Suppression of ICAM-1 in retinal and choroidal endothelial cells by plasmid small-interfering RNAs in vivo.

abstract：:The hypotensive effect of ascorbate on intraocular pressure has been reported following topical application, oral administration, or anterior chamber infusion in animals. The present report describes the correlation of aqueous humor ascorbate concentration with intraocular pressure as well as outflow facility in vivo....

journal_title：Investigative ophthalmology & visual science

authors： Lee PF,Fox R,Henrick I,Lam WK

更新日期：1978-08-01 00:00:00

abstract：PURPOSE:To determine whether caspase or cathepsin pathways are activated in human retinal pigment epithelial cells (ARPE-19) after exposure to 7-ketocholesterol (7kCh). METHODS:ARPE-19 cells were exposed to 7kCh with or without z-VAD-fmk, a pan-caspase inhibitor. Caspase-3, -8, and -9 activities were measured by a flu...

journal_title：Investigative ophthalmology & visual science

authors： Luthra S,Fardin B,Dong J,Hertzog D,Kamjoo S,Gebremariam S,Butani V,Narayanan R,Mungcal JK,Kuppermann BD,Kenney MC

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:To validate velocity measurements produced by spectral domain optical coherence tomography (SD-OCT) in an in vitro laminar flow model. METHODS:A 30-mL syringe filled with skim milk was inserted into a syringe pump. Intravenous (i.v.) tubing connected the syringe within the pump to a glass capillary tube (inter...

journal_title：Investigative ophthalmology & visual science

authors： Kagemann L,Wollstein G,Ishikawa H,Townsend KA,Schuman JS

更新日期：2009-02-01 00:00:00

abstract：Purpose:To investigate the effects of tear film instability (TFI) induced by sustained tear exposure (STARE) on sensory responses to corneal cold, mechanical, and chemical stimuli. Methods:Fifteen normal subjects were enrolled. TFI was induced during 10 repeated trials of STARE. Pneumatic cold, mechanical, and chemica...

journal_title：Investigative ophthalmology & visual science

authors： Situ P,Begley CG,Simpson TL

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Fibroblast growth factor-10 (FGF10) can modulate extracellular matrix associated genes and, therefore, it could be a myopia susceptibility gene. This study used an animal model, single nucleotide polymorphisms (SNPs) association, and genetic functional assay to evaluate FGF10 gene for myopia. METHODS:The expre...

journal_title：Investigative ophthalmology & visual science

authors： Hsi E,Chen KC,Chang WS,Yu ML,Liang CL,Juo SH

更新日期：2013-05-07 00:00:00

abstract：:Cell membranes from the human lens contain two major polypeptides with molecular weights near 26,000 and 22,000. These two species have been isolated in a highly purified state and purified by means of an antiserum against the 26,000 dalton membrane polypeptide from bovine lens. Immunochemical data are presented that ...

journal_title：Investigative ophthalmology & visual science

authors： Zigler JS Jr,Horwitz J

更新日期：1981-07-01 00:00:00

abstract：:Immune complexes from retinoblastoma sera were characterized with molecular sieve chromatography, affinity chromatography, and polyacrylamide gel electrophoresis (PAGE). Retinoblastoma patients' sera had two well-defined peaks of immune complex activity after molecular sieve chromatography. These protein fractions had...

journal_title：Investigative ophthalmology & visual science

authors： Stein PC,Christensen M,Char DH

更新日期：1980-03-01 00:00:00

abstract：PURPOSE:Oxidative stress seems to be an important factor in the development of age-related macular degeneration (AMD). The role of DNA repair mechanisms has also received attention recently in AMD pathogenesis. This case-control study was conducted to determine the frequency of polymorphisms in two DNA repair enzyme ge...

journal_title：Investigative ophthalmology & visual science

authors： Görgün E,Güven M,Unal M,Batar B,Güven GS,Yenerel M,Tatlipinar S,Seven M,Yüksel A

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Recently, a segregation study in families with uveal and cutaneous melanoma identified 9q21 as a potential locus harboring a tumor-suppressor gene (TSG). One of the genes in this area, RASEF, was then analyzed as a candidate TSG, but lack of point mutations and copy number changes could not confirm this. In thi...

journal_title：Investigative ophthalmology & visual science

authors： Maat W,Beiboer SH,Jager MJ,Luyten GP,Gruis NA,van der Velden PA

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:The authors investigated the effect of brain-derived neurotrophic factor (BDNF) administration on the expression of Ca(2+)-binding proteins in the developing bdnf(-/-) mouse retina. METHODS:Intraocular injections of BDNF (0.5 microg) were applied on postnatal day (P) 11 bdnf(-/-) mice, and their effects were e...

journal_title：Investigative ophthalmology & visual science

authors： Arango-González B,Cellerino A,Kohler K

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Vanishing optotypes (VOs) are pseudo high-pass letters whose mean luminance matches the background so that they "vanish" when the recognition acuity threshold is reached in the fovea. We determined the effect of increasing blur on acuity for these optotypes and conventional letters, in both foveal and extrafove...

journal_title：Investigative ophthalmology & visual science

authors： Shah N,Dakin SC,Anderson RS

更新日期：2012-10-09 00:00:00

abstract：PURPOSE:Corneal confocal microscopy is a reiterative, rapid, noninvasive in vivo clinical examination technique capable of imaging corneal nerve fibers. Nerve fiber tortuosity may indicate a degenerative and attempted regenerative response of nerve fibers to diabetes. The purpose of this study was to define alterations...

journal_title：Investigative ophthalmology & visual science

authors： Kallinikos P,Berhanu M,O'Donnell C,Boulton AJ,Efron N,Malik RA

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:To examine the expression of VEGF in extranodal marginal zone B-cell lymphoma (EMZL) and reactive lymphoid hyperplasia (RLH) of human ocular adnexa, and analyze the correlation with the intratumoral microvessel density (MVD). METHODS:Twenty-two EMZL and 16 RLH tissues were examined in this study. Paraformaldeh...

journal_title：Investigative ophthalmology & visual science

authors： Kinoshita S,Kase S,Ando R,Dong Z,Fukuhara J,Dong Y,Inafuku S,Noda K,Noda M,Kanda A,Ishida S

更新日期：2014-05-13 00:00:00

abstract：:Sodium removal from the solution bathing the isolated rabbit corneal endothelium caused a reduction in both unidirectional and net flux of bicarbonate, whereas chloride withdrawal from the solution had no effect on the net bicarbonate flux but increased the unidirectional fluxes. These data correlate with previously p...

journal_title：Investigative ophthalmology & visual science

authors： Green K,Simon S,Kelly GM Jr,Bowman KA

更新日期：1981-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine ocular surface and tear film, contact lens, care solution, medical, and patient-related factors that are associated with corneal staining in contact lens wearers. METHODS:In this cross-sectional/nested case-control study, in addition to the assessment of corneal stainin...

journal_title：Investigative ophthalmology & visual science

authors： Nichols JJ,Sinnott LT

更新日期：2011-02-28 00:00:00

abstract：PURPOSE:To determine whether ciliary neurotrophic factor (CNTF) or brain-derived neurotrophic factor (BDNF) treatment leads to long-term photoreceptor survival in hereditary retinal degeneration. METHODS:An autosomal dominant feline model of rod-cone dystrophy was used throughout the study with two normal animals. In ...

journal_title：Investigative ophthalmology & visual science

authors： Chong NH,Alexander RA,Waters L,Barnett KC,Bird AC,Luthert PJ

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:The S1 RNA binding domain 1 (SRBD1) and elongation of long-chain fatty acids family member 5 (ELOVL5) have been reported to be susceptibility genes for early-onset normal-tension glaucoma (NTG). The present study we conducted to assess whether these genes were associated with primary open-angle glaucoma (POAG),...

journal_title：Investigative ophthalmology & visual science

authors： Mabuchi F,Sakurada Y,Kashiwagi K,Yamagata Z,Iijima H,Tsukahara S

更新日期：2011-06-28 00:00:00

abstract：PURPOSE:Chronic, subclinical inflammation contributes to the pathogenesis of several ocular diseases, including age-related macular degeneration. Proinflammatory cytokines affect tight junctions in epithelia that lack claudin-19, but in the retinal pigment epithelium claudin-19 predominates. We examined the effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Peng S,Gan G,Rao VS,Adelman RA,Rizzolo LJ

更新日期：2012-07-27 00:00:00

abstract：PURPOSE:To determine the effect of taxol and etoposide, hydrophobic drugs with antifibrosis activity, on the outcome of filtration surgery in glaucomatous monkeys. METHODS:Elevated intraocular pressure was produced bilaterally in eight cynomolgus monkeys by laser treatment of the trabecular meshwork. Four animals subc...

journal_title：Investigative ophthalmology & visual science

authors： Jampel HD,Thibault D,Leong KW,Uppal P,Quigley HA

更新日期：1993-10-01 00:00:00

abstract：PURPOSE:A human biovar of Chlamydia trachomatis was used to develop a murine model of ocular chlamydial infection. The inbred mouse model will allow detailed immunologic studies during ocular infection, and use of a human biovar for infection may aid in identification of appropriate vaccine strategies against chlamydia...

journal_title：Investigative ophthalmology & visual science

authors： Whittum-Hudson JA,O'Brien TP,Prendergast RA

更新日期：1995-09-01 00:00:00

abstract：PURPOSE:The anatomy of individual myofibers within the orbicularis oculi muscle was examined to determine individual myofiber lengths in the different regions of the muscle. A wide variety of eyelid conditions require eyelid surgery or drug injections directly into the eyelid. Knowledge of regional myofiber anatomy and...

journal_title：Investigative ophthalmology & visual science

authors： Lander T,Wirtschafter JD,McLoon LK

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:To determine whether a novel peroxynitrite-based photosensitizer S-nitrosoglutathione (GSNO) can produce specific in vitro light-induced cell death of both standard animal lung and human Tenon's capsule (TC) fibroblasts and to compare this effect with that produced by the established photodynamic porphyrin prec...

journal_title：Investigative ophthalmology & visual science

authors： Tannous M,Hutnik CM,Tingey DP,Mutus B

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:Retinal neovascularization is one of the leading causes of blindness. A crucial event in this process is the remodeling and penetration of the capillary basement membrane by migrating endothelial cells. This process requires proteolysis of basement membrane components by a variety of proteinases. The objective ...

journal_title：Investigative ophthalmology & visual science

authors： Das A,McGuire PG,Eriqat C,Ober RR,DeJuan E Jr,Williams GA,McLamore A,Biswas J,Johnson DW

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:Recent studies on ocular shape have raised increased interest in the peripheral characteristics of the eye, as it potentially triggers changes in the central vision. Current techniques are, however, not capable of accurately measuring the three-dimensional shape of the retina. We describe a new magnetic resonan...

journal_title：Investigative ophthalmology & visual science

authors： Beenakker JW,Shamonin DP,Webb AG,Luyten GP,Stoel BC

更新日期：2015-01-15 00:00:00

abstract：:Evoked potentials (EP's) in response to phase-alternating gratings were recorded from normal and stereoblind or stereodefective subjects (adults and children) under monocular and binocular viewing conditions. The amplitude of the binocular EP was found to exceed the larger monocular EP in normal but not in stereodefec...

journal_title：Investigative ophthalmology & visual science

authors： Amigo G,Fiorentini A,Pirchio M,Spinelli D

更新日期：1978-09-01 00:00:00

abstract：PURPOSE:To evaluate the performance of an automated retinal image quality assessment system for use in automated diabetic retinopathy grading. METHODS:Algorithmic methods have been developed for assessing the quality of 45 degrees single field retinal images for use in diabetic retinopathy screening. For this purpose,...

journal_title：Investigative ophthalmology & visual science

authors： Fleming AD,Philip S,Goatman KA,Olson JA,Sharp PF

更新日期：2006-03-01 00:00:00

abstract：:Male albino rats, injected intravenously or intracerebroventricularly with delta 1-tetrahydrocannabinol (THC), develop mudriasis. The median effective dose of the intravenous administration group was 5 mg/kg THC, whereas that for the intracerebroventricular route was 150 microgram/kg THC. Sympathectomy significantly d...

journal_title：Investigative ophthalmology & visual science

authors： Korczyn AD,Eshel Y

更新日期：1982-03-01 00:00:00

abstract：PURPOSE:The primary purpose of this study was to characterize photoreceptor apoptosis in the rd mouse. Given that apoptosis is the final common pathway in many cases of retinal degeneration, the ability to retard or even arrest this process may ameliorate retinal disorders such as retinitis pigmentosa (RP). The absence...

journal_title：Investigative ophthalmology & visual science

authors： Doonan F,Donovan M,Cotter TG

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To explore differences in optic disc tilt and torsion between normal control and glaucoma subjects, and to determine whether the direction of optic disc tilt is consistent with the initial location of glaucomatous visual field (VF) defect. METHODS:Glaucoma patients with isolated superior or inferior hemifield ...

journal_title：Investigative ophthalmology & visual science

authors： Choi JA,Park HY,Shin HY,Park CK

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:The transformed RGC-5 retinal ganglion cell line is used widely in glaucoma research. Increased resistance to glutamate was noted in published literature and led to the recharacterization of the RGC-5 cell line. METHODS:Characterization of the RGC-5 cell line was performed by sequencing of a region of the nucl...

journal_title：Investigative ophthalmology & visual science

authors： Van Bergen NJ,Wood JP,Chidlow G,Trounce IA,Casson RJ,Ju WK,Weinreb RN,Crowston JG

更新日期：2009-09-01 00:00:00