The balance between proteinases and inhibitors in a murine model of proliferative retinopathy.

abstract：PURPOSE:Clonidine and brimonidine, two alpha-2 agonists, have been shown to reduce intraocular pressure (IOP) in patients with glaucoma. Little is known, however, about the exact role of alpha receptors in the control of ocular blood flow in the posterior pole of the eye. Hence, the study was conducted to investigate t...

journal_title：Investigative ophthalmology & visual science

authors： Weigert G,Resch H,Garhofer G,Fuchsjäger-Mayrl G,Schmetterer L

更新日期：2007-09-01 00:00:00

abstract：:Checkerboard reversal stimuli were used to evoke transient pattern electroretinograms (P-ERGs) from the eyes of 14 patients with amblyopia and 14 normal subjects. In the control group, and in normal eyes of patients, pattern electroretinograms were obtained with monocular central fixation. Amblyopic eyes were examined...

journal_title：Investigative ophthalmology & visual science

authors： Gottlob I,Welge-Lüssen L

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To compare EyeCam (Clarity Medical Systems, Pleasanton, CA) imaging with gonioscopy for detecting angle closure. METHODS:In this prospective, hospital-based study, subjects underwent gonioscopy by a single observer and EyeCam imaging by a different operator. EyeCam images were graded by two masked observers. T...

journal_title：Investigative ophthalmology & visual science

authors： Perera SA,Baskaran M,Friedman DS,Tun TA,Htoon HM,Kumar RS,Aung T

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Floppy eyelid syndrome (FES) is an acquired hyperelasticity disorder affecting the upper eyelid. The tarsal plate becomes hyperelastic with a loss of intrinsic rigidity. As a result, the eyelid is subjected to cyclic mechanical stress. This condition was used as a model to investigate changes in dynamic fibrobl...

journal_title：Investigative ophthalmology & visual science

authors： Ezra DG,Ellis JS,Beaconsfield M,Collin R,Bailly M

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To determine the effect of continuous light exposure on ocular growth and emmetropization in infant monkeys. METHODS:Nine infant rhesus monkeys were reared with the normal vivarium lights on continuously. The 24-hour light cycle was initiated between 1 and 4 weeks of age and maintained for 6 months. The ocular...

journal_title：Investigative ophthalmology & visual science

authors： Smith EL 3rd,Bradley DV,Fernandes A,Hung LF,Boothe RG

更新日期：2001-05-01 00:00:00

abstract：:The irides of albino guinea pigs were photographed, and the iris arteriolar diameters were measured with the animal breathing room air, 10% O2/90% N2, or 100% O2. The iris arterioles constrict significantly in hyperoxia and dilate in hypoxia. The average constriction in 100% O2 was 27% +/- 8%, and the average dilatati...

journal_title：Investigative ophthalmology & visual science

authors： Stefansson E,Shelton RA,Landers MB 3rd,Walsh AW,Wolbarsht ML

更新日期：1983-06-01 00:00:00

abstract：PURPOSE:Chronic, subclinical inflammation contributes to the pathogenesis of several ocular diseases, including age-related macular degeneration. Proinflammatory cytokines affect tight junctions in epithelia that lack claudin-19, but in the retinal pigment epithelium claudin-19 predominates. We examined the effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Peng S,Gan G,Rao VS,Adelman RA,Rizzolo LJ

更新日期：2012-07-27 00:00:00

abstract：PURPOSE:Oxidative stress and metabolic dysregulation of the RPE have been implicated in AMD; however, the molecular regulation of RPE metabolism remains unclear. The transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) is a powerful mediator of mitochondrial function. Th...

journal_title：Investigative ophthalmology & visual science

authors： Iacovelli J,Rowe GC,Khadka A,Diaz-Aguilar D,Spencer C,Arany Z,Saint-Geniez M

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Lenses from selenite-treated animals develop reversible "cold cataract" at a lower temperature than is required for lenses from age-matched control animals. This unexplained, stabilized phase transition is readily observed in intact lenses 36 to 48 hours after treatment and occurs in lenses before the appearanc...

journal_title：Investigative ophthalmology & visual science

authors： Mitton KP,Hess JL,Bunce GE

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:Dry eye syndrome (DES) is characterized by an increase in tear osmolarity and induction of the expression and nuclear localization of an osmoprotective transcription factor (nuclear factor of activated T-cells 5 [NFAT5]) that plays an important role in providing protection against hyperosmotic tears. In this st...

journal_title：Investigative ophthalmology & visual science

authors： Sawazaki R,Ishihara T,Usui S,Hayashi E,Tahara K,Hoshino T,Higuchi A,Nakamura S,Tsubota K,Mizushima T

更新日期：2014-04-21 00:00:00

abstract：:Although the lens has been shown to have the capacity to respond to insulin in vitro, little is known concerning the biochemical relationships of insulin to the lens in vivo. Therefore we have measured insulin in the aqueous humor of rabbits by a sensitive radioimmunoassay after paracentesis and feeding. The insulin c...

journal_title：Investigative ophthalmology & visual science

authors： Coulter JB 3rd,Engelke JA,Eaton DK

更新日期：1980-12-01 00:00:00

abstract：PURPOSE:To characterize the reactions of retinal glial cells (astrocytes and Müller cells) to retinal injury in mice that lack glial fibrillary acidic protein (GFAP) and vimentin (GFAP-/-Vim-/-) and to determine the role of glial cells in retinal detachment (RD)-induced photoreceptor degeneration. METHODS:RD was induc...

journal_title：Investigative ophthalmology & visual science

authors： Nakazawa T,Takeda M,Lewis GP,Cho KS,Jiao J,Wilhelmsson U,Fisher SK,Pekny M,Chen DF,Miller JW

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:Erythropoietin (EPO) modulates erythropoiesis by inhibiting apoptosis in erythrocyte progenitors. Recently, EPO has been shown to be protective in experimental models of mechanical trauma, neuroinflammation, cerebral and retinal ischemia, and even in a human stroke trial. However, little is known about EPO sign...

journal_title：Investigative ophthalmology & visual science

authors： Weishaupt JH,Rohde G,Pölking E,Siren AL,Ehrenreich H,Bähr M

更新日期：2004-05-01 00:00:00

abstract：:We describe a new technique for the separation and isolation of nonpigmented ciliary body epithelial cells from rabbit. Excised ciliary body is incubated in a medium buffered with EGTA to a free-Ca2+ concentration of 10(-8) M, and the nonpigmented cell layer is separated from the pigmented layer by microdissection und...

journal_title：Investigative ophthalmology & visual science

authors： Fain GL,Cilluffo MC,Fain MJ,Lee DA

更新日期：1988-05-01 00:00:00

abstract：PURPOSE:CD4(+)CD25(+)FoxP3(+) naturally occurring regulatory T cells (Tregs) maintain self-tolerance and function to suppress overly exuberant immune responses. However, it is unclear whether innate immune cells modulate Treg function. Here the authors examined the role of innate immunity in lymphomyeloid homeostasis. ...

journal_title：Investigative ophthalmology & visual science

authors： Mott KR,Gate D,Zandian M,Allen SJ,Rajasagi NK,van Rooijen N,Chen S,Arditi M,Rouse BT,Flavell RA,Town T,Ghiasi H

更新日期：2011-04-08 00:00:00

abstract：PURPOSE:The sense of vision in humans is robust, and visual flickering is rarely experienced. To investigate this mechanism, electrophysiological and molecular biological techniques were used on human cone and rod photoreceptors. METHODS:Voltage-gated currents were recorded using the patch-clamp technique on isolated ...

journal_title：Investigative ophthalmology & visual science

authors： Kawai F,Horiguchi M,Ichinose H,Ohkuma M,Isobe R,Miyachi E

更新日期：2005-01-01 00:00:00

abstract：:A stimulus consisting of 96 red LEDs mounted in the rear of a ganzfeld bowl was used to elicit focal electroretinograms (FERG) from the central 9 degrees of the retina in human subjects. The luminance of the stimulus was driven sinusoidally at frequencies from 10-60 Hz. The temporal responsiveness and response phase l...

journal_title：Investigative ophthalmology & visual science

authors： Seiple WH,Siegel IM,Carr RE,Mayron C

更新日期：1986-07-01 00:00:00

abstract：PURPOSE:To investigate if topical treatment of neuroprotectin D1 (NPD1) increases regeneration of functional nerves after lamellar keratectomy. METHODS:An 8-mm stromal dissection was performed in the left eye of each rabbit. The rabbits were treated with NPD1, pigment epithelial-derived factor (PEDF) in combination wi...

journal_title：Investigative ophthalmology & visual science

authors： Cortina MS,He J,Russ T,Bazan NG,Bazan HE

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:To measure interspecies thickness differences in the central anterior and posterior capsules of postmortem crystalline lenses, by a technique that maintains the anatomic integrity of the lens. METHODS:Central capsule thickness was measured with a custom-built, noncontact optical system, using a focus detection...

journal_title：Investigative ophthalmology & visual science

authors： Ziebarth NM,Manns F,Uhlhorn SR,Venkatraman AS,Parel JM

更新日期：2005-05-01 00:00:00

abstract：Purpose:To use laser speckle flowgraphy (LSFG) to assess blood flow (BF) in the optic nerve head (ONH) tissue and choroid during elevated intraocular pressure (IOP). Methods:This prospective study included 20 eyes of 20 healthy volunteers. The testing protocol had a baseline phase, two elevated IOP phases (+10 and +20...

journal_title：Investigative ophthalmology & visual science

authors： Kiyota N,Shiga Y,Ichinohasama K,Yasuda M,Aizawa N,Omodaka K,Honda N,Kunikata H,Nakazawa T

更新日期：2018-07-02 00:00:00

abstract：:Corneas of fetal and young albino rabbits were examined by light and transmission electron microscopy. In addition, DNA and hydroxyproline content were measured in developing stroma. The results were compared with similar data from healing corneas in adult rabbits and from developing corneas of other animal species. I...

journal_title：Investigative ophthalmology & visual science

authors： Cintron C,Covington H,Kublin CL

更新日期：1983-05-01 00:00:00

abstract：PURPOSE:We investigated the therapeutic effect of liposomal doxorubicin (Lipo-dox) on experimental proliferative vitreoretinopathy (PVR). METHODS:The toxicity of Lipo-dox was determined in vitro in cultured rabbit retinal pigment epithelium (RPE) cells by tetrazolium-based (MTT) assay for cell viability performed 48 a...

journal_title：Investigative ophthalmology & visual science

authors： Kuo HK,Chen YH,Wu PC,Wu YC,Huang F,Kuo CW,Lo LH,Shiea J

更新日期：2012-06-29 00:00:00

abstract：Purpose:To investigate the difference in intraocular vascular endothelial growth factor (VEGF) concentration between pachychoroid neovasculopathy and neovascular age-related macular degeneration (nAMD) and its associations with responses to three monthly anti-VEGF injections as an initial treatment for the two conditio...

journal_title：Investigative ophthalmology & visual science

authors： Hata M,Yamashiro K,Ooto S,Oishi A,Tamura H,Miyata M,Ueda-Arakawa N,Takahashi A,Tsujikawa A,Yoshimura N

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To identify the genetic cause in five families with autosomal recessive retinitis pigmentosa, a genetic disorder involving retinal degeneration and visual loss with high genetic heterogeneity. METHODS:We performed whole-genome single nucleotide polymorphism genotyping on 35 members from the five families to ma...

journal_title：Investigative ophthalmology & visual science

authors： Wang NH,Chen SJ,Yang CF,Chen HW,Chuang HP,Lu YH,Chen CH,Wu JY,Niu DM,Chen YT

更新日期：2016-07-01 00:00:00

abstract：Purpose:The purpose of this work was to test whether palisade endings express structural and molecular features of exocytotic machinery, and are associated with acetylcholine receptors, and enzymes for neurotransmitter breakdown. Methods:Extraocular rectus muscles from six cats were studied. Whole-mount preparations o...

journal_title：Investigative ophthalmology & visual science

authors： Blumer R,Streicher J,Carrero-Rojas G,Calvo PM,de la Cruz RR,Pastor AM

更新日期：2020-12-01 00:00:00

abstract：:The earlier reports from this laboratory that the renewal of rat photoreceptor membranes was dependent on essential fatty acids have not been confirmed in more recent studies. ...

journal_title：Investigative ophthalmology & visual science

authors： Anderson RE

更新日期：1978-11-01 00:00:00

abstract：PURPOSE:The incidence of blindness is increasing, in part, because of abnormal ocular neovascularization. Anti-VEGF therapies have yielded impressive results; however, they are not a cure for blindness. Recently, metallothioneins (MTs) 1 and 2 have been implicated in the process of angiogenesis. Therefore, we investiga...

journal_title：Investigative ophthalmology & visual science

authors： Nakamura S,Shimazawa M,Inoue Y,Takata S,Ito Y,Tsuruma K,Ikeda T,Honda A,Satoh M,Hara H

更新日期：2014-09-23 00:00:00

abstract：:Drusen are small, yellowish deposits that form under the retinal pigment epithelium (RPE) with senescence or under certain pathological conditions. The present study examined these structures under the scanning electron microscope. Tissue came from four eyes of 66- and 75-year-old donors who demonstrated widespread dr...

journal_title：Investigative ophthalmology & visual science

authors： Ulshafer RJ,Allen CB,Nicolaissen B Jr,Rubin ML

更新日期：1987-04-01 00:00:00

abstract：:Upper eyelid movements were recorded in nine human subjects by mounting a miniature coil of wire directly on the eyelid and subjecting the search coil to a vertically directed alternating magnetic field. The metrics of blinks and lid movements accompanying saccades were described by "main sequence" relationships, link...

journal_title：Investigative ophthalmology & visual science

authors： Guitton D,Simard R,Codère F

更新日期：1991-12-01 00:00:00

abstract：Purpose:To evaluate choroidal structural changes in eyes with myopic choroidal neovascularization (mCNV) treated with anti-VEGF over 12 months. Methods:We prospectively evaluated subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) using spectral-domain optical coherence tomography (SD-OCT) at ba...

journal_title：Investigative ophthalmology & visual science

authors： Ng WY,Ting DS,Agrawal R,Khandelwal N,Htoon HM,Lee SY,Wong TY,Cheung GC

更新日期：2016-09-01 00:00:00