Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration.

abstract：PURPOSE:To determine whether vascular tone of isolated porcine retinal veins can be modulated by tissue-generated vasoactive factors such as endothelin-1 and adenosine. Such information may be useful in understanding the role of the retinal veins in regulating blood flow, and also provide a model for investigating new ...

journal_title：Investigative ophthalmology & visual science

authors： Yu DY,Su EN,Cringle SJ,Morgan WH,McAllister IL,Yu PK

更新日期：2016-02-01 00:00:00

abstract：:Postmitochondrial supernatant, cytosol, and microsomes were exposed to near-ultraviolet light and assayed for incorporation of (3H)leucine. The results indicate that near-ultraviolet light decreased the incorporation of radioactivity into the aminoacyl-tRNA fraction and into proteins. This effect depended on the wavel...

journal_title：Investigative ophthalmology & visual science

authors： Matuk Y,Lou P,Parker JA

更新日期：1977-12-01 00:00:00

abstract：PURPOSE:The anatomy of individual myofibers within the orbicularis oculi muscle was examined to determine individual myofiber lengths in the different regions of the muscle. A wide variety of eyelid conditions require eyelid surgery or drug injections directly into the eyelid. Knowledge of regional myofiber anatomy and...

journal_title：Investigative ophthalmology & visual science

authors： Lander T,Wirtschafter JD,McLoon LK

更新日期：1996-08-01 00:00:00

abstract：:Exposure of denuded rabbit corneal stromal carriers for 24 hr at 37 degrees C to suspensions of rabbit corneal epithelial cells grown in tissue culture resulted in the establishment of a cell layer on the carriers. The cell layers persisted for at least 1 week of incubation and were one to three cells thick. They cons...

journal_title：Investigative ophthalmology & visual science

authors： Friend J,Kinoshita S,Thoft RA,Eliason JA

更新日期：1982-07-01 00:00:00

abstract：PURPOSE:To assess the effect of group B streptococcal (GBS) meningitis on retinal blood flow (RetBF) and choroidal blood flow (ChBF) autoregulation in sedated newborn piglets (1 to 5 days of age). METHODS:Fourteen study animals injected with 0.5 ml heat-killed GBS (10(9)) were compared to 10 control animals injected w...

journal_title：Investigative ophthalmology & visual science

authors： Bottoli I,Beharry K,Modanlou HD,Norris K,Ling E,Noya F,Amato MM,Aranda JV

更新日期：1995-06-01 00:00:00

abstract：:An animal model of chronic cicatrizing trachoma has been produced by repeated ocular inoculation with Chlamydia trachomatis serotype E, a genitally transmitted strain. We have now produced a chronic follicular conjunctivitis on cynomolgus monkeys by repeated inoculation with C. trachomatis serotype A, which has been i...

journal_title：Investigative ophthalmology & visual science

authors： Taylor HR,Johnson SL,Prendergast RA,Schachter J,Dawson CR,Silverstein AM

更新日期：1982-10-01 00:00:00

abstract：Purpose:This study investigated the expression of insulin-like growth factor binding protein-3 (IGFBP-3) in basal tears of patients with type 2 diabetes mellitus compared to nondiabetic controls; and correlated tear levels of IGFBP-3 with morphologic changes in the subbasal nerve plexus and density of basal corneal epi...

journal_title：Investigative ophthalmology & visual science

authors： Stuard WL,Titone R,Robertson DM

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:The objective of this systematic review was to examine the evidence on zinc intake from foods and supplements in the primary prevention and treatment of AMD. METHODS:Randomized controlled trials (RCTs), prospective cohort, retrospective cohort, and case-control studies that investigated zinc intake from foods ...

journal_title：Investigative ophthalmology & visual science

authors： Vishwanathan R,Chung M,Johnson EJ

更新日期：2013-06-12 00:00:00

abstract：:The short-term fluctuation in regular grid threshold static fields is commonly determined from repeated observations of a number of threshold points. In this study we estimated the short-term fluctuation from a single determination of the field. Sixty-two eyes of 62 patients were tested, using three consecutive repeti...

journal_title：Investigative ophthalmology & visual science

authors： Schulzer M,Mills RP,Hopp RH,Lau W,Drance SM

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:Corneal allografts placed in human eyes at high risk often fail, and immune rejection is thought to be a major pathogenic factor. To understand the immunologic factors responsible for rejection in this instance, the authors have created "high-risk" eyes in mice by inducing corneal neovascularization. The author...

journal_title：Investigative ophthalmology & visual science

authors： Sano Y,Ksander BR,Streilein JW

更新日期：1995-10-01 00:00:00

abstract：Purpose:We compare the choroidal vascular area between Bietti crystalline dystrophy (BCD) patients with CYP4V2 mutations, retinitis pigmentosa (RP) patients with EYS mutations, and normal controls, and investigate the correlation between choroidal vascular area and associated parameters. Methods:This prospective case-...

journal_title：Investigative ophthalmology & visual science

authors： Hirashima T,Miyata M,Ishihara K,Hasegawa T,Sugahara M,Ogino K,Yoshikawa M,Hata M,Kuroda Y,Muraoka Y,Ooto S,Yoshimura N

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:The incidence of blindness is increasing, in part, because of abnormal ocular neovascularization. Anti-VEGF therapies have yielded impressive results; however, they are not a cure for blindness. Recently, metallothioneins (MTs) 1 and 2 have been implicated in the process of angiogenesis. Therefore, we investiga...

journal_title：Investigative ophthalmology & visual science

authors： Nakamura S,Shimazawa M,Inoue Y,Takata S,Ito Y,Tsuruma K,Ikeda T,Honda A,Satoh M,Hara H

更新日期：2014-09-23 00:00:00

abstract：Purpose:Candida remains the leading cause of fungal endophthalmitis. However, the pathobiology and innate immune responses in this disease are not well characterized. Here, we developed two murine models of candida endophthalmitis and evaluated their disease susceptibility and differential immune response. Methods:End...

journal_title：Investigative ophthalmology & visual science

authors： Rottmann BG,Singh PK,Singh S,Revankar SG,Chandrasekar PH,Kumar A

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To explore changes in corneal sensitivity that develop in patients with dry eye and the relationship between sensibility and severity of the dry eye disease. METHODS:Experiments were performed in 44 patients with dry eye and 42 healthy individuals. Corneal sensitivity was measured with the Belmonte noncontact ...

journal_title：Investigative ophthalmology & visual science

authors： Bourcier T,Acosta MC,Borderie V,Borrás F,Gallar J,Bury T,Laroche L,Belmonte C

更新日期：2005-07-01 00:00:00

abstract：:In vivo conjunctival epithelial healing in albino rabbits was investigated by light microscopy following both n-heptanol and trephined conjunctival wounding. Reepithelialization occurred faster following n-heptanol treatment (3 days) versus trephination (6-7 days). No goblet cells were present in the migrating epithel...

journal_title：Investigative ophthalmology & visual science

authors： Geggel HS,Friend J,Thoft RA

更新日期：1984-07-01 00:00:00

abstract：PURPOSE:Subretinal drusenoid deposits (SDD) have been associated with the progression to late age-related macular degeneration (AMD). To determine whether SDD in eyes in normal macular health increases risk for early AMD, this study examined the association between presence of SDD at baseline in a cohort of older adult...

journal_title：Investigative ophthalmology & visual science

authors： Huisingh C,McGwin G Jr,Neely D,Zarubina A,Clark M,Zhang Y,Curcio CA,Owsley C

更新日期：2016-02-01 00:00:00

abstract：:A single injection of an aqueous suspension of group A streptococcal peptidoglycan-polysaccharide complexes (PG-PS) when injected intraperitoneally into Lewis rats induced a self-limiting bilateral uveitis with associated perpetuating polyarthritis. The uveitis was characterized clinically during the first 72 h by iri...

journal_title：Investigative ophthalmology & visual science

authors： Wells A,Pararajasegaram G,Baldwin M,Yang CH,Hammer M,Fox A

更新日期：1986-06-01 00:00:00

abstract：:A method to quantify different glaucomatous visual field defects is presented. Three visual field indices are calculated: the short-term fluctuation, the mean defect, and the corrected loss variation. The method was applied to visual fields tested with program JO on the Octopus automated perimeter. The indices of 130 ...

journal_title：Investigative ophthalmology & visual science

authors： Flammer J,Drance SM,Augustiny L,Funkhouser A

更新日期：1985-02-01 00:00:00

abstract：PURPOSE:Focal opacities are signs of early cataractogenesis in the human lens. They progress slowly over a lifetime and may be precursors of mature cataracts. The authors analyzed changes in proteins, phospholipids, and cholesterol in these opacities using in situ techniques: Raman microspectroscopy, filipin cytochemis...

journal_title：Investigative ophthalmology & visual science

authors： Duindam JJ,Vrensen GF,Otto C,Greve J

更新日期：1998-01-01 00:00:00

abstract：:To compare the effects on the postnatal development of the eye of both total and partial form deprivation in diurnally reared chicks and of dark-rearing, chicks were reared with occluders covering one eye from hatching for up to 6 weeks. In diurnally reared birds, both total and partial form deprivation resulted in se...

journal_title：Investigative ophthalmology & visual science

authors： Gottlieb MD,Fugate-Wentzek LA,Wallman J

更新日期：1987-08-01 00:00:00

abstract：Purpose:To investigate the effect of short-wavelength light (SL) on guinea pigs with lens-induced myopia (LIM) and the possible retinoic acid (RA)-related mechanisms. Methods:Two-week-old guinea pigs (n = 60) with monocular -5D lenses were reared under white light (WL, 580 lux) or SL (440 nm, 500 lux). The left eyes w...

journal_title：Investigative ophthalmology & visual science

authors： Yu M,Liu W,Wang B,Dai J

更新日期：2021-01-04 00:00:00

abstract：PURPOSE:To compare the developmental sequences of two basic measures of pattern vision, Vernier acuity and grating acuity, using steady state visual-evoked potentials (VEPs) and an analysis designed to isolate pattern-specific responses from those due to motion in the Vernier stimulus. METHODS:The authors recorded VEP...

journal_title：Investigative ophthalmology & visual science

authors： Skoczenski AM,Norcia AM

更新日期：1999-09-01 00:00:00

abstract：:The purpose of this study was to determine whether unilateral gonadectomy caused any change in intraocular pressure. Repeated measurements in 22 male and nine female rabbits after unilateral gonadectomy were made by three different methods of determining intraocular pressure. We were unable to find a decrease in intra...

journal_title：Investigative ophthalmology & visual science

authors： van den Pol A,Maul E,Sears M

更新日期：1977-03-01 00:00:00

abstract：:The relationship between intraocular and systemic blood pressures was investigated in a prospective study of 572 middle-aged men. There was no consistent relationship between intraocular pressure at first visit and age. Subjects with an intraocular pressure greater than 20 mm Hg had a significantly higher systolic blo...

journal_title：Investigative ophthalmology & visual science

authors： McLeod SD,West SK,Quigley HA,Fozard JL

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:The flavonoids have potent antioxidant and free-radical scavenging properties and are beneficial in the prevention and treatment of ocular diseases including glaucoma. The authors have previously reported that antiglaucoma agents could transcriptionally activate the antioxidant protein peroxiredoxin (PRDX)2. Th...

journal_title：Investigative ophthalmology & visual science

authors： Miyamoto N,Izumi H,Miyamoto R,Kondo H,Tawara A,Sasaguri Y,Kohno K

更新日期：2011-02-22 00:00:00

abstract：PURPOSE:Mutations in the mitochondrial dynamin-related GTPase OPA1 cause autosomal dominant optic atrophy (ADOA), but the pathophysiology of this disease is unknown. As a first step in functional studies, this study was conducted to evaluate the expression of Opa1 in whole retina and in isolated retinal ganglion cells ...

journal_title：Investigative ophthalmology & visual science

authors： Kamei S,Chen-Kuo-Chang M,Cazevieille C,Lenaers G,Olichon A,Bélenguer P,Roussignol G,Renard N,Eybalin M,Michelin A,Delettre C,Brabet P,Hamel CP

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:Because immune rejection is likely to be a major barrier to successful retinal transplantation, it is important to determine whether immune privilege for allogeneic retinal grafts is a feature of the subretinal space and vitreous cavity. METHODS:Newborn neural retinas of C57BL/6 mice were implanted into the su...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Jorquera M,Streilein JW

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:To investigate the induction of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) gene expression by prostaglandin E2 (PGE2) in cultured rat Müller cells and to study the mechanism of the induction. METHODS:Müller cells were obtained from neonatal Sprague-Dawley rat retinas an...

journal_title：Investigative ophthalmology & visual science

authors： Cheng T,Cao W,Wen R,Steinberg RH,LaVail MM

更新日期：1998-03-01 00:00:00

abstract：:Interocular differences in apparent size (aniseikonia) are typically associated with interocular differences in refractive error (anisometropia). Aniseikonia is generally thought to reflect disparities in retinal image size that often accompany anisometropia. This assumption was examined with seven highly anisometropi...

journal_title：Investigative ophthalmology & visual science

authors： Bradley A,Rabin J,Freeman RD

更新日期：1983-04-01 00:00:00

abstract：PURPOSE:To explore factors affecting the glaucoma diagnostic capability of macular thickness and circumpapillary retinal nerve fiber layer (cRNFL) thickness as determined by spectral domain-optical coherence tomography. METHODS:Area under the curve (AUC) of the receiver operating characteristics (ROC) discriminating h...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Sun JH,Lee Y

更新日期：2011-10-11 00:00:00