Measurement of evoked potentials after electrical stimulation of the human optic nerve.

abstract：PURPOSE:TGF-betas regulate cell proliferation and differentiation, and they play important roles in maintenance of corneal epithelium. However, the precise function of TGF-betas in the corneal epithelium remains unclear. In this study, cDNA expression array technology was used to demonstrate the effect of TGF-beta1 on ...

journal_title：Investigative ophthalmology & visual science

authors： Hayashida-Hibino S,Watanabe H,Nishida K,Tsujikawa M,Tanaka T,Hori Y,Saishin Y,Tano Y

更新日期：2001-07-01 00:00:00

abstract：Purpose:To refine the Minnesota Grading System (MGS) using definitions from the Age-Related Eye Disease Studies (AREDS) into a nine-step grading scale (MGS-9). Methods:A nine-step grading scale descriptive analysis using three key phenotypic features (total drusen area, increased, and decreased pigmentation) of human ...

journal_title：Investigative ophthalmology & visual science

authors： Olsen TW,Liao A,Robinson HS,Palejwala NV,Sprehe N

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:To elucidate the role of signals mediated by EphB4 receptor tyrosine kinase and its transmembrane ephrinB2 ligand in corneal lymphatic capillaries. METHODS:To detect expression of ephrinB2 and EphB4 in mouse corneas, immunohistochemistry of flat-mount corneas from 6- to 10-week-old wild-type, Efnb2-lacZ, and E...

journal_title：Investigative ophthalmology & visual science

authors： Katsuta H,Fukushima Y,Maruyama K,Hirashima M,Nishida K,Nishikawa S,Uemura A

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:To investigate whether a recently described retinal ganglion cell (RGC) marker Rbpms (RNA binding protein with multiple splicing) could be used for RGC quantification in various models of RGC degeneration. METHODS:Optic nerve crush, excitotoxicity, and elevated intraocular pressure (IOP) rat models were used. ...

journal_title：Investigative ophthalmology & visual science

authors： Kwong JM,Quan A,Kyung H,Piri N,Caprioli J

更新日期：2011-12-28 00:00:00

abstract：PURPOSE:To study retinal microstructure in Usher Syndrome type 1B (USH1B) caused by MYO7A mutations as a prelude to treatment initiatives. METHODS:Patients with MYO7A-USH1B (n=17; ages 5-61) were studied with optical coherence tomography. Retinal laminae across horizontal and vertical meridians were measured. Colocali...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Aleman TS,Sumaroka A,Cideciyan AV,Roman AJ,Windsor EA,Schwartz SB,Rehm HL,Kimberling WJ

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:To study the diameter response of retinal arterioles as a function of the arteriolar diameter. METHODS:Ten healthy young volunteers aged 22 to 33 years were subjected to diameter measurement of four successive segments of a retinal arteriole with a retinal vessel analyzer (RVA). At each of the segments, the di...

journal_title：Investigative ophthalmology & visual science

authors： Jeppesen P,Sanye-Hajari J,Bek T

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Retinal injuries that affect the photoreceptors and/or the retinal pigment epithelium (RPE) may result in the leakage of retinal proteins into the systemic circulation. This study was designed to determine whether an immune response is elicited after an acute retinal injury resulting in circulating anti-retinal...

journal_title：Investigative ophthalmology & visual science

authors： Scott SE,Bouhenni RA,Chomyk AM,Dunmire JJ,Patil J,Nakamura H,Deepak P

更新日期：2012-04-06 00:00:00

abstract：PURPOSE:Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic. One such ligand, TCDD, was found to exert potent immunosuppressive capacities in mice developing pathogenic autoimmune processes, including EAU, but its toxicity makes it unusable for humans. A recently identified endogenous AHR lig...

journal_title：Investigative ophthalmology & visual science

authors： Nugent LF,Shi G,Vistica BP,Ogbeifun O,Hinshaw SJ,Gery I

更新日期：2013-11-13 00:00:00

abstract：PURPOSE:To understand the genetic regulatory pathways underlying the retinoic acid (RA) induction of cone arrestin, gene array technology and other molecular tools were used to profile global gene expression changes in human retinoblastoma cells. METHODS:Weri-Rb-1 retinoblastoma cells were cultured in the absence or p...

journal_title：Investigative ophthalmology & visual science

authors： Li A,Zhu X,Brown B,Craft CM

更新日期：2003-03-01 00:00:00

abstract：Purpose:Retinal nonperfusion and hypoxia are important factors in human diabetic retinopathy, and these presumably inhibit energy production and lead to cell death. The purpose of this study was to elucidate the effect of diabetes on inner retinal oxygen delivery and metabolism in a mouse model of diabetes. Methods:Ph...

journal_title：Investigative ophthalmology & visual science

authors： Blair NP,Wanek J,Felder AE,Brewer KC,Joslin CE,Shahidi M

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:The effects of adrenergic agonists and antagonists on Na+, K+, Cl- cotransport in fetal human nonpigmented ciliary epithelial (NPE) cells were investigated. METHODS:86Rb+ as a marker for K+ was used to study ouabain-insensitive, bumetanide-sensitive 86Rb+ uptake in cultured NPE monolayers. Cyclic adenosine mon...

journal_title：Investigative ophthalmology & visual science

authors： Crook RB,Riese K

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:To investigate whether time outdoors and a range of other activities are associated with change in spherical equivalent (SE) and axial length in Chinese children over a period of 2 years. METHODS:A total of 1997 children aged 12.7 ± 0.5 (10.9-15.6) years in the Anyang Childhood Eye Study (ACES) were examined a...

journal_title：Investigative ophthalmology & visual science

authors： Li SM,Li H,Li SY,Liu LR,Kang MT,Wang YP,Zhang F,Zhan SY,Gopinath B,Mitchell P,Wang N,Anyang Childhood Eye Study Group.

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:The Y402H polymorphism in the complement regulator factor H (fH) is strongly associated with age-related macular degeneration (AMD) across diverse populations. Persons homozygous for histidine at this position have up to 12-fold greater risk for AMD than those homozygous for tyrosine. Knowledge of fH-Y402H stat...

journal_title：Investigative ophthalmology & visual science

authors： Hakobyan S,Harris CL,Tortajada A,Goicochea de Jorge E,García-Layana A,Fernández-Robredo P,Rodríguez de Córdoba S,Morgan BP

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:To describe the clinical findings and to identify the genetic locus in a Dutch family with autosomal dominant benign concentric annular macular dystrophy (BCAMD). METHODS:All family members underwent ophthalmic examination. Linkage analysis of candidate retinal dystrophy loci and a whole genome scan were perfo...

journal_title：Investigative ophthalmology & visual science

authors： van Lith-Verhoeven JJ,Hoyng CB,van den Helm B,Deutman AF,Brink HM,Kemperman MH,de Jong WH,Kremer H,Cremers FP

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:Migration of Müller glial cells is enhanced in proliferative retinopathies, but the mechanisms involved are ill defined. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid synthesized by sphingosine kinase (SphK), which promotes proliferation, migration, and inflammation, acting as an intracellular media...

journal_title：Investigative ophthalmology & visual science

authors： Simón MV,Prado Spalm FH,Politi LE,Rotstein NP

更新日期：2015-09-01 00:00:00

abstract：:Vitrectomy has been shown to halt diabetic retinal neovascularization, but the mechanism of this process is unknown. We propose that vitrectomy improves the oxygen supply to ischemic inner retina by way of fluid currents in the vitreous cavity. In order to test this hypothesis, we induced branch retinal vein occlusion...

journal_title：Investigative ophthalmology & visual science

authors： Stefánsson E,Novack RL,Hatchell DL

更新日期：1990-02-01 00:00:00

abstract：PURPOSE:During early development, the ganglioside composition of the retina changes significantly, in that GD3 becomes the primary ganglioside in the mammalian retina. Because gangliosides play an important role in neuronal cell differentiation and proliferation, this change in ganglioside profile may indicate retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Park EJ,Suh M,Clandinin MT

更新日期：2005-07-01 00:00:00

abstract：Purpose:Mutations in CACNA2D4, encoding the α2δ4 subunit of retinal voltage-gated calcium channels (Cav), cause a rare type of retinal dysfunction in human, mainly affecting cone vision. Here, we investigate the role of CACNA2D4 in targeting of Cav, its influence on cone-mediated signal transmission, and the cellular a...

journal_title：Investigative ophthalmology & visual science

authors： Schlegel DK,Glasauer SMK,Mateos JM,Barmettler G,Ziegler U,Neuhauss SCF

更新日期：2019-12-02 00:00:00

abstract：Purpose:Adult central nervous system (CNS) neurons are unable to regenerate their axons after injury. Krüppel-like transcription factor (KLF) family members regulate intrinsic axon growth ability in vitro and in vivo, but mechanisms downstream of these transcription factors are not known. Methods:Purified retinal gang...

journal_title：Investigative ophthalmology & visual science

authors： Galvao J,Iwao K,Apara A,Wang Y,Ashouri M,Shah TN,Blackmore M,Kunzevitzky NJ,Moore DL,Goldberg JL

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:The objective of this study was to determine whether alteration in mucins could be detected in patients with dry eye symptoms by using the monoclonal antibody H185, which recognizes carbohydrate epitopes on mucin molecules. METHODS:Immunohistochemistry and immunoelectron microscopy was used to examine binding ...

journal_title：Investigative ophthalmology & visual science

authors： Danjo Y,Watanabe H,Tisdale AS,George M,Tsumura T,Abelson MB,Gipson IK

更新日期：1998-12-01 00:00:00

abstract：PURPOSE:To study the survival of adult retinal grafts prepared in a physiologically optimized way. METHODS:Twenty-three rabbits received an adult full-thickness rabbit retinal transplant positioned under the host retina, using a vitrectomy technique. The transplants were prepared using a procedure based on a previousl...

journal_title：Investigative ophthalmology & visual science

authors： Wassélius J,Ghosh F

更新日期：2001-10-01 00:00:00

abstract：Purpose:To quantify the effect of induced stray light on halo size, luminance threshold, and contrast sensitivity. Methods:Retinal stray light was induced in five healthy subjects using different photographic filters. The stray light induced ranged from levels observed in intraocular lenses (IOLs) with glistenings (lo...

journal_title：Investigative ophthalmology & visual science

authors： van der Mooren M,Rosén R,Franssen L,Lundström L,Piers P

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Interphotoreceptor retinoid-binding protein (IRBP) binds and transports retinoids and fatty acids in the interphotoreceptor space (IPS). To understand the relationship between the protein structure and its functions requires bulk quantities of human IRBP. The authors sought to produce recombinant human IRBP (rh...

journal_title：Investigative ophthalmology & visual science

authors： Lin ZY,Si JS,Nickerson JM

更新日期：1994-09-01 00:00:00

abstract：PURPOSE:To demonstrate the effectiveness of Hierarchical Bayesian (HB) approach in a modeling framework for association effects that accounts for SEs of vision-specific latent traits assessed using Rasch analysis. METHODS:A systematic literature review was conducted in four major ophthalmic journals to evaluate Rasch ...

journal_title：Investigative ophthalmology & visual science

authors： Wong WL,Li X,Li J,Wong TY,Cheng CY,Lamoureux EL

更新日期：2014-07-11 00:00:00

abstract：PURPOSE:Metabolism and transport of cysteine are critical for maintenance of the intracellular glutathione (GSH) level. In this study, transport mechanisms of L-cystine and regulation of GSH biosynthesis in the absence or presence of NO-induced oxidant stress were investigated in primary cultured rabbit conjunctival ep...

journal_title：Investigative ophthalmology & visual science

authors： Gukasyan HJ,Kannan R,Lee VH,Kim KJ

更新日期：2003-03-01 00:00:00

abstract：:Tendon and cornea of 17-day-old chick embryos primarily synthesize type I collagen as the major collagenous component nd type V collagen as a minor collagenous component. Matrix-free cells isolated from cornea and tendon synthesize and secrete mainly type I procollagen. A short lag period for the secretion of collagen...

journal_title：Investigative ophthalmology & visual science

authors： Kao WW,Mai SH,Chou KL

更新日期：1982-12-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and d-ala2-methionine enkephalinamide (DALA, a long-lasting enkephalin analogue) were used to investigate the peptidergic control of lacrimal gland function. To characterize the mechanism by which VIP stimulates and DALA inhibits lacrimal peroxidase secretion, the effect of these pe...

journal_title：Investigative ophthalmology & visual science

authors： Cripps MM,Bennett DJ

更新日期：1990-10-01 00:00:00

abstract：:Nonenzymatic glycated lens alpha-crystallin, isolated from human diabetic cataract lenses, does not differ in subunit size and secondary structure from nonglycated alpha-crystallin. The tertiary structure, however, has undergone a significant change as reflected in the changes of near-ultraviolet (UV) circular dichroi...

journal_title：Investigative ophthalmology & visual science

authors： Liang JN,Chylack LT Jr

更新日期：1987-05-01 00:00:00

abstract：Purpose:Sjögren syndrome (SS) is an autoimmune disease characterized by the inflammatory destruction of salivary and lacrimal glands (LG). Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy. The purpose of the study is to investigate the effect of CQ on the development of dry eye ...

journal_title：Investigative ophthalmology & visual science

authors： Lee HJ,Shin S,Yoon SG,Cheon EJ,Chung SH

更新日期：2019-09-03 00:00:00

abstract：:Purpose. Experimental autoimmune uveoretinitis (EAU), a Th1/Th17 cell-mediated autoimmune disease induced in mice, serves as a model of human endogenous uveitis. In this model, proinflammatory cytokines and various stimuli activate the transcriptional factor, nuclear factor-kappaB (NF-kappaB), in the retina. The thera...

journal_title：Investigative ophthalmology & visual science

authors： Iwata D,Kitaichi N,Miyazaki A,Iwabuchi K,Yoshida K,Namba K,Ozaki M,Ohno S,Umezawa K,Yamashita K,Todo S,Ishida S,Onoé K

更新日期：2010-04-01 00:00:00