckle flowgraphy (LSFG) to assess blood flow (BF) in the optic nerve head (ONH) tissue and choroid during elevated intraocular pressure (IOP). Methods:This prospective study included 20 eyes of 20 healthy volunteers. The testing protocol had a baseline phase, two elevated IOP phases (+10 and +20...

journal_title：Investigative ophthalmology & visual science

authors： Kiyota N,Shiga Y,Ichinohasama K,Yasuda M,Aizawa N,Omodaka K,Honda N,Kunikata H,Nakazawa T

更新日期：2018-07-02 00:00:00