Paradoxic effect of anti-CD4 therapy on lacrimal gland disease in MRL/Mp-lpr/lpr mice.

abstract：PURPOSE:Targeted drug delivery to the ocular tissues remains a challenge. Biodegradable intraocular implants allow prolonged controlled release of drugs directly into the eye. In this study, we evaluated an anterior suprachoroidal polyurethane implant containing dexamethasone polyurethane dispersions (DX-PUD) as a drug...

journal_title：Investigative ophthalmology & visual science

authors： Barbosa Saliba J,Vieira L,Fernandes-Cunha GM,Rodrigues Da Silva G,Ligório Fialho S,Silva-Cunha A,Bousquet E,Naud MC,Ayres E,Oréfice RL,Tekaya M,Kowalczuk L,Zhao M,Behar-Cohen F

更新日期：2016-04-01 00:00:00

abstract：Purpose:Evidence from animals and blind humans suggests that early visual experience influences the developmental calibration of auditory localization. Hypothesizing that unilateral amblyopia may involve cross-modal deficits in spatial hearing, we measured the precision and accuracy of sound localization in humans with...

journal_title：Investigative ophthalmology & visual science

authors： Richards MD,Goltz HC,Wong AMF

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To create a binocular statistical eye model based on previously measured ocular biometric data. METHODS:Thirty-nine parameters were determined for a group of 127 healthy subjects (37 male, 90 female; 96.8% Caucasian) with an average age of 39.9 ± 12.2 years and spherical equivalent refraction of -0.98 ± 1.77 D...

journal_title：Investigative ophthalmology & visual science

authors： Rozema JJ,Atchison DA,Tassignon MJ

更新日期：2011-06-23 00:00:00

abstract：Purpose:Examine associations between the vasculature at arteriovenous (AV) crossings and the onset of branch retinal vein occlusion (BRVO). Methods:We included 78 patients with major BRVO, 35 patients with macular BRVO, and 110 controls without BRVO and determined the vessel positions at AV crossings, where the first-...

journal_title：Investigative ophthalmology & visual science

authors： Kogo T,Muraoka Y,Iida Y,Ooto S,Murakami T,Kadomoto S,Iida-Miwa Y,Numa S,Miyake M,Miyata M,Uji A,Tsujikawa A

更新日期：2020-02-07 00:00:00

abstract：Purpose:To investigate brain white matter pathways using magnetic resonance diffusion tensor imaging (DTI) and correlate the findings with developmental outcomes at 18 months of corrected age in preterm infants with and without retinopathy of prematurity (ROP). Methods:In this prospective cohort study, probabilistic m...

journal_title：Investigative ophthalmology & visual science

authors： Ahn SJ,Lee JY,Lee JY,Lee YJ,Lee JM,Lee BR,Kim J,Lee HJ

更新日期：2021-02-01 00:00:00

abstract：:Patients with choroidal melanomas and simulating choroidal tumors were tested in a masked manner in a leukocyte-migration inhibition (LMI) assay with a 3M KCl antigen derived from a metastatic choroidal melanoma. Good discrimination petween patient groups was observed with this antigen. The sensitivity and specificity...

journal_title：Investigative ophthalmology & visual science

authors： Char DH

更新日期：1977-02-01 00:00:00

abstract：PURPOSE:To investigate whether oxygen stresses experienced in retinopathy of prematurity (ROP) trigger signaling through reactive oxygen species (ROS) and whether the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway lead to intravitreous neovascularization (IVNV) in an oxygen-induced ret...

journal_title：Investigative ophthalmology & visual science

authors： Byfield G,Budd S,Hartnett ME

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative disease of the eye that is the largest cause of irreversible blindness. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Kaurani L,Vishal M,Kumar D,Sharma A,Mehani B,Sharma C,Chakraborty S,Jha P,Ray J,Sen A,Dash D,Ray K,Mukhopadhyay A

更新日期：2014-04-24 00:00:00

abstract：PURPOSE:The anterior surface of the eye is covered by several physically contiguous but histologically distinguishable epithelial overlying the cornea, limbus, bulbar conjunctiva, fornix conjunctiva, and palpebral conjunctiva. It is important to determine whether the different phenotypes of these epithelia are the resu...

journal_title：Investigative ophthalmology & visual science

authors： Wei ZG,Wu RL,Lavker RM,Sun TT

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:To investigate the effect of varying levels of ocular surface stimulation on the timing and amplitude of the blink and tear secretion. METHODS:Following instillation of fluorescein dye, increasing levels of air flow were directed toward the central corneas of 10 healthy subjects. Interblink interval (IBI), tea...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Begley CG,Port N,Bradley A,Braun R,King-Smith E

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:T cells play an important role in the pathogenesis of uveitis. Recent studies have indicated that the TNFSF15 gene that encodes the TL1A protein can regulate the differentiation and activation of T cells. TNFSF15 gene polymorphisms have been found to be associated with several autoimmune disorders. A possible a...

journal_title：Investigative ophthalmology & visual science

authors： Li H,Hou S,Yu H,Zheng M,Zhang L,Zhang J,Zhang Q,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To determine whether adenovirus vectors are capable of transferring a foreign active protein to the perfused anterior segment of the human eye. METHODS:Primary cultures from the human trabecular meshwork tissue were exposed to replication-deficient adenovirus Av1LacZ4 carrying the reporter beta-galactosidase g...

journal_title：Investigative ophthalmology & visual science

authors： Borrás T,Matsumoto Y,Epstein DL,Johnson DH

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:To determine whether retinal progenitor cells in the inner nuclear layer give rise to regenerated cones after laser ablation of photoreceptors in adult goldfish retina. METHODS:Using a technique developed previously in this laboratory, photoreceptors in the retina of adult goldfish were ablated with an argon l...

journal_title：Investigative ophthalmology & visual science

authors： Wu DM,Schneiderman T,Burgett J,Gokhale P,Barthel L,Raymond PA

更新日期：2001-08-01 00:00:00

abstract：:Stiles-Crawford functions were obtained from the maculas of 22 patients with different genetic types of retinitis pigmentosa and visual acuity of 20/40 or better. Reduced cone directional sensitivity was seen in the fovea with both focal cone electroretinographic testing and psychophysical testing. Functions from the ...

journal_title：Investigative ophthalmology & visual science

authors： Birch DG,Sandberg MA,Berson EL

更新日期：1982-02-01 00:00:00

abstract：PURPOSE:Adipose-derived stem cells (ASCs) have gained importance due to their myriad potential clinical applications. We hypothesize that progenitor cells also exist besides those conventionally isolated from the stromal vascular fraction (SVF). METHOD:Central and medial orbital adipose tissues obtained from patients ...

journal_title：Investigative ophthalmology & visual science

authors： Chen SY,Mahabole M,Horesh E,Wester S,Goldberg JL,Tseng SC

更新日期：2014-07-03 00:00:00

abstract：PURPOSE:To improve the interpretation of Heidelberg Retina Flowmeter (HRF; Heidelberg Engineering GmBH, Dosselheim, Germany) flow maps by examining the influence of specific vascular structures and focus depth in the presence and absence of retinal blood flow. METHODS:HRF flow maps were recorded from the inferior reti...

journal_title：Investigative ophthalmology & visual science

authors： Yu DY,Townsend R,Cringle SJ,Chauhan BC,Morgan WH

更新日期：2005-01-01 00:00:00

abstract：:The circulating renin-angiotensin system (RAS) is an important determinant in maintaining adequate systemic blood pressure, and it also may modify organ-specific blood flow. All recognized RAS components have been identified in the eye. In this study, angiotensinogen (ANG) was localized using an affinity-purified anti...

journal_title：Investigative ophthalmology & visual science

authors： Sramek SJ,Wallow IH,Tewksbury DA,Brandt CR,Poulsen GL

更新日期：1992-04-01 00:00:00

abstract：PURPOSE:The mouse has become an important wound healing model with which to study corneal fibrosis, a frequent complication of refractive surgery. The aim of the current study was to quantify changes in stromal ultrastructure and light scatter that characterize fibrosis in mouse corneal debridement wounds. METHODS:Epi...

journal_title：Investigative ophthalmology & visual science

authors： Boote C,Du Y,Morgan S,Harris J,Kamma-Lorger CS,Hayes S,Lathrop KL,Roh DS,Burrow MK,Hiller J,Terrill NJ,Funderburgh JL,Meek KM

更新日期：2012-05-14 00:00:00

abstract：PURPOSE:In amblyopia, neuronal deficits deteriorate spatial vision including visual acuity, possibly because of a lack of use-dependent fine-tuning of afferents to the visual cortex during infancy; but temporal processing may deteriorate as well. METHODS:Temporal, rather than spatial, resolution was investigated in pa...

journal_title：Investigative ophthalmology & visual science

authors： Spang K,Fahle M

更新日期：2009-11-01 00:00:00

abstract：Purpose:Intraocular pressure (IOP), the primary risk factor for primary open-angle glaucoma, is determined by resistance to aqueous outflow through the trabecular meshwork (TM). IOP homeostasis relies on TM responses to mechanical stretch. To model the effects of elevated IOP on the TM, this study sought to identify co...

journal_title：Investigative ophthalmology & visual science

authors： Youngblood H,Cai J,Drewry MD,Helwa I,Hu E,Liu S,Yu H,Mu H,Hu Y,Perkumas K,Aboobakar IF,Johnson WM,Stamer WD,Liu Y

更新日期：2020-05-11 00:00:00

abstract：Purpose:We investigate morphologic and physiologic alterations of ganglion cells (GCs) in a streptozocin (STZ)-induced diabetic mouse model. Methods:Experiments were conducted in flat-mount retinas of mice 3 months after the induction of diabetes. Changes in morphology of four subtypes of GCs (ON-type RGA2 [ON-RGA2], ...

journal_title：Investigative ophthalmology & visual science

authors： Cui RZ,Wang L,Qiao SN,Wang YC,Wang X,Yuan F,Weng SJ,Yang XL,Zhong YM

更新日期：2019-04-01 00:00:00

abstract：:Total outflow facility was determined by two-level constant pressure perfusion of the anterior chamber in surgically virgin, aniridic, and ciliary muscle disinserted cynomolgus monkey eyes 6 to 13 times at 1- to 2-month intervals over periods of 8 to 24 months. Facility decreased approximately 15 to 20% between consec...

journal_title：Investigative ophthalmology & visual science

authors： Kaufman PL,Erickson KA,Bárány EH

更新日期：1983-02-01 00:00:00

abstract：PURPOSE:Pathology in the primary drainage pathway for aqueous humor in the eye is responsible for ocular hypertension, the only treatable risk factor in patients with glaucoma. Unfortunately, the mechanisms that regulate pressure-dependent drainage of aqueous humor and thus intraocular pressure (IOP) are unknown. To be...

journal_title：Investigative ophthalmology & visual science

authors： Stamer WD,Lei Y,Boussommier-Calleja A,Overby DR,Ethier CR

更新日期：2011-12-09 00:00:00

abstract：:In recent years, there has been great interest in recording the pattern electroretinogram (PERG) in glaucomatous and diabetic populations. The Dawson, Trick, and Litzkow thread electrode (DTLTE) and the gold foil electrode (GFE), commonly used for recording PERGs, were compared for variations in amplitude of response,...

journal_title：Investigative ophthalmology & visual science

authors： Prager TC,Saad N,Schweitzer FC,Garcia CA,Arden GB

更新日期：1992-02-01 00:00:00

abstract：PURPOSE:To evaluate the rate and location of visual field (VF) progression before and after detection of disc hemorrhage (DH). METHODS:Disc photographs of consecutive patients with glaucoma with >or=5 SITA-Standard 24-2 VF in either eye were evaluated for the presence and location of DH. Exclusion criteria included di...

journal_title：Investigative ophthalmology & visual science

authors： De Moraes CG,Prata TS,Liebmann CA,Tello C,Ritch R,Liebmann JM

更新日期：2009-10-01 00:00:00

abstract：:Analysis of cell populations in the cornea may be performed rapidly and accurately employing the technique of enzymatic disaggregation. To illustrate this method normal rat corneas and corneas infected 24 and 48 hours previously with Staphylococcus aureus were disaggregated in a solution containing pancreatin and coll...

journal_title：Investigative ophthalmology & visual science

authors： Badenoch PR,Finlay-Jones JJ,Coster DJ

更新日期：1983-02-01 00:00:00

abstract：PURPOSE:To evaluate the relationship between retinal vascular caliber (RVC), iris color, and age-related macular degeneration (AMD) in elderly Irish nuns. METHODS:Data from 1233 participants in the cross-sectional observational Irish Nun Eye Study were assessed from digital photographs with a standardized protocol usi...

journal_title：Investigative ophthalmology & visual science

authors： McGowan A,Silvestri G,Moore E,Silvestri V,Patterson CC,Maxwell AP,McKay GJ

更新日期：2014-12-18 00:00:00

abstract：PURPOSE:We evaluated the clinical use of segmented macular layer thickness measurement in terms of glaucoma diagnosis and the ability to detect progression, and to compare such outcomes to those by circumpapillary retinal nerve fiber layer (cRNFLT) and total macular thickness (TMT) measurements. METHODS:The study incl...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Kim YJ,Durbin MK,Lee HJ,Kim HK,Sohn YH

更新日期：2012-06-20 00:00:00

abstract：PURPOSE:Modalities for inhibiting neovascularization may be one avenue to the development of effective therapies for retinopathy. The effect of squalamine, an antiangiogenic amino sterol, on oxygen-induced retinopathy (OIR) was assessed in a mouse model. METHODS:OIR was induced in C57BL6 mice by a 5-day exposure to 75...

journal_title：Investigative ophthalmology & visual science

authors： Higgins RD,Sanders RJ,Yan Y,Zasloff M,Williams JI

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:To study the spatial distribution of posterior pole choroidal thickness (CT) in healthy eyes using spectral domain optical coherence tomography (SD-OCT). METHODS:Fifty-nine eyes from 30 subjects with no retinal or choroidal disease were examined with high-definition (HD) OCT using macular volume cube scanning ...

journal_title：Investigative ophthalmology & visual science

authors： Ouyang Y,Heussen FM,Mokwa N,Walsh AC,Durbin MK,Keane PA,Sanchez PJ,Ruiz-Garcia H,Sadda SR

更新日期：2011-09-01 00:00:00