Characterization of the conjunctival vasopermeability response to leukotrienes and their involvement in immediate hypersensitivity.

abstract：Purpose:The purpose of this study was to determine the relative roles of the sympathetic (SNS) and parasympathetic nervous system (PNS) in pupillary hippus. Methods:We used a paired-eye control study design with three cohorts receiving either 1.0% tropicamide (PNS antagonist) in light (TL), 1.0% tropicamide in dark (T...

journal_title：Investigative ophthalmology & visual science

authors： Turnbull PR,Irani N,Lim N,Phillips JR

更新日期：2017-01-01 00:00:00

abstract：:The acute effect of topical epinephrine HCl 2% on macular capillary blood flow was studied in 18 healthy human volunteers using the blue-field simulation technique. This technique provides a method for quantifying the velocity of leukocytes flowing in macular capillaries. Subjects adjusted the velocity of simulated le...

journal_title：Investigative ophthalmology & visual science

authors： Robinson F,Chen S,Petrig BL,Grunwald JE,Riva CE

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To determine the effect of dilute alcohol on human corneal epithelial cellular morphology and viability. Dilute alcohol is used for epithelial removal during photorefractive keratectomy (PRK) and laser subepithelial keratomileusis (LASEK). METHODS:Corneal epithelial sheets harvested from human eyes after alcoh...

journal_title：Investigative ophthalmology & visual science

authors： Chen CC,Chang JH,Lee JB,Javier J,Azar DT

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:To describe the normal physiological relationship between retinal arteriolar and venular caliber and retinal nerve fiber layer (RNFL), macular, and optic nerve head parameters. METHODS:The Sydney Childhood Eye Study assessed 2038 adolescents aged 12 years. Retinal vessel calibers were measured from digital fun...

journal_title：Investigative ophthalmology & visual science

authors： Samarawickrama C,Huynh SC,Wang JJ,Pai A,Joachim N,Burlutsky G,Wong TY,Mitchell P

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:To our knowledge, studies comparing binocular eye movements during reading task in strabismic children are scarce. The goal of our study was to examine binocular coordination of saccades during reading in strabismic children. METHODS:Binocular eye movements were recorded by an infrared system (mobile EBT) in 1...

journal_title：Investigative ophthalmology & visual science

authors： Lions C,Bui-Quoc E,Seassau M,Bucci MP

更新日期：2013-01-21 00:00:00

abstract：PURPOSE:To link psychophysical thresholds for blind spot awareness and filling-in with early neural components that underpin these perceptions. METHODS:Blind spot dimensions were quantified, after which an intrinsic stimulus (i.e., a rectangular bar of varying length centered within the blind spot) was used to determi...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Jeffery G,Murphy JS

更新日期：2011-01-25 00:00:00

abstract：PURPOSE:The relative effect of simultaneously administered oxygen and carbon dioxide on the retinal and cerebral vessels is still controversial. The purpose of this study was to quantify and compare the superior-temporal retinal arteriole (RA) and middle cerebral artery (MCA) responses to hypercarbic and combined hyper...

journal_title：Investigative ophthalmology & visual science

authors： Kisilevsky M,Mardimae A,Slessarev M,Han J,Fisher J,Hudson C

更新日期：2008-12-01 00:00:00

abstract：:Vitreous and macrophage samples were tested for the ability to stimulate proliferation and cell migration in cultured rabbit retinal pigment epithelium (RPE). A macrophage invasion was elicited by the intravitreal injection of latex particles in rabbits and after 3 days the vitreal macrophages were collected. The macr...

journal_title：Investigative ophthalmology & visual science

authors： Burke JM,Twining SS

更新日期：1987-07-01 00:00:00

abstract：PURPOSE:The inner vasculature of the retina develops as a spreading network, which is preceded by spindle-shaped cells. These cells are alleged to be vascular precursor cells (angioblasts). This study was designed to test whether such angioblasts exist in neonatal mouse retina. METHODS:In situ hybridization and immuno...

journal_title：Investigative ophthalmology & visual science

authors： Fruttiger M

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:To evaluate genotypic and macular morphologic correlations in patients with RPE65-, CEP290-, GUCY2D-, or AIPL1-related Leber congenital amaurosis (LCA) using spectral-domain optical coherence tomography (SD-OCT). METHODS:SD-OCT macular scans were performed in 21 patients, including 10 with RPE65, 7 with CEP290...

journal_title：Investigative ophthalmology & visual science

authors： Pasadhika S,Fishman GA,Stone EM,Lindeman M,Zelkha R,Lopez I,Koenekoop RK,Shahidi M

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To investigate functional interactions between the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and the nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant system in cultured human retinal pigment epithelium (RPE) cells. METHODS:Cultured ARPE-19 cells were treated with different concen...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Chen Y,Sternberg P,Cai J

更新日期：2008-04-01 00:00:00

abstract：:Laser densitometric analysis of immunoperoxidase stained tissue was used to quantitate class I HLA (HLA-A,B,C) antigen expression by human corneal epithelium. Frozen sections of human donor corneas stored in modified McCarey-Kaufman medium for less than 24 hr were evaluated for class I HLA antigen by an indirect immun...

journal_title：Investigative ophthalmology & visual science

authors： Dreizen NG,Whitsett CF,Austin GE,Stulting RD

更新日期：1986-06-01 00:00:00

abstract：PURPOSE:In a group of humans with strabismic amblyopia, the relationship was examined between the structure and function of different brain regions. Three question were addressed: (1) Is the lateral geniculate nucleus (LGN) in humans with amblyopia structurally as well as functionally abnormal? (2) Do structural anomal...

journal_title：Investigative ophthalmology & visual science

authors： Barnes GR,Li X,Thompson B,Singh KD,Dumoulin SO,Hess RF

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To assess corneal epithelial cell survival after keratoplasty. METHODS:Corneal impression cytology (CIC) was performed on sex-mismatched corneal transplants. Fluorescent in situ hybridization (FISH) with sex chromosome-specific probes was performed to identify epithelial cell mosaicism and therefore allocate t...

journal_title：Investigative ophthalmology & visual science

authors： Catanese M,Popovici C,Proust H,Hoffart L,Matonti F,Cochereau I,Conrath J,Gabison EE

更新日期：2011-02-22 00:00:00

abstract：Purpose:Contrast agents applicable for optical coherence tomography (OCT) imaging are rare. The intrascleral aqueous drainage system would be a potential application for a contrast agent, because the aqueous veins are of small diameter and located deep inside the highly scattering sclera. We tested lipid emulsions (LEs...

journal_title：Investigative ophthalmology & visual science

authors： Gottschalk HM,Wecker T,Khattab MH,Fischer CV,Callizo J,Rehfeldt F,Lubjuhn R,Russmann C,Hoerauf H,van Oterendorp C

更新日期：2019-01-02 00:00:00

abstract：PURPOSE:To examine whether Na(+)-K(+)-2Cl(-) cotransport has the potential to contribute to corneal endothelial ion and fluid transport in cultured and fresh bovine corneal endothelial cells. METHODS:Cl- and Na+ sensitive fluorescent dyes were used to measure furosemide-dependent ion fluxes in cultured and fresh endot...

journal_title：Investigative ophthalmology & visual science

authors： Jelamskii S,Sun XC,Herse P,Bonanno JA

更新日期：2000-02-01 00:00:00

abstract：:This study used primary cultures of conjunctival and corneal epithelial cells from rabbit, monkey and humans to investigate the infection process and host interactions of chlamydia. The epithelial cells were isolated from bulbar and palpebral conjunctivae and the cornea following incubation with EDTA or dispase and mi...

journal_title：Investigative ophthalmology & visual science

authors： Patton DL,Chan KY,Kuo CC,Cosgrove YT,Langley L

更新日期：1988-07-01 00:00:00

abstract：PURPOSE:To examine the expression of VEGF in extranodal marginal zone B-cell lymphoma (EMZL) and reactive lymphoid hyperplasia (RLH) of human ocular adnexa, and analyze the correlation with the intratumoral microvessel density (MVD). METHODS:Twenty-two EMZL and 16 RLH tissues were examined in this study. Paraformaldeh...

journal_title：Investigative ophthalmology & visual science

authors： Kinoshita S,Kase S,Ando R,Dong Z,Fukuhara J,Dong Y,Inafuku S,Noda K,Noda M,Kanda A,Ishida S

更新日期：2014-05-13 00:00:00

abstract：PURPOSE:To determine the potential efficacy and anatomic sites of action of prophylactic oral acyclovir using a murine model of ultraviolet-B-induced reactivation of herpes simplex 1 keratitis. METHODS:Latent infection with herpes simplex 1 (McKrae) was established in 80 National Institutes of Health inbred strain of ...

journal_title：Investigative ophthalmology & visual science

authors： Blatt AN,Laycock KA,Brady RH,Traynor P,Krogstad DJ,Pepose JS

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:To explore factors affecting the glaucoma diagnostic capability of macular thickness and circumpapillary retinal nerve fiber layer (cRNFL) thickness as determined by spectral domain-optical coherence tomography. METHODS:Area under the curve (AUC) of the receiver operating characteristics (ROC) discriminating h...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Sun JH,Lee Y

更新日期：2011-10-11 00:00:00

abstract：PURPOSE:We tested the hypothesis that retinal blood flow has a postocclusive reactive hyperemia response modulated by occlusion duration and metabolic activity, and that choroidal blood flow does not. METHODS:Anesthetized and paralyzed rats (n = 34) were studied. Retinal and choroidal blood flow was measured by laser ...

journal_title：Investigative ophthalmology & visual science

authors： Li G,Kiel JW,Cardenas DP,De La Garza BH,Duong TQ

更新日期：2013-07-30 00:00:00

abstract：:Inoculation of the neurotropic coronavirus mouse hepatitis virus strain JHM intravitreally or into the anterior chamber causes acute infection of the retinal pigment epithelium (RPE) and neural retina. Weeks later, many retinas have foci of moderate to severe atrophy. The effect of coronavirus infection (after intravi...

journal_title：Investigative ophthalmology & visual science

authors： Robbins SG,Wiggert B,Kutty G,Chader GJ,Detrick B,Hooks JJ

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Heavy chain-hyaluronic acid (HC-HA)/PTX3 purified from human amniotic membrane (AM) was previously observed to suppress inflammatory responses in vitro. We now examine whether HC-HA/PTX3 is able to exert a similar effect in vivo, using murine models for keratitis and corneal allograft rejection. METHODS:The in...

journal_title：Investigative ophthalmology & visual science

authors： He H,Tan Y,Duffort S,Perez VL,Tseng SC

更新日期：2014-03-19 00:00:00

abstract：PURPOSE:Nd:YAG laser photodisruption with nanosecond (ns) pulses in the millijoule range is an established tool for intraocular surgery. This study investigates tissue effects in cornea, lens, and retina to assess whether picosecond (ps) pulses with energies in the microjoule range can increase the surgical precision, ...

journal_title：Investigative ophthalmology & visual science

authors： Vogel A,Capon MR,Asiyo-Vogel MN,Birngruber R

更新日期：1994-06-01 00:00:00

abstract：PURPOSE:To evaluate the glaucoma progression in patients with a history of refractive corneal surgery (RCS). METHODS:A total of 313 eyes of 313 glaucoma patients (RCS group, 34 eyes; non-RCS group, 279 eyes) with a mean follow-up period of 2.7 years were included. Glaucoma progression was determined either by experts'...

journal_title：Investigative ophthalmology & visual science

authors： Kim YJ,Yun SC,Na JH,Tchah HW,Jung JJ,Sung KR

更新日期：2012-07-03 00:00:00

abstract：Purpose:We investigated the cross-sectional associations between macular pigment optical density (MPOD), plasma lutein (L), and zeaxanthin (Z) concentrations and cognitive function in 184 older adults of the 3-City-Bordeaux cohort. Methods:MPOD was measured using the two-wavelength autofluorescence method with a modif...

journal_title：Investigative ophthalmology & visual science

authors： Ajana S,Weber D,Helmer C,Merle BM,Stuetz W,Dartigues JF,Rougier MB,Korobelnik JF,Grune T,Delcourt C,Féart C

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Vergence eye movements undergo adaptive recalibration in response to a training stimulus in which the initial disparity is changed just after vergence begins (the double-step paradigm). In the present study the changes in the dynamic properties of convergence, speed and acceleration, were examined by using this...

journal_title：Investigative ophthalmology & visual science

authors： Takagi M,Oyamada H,Abe H,Zee DS,Hasebe H,Miki A,Usui T,Hasegawa S,Bando T

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:To investigate the effect of tear hyperosmolarity and signs of clinical ocular surface pathology on conjunctival goblet cell population. METHODS:111 participants were assessed using tear osmolarity (TO) measurements and a comprehensive selection of clinical ophthalmic tests. The resultant clinical database was...

journal_title：Investigative ophthalmology & visual science

authors： Moore JE,Vasey GT,Dartt DA,McGilligan VE,Atkinson SD,Grills C,Lamey PJ,Leccisotti A,Frazer DG,Moore TC

更新日期：2011-08-03 00:00:00

abstract：:In an anisotonic medium the tendency of the lens to swell or shrink in response to the osmotic gradient is countered by a change in the content of lens solute, so that the change in the volume of lens water is minimal. This phenomenon is known as volume regulation. The rapid phase of volume regulation occurs in less t...

journal_title：Investigative ophthalmology & visual science

authors： Patterson JW

更新日期：1981-01-01 00:00:00

abstract：Purpose:Dense deposit disease (DDD) is caused by dysregulation of the alternative pathway of the complement cascade and characterized by electron-dense deposits in the kidney glomerular basement membrane (GBM) and drusen in Bruch's membrane (BrM). Complement factor H (fH) and factor properdin (fP) regulate complement a...

journal_title：Investigative ophthalmology & visual science

authors： Song D,Mohammed I,Bhuyan R,Miwa T,Williams AL,Gullipalli D,Sato S,Song Y,Dunaief JL,Song WC

更新日期：2018-07-02 00:00:00