Paclitaxel in the treatment of retinal tumors of LH beta-Tag murine transgenic model of retinoblastoma.

abstract：PURPOSE:Videokeratography of early keratoconus may be difficult to distinguish from contact lens-induced corneal warpage, even by experienced examiners. Furthermore, topographic irregularity may be judged inconsistently if quantitative standards are not applied. Quantitative measures based on videokeratographic data we...

journal_title：Investigative ophthalmology & visual science

authors： Smolek MK,Klyce SD,Maeda N

更新日期：1994-12-01 00:00:00

abstract：PURPOSE:Autophagy is a lysosomal machinery-dependent process that catabolizes cellular components/organelles and proteins in an autophagic vacuole (AV)-dependent and -independent manner, respectively. Short-term exposure of the retina to bright light results in shortening of the outer segments, concomitant with AV form...

journal_title：Investigative ophthalmology & visual science

authors： Kunchithapautham K,Coughlin B,Lemasters JJ,Rohrer B

更新日期：2011-05-05 00:00:00

abstract：PURPOSE:Human leukocyte antigen (HLA) polymorphisms have been associated with the development of autoimmune diseases. In uveal melanoma, a high expression of HLA classes I and II, and infiltration with lymphocytes and macrophages are associated with a bad prognosis. Inflammation has an important role in this malignancy...

journal_title：Investigative ophthalmology & visual science

authors： van Essen TH,Bronkhorst IH,Maat W,Verduyn W,Roelen DL,Luyten GP,Jager MJ

更新日期：2012-05-04 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether messenger RNA coding for hepatocyte growth factor (HGF), HGF receptor (MET), keratinocyte growth factor (KGF), KGF receptor, and fibroblast growth factor (FGF) receptor-2 were produced in primary cultures of human corneal epithelial, stromal fibroblast, and end...

journal_title：Investigative ophthalmology & visual science

authors： Wilson SE,Walker JW,Chwang EL,He YG

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:To detect the expression of cell adhesion molecules (CAMs), including beta integrins, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1, leukocyte-endothelial cell adhesion molecule-2, E-cadherin, and CD44, in cultured lens epithelial cells (LECs) of human cataracts. To show that LEC...

journal_title：Investigative ophthalmology & visual science

authors： Nishi O,Nishi K,Akaishi T,Shirasawa E

更新日期：1997-03-01 00:00:00

abstract：:Light reflected from 50 micrometer diameter spots on the fundi of two adult rhesus monkeys was measured as a function of wavelength in 10 nm jumps from 400 to 900 nm. The areas measured were a retinal artery and vein, areas of the disk, macula, and retina devoid of visible blood vessels, and the foveola. The eyes of t...

journal_title：Investigative ophthalmology & visual science

authors： Flower RW,McLeod DS,Pitts SM

更新日期：1978-06-01 00:00:00

abstract：:The Early Treatment Diabetic Retinopathy Study (ETDRS) and other standardized classification schemes have laid a foundation for tremendous advances in the understanding and management of diabetic retinopathy (DR). However, technological advances in optics and image analysis, especially optical coherence tomography (OC...

journal_title：Investigative ophthalmology & visual science

authors： Abramoff MD,Fort PE,Han IC,Jayasundera KT,Sohn EH,Gardner TW

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Patients with sickle cell disease have elevated circulating levels of cytokines including tumor necrosis factor (TNF) alpha. TNF-alpha stimulates expression by endothelial cells of adhesion molecules, including vascular cell adhesion molecule (VCAM) 1. Others have demonstrated that VLA-4 (alpha(4)beta(1)), a li...

journal_title：Investigative ophthalmology & visual science

authors： Lutty GA,Taomoto M,Cao J,McLeod DS,Vanderslice P,McIntyre BW,Fabry ME,Nagel RL

更新日期：2001-05-01 00:00:00

abstract：:Overall corneal hydration control expressed as the percent recovery per hour (PRPH) can be assessed with an exponential model that uses data derived from two kinds of corneal thickness measurements; one from monitoring recovery after inducing corneal swelling, and the other from measurements made after the eye has bee...

journal_title：Investigative ophthalmology & visual science

authors： Cohen SR,Polse KA,Brand RJ,Mandell RB

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:Evidence suggests that capillary degeneration in early diabetic retinopathy results from chronic inflammation, and leukotrienes have been implicated in this process. The authors investigated the cellular sources of leukotriene biosynthesis in diabetic retinas and the effects of hyperglycemia on leukotriene prod...

journal_title：Investigative ophthalmology & visual science

authors： Talahalli R,Zarini S,Sheibani N,Murphy RC,Gubitosi-Klug RA

更新日期：2010-03-01 00:00:00

abstract：Purpose:Candida remains the leading cause of fungal endophthalmitis. However, the pathobiology and innate immune responses in this disease are not well characterized. Here, we developed two murine models of candida endophthalmitis and evaluated their disease susceptibility and differential immune response. Methods:End...

journal_title：Investigative ophthalmology & visual science

authors： Rottmann BG,Singh PK,Singh S,Revankar SG,Chandrasekar PH,Kumar A

更新日期：2020-09-01 00:00:00

abstract：:In the 2-deoxyglucose technique, the rate of glucose utilization in small areas of the central nervous system is measured using a standard operational equation that assumes negligible glucose-6-phosphatase activity. Hoping to apply this technique in the mammalian retina, we sought to identify the extent of this enzyme...

journal_title：Investigative ophthalmology & visual science

authors： Blair NP,Shaw WE,Yue B

更新日期：1989-10-01 00:00:00

abstract：Purpose:To characterize inheritance, penetrance, and trinucleotide repeat expansion stability in Fuchs endothelial corneal dystrophy (FECD). Methods:One thousand unrelated and related subjects with and without FECD were prospectively recruited. CTG18.1 repeat length (CTG18.1L) was determined via short tandem repeat as...

journal_title：Investigative ophthalmology & visual science

authors： Xu TT,Li YJ,Afshari NA,Aleff RA,Rinkoski TA,Patel SV,Maguire LJ,Edwards AO,Brown WL,Fautsch MP,Wieben ED,Baratz KH

更新日期：2021-01-04 00:00:00

abstract：PURPOSE:To examine the accommodative accuracy and amplitude in children with Down syndrome. Accommodation is usually assumed to be good in children and is rarely measured. METHODS:A dynamic retinoscopy technique was developed that allows rapid and reliable measures of accuracy and amplitude of accommodation in infants...

journal_title：Investigative ophthalmology & visual science

authors： Woodhouse JM,Meades JS,Leat SJ,Saunders KJ

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:To compare the effectiveness of upper punctal occlusion versus that of lower punctal occlusion in dry eye patients. METHODS:One eye's upper punctum and the contralateral eye's lower punctum were occluded with collagen plugs in 20 dry eye patients. The same procedure was performed in 20 normal subjects. The upp...

journal_title：Investigative ophthalmology & visual science

authors： Chen F,Wang J,Chen W,Shen M,Xu S,Lu F

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:Leukocytes play a critical role in ocular diseases such as uveitis, diabetic retinopathy, and choroidal neovascularization. Intercellular adhesion molecule (ICAM)-1 is essential for the migration of leukocytes. Control of ICAM-1 expression may lead to therapies for these diseases. Small-interfering ribonucleic ...

journal_title：Investigative ophthalmology & visual science

authors： Hirano Y,Sakurai E,Matsubara A,Ogura Y

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Leber congenital amaurosis (LCA) is an inherited retinal disease that causes early-onset severe visual impairment. To evaluate the mutation spectrum in the Chinese population, we performed a mutation screen in 145 Chinese LCA families. METHODS:First, we performed direct Sanger sequencing of 7 LCA disease genes...

journal_title：Investigative ophthalmology & visual science

authors： Wang H,Wang X,Zou X,Xu S,Li H,Soens ZT,Wang K,Li Y,Dong F,Chen R,Sui R

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:It has been suggested that early menopause increases the risk of aging-macula disorder (AMD), the major cause of incurable blindness with a dry and wet late subtype, and that exposure to endogenous or postmenopausal exogenous estrogens reduces this risk. This study was undertaken to investigate whether genetic ...

journal_title：Investigative ophthalmology & visual science

authors： Boekhoorn SS,Vingerling JR,Uitterlinden AG,Van Meurs JB,van Duijn CM,Pols HA,Hofman A,de Jong PT

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To test whether a diet supplemented with coenzyme Q10 (CoQ10) ameliorates glutamate excitotoxicity and oxidative stress-mediated retinal ganglion cell (RGC) degeneration by preventing mitochondrial alterations in the retina of glaucomatous DBA/2J mice. METHODS:Preglaucomatous DBA/2J and age-matched control DBA...

journal_title：Investigative ophthalmology & visual science

authors： Lee D,Shim MS,Kim KY,Noh YH,Kim H,Kim SY,Weinreb RN,Ju WK

更新日期：2014-02-18 00:00:00

abstract：PURPOSE:The authors compared the efficacy of two different forms of flicker perimetry: temporal modulation perimetry (TMP), which measures contrast thresholds for a fixed temporal frequency, and critical flicker frequency (CFF), which measures the highest frequency for which flicker is detected at a fixed contrast. ME...

journal_title：Investigative ophthalmology & visual science

authors： Yoshiyama KK,Johnson CA

更新日期：1997-10-01 00:00:00

abstract：PURPOSE:To investigate the protective effect of pioglitazone on the rat retina after ischemia/reperfusion (I/R) injury and to explore its possible mechanisms. METHODS:Retinal ischemia was induced by increasing the intraocular pressure to 110 mm Hg for 60 minutes, and pioglitazone was delivered 3 hours before the I/R. ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang XY,Xiao YQ,Zhang Y,Ye W

更新日期：2013-06-06 00:00:00

abstract：PURPOSE:Mutations in the coding region of the OPTN gene are associated with certain glaucomas. Although the function of the optineurin protein is yet to be elucidated, the most common mutation, E50K, is associated with a severe phenotype. This study explores some functional features of optineurin and its mutants. METH...

journal_title：Investigative ophthalmology & visual science

authors： Chalasani ML,Radha V,Gupta V,Agarwal N,Balasubramanian D,Swarup G

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:To develop and characterize a feline model of retinal degeneration induced by intravitreal injection of adenosine triphosphate (ATP). METHODS:Nineteen normally sighted adult cats received 100 μL intravitreal injections of ATP with a final concentration of 11, 22, or 55 mM at the retina. Four animals were eutha...

journal_title：Investigative ophthalmology & visual science

authors： Aplin FP,Luu CD,Vessey KA,Guymer RH,Shepherd RK,Fletcher EL

更新日期：2014-11-25 00:00:00

abstract：PURPOSE:To test the hypothesis that changes in the viscoelastic material properties of peripapillary sclera are present within monkey eyes at the onset of early experimental glaucoma detected by confocal scanning laser tomography (CSLT). METHODS:Short-term (3-9 weeks), moderate (< or =44 mm Hg) intraocular pressure (I...

journal_title：Investigative ophthalmology & visual science

authors： Downs JC,Suh JK,Thomas KA,Bellezza AJ,Hart RT,Burgoyne CF

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:To investigate the potential use of amniotic membrane transplantation (AMT) in the construction of glaucoma filtering blebs. METHODS:Twenty-four albino rabbits underwent glaucoma filtration surgery in one eye. In alternate cases, the conjunctival flap was replaced with AMT. Postoperative examination data were ...

journal_title：Investigative ophthalmology & visual science

authors： Barton K,Budenz DL,Khaw PT,Tseng SC

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:Fibroblast growth factor-10 (FGF10) can modulate extracellular matrix associated genes and, therefore, it could be a myopia susceptibility gene. This study used an animal model, single nucleotide polymorphisms (SNPs) association, and genetic functional assay to evaluate FGF10 gene for myopia. METHODS:The expre...

journal_title：Investigative ophthalmology & visual science

authors： Hsi E,Chen KC,Chang WS,Yu ML,Liang CL,Juo SH

更新日期：2013-05-07 00:00:00

abstract：PURPOSE:To measure changes in nuclear gene expression resulting from mitochondrial dysfunction in retinal pigment epithelial cells. METHODS:ARPE-19 retinal pigment epithelial cells were depleted of their mitochondrial (mt)DNA by passaging in a low concentration of ethidium bromide. Loss of mitochondrial DNA was determ...

journal_title：Investigative ophthalmology & visual science

authors： Miceli MV,Jazwinski SM

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative disease of the eye that is the largest cause of irreversible blindness. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Kaurani L,Vishal M,Kumar D,Sharma A,Mehani B,Sharma C,Chakraborty S,Jha P,Ray J,Sen A,Dash D,Ray K,Mukhopadhyay A

更新日期：2014-04-24 00:00:00

abstract：:We use a population balance model to study the mechanism and the rate of centripetal migration of epithelial cells, renewal of the corneal epithelial population by the cell derived from (progeny of) the limbal stem cells and the kinetics of the replacement of the donor corneal epithelium. The epithelial mass is consta...

journal_title：Investigative ophthalmology & visual science

authors： Sharma A,Coles WH

更新日期：1989-09-01 00:00:00

abstract：PURPOSE:The Y402H polymorphism in the complement regulator factor H (fH) is strongly associated with age-related macular degeneration (AMD) across diverse populations. Persons homozygous for histidine at this position have up to 12-fold greater risk for AMD than those homozygous for tyrosine. Knowledge of fH-Y402H stat...

journal_title：Investigative ophthalmology & visual science

authors： Hakobyan S,Harris CL,Tortajada A,Goicochea de Jorge E,García-Layana A,Fernández-Robredo P,Rodríguez de Córdoba S,Morgan BP

更新日期：2008-05-01 00:00:00