Delayed regeneration of foveal cone photopigments in Vogt-Koyanagi-Harada disease at the convalescent stage.

abstract：PURPOSE:The inherited early-onset macular degenerative disease known as malattia leventinese (ML) and Doyne honeycomb retinal dystrophy (DHRD) have been linked to a missense mutation leading to production of a mutant fibulin-3 protein (R345W). R345W is poorly secreted and accumulates in the RPE of ML/DHRD retinas. Accu...

journal_title：Investigative ophthalmology & visual science

authors： Roybal CN,Marmorstein LY,Vander Jagt DL,Abcouwer SF

更新日期：2005-11-01 00:00:00

abstract：:Photoreceptors can segregate inner segment proteins from outer segment proteins. It is uncertain whether such a sorting process occurs during disc morphogenesis in rods, thereby resulting in an outer segment plasma membrane which differs compositionally from the discs. In this study, the plasma membranes of intact, pu...

journal_title：Investigative ophthalmology & visual science

authors： Polans AS,Burton MD

更新日期：1988-10-01 00:00:00

abstract：PURPOSE:To determine the effect of pyrrolidine dithiocarbamate (PDTC), a nuclear factor (NF)-kappaB inhibitor, on chemokine and chemokine receptor expression and thus elucidate the role of NF-kappaB in the pathogenesis of experimental autoimmune anterior uveitis (EAAU). METHODS:Uveitis was induced in Lewis rats with t...

journal_title：Investigative ophthalmology & visual science

authors： Yang CH,Fang IM,Lin CP,Yang CM,Chen MS

更新日期：2005-04-01 00:00:00

abstract：Purpose:The purpose of this study was to clarify the interactions between macrophages (MPs) and RPE cells in coculture systems to investigate the functional plasticity of RPE cells. Methods:Adherent peritoneal cells or murine MP cell line Raw 264.7 was cocultured with primary RPE cells taken from C57BL/6 mice, with or...

journal_title：Investigative ophthalmology & visual science

authors： Yamawaki T,Ito E,Mukai A,Ueno M,Yamada J,Sotozono C,Kinoshita S,Hamuro J

更新日期：2016-11-01 00:00:00

abstract：Purpose:To investigate the effect of short-wavelength light (SL) on guinea pigs with lens-induced myopia (LIM) and the possible retinoic acid (RA)-related mechanisms. Methods:Two-week-old guinea pigs (n = 60) with monocular -5D lenses were reared under white light (WL, 580 lux) or SL (440 nm, 500 lux). The left eyes w...

journal_title：Investigative ophthalmology & visual science

authors： Yu M,Liu W,Wang B,Dai J

更新日期：2021-01-04 00:00:00

abstract：:Cellular retinol binding protein (CRBP) was localized in the rat retina by means of light and electron microscopic immunocytochemistry. The peroxidase-antiperoxidase (PAP) method employed at the light microscopic level showed that CRBP is sharply localized to the retinal pigment epithelium (RPE). None was detectable i...

journal_title：Investigative ophthalmology & visual science

authors： Bok D,Ong DE,Chytil F

更新日期：1984-08-01 00:00:00

abstract：Purpose:Little is known regarding the therapeutic effect of carbonic anhydrase inhibitors (CAIs) in the management of cystic macular lesions in children with X-linked juvenile retinoschisis (XLRS) despite the fact that this disease often manifests during childhood. Therefore, our goal was to determine the efficacy of C...

journal_title：Investigative ophthalmology & visual science

authors： Verbakel SK,van de Ven JP,Le Blanc LM,Groenewoud JM,de Jong EK,Klevering BJ,Hoyng CB

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Adipogenesis contributes to the pathogenesis of thyroid eye disease (TED). Thyrotropin receptor (TSHR) transcripts are present in orbital fat. This study was conducted to determine whether they are expressed as functional protein, and if so, whether this is restricted to TED orbits or to a particular stage in a...

journal_title：Investigative ophthalmology & visual science

authors： Crisp M,Starkey KJ,Lane C,Ham J,Ludgate M

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:Endogenous anterior uveitis (AU), when untreated, may lead to vision loss. This study compared the safety and efficacy of difluprednate versus prednisolone acetate for the treatment of this condition. METHODS:This phase III, double-masked, noninferiority study randomized patients with mild to moderate endogeno...

journal_title：Investigative ophthalmology & visual science

authors： Sheppard JD,Toyos MM,Kempen JH,Kaur P,Foster CS

更新日期：2014-05-06 00:00:00

abstract：:Determination of intraocular antibody synthesis against certain microorganisms is a diagnostic aid in identifying the causative agent in clinical uveitis. Little is known, however, concerning the kinetics and specificity of antibodies produced during intraocular inflammation. To investigate this subject we induced uve...

journal_title：Investigative ophthalmology & visual science

authors： van der Voet JC,Liem A,Otto AJ,Kijlstra A

更新日期：1989-02-01 00:00:00

abstract：PURPOSE:To investigate whether enzymatic collagen breakdown is an active process in the human vitreous. METHODS:Human donor eyes were used for immunohistochemistry to detect the possible presence of the matrix metalloproteinase (MMP)-induced type II collagen breakdown product col2-3/4C-short in the vitreous. Western b...

journal_title：Investigative ophthalmology & visual science

authors： van Deemter M,Pas HH,Kuijer R,van der Worp RJ,Hooymans JM,Los LI

更新日期：2009-10-01 00:00:00

abstract：Purpose:To characterize intraocular pressure (IOP) dynamics by identifying the sources of transient IOP fluctuations and quantifying the frequency, magnitude, associated cumulative IOP-related mechanical energy, and temporal distribution. Methods:IOP was monitored at 500 Hz for periods of 16 to 451 days in nine normal...

journal_title：Investigative ophthalmology & visual science

authors： Turner DC,Edmiston AM,Zohner YE,Byrne KJ,Seigfreid WP,Girkin CA,Morris JS,Downs JC

更新日期：2019-06-03 00:00:00

abstract：PURPOSE:To determine the effect of the nitric oxide donor sodium nitroprusside (SNP) on rat retinas and to see whether detrimental changes could be attenuated by known antiglaucoma drugs. METHODS:SNP was injected into the rat eye and retinas were analyzed by the terminal-deoxynucleotidyl transferase dUTP-linked nick e...

journal_title：Investigative ophthalmology & visual science

authors： Osborne NN,Wood JP

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to develop a murine model of allergic conjunctivitis induced by house dust mite (HDM) extract from Dermatophagoides pteronyssinus, a major allergen in humans. METHODS:Forty BALB/c mice were divided into five groups, immunized with placebo, ovalbumin (10 μg), or HDM extract followi...

journal_title：Investigative ophthalmology & visual science

authors： Lee YJ,Han SJ,Lee H,Kim JS,Seo KY

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To analyze the roles of vitreal macrophages and circulating leukocytes in retinal vascular growth. METHODS:Bone marrow (BM) cells from green fluorescent protein (GFP) transgenic mice were transplanted into postnatal day (P)1 mice after irradiation. The mice were exposed to 76% to 78% oxygen (P7-P12), to initia...

journal_title：Investigative ophthalmology & visual science

authors： Kataoka K,Nishiguchi KM,Kaneko H,van Rooijen N,Kachi S,Terasaki H

更新日期：2011-03-14 00:00:00

abstract：PURPOSE:To identify the changes in postnatal mouse conjunctival forniceal gene expression and their regulation by Klf4 during the eye-opening stage when the goblet cells first appear. METHODS:Laser microdissection (LMD) was used to collect conjunctival forniceal cells from postnatal (PN) day 9, PN14 and PN20 wild-type...

journal_title：Investigative ophthalmology & visual science

authors： Gupta D,Harvey SA,Kaminski N,Swamynathan SK

更新日期：2011-07-01 00:00:00

abstract：Purpose:To evaluate the microvascular changes in eyes with RP quantitatively using optical coherence tomography angiography (OCTA) and to determine whether the correlations between these indices and the severity of RP are significant. Methods:This was a retrospective, observational study. The medical records of 53 RP ...

journal_title：Investigative ophthalmology & visual science

authors： Inooka D,Ueno S,Kominami T,Sayo A,Okado S,Ito Y,Terasaki H

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Cigarette smoking is the most consistent risk factor for age-related macular degeneration (AMD), especially the choroidal neovascularization (CNV)-mediated exudative type. Dioxins and dioxin-like compounds have various effects on living organisms and are also contained in cigarette smoke. However, the effects o...

journal_title：Investigative ophthalmology & visual science

authors： Takeuchi A,Takeuchi M,Oikawa K,Sonoda KH,Usui Y,Okunuki Y,Takeda A,Oshima Y,Yoshida K,Usui M,Goto H,Kuroda M

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:In the Gbeta5(-/-) mouse, the electroretinogram (ERG) b-wave is absent, and the R7 subfamily of regulators of G protein signaling (RGS), which includes RGS6, -7, -9, and -11, is downregulated. Mutant mouse strains deficient in RGS7 or -11 were characterized, and the SG711 strain which is deficient in both prote...

journal_title：Investigative ophthalmology & visual science

authors： Chen FS,Shim H,Morhardt D,Dallman R,Krahn E,McWhinney L,Rao A,Gold SJ,Chen CK

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:We sought to determine whether conjunctival ultraviolet autofluorescence (UVAF), a biomarker of outdoor light exposure, is associated with myopia. METHODS:We performed a cross-sectional study on Norfolk Island and recruited individuals aged ≥ 15 years. Participants completed a sun-exposure questionnaire and un...

journal_title：Investigative ophthalmology & visual science

authors： Sherwin JC,Hewitt AW,Coroneo MT,Kearns LS,Griffiths LR,Mackey DA

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:To examine the involvement of p27(KIP1) in the regulation of the proliferation of the developing corneal endothelium. METHODS:Central and peripheral corneas in C57Bl6 mice at postnatal day (P)1, P11, and 12 weeks after birth were analyzed by immunocytochemistry with anti-p27(KIP1), -p57(KIP2), and -proliferati...

journal_title：Investigative ophthalmology & visual science

authors： Yoshida K,Kase S,Nakayama K,Nagahama H,Harada T,Ikeda H,Harada C,Imaki J,Ohgami K,Shiratori K,Ilieva IB,Ohno S,Nishi S,Nakayama KI

更新日期：2004-07-01 00:00:00

abstract：:Patients with choroidal melanomas and simulating choroidal tumors were tested in a masked manner in a leukocyte-migration inhibition (LMI) assay with a 3M KCl antigen derived from a metastatic choroidal melanoma. Good discrimination petween patient groups was observed with this antigen. The sensitivity and specificity...

journal_title：Investigative ophthalmology & visual science

authors： Char DH

更新日期：1977-02-01 00:00:00

abstract：PURPOSE:To explore the correlation between optical coherence tomography (OCT) and stereoscopic fundus photographs (FP) for the assessment of retinal thickening (RT) in diabetic macular edema (DME) within a clinical trial. METHODS:OCT, FP, and best corrected visual acuity (VA) measurements were obtained in both eyes of...

journal_title：Investigative ophthalmology & visual science

authors： Davis MD,Bressler SB,Aiello LP,Bressler NM,Browning DJ,Flaxel CJ,Fong DS,Foster WJ,Glassman AR,Hartnett ME,Kollman C,Li HK,Qin H,Scott IU,Diabetic Retinopathy Clinical Research Network Study Group.

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:To evaluate the change in ocular function by eye in patients with unilateral pigmentary retinopathy. METHODS:Longitudinal regression was used to estimate mean exponential rates of change in Goldmann visual field area (V4e white test light) and in full-field electroretinogram (ERG) amplitudes to 0.5- and 30-Hz ...

journal_title：Investigative ophthalmology & visual science

authors： Potsidis E,Berson EL,Sandberg MA

更新日期：2011-11-29 00:00:00

abstract：PURPOSE:The phenoxyacetic acid, ethacrynic acid (ECA), has potential use in glaucoma therapy because it acts to increase aqueous outflow in vivo and in vitro. In human trabecular meshwork (HTM) cell culture, ECA acts to change cell shape and attachment, effects that have been correlated with microtubule (MT) alteration...

journal_title：Investigative ophthalmology & visual science

authors： Epstein DL,Roberts BC,Skinner LL

更新日期：1997-07-01 00:00:00

abstract：:Visual thresholds and rhodopsin levels were determined in nine subjects with autosomal dominant retinitis pigmentosa. The subjects fell into two groups, corresponding to two subtypes of the disease revealed by two-color, dark-adapted static perimetry. In the first of these subtypes, rod-mediated function was variably ...

journal_title：Investigative ophthalmology & visual science

authors： Kemp CM,Jacobson SG,Faulkner DJ

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:To study the relationships between the refractive power of the crystalline lens, overall refractive error of the eye, and degree of nuclear cataract. METHODS:All phakic participants of the population-based Central India Eye and Medical Study with an age of 50+ years were included. Calculation of the refractive...

journal_title：Investigative ophthalmology & visual science

authors： Iribarren R,Morgan IG,Nangia V,Jonas JB

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:To examine the expression and localization of the neuroplastins (np), two synapse-enriched members of the immunoglobulin (Ig) superfamily of cell-adhesion molecules, in the developing and adult retina and optic nerve. METHODS:Expressions of the two isoforms np55 and np65 and carboxyl-terminal splice variants w...

journal_title：Investigative ophthalmology & visual science

authors： Kreutz MR,Langnaese K,Dieterich DC,Seidenbecher CI,Zuschratter W,Beesley PW,Gundelfinger ED

更新日期：2001-07-01 00:00:00

abstract：:Cyclodestructive modalities in humans have been shown to be effective when applied 3.5 mm or more posterior to the limbus. Therefore, CW Nd:YAG contact transscleral laser and cryopexy were applied 6 mm posterior to the limbus of pigmented rabbits. The intraocular pressure (IOP), flare, iritis, cells and conjunctival h...

journal_title：Investigative ophthalmology & visual science

authors： Schubert HD,Federman JL

更新日期：1989-03-01 00:00:00

abstract：PURPOSE:To determine the molecular mechanisms underlying the protective effects of zinc against oxidative stress in cultured retinal pigment epithelial (RPE) cells. METHODS:Cultured ARPE-19 cells were treated with different concentrations of zinc for various times. Cellular glutathione (GSH) and glutathione disulfide ...

journal_title：Investigative ophthalmology & visual science

authors： Ha KN,Chen Y,Cai J,Sternberg P Jr

更新日期：2006-06-01 00:00:00