Soluble forms of the high-affinity fibroblast growth factor receptor in human vitreous fluid.

abstract：PURPOSE:To link psychophysical thresholds for blind spot awareness and filling-in with early neural components that underpin these perceptions. METHODS:Blind spot dimensions were quantified, after which an intrinsic stimulus (i.e., a rectangular bar of varying length centered within the blind spot) was used to determi...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Jeffery G,Murphy JS

更新日期：2011-01-25 00:00:00

abstract：PURPOSE:The pattern electroretinogram (PERG) is reduced in early glaucoma and in some eyes with ocular hypertension (OHT). This study was designed to test the ability of the PERG to predict the development of visual field loss in OHT eyes. METHODS:In 29 eyes of 18 patients with high-risk OHT, the visual fields were te...

journal_title：Investigative ophthalmology & visual science

authors： Pfeiffer N,Tillmon B,Bach M

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:Mutations in the frizzled-4 gene (FZD4) have recently been associated with autosomal dominant familial exudative vitreoretinopathy (FEVR) in families linking to the EVR1 locus on the long arm of chromosome 11. The purpose of this study was to screen FZD4 in a panel of 40 patients with FEVR to identify the types...

journal_title：Investigative ophthalmology & visual science

authors： Toomes C,Bottomley HM,Scott S,Mackey DA,Craig JE,Appukuttan B,Stout JT,Flaxel CJ,Zhang K,Black GC,Fryer A,Downey LM,Inglehearn CF

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:To compare the effectiveness of upper punctal occlusion versus that of lower punctal occlusion in dry eye patients. METHODS:One eye's upper punctum and the contralateral eye's lower punctum were occluded with collagen plugs in 20 dry eye patients. The same procedure was performed in 20 normal subjects. The upp...

journal_title：Investigative ophthalmology & visual science

authors： Chen F,Wang J,Chen W,Shen M,Xu S,Lu F

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To determine the functional contribution of retinoic acid receptor (RAR)-alpha in the developing murine neural retina, through a phenotypic analysis of the corresponding null mutants. METHODS:RARalpha mutant (Rara(-/-)) mice were compared with wild-type littermates at several stages of pre- and postnatal devel...

journal_title：Investigative ophthalmology & visual science

authors： Cammas L,Trensz F,Jellali A,Ghyselinck NB,Roux MJ,Dollé P

更新日期：2010-06-01 00:00:00

abstract：:Topical commercial phenylephrine HCl (Neo-Synephrine 10%) has been shown to cause an increase in corneal thickness and reversible vacuolization of corneal endothelial cells in rabbits. Using an in vivo model of regenerated corneal endothelial cells in the cat, we compared the cytotoxicity of phenylephrine-HCl 10% to r...

journal_title：Investigative ophthalmology & visual science

authors： Cohen KL,Van Horn DL,Edelhauser HF,Schultz RO

更新日期：1979-03-01 00:00:00

abstract：PURPOSE:To compare visual function assessment, optic disc evaluation by indirect ophthalmoscopy, and retinal nerve fiber layer analysis by optical coherence tomography (OCT) for the screening of optic pathway gliomas in pediatric patients (2-15 years old) affected by neurofibromatosis type 1. METHODS:Fifty-seven conse...

journal_title：Investigative ophthalmology & visual science

authors： Parrozzani R,Clementi M,Kotsafti O,Miglionico G,Trevisson E,Orlando G,Pilotto E,Midena E

更新日期：2013-12-17 00:00:00

abstract：PURPOSE:Accommodative effort during nearwork is thought to be a causative factor in the development of myopia. It has been proposed that an anomaly in autonomic control may be a precursor to the development of myopia. In the present study the closed-loop accommodation response after variations in fixation period was in...

journal_title：Investigative ophthalmology & visual science

authors： Culhane HM,Winn B

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:MRL/MpJ-+/+ (MRL/+) and MRL/MpJ-lpr/lpr (MRL/lpr) mice show spontaneous development of a T-cell-driven lacrimal gland inflammation that is a model for Sjögren syndrome. The lacrimal gland lesions in these mice were evaluated by quantitative RT-PCR for selected cytokine mRNA for the relative contributions of T-h...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Prendergast RA,Rorer EM,Hudson AP,Whittum-Hudson JA

更新日期：2001-10-01 00:00:00

abstract：:The impact of aging on cell loss in the human retina was examined in foveal and temporal equatorial regions in eyes from 35 donors with ages spanning a 78-yr period from the second to the ninth decade of life. Equatorial cones and retinal pigment epithelial cells (RPE) decreased at uniform rates from the second to the...

journal_title：Investigative ophthalmology & visual science

authors： Gao H,Hollyfield JG

更新日期：1992-01-01 00:00:00

abstract：:Membrane-bound proteins in plasma membrane enriched fractions from cultured rat RPE were analyzed by two-dimensional gel electrophoresis. Membrane proteins were characterized on three increasingly specific levels. Total protein was visualized by silver staining. A maximum of 102 separate proteins were counted in silve...

journal_title：Investigative ophthalmology & visual science

authors： Clark VM,Hall MO

更新日期：1986-02-01 00:00:00

abstract：:The distribution and organization of type I and type V collagens were studied in the embryonic chicken cornea using anti-collagen, type specific, monoclonal antibodies and immunoelectron microscopy. These studies were performed on lathyritic 17-day corneas treated at 4 degrees C or 37 degrees C. At the lower temperatu...

journal_title：Investigative ophthalmology & visual science

authors： Birk DE,Fitch JM,Linsenmayer TF

更新日期：1986-10-01 00:00:00

abstract：PURPOSE:To identify proteinases and growth factors abnormally expressed in human corneas of donors with diabetic retinopathy (DR), additional to previously described matrix metalloproteinase (MMP)-10 and -3 and insulin-like growth factor (IGF)-I. METHODS:RNA was isolated from 35 normal, diabetic, and DR autopsy human ...

journal_title：Investigative ophthalmology & visual science

authors： Saghizadeh M,Kramerov AA,Tajbakhsh J,Aoki AM,Wang C,Chai NN,Ljubimova JY,Sasaki T,Sosne G,Carlson MR,Nelson SF,Ljubimov AV

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To compare directly the robustness of standard automated perimetry (SAP), short-wavelength automated perimetry (SWAP), frequency-doubling perimetry (FDP), and grating-resolution perimetry (GRP) stimuli to different degrees of intraocular stray light induced by commercially available opacity-containing filters. ...

journal_title：Investigative ophthalmology & visual science

authors： Anderson RS,Redmond T,McDowell DR,Breslin KM,Zlatkova MB

更新日期：2009-08-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) can infect the cornea and achieve ganglionic latency. HSV-1 can later be activated by a variety of effectors although the exact mechanism of reactivation is unknown. Rabbits harboring latent HSV-1 strain McKrae can be induced to shed virus by ocular iontophoresis of epinephrine to t...

journal_title：Investigative ophthalmology & visual science

authors： Rootman DS,Haruta Y,Hill JM,Kaufman HE

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:To study the effect of aminoguanidine (AMG), an inhibitor of nitric oxide production, on the ocular infection of Balb/c mice with herpes simplex virus (HSV) type 1 strain F and HSV-2 strain G. METHODS:Animals were treated with different amounts of AMG (0.5, 0.1, and 0.05 mg/mouse) by topical application in the...

journal_title：Investigative ophthalmology & visual science

authors： Benencia F,Courrèges MC,Gamba G,Cavalieri H,Massouh EJ

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:The authors conducted a morphology analysis of filtering blebs with anterior segment optical coherence tomography (AS-OCT) in patients shortly after trabeculectomy to find further criteria for success or failure of a filtering bleb. METHODS:Thirty-seven patients (43 eyes) who had recently (<2 years) undergone ...

journal_title：Investigative ophthalmology & visual science

authors： Pfenninger L,Schneider F,Funk J

更新日期：2011-04-14 00:00:00

abstract：:A group of 26 subjects with myotonic dystrophy were studied with fluorophotometry to evaluate the relationship between aqueous humor dynamics and the hypotony found in this disorder. All 26 received topical fluorescein to determine the anterior chamber elimination coefficient; five received systemic fluorescein to eva...

journal_title：Investigative ophthalmology & visual science

authors： Walker SD,Brubaker RF,Nagataki S

更新日期：1982-06-01 00:00:00

abstract：PURPOSE:Glaucomatous optic neuropathy is characterized by remodeling of the extracellular matrix with disorganization of elastic fibers in the optic nerve head (ONH). There are significant differences in prevalence of glaucomatous optic neuropathy between African Americans (AAs) and Caucasian Americans (CAs). The goal ...

journal_title：Investigative ophthalmology & visual science

authors： Urban Z,Agapova O,Hucthagowder V,Yang P,Starcher BC,Hernandez MR

更新日期：2007-07-01 00:00:00

abstract：Purpose:The purpose of this study was to clinically characterize patients with CNGA3-linked achromatopsia (CNGA3-ACHM) in preparation of a gene therapy trial. Methods:Thirty-six patients (age 7-56 years) with complete (cACHM) or incomplete (iACHM) CNGA3-ACHM were examined, including detailed psychophysical tests, exte...

journal_title：Investigative ophthalmology & visual science

authors： Zobor D,Werner A,Stanzial F,Benedicenti F,Rudolph G,Kellner U,Hamel C,Andréasson S,Zobor G,Strasser T,Wissinger B,Kohl S,Zrenner E,RD-CURE Consortium.

更新日期：2017-02-01 00:00:00

abstract：Purpose:To quantify associations between microvascular density and retinal ganglion cell (RGC) axonal volume in the laminar compartments of the human optic nerve head (ONH). Methods:Eleven normal human ONHs were evaluated. Antibodies were used to label the vascular endothelium (factor VIII-related antigen/von Willebra...

journal_title：Investigative ophthalmology & visual science

authors： Kang MH,Suo M,Balaratnasingam C,Yu PK,Morgan WH,Yu DY

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To determine whether a novel optical treatment using contact lenses to reduce relative peripheral hyperopia can slow the rate of progress of myopia. METHODS:Chinese children, aged 7 to 14 years, with baseline myopia from sphere -0.75 to -3.50 D and cylinder ≤1.00 D, were fitted with novel contact lenses (n = 4...

journal_title：Investigative ophthalmology & visual science

authors： Sankaridurg P,Holden B,Smith E 3rd,Naduvilath T,Chen X,de la Jara PL,Martinez A,Kwan J,Ho A,Frick K,Ge J

更新日期：2011-12-09 00:00:00

abstract：PURPOSE:To examine the effects of transcorneal electrical stimulation (TES) on retinal degeneration of light-exposed rats. METHODS:Thirty-three Sprague Dawley albino rats were divided into three groups: STIM (n = 15) received 60 minutes of TES, whereas SHAM (n = 15) received identical sham stimulation 2 hours before e...

journal_title：Investigative ophthalmology & visual science

authors： Schatz A,Arango-Gonzalez B,Fischer D,Enderle H,Bolz S,Röck T,Naycheva L,Grimm C,Messias A,Zrenner E,Bartz-Schmidt KU,Willmann G,Gekeler F

更新日期：2012-08-15 00:00:00

abstract：PURPOSE:To examine sex- and race-associated differences in macular thickness and foveal pit morphology by using spectral-domain optical coherence tomography (SD-OCT). METHODS:One hundred eighty eyes of 90 healthy patients (43 women, 47 men) underwent retinal imaging with spectral-domain OCT. The lateral scale of each ...

journal_title：Investigative ophthalmology & visual science

authors： Wagner-Schuman M,Dubis AM,Nordgren RN,Lei Y,Odell D,Chiao H,Weh E,Fischer W,Sulai Y,Dubra A,Carroll J

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:This study describes the effects of the cyclic adenosine monophosphate (cAMP) pathway on the tight junctional barrier of the corneal endothelium, which plays a critical role in maintaining the corneal stroma in an underhydrated, transparent state. METHODS:Subcultured bovine corneal endothelial cells grown on f...

journal_title：Investigative ophthalmology & visual science

authors： Le Varlet B,Ducroc R,Dagonet FB,Pouliquen Y,Vandewalle A,Hirsch M

更新日期：1995-11-01 00:00:00

abstract：:Secretory component (SC) was studied by indirect immunofluorescence of the ocular surface epithelium. We find that conjunctival epithelium produces this component, and that it is absent in the corneal epithelium. Conjunctival epithelium loses its SC staining within 1 to 2 days as it grows over a denuded corneal stroma...

journal_title：Investigative ophthalmology & visual science

authors： Liu SH,Tagawa Y,Prendergast RA,Franklin RM,Silverstein AM

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:To evaluate the expression of tissue inhibitor of metalloproteinases (TIMP) mRNA in corneal tissues before and at early time points (6 and 12 hours and 1, 3, and 5 days) after corneal infection with Pseudomonas aeruginosa. METHODS:Ribonuclease protection assays were used to detect and quantitate TIMP mRNA expr...

journal_title：Investigative ophthalmology & visual science

authors： Kernacki KA,Goebel DJ,Poosch MS,Hazlett LD

更新日期：1998-02-01 00:00:00

abstract：:In order to investigate the effect of traction of the vasculature on induction or acceleration of neovascularization, the chorioallantoic membranes (CAMs) of the developing chick embryo were placed under tension with 10-0 nylon sutures and subsequently examined histologically. In the initial phase of the study, CAMs f...

journal_title：Investigative ophthalmology & visual science

authors： Yamashita H,Hori S,Yamamoto T

更新日期：1989-04-01 00:00:00

abstract：PURPOSE:Oxidative stress in the human lens leads to a wide range of damage including DNA strand breaks, which are likely to contribute to cataract formation. The protein Ku80 is a fundamental component of the nonhomologous end-joining pathway that repairs DNA double strand breaks. This study investigates the putative i...

journal_title：Investigative ophthalmology & visual science

authors： Smith AJ,Ball SS,Manzar K,Bowater RP,Wormstone IM

更新日期：2015-12-01 00:00:00

abstract：Purpose:To accelerate the development of new therapies, an inherited retinal degeneration model in a nonhuman primate would be useful to confirm the efficacy in preclinical studies. In this study, we describe the discovery of retinitis pigmentosa in a cynomolgus monkey (Macaca fascicularis) pedigree. Methods:First, sc...

journal_title：Investigative ophthalmology & visual science

authors： Ikeda Y,Nishiguchi KM,Miya F,Shimozawa N,Funatsu J,Nakatake S,Fujiwara K,Tachibana T,Murakami Y,Hisatomi T,Yoshida S,Yasutomi Y,Tsunoda T,Nakazawa T,Ishibashi T,Sonoda KH

更新日期：2018-02-01 00:00:00