Biosynthesis of proteins by the retina. Inactivation by near-ultraviolet light and the effects of tryptophan, epinephrine, and catalase.

abstract：PURPOSE:To investigate the effect of tear hyperosmolarity and signs of clinical ocular surface pathology on conjunctival goblet cell population. METHODS:111 participants were assessed using tear osmolarity (TO) measurements and a comprehensive selection of clinical ophthalmic tests. The resultant clinical database was...

journal_title：Investigative ophthalmology & visual science

authors： Moore JE,Vasey GT,Dartt DA,McGilligan VE,Atkinson SD,Grills C,Lamey PJ,Leccisotti A,Frazer DG,Moore TC

更新日期：2011-08-03 00:00:00

abstract：Purpose:Diabetes leads to the downregulation of the retinal Kir4.1 channels and Müller cell dysfunction. The insulin receptor substrate-1 (IRS-1) is a critical regulator of insulin signaling in Müller cells. Circadian rhythms play an integral role in normal physiology; however, diabetes leads to a circadian dysrhythmia...

journal_title：Investigative ophthalmology & visual science

authors： Luo Q,Xiao Y,Alex A,Cummins TR,Bhatwadekar AD

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To investigate the biometric characteristics of eyes with idiopathic central serous chorioretinopathy (CSC). METHODS:Medical records of 52 consecutive patients with unilateral CSC were reviewed. Central serous chorioretinopathy was diagnosed using spectral-domain optical coherence tomography (SD-OCT) and fluor...

journal_title：Investigative ophthalmology & visual science

authors： Oh JH,Oh J,Togloom A,Kim SW,Huh K

更新日期：2014-03-13 00:00:00

abstract：:Tendon and cornea of 17-day-old chick embryos primarily synthesize type I collagen as the major collagenous component nd type V collagen as a minor collagenous component. Matrix-free cells isolated from cornea and tendon synthesize and secrete mainly type I procollagen. A short lag period for the secretion of collagen...

journal_title：Investigative ophthalmology & visual science

authors： Kao WW,Mai SH,Chou KL

更新日期：1982-12-01 00:00:00

abstract：PURPOSE:Retinal neovascularization is one of the leading causes of blindness. A crucial event in this process is the remodeling and penetration of the capillary basement membrane by migrating endothelial cells. This process requires proteolysis of basement membrane components by a variety of proteinases. The objective ...

journal_title：Investigative ophthalmology & visual science

authors： Das A,McGuire PG,Eriqat C,Ober RR,DeJuan E Jr,Williams GA,McLamore A,Biswas J,Johnson DW

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:The authors conducted a morphology analysis of filtering blebs with anterior segment optical coherence tomography (AS-OCT) in patients shortly after trabeculectomy to find further criteria for success or failure of a filtering bleb. METHODS:Thirty-seven patients (43 eyes) who had recently (<2 years) undergone ...

journal_title：Investigative ophthalmology & visual science

authors： Pfenninger L,Schneider F,Funk J

更新日期：2011-04-14 00:00:00

abstract：:In an anisotonic medium the tendency of the lens to swell or shrink in response to the osmotic gradient is countered by a change in the content of lens solute, so that the change in the volume of lens water is minimal. This phenomenon is known as volume regulation. The rapid phase of volume regulation occurs in less t...

journal_title：Investigative ophthalmology & visual science

authors： Patterson JW

更新日期：1981-01-01 00:00:00

abstract：:Secretory component (SC) was studied by indirect immunofluorescence of the ocular surface epithelium. We find that conjunctival epithelium produces this component, and that it is absent in the corneal epithelium. Conjunctival epithelium loses its SC staining within 1 to 2 days as it grows over a denuded corneal stroma...

journal_title：Investigative ophthalmology & visual science

authors： Liu SH,Tagawa Y,Prendergast RA,Franklin RM,Silverstein AM

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Amblyopia is the commonest visual disorder of childhood. Yet the contributions of the two principal treatments (spectacle wear and occlusion) to outcome are unknown. This study was undertaken to investigate the dose-response relationship of amblyopia therapy. METHODS:The study comprised three distinct phases: ...

journal_title：Investigative ophthalmology & visual science

authors： Stewart CE,Moseley MJ,Stephens DA,Fielder AR

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:To examine the retinotoxic effect of naphthalene, a powerful oxidative agent and a well-known cataractogenic agent. METHODS:A 10% solution of naphthalene dissolved in paraffin oil was given every other day by gavage to 31 pigmented rabbits for 5 weeks, at a dose of 1 g/kg body weight. Four rabbits who received...

journal_title：Investigative ophthalmology & visual science

authors： Orzalesi N,Migliavacca L,Miglior S

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:Migration of retinal pigment epithelial (RPE) cells can be triggered by disruption of the RPE monolayer or injury to the neural retina. Migrating cells may re-establish a confluent monolayer, or they may invade the neural retina and disrupt visual function. The purpose of this study was to examine the role of e...

journal_title：Investigative ophthalmology & visual science

authors： Johnson DA,Fields C,Fallon A,Fitzgerald ME,Viar MJ,Johnson LR

更新日期：2002-04-01 00:00:00

abstract：Purpose:To determine the relationship between the sensitivity of the retina in the central 10° and the thickness of the retinal layers in patients with retinitis pigmentosa (RP). Methods:Fifty-two RP patients were studied. All of the patients had been examined by the Humphrey Field Analyzer 10-2 program (HFA10-2) and ...

journal_title：Investigative ophthalmology & visual science

authors： Sayo A,Ueno S,Kominami T,Okado S,Inooka D,Komori S,Terasaki H

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:A human biovar of Chlamydia trachomatis was used to develop a murine model of ocular chlamydial infection. The inbred mouse model will allow detailed immunologic studies during ocular infection, and use of a human biovar for infection may aid in identification of appropriate vaccine strategies against chlamydia...

journal_title：Investigative ophthalmology & visual science

authors： Whittum-Hudson JA,O'Brien TP,Prendergast RA

更新日期：1995-09-01 00:00:00

abstract：PURPOSE:The selective degeneration of pericytes and the proliferation of endothelial cells (ECs) appear to be associated with microaneurysm formation, an initial deficit in the early stage of diabetic retinopathy. The preventive effect of aldose reductase (AR) inhibitor (ARI) for high glucose-induced pericyte loss and ...

journal_title：Investigative ophthalmology & visual science

authors： Takamura Y,Tomomatsu T,Kubo E,Tsuzuki S,Akagi Y

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:Elevated levels of extracellular glutamate have been implicated in the pathophysiology of neuronal loss in both central nervous system and ophthalmic disorders, including glaucoma. This increase in glutamate may result from a failure of glutamate transporters (molecules that ordinarily regulate extracellular gl...

journal_title：Investigative ophthalmology & visual science

authors： Vorwerk CK,Naskar R,Schuettauf F,Quinto K,Zurakowski D,Gochenauer G,Robinson MB,Mackler SA,Dreyer EB

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to characterize a Krt12-Cre knock-in mouse line for corneal epithelium-specific gene ablation and to analyze the allelic selection of the keratin 12 (Krt12) gene during corneal type-epithelium differentiation. METHODS:Knock-in mice were generated by gene targeting. The authors exa...

journal_title：Investigative ophthalmology & visual science

authors： Hayashi Y,Call MK,Liu CY,Hayashi M,Babcock G,Ohashi Y,Kao WW

更新日期：2010-09-01 00:00:00

abstract：:The temporal modulation sensitivity function was studied in eight strabismic and/or anisometropic amblyopes and in two subjects with amblyopia resulting from monocular stimulus deprivation (cataract and ptosis). Half of the strabismic/anisometropic amblyopes showed a reduction in the sensitivity of the amblyopic eye. ...

journal_title：Investigative ophthalmology & visual science

authors： Manny RE,Levi DM

更新日期：1982-04-01 00:00:00

abstract：PURPOSE:Because immune rejection is likely to be a major barrier to successful retinal transplantation, it is important to determine whether immune privilege for allogeneic retinal grafts is a feature of the subretinal space and vitreous cavity. METHODS:Newborn neural retinas of C57BL/6 mice were implanted into the su...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Jorquera M,Streilein JW

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether human corneal epithelial cells and keratocytes synthesize both the soluble and membrane forms of the type II IL-1 receptor (IL-1RII). METHODS:Primary cell cultures of human corneal epithelial cells and keratocytes were established from human corneas. RT-PCR wa...

journal_title：Investigative ophthalmology & visual science

authors： Cubitt CL,Lausch RN,Oakes JE

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:To describe a method for assessment and individualized compensation of anterior segment birefringence with scanning laser polarimetry. METHODS:A scanning laser polarimeter (GDx Nerve Fiber Analyzer; Laser Diagnostic Technologies, Inc., San Diego, CA) was modified to accommodate a variable compensator. The magn...

journal_title：Investigative ophthalmology & visual science

authors： Zhou Q,Weinreb RN

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:To investigate feasibility and potential uses of flow cytometry in impression cytology as a new procedure to assess and quantify conjunctival inflammation. METHODS:Specimens for cytology were collected by impression from 30 patients with various chronic ocular surface disorders and from 10 normal subjects. Two...

journal_title：Investigative ophthalmology & visual science

authors： Baudouin C,Brignole F,Becquet F,Pisella PJ,Goguel A

更新日期：1997-06-01 00:00:00

abstract：PURPOSE:To determine a time window in the rhodopsin knockout (Rho(-/-)) mouse during which retinal function is already sufficiently developed but cone degeneration is not yet substantial, thus representing an all-cone retina. METHODS:Electroretinograms (ERGs) were obtained from 14 homozygous Rho(-/-) mice and eight C5...

journal_title：Investigative ophthalmology & visual science

authors： Jaissle GB,May CA,Reinhard J,Kohler K,Fauser S,Lütjen-Drecoll E,Zrenner E,Seeliger MW

更新日期：2001-02-01 00:00:00

abstract：:The corneas of 12 eye donors with maturity-onset diabetes were obtained, and the corneal epithelial basement membranes were studied by transmission electron microscopy. Similar tissue was obtained from 12 nondiabetic eye donors who were matched for age (within 2 years) and race. The mean thickness of the corneal epith...

journal_title：Investigative ophthalmology & visual science

authors： Taylor HR,Kimsey RA

更新日期：1981-04-01 00:00:00

abstract：PURPOSE:The epidermal growth factor receptor (EGFR) appears in astrocytes after neural injury. The authors' laboratory has reported the presence of EGFR in glaucomatous optic nerves. The activation of EGFR is often associated with induction of cyclooxygenase (COX)-2. In this study, the induction of COX-2 pathway in rat...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Neufeld AH

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:Oxidative stress seems to be an important factor in the development of age-related macular degeneration (AMD). The role of DNA repair mechanisms has also received attention recently in AMD pathogenesis. This case-control study was conducted to determine the frequency of polymorphisms in two DNA repair enzyme ge...

journal_title：Investigative ophthalmology & visual science

authors： Görgün E,Güven M,Unal M,Batar B,Güven GS,Yenerel M,Tatlipinar S,Seven M,Yüksel A

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To determine the toxicity of various doses of intravitreal amphotericin B deoxycholate, amphotericin B lipid complex (ABLC), and liposomal amphotericin B (L-AmB). METHODS:Fifty-two rabbits were divided into two treatment groups (groups A and B). Thirteen treatments were administered intravitreally to the 104 r...

journal_title：Investigative ophthalmology & visual science

authors： Cannon JP,Fiscella R,Pattharachayakul S,Garey KW,De Alba F,Piscitelli S,Edward DP,Danziger LH

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:Persistent hyperplastic primary vitreous (PHPV) is an idiopathic developmental eye disease associated with failed involution of the hyaloid vasculature. The present work addressed the pathogenesis of PHPV in a mouse model that replicates many aspects of the human disease. METHODS:Ophthalmoscopic and histologic...

journal_title：Investigative ophthalmology & visual science

authors： Martin AC,Thornton JD,Liu J,Wang X,Zuo J,Jablonski MM,Chaum E,Zindy F,Skapek SX

更新日期：2004-10-01 00:00:00

abstract：:Retinal ultrastructure was examined at various intervals following a single intravitreal injection of 100-4,000 micrograms of gentamicin in rabbit eyes. Three days after injections of 100-500 micrograms, numerous abnormal lamellar lysosomal inclusions were observed in the retinal pigment epithelium (RPE) and in macrop...

journal_title：Investigative ophthalmology & visual science

authors： D'Amico DJ,Libert J,Kenyon KR,Hanninen LA,Caspers-Velu L

更新日期：1984-05-01 00:00:00

abstract：PURPOSE:To investigate whether signaling pathways that incorporate protein tyrosine kinases and phosphatases regulate PKC-sensitive, volume-sensitive Cl(-) currents (I(Cl,vol)) in cultured rabbit nonpigmented ciliary epithelial cells. METHODS:Activation of I(Cl,vol) in response to hyposmotic stimulation was recorded w...

journal_title：Investigative ophthalmology & visual science

authors： Shi C,Barnes S,Coca-Prados M,Kelly ME

更新日期：2002-05-01 00:00:00

abstract：:PURPOSE. Mitochondrial function and the presence of somatic mitochondrial DNA (mtDNA) defects were investigated in extraocular muscles (EOMs) collected from individuals covering a wide age range, to document the changes seen with normal aging. METHODS. Cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histo...

journal_title：Investigative ophthalmology & visual science

authors： Yu-Wai-Man P,Lai-Cheong J,Borthwick GM,He L,Taylor GA,Greaves LC,Taylor RW,Griffiths PG,Turnbull DM

更新日期：2010-07-01 00:00:00