Spectrophotometric quantitation of rhodopsin in the human retina.

abstract：Purpose:Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine that initiates allergic inflammatory reaction between epithelial and dendritic cells (DCs). miR-19b was reported to suppress TSLP expression. The present study aimed to examine miR-19b expression, regulation, and function in allergic conjunctivitis ...

journal_title：Investigative ophthalmology & visual science

authors： Guo C,Liu J,Hao P,Wang Y,Sui S,Li L,Ying M,Han R,Wang L,Li X

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:Perinatal inflammatory stress in preterm babies is associated with increased rates of severe retinopathy of prematurity (ROP) and adverse neurological dysfunction. In this study, we set out to determine the consequences of severe systemic inflammatory stress on developmental retinal vascularization and evaluate...

journal_title：Investigative ophthalmology & visual science

authors： Tremblay S,Miloudi K,Chaychi S,Favret S,Binet F,Polosa A,Lachapelle P,Chemtob S,Sapieha P

更新日期：2013-12-17 00:00:00

abstract：Purpose:To improve the transparency of the acellular dermal matrix (ADM) and investigate the optical, mechanical and histologic properties and biocompatibility of transparent ADM (TADM) in lamellar keratoplasty. Methods:A stepwise sectioning strategy was applied to determine the transparency distribution of the ADM, a...

journal_title：Investigative ophthalmology & visual science

authors： Wang Y,Ma J,Jiang X,Liu Z,Yang J,Li X

更新日期：2020-01-23 00:00:00

abstract：PURPOSE:To investigate the topographic relationship between ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) defects in open-angle glaucoma patients with localized RNFL defects, using spectral-domain optical coherence tomography (SD-OCT). METHODS:We analyzed 140 eyes of 1...

journal_title：Investigative ophthalmology & visual science

authors： Kim KE,Park KH,Yoo BW,Jeoung JW,Kim DM,Kim HC

更新日期：2014-05-06 00:00:00

abstract：PURPOSE:To investigate the impact of diabetic macular ischemia (DMI) on visual acuity (VA), through the analysis of novel fluorescein angiography (FA) parameters. METHODS:Data were retrospectively collected over a 6-month period. DMI severity was graded using Early Treatment Diabetic Retinopathy Study (ETDRS) protocol...

journal_title：Investigative ophthalmology & visual science

authors： Sim DA,Keane PA,Zarranz-Ventura J,Fung S,Powner MB,Platteau E,Bunce CV,Fruttiger M,Patel PJ,Tufail A,Egan CA

更新日期：2013-03-28 00:00:00

abstract：Purpose:To analyze the anti-inflammatory and antioxidative effects of Camellia japonica (CJ) on human corneal epithelial (HCE) cells and its therapeutic effects in a mouse model of experimental dry eye (EDE). Methods:Camellia japonica extracts of varying concentrations (0.001%, 0.01%, and 0.1%) were used to treat HCE ...

journal_title：Investigative ophthalmology & visual science

authors： Lee HS,Choi JH,Cui L,Li Y,Yang JM,Yun JJ,Jung JE,Choi W,Yoon KC

更新日期：2017-02-01 00:00:00

abstract：:Laser densitometric analysis of immunoperoxidase stained tissue was used to quantitate class I HLA (HLA-A,B,C) antigen expression by human corneal epithelium. Frozen sections of human donor corneas stored in modified McCarey-Kaufman medium for less than 24 hr were evaluated for class I HLA antigen by an indirect immun...

journal_title：Investigative ophthalmology & visual science

authors： Dreizen NG,Whitsett CF,Austin GE,Stulting RD

更新日期：1986-06-01 00:00:00

abstract：PURPOSE:The endothelium produces nitric oxide and endothelin (ET). This study was designed to investigate the endothelium-dependent regulation of the porcine ophthalmic microcirculation. METHODS:Isolated porcine eyes were perfused with a modified Langendorff setup (Hugo Sachs Elektronik KG, Freiburg, Germany) at a per...

journal_title：Investigative ophthalmology & visual science

authors： Meyer P,Flammer J,Lüscher TF

更新日期：1993-12-01 00:00:00

abstract：Purpose:Dry eye disease (DED) is a multifactorial disease associated with ocular surface inflammation. Toll-like receptors (TLRs) are integral in the initiation of inflammatory signaling. Therefore, we evaluated the effect of TLR-deficiency on dry eye-related ocular surface damage and inflammation using a mouse model o...

journal_title：Investigative ophthalmology & visual science

authors： Reins RY,Lema C,Courson J,Kunnen CME,Redfern RL

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:The potential of stem cells (SCs) as a source for cell-based therapy on a wide range of degenerative diseases and damaged tissues such as retinal degeneration has been recognized. Generation of a high number of retinal stem cells (RSCs) in vitro would thus be beneficial for transplantation in the retina. Howeve...

journal_title：Investigative ophthalmology & visual science

authors： Djojosubroto M,Bollotte F,Wirapati P,Radtke F,Stamenkovic I,Arsenijevic Y

更新日期：2009-12-01 00:00:00

abstract：:The metabolism of the polyunsaturated fatty acid, arachidonic acid (20:4, n-6) in rabbit cornea with varying severities of herpes simplex viral infection was investigated. The results indicate an active synthesis of the lipoxygenase and cyclooxygenase reaction products of arachidonic acid in central cornea and corneal...

journal_title：Investigative ophthalmology & visual science

authors： Birkle DL,Sanitato JJ,Kaufman HE,Bazan NG

更新日期：1986-10-01 00:00:00

abstract：PURPOSE:Previous studies assessed the associations between Helicobacter pylori infection and open-angle glaucoma (OAG) and produced inconsistent results. Therefore, we performed a meta-analysis to evaluate the effects of H. pylori infection on OAG risk. METHODS:Relevant studies that reported the associations between H...

journal_title：Investigative ophthalmology & visual science

authors： Zeng J,Liu H,Liu X,Ding C

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To determine whether tonometric readings of increases in intraocular pressure (IOP) during the water-drinking test (WDT) are affected by variations in central corneal thickness (CCT) induced by photorefractive keratectomy (PRK). METHODS:Data from 30 randomly selected eyes of 30 patients (18 men and 12 women; m...

journal_title：Investigative ophthalmology & visual science

authors： Tamburrelli C,Giudiceandrea A,Vaiano AS,Caputo CG,Gullà F,Salgarello T

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To evaluate the physiological characteristics of the macula in patients with Vogt-Koyanagi-Harada disease during the convalescent stage with specific reference to the kinetics of foveal cone photopigment regeneration. METHODS:Six eyes of three patients at the convalescent stage of Vogt-Koyanagi-Harada disease ...

journal_title：Investigative ophthalmology & visual science

authors： Okamoto Y,Miyake Y,Horio N,Takakuwa H,Yamamoto E,Terasaki H

更新日期：2004-01-01 00:00:00

abstract：:Tissue culture of retinal vessels from fetal calf eyes produced colonies of endothelium, pericytes, and smooth muscle. Identification of endothelial cells was based upon culture morphology, [3H]thymidine labeling of isolated vessels, and factor VIII immunofluorescence. Thimerosal added to the culture medium destroyed ...

journal_title：Investigative ophthalmology & visual science

authors： Buzney SM,Massicotte SJ

更新日期：1979-11-01 00:00:00

abstract：PURPOSE:The ultrastructure of tight junctions in the corneal endothelium has been studied extensively, yet little is known about their molecular composition. Junctional adhesion molecule-A (JAM-A) is a tight junction-associated adhesion protein previously implicated in tight junction assembly and regulation of barrier ...

journal_title：Investigative ophthalmology & visual science

authors： Mandell KJ,Holley GP,Parkos CA,Edelhauser HF

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To examine the visual evoked potentials (VEP) and electroretinograms (ERG) generated during electrical stimulation of the human optic nerve using the optic nerve visual prosthesis. METHODS:Two volunteers blind from retinitis pigmentosa (RP) and with no light perception each received a chronically implanted opt...

journal_title：Investigative ophthalmology & visual science

authors： Brelén ME,Vince V,Gérard B,Veraart C,Delbeke J

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:In glaucoma, the optic nerve head (ONH) is the principal site of initial axonal injury, and elevated intraocular pressure (IOP) is the predominant risk factor. However, the initial responses of the ONH to elevated IOP are unknown. Here the authors use a rat glaucoma model to characterize ONH gene expression cha...

journal_title：Investigative ophthalmology & visual science

authors： Johnson EC,Doser TA,Cepurna WO,Dyck JA,Jia L,Guo Y,Lambert WS,Morrison JC

更新日期：2011-01-25 00:00:00

abstract：PURPOSE:Retinal ganglion cells die by apoptosis during development and after trauma such as axonal damage and exposure to excitotoxins. Apoptosis is associated with changes in the expression of genes that regulate this process. The genes that regulate apoptosis in retinal ganglion cells have not been characterized prim...

journal_title：Investigative ophthalmology & visual science

authors： Li Y,Schlamp CL,Nickells RW

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:Intraocular pressure (IOP) is dynamic and can be influenced by the use of tonometers. The authors developed a technique to implant a telemetric pressure transducer to measure IOP continuously in unrestrained rabbits. METHODS:A commercial telemetric pressure transducer was implanted subcutaneously on the dorsal...

journal_title：Investigative ophthalmology & visual science

authors： McLaren JW,Brubaker RF,FitzSimon JS

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:Varicella zoster virus (VZV) is a common cause of infectious uveitis associated with an intraocular inflammatory response involving virus-specific T cells. In the current study, the functional characteristics and the antigen specificity of VZV-reactive T cells recovered from intraocular fluid (IOF) samples of f...

journal_title：Investigative ophthalmology & visual science

authors： Milikan JC,Kinchington PR,Baarsma GS,Kuijpers RW,Osterhaus AD,Verjans GM

更新日期：2007-08-01 00:00:00

abstract：:On the assumption that myelin intrusion into the papilla and peripapillary region might occur with traumatic lesions of the optic nerve, a study was made of the clinical and histopathologic changes that might be expected. Nine monkey eyes were subjected to hemostat compression of the nerve close to the globe and studi...

journal_title：Investigative ophthalmology & visual science

authors： Cogan DG,Yee RD

更新日期：1977-05-01 00:00:00

abstract：PURPOSE:Retinal ganglion cell (RGC) degeneration is an important cause of visual impairment and can be modeled by optic nerve transection, which causes the death of 90% of RGCs within 14 days postaxotomy. We performed a proteomic study to identify and quantify proteins in the rat retina after optic nerve transection. O...

journal_title：Investigative ophthalmology & visual science

authors： Hollander A,D'Onofrio PM,Magharious MM,Lysko MD,Koeberle PD

更新日期：2012-06-26 00:00:00

abstract：PURPOSE:Subretinal drusenoid deposits (SDD) have been associated with the progression to late age-related macular degeneration (AMD). To determine whether SDD in eyes in normal macular health increases risk for early AMD, this study examined the association between presence of SDD at baseline in a cohort of older adult...

journal_title：Investigative ophthalmology & visual science

authors： Huisingh C,McGwin G Jr,Neely D,Zarubina A,Clark M,Zhang Y,Curcio CA,Owsley C

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration is a common form of vision loss affecting older adults. The etiology of AMD is multifactorial and is influenced by environmental and genetic risk factors. In this study, we examine how 19 common risk variants contribute to drusen progression, a hallmark of AMD pathogenesis. MET...

journal_title：Investigative ophthalmology & visual science

authors： Hoffman JD,van Grinsven MJ,Li C,Brantley M Jr,McGrath J,Agarwal A,Scott WK,Schwartz SG,Kovach J,Pericak-Vance M,Sanchez CI,Haines JL

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To determine the morphologic changes in the retina in the macula and around the optic disc in patients with autosomal dominant optic atrophy (ADOA) associated with a mutation in the OPA1 gene. METHODS:Cross-sectional images of the macular area of the retina were obtained by optical coherence tomography (OCT) i...

journal_title：Investigative ophthalmology & visual science

authors： Ito Y,Nakamura M,Yamakoshi T,Lin J,Yatsuya H,Terasaki H

更新日期：2007-09-01 00:00:00

abstract：:The susceptibility of Candida albicans to topical amphotericin B and natamycin was evaluated in a model of stromal keratitis in Dutch-belted rabbits and compared with minimal inhibitory concentrations in vitro. Treatment was delayed 24 hr to allow invasive disease to occur and was then continued for 5 days. Ten strain...

journal_title：Investigative ophthalmology & visual science

authors： O'Day DM,Ray WA,Robinson RD,Head WS,Savage AM

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:To investigate the distribution of inflammatory mediators such as interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha and angiogenic cytokines such as vascular endothelial growth factor (VEGF) and to identify their cellular source in surgically excised choroidal neovascular membranes (CNVMs) of various...

journal_title：Investigative ophthalmology & visual science

authors： Oh H,Takagi H,Takagi C,Suzuma K,Otani A,Ishida K,Matsumura M,Ogura Y,Honda Y

更新日期：1999-08-01 00:00:00

abstract：Purpose:To determine if there is structural and functional recovery of the retina from light induced retinal degeneration, and to evaluate the role of the oxidative stress response elements Nrf2, SOD1, DJ-1, and Parkin in such a recovery process. Methods:Eyes from C57BL/6J (B6J) mice and from oxidative stress response...

journal_title：Investigative ophthalmology & visual science

authors： Chen B,Aredo B,Zhu Y,Ding Y,Xin-Zhao C,Ufret-Vincenty RL

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To map the spatiotemporal decline in retinally driven activity in the superior colliculus (SC) of transgenic S334ter-line-3 rats that express a mutated rhodopsin, which causes photoreceptor degeneration. To determine whether transplantation of fetal retinal sheets into the subretinal space of these rats can rec...

journal_title：Investigative ophthalmology & visual science

authors： Sagdullaev BT,Aramant RB,Seiler MJ,Woch G,McCall MA

更新日期：2003-04-01 00:00:00