Cone photoreceptor packing density and the outer nuclear layer thickness in healthy subjects.

abstract：PURPOSE:The existence of an organic cation transport process in rabbit cornea and conjunctiva that mediates absorption of carnitine has previously been suggested. This study was conducted to determine the expression and localization of the carnitine/organic cation transporter (OCTN1 and OCTN2) in corneal or conjunctiva...

journal_title：Investigative ophthalmology & visual science

authors： Garrett Q,Xu S,Simmons PA,Vehige J,Flanagan JL,Willcox MD

更新日期：2008-11-01 00:00:00

abstract：PURPOSE:The prevalence of cataract increases with age. Conversely, the abundance of native α-crystallin diminishes with age and cataract development. We hypothesize replenishing lens α-crystallin may delay or prevent cataract. Herein we investigated the ability of cell penetration peptides (CPP) to enhance entry of α-c...

journal_title：Investigative ophthalmology & visual science

authors： Mueller NH,Ammar DA,Petrash JM

更新日期：2013-01-02 00:00:00

abstract：PURPOSE:To study the diameter response of retinal arterioles as a function of the arteriolar diameter. METHODS:Ten healthy young volunteers aged 22 to 33 years were subjected to diameter measurement of four successive segments of a retinal arteriole with a retinal vessel analyzer (RVA). At each of the segments, the di...

journal_title：Investigative ophthalmology & visual science

authors： Jeppesen P,Sanye-Hajari J,Bek T

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Excessive and continuously produced free radicals in the outer retina are implicated in retinal aging and the pathogenesis of sight-threatening retinopathies, yet measuring outer retinal oxidative stress in vivo remains a challenge. Here, we test the hypothesis that continuously produced paramagnetic free radic...

journal_title：Investigative ophthalmology & visual science

authors： Berkowitz BA,Bredell BX,Davis C,Samardzija M,Grimm C,Roberts R

更新日期：2015-12-01 00:00:00

abstract：Purpose:To assess if ripasudil has a neuroprotective effect using mice with excitatory amino acid carrier 1 (EAAC1) deletion (EAAC1 knockout [KO] mice), a mouse model of normal tension glaucoma. Methods:Topical administration (5 μL/day) of two different concentrations of ripasudil (0.4% and 2%) were applied to EAAC1 K...

journal_title：Investigative ophthalmology & visual science

authors： Akaiwa K,Namekata K,Azuchi Y,Sano H,Guo X,Kimura A,Harada C,Mitamura Y,Harada T

更新日期：2018-04-01 00:00:00

abstract：Purpose:Contrast agents applicable for optical coherence tomography (OCT) imaging are rare. The intrascleral aqueous drainage system would be a potential application for a contrast agent, because the aqueous veins are of small diameter and located deep inside the highly scattering sclera. We tested lipid emulsions (LEs...

journal_title：Investigative ophthalmology & visual science

authors： Gottschalk HM,Wecker T,Khattab MH,Fischer CV,Callizo J,Rehfeldt F,Lubjuhn R,Russmann C,Hoerauf H,van Oterendorp C

更新日期：2019-01-02 00:00:00

abstract：PURPOSE:To explore factors affecting the glaucoma diagnostic capability of macular thickness and circumpapillary retinal nerve fiber layer (cRNFL) thickness as determined by spectral domain-optical coherence tomography. METHODS:Area under the curve (AUC) of the receiver operating characteristics (ROC) discriminating h...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Sun JH,Lee Y

更新日期：2011-10-11 00:00:00

abstract：PURPOSE:Increased stromal accumulation of macrophages and submucosal fibrosis due to excessive accumulation of collagens are central histologic features in ocular cicatricial pemphigoid (OCP). Interleukin (IL)-4 plays an important role in both the inflammatory and fibrotic events in several human and experimental disea...

journal_title：Investigative ophthalmology & visual science

authors： Razzaque MS,Ahmed BS,Foster CS,Ahmed AR

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:The betaB2-crystallin gene (Crybb2) is expressed at an increasing level in the postnatal lens cortex. It has been assumed that the gene functions as structural protein, although this has not been directly tested. Here the in vivo functions of betaB2-crystallin are examined via the generation of mice with a targ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang J,Li J,Huang C,Xue L,Peng Y,Fu Q,Gao L,Zhang J,Li W

更新日期：2008-12-01 00:00:00

abstract：:A simple clinical method for measurement of light backscatter from defined regions of the lens in vivo is described. Light scattering was quantitated in 168 lenses of 85 "normal" subjects spanning 8 decades of life. The results indicate that light scatter from the anterior capsule does not change with age. The light s...

journal_title：Investigative ophthalmology & visual science

authors： Ben-Sira I,Weinberger D,Bodenheimer J,Yassur Y

更新日期：1980-04-01 00:00:00

abstract：Purpose:IFT81, a core component of the IFT-B complex, involved in the bidirectional transport of ciliary proteins, has been recently implicated in syndromic ciliopathies. However, none of the IFT-B core complex proteins have been associated with nonsyndromic retinal dystrophies. Given the importance of ciliary transpor...

journal_title：Investigative ophthalmology & visual science

authors： Dharmat R,Liu W,Ge Z,Sun Z,Yang L,Li Y,Wang K,Thomas K,Sui R,Chen R

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To compare a multisampling suprathreshold strategy with conventional suprathreshold and full-threshold strategies in detecting localized visual field defects and in quantifying the area of loss. METHODS:Probability theory was applied to examine various suprathreshold pass criteria (i.e., the number of stimuli ...

journal_title：Investigative ophthalmology & visual science

authors： Artes PH,Henson DB,Harper R,McLeod D

更新日期：2003-06-01 00:00:00

abstract：:Liposomes 0.5 to 5 micron in diameter and of various phospholipid compositions were used as a simplified model of rod outer segment membranes to examine the phagocytic mechanism of cultured explants of retinal dystrophic Royal College of Surgeons (RCS) and normal Long-Evans (LE) rat pigment epithelium. RCS pigment epi...

journal_title：Investigative ophthalmology & visual science

authors： Effron JT,Szamier RB,Edwards RB

更新日期：1981-10-01 00:00:00

abstract：PURPOSE:To assess vascular endothelial function in patients with normal pressure glaucoma using forearm blood flow responses to intra-arterial infusions of endothelial-dependent and -independent vasoactive agents. METHODS:Eight patients with newly diagnosed and untreated normal pressure glaucoma and eight healthy age-...

journal_title：Investigative ophthalmology & visual science

authors： Henry E,Newby DE,Webb DJ,O'Brien C

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:To study the antineoplastic effect of vitamin D analogues in a xenograft model of human retinoblastoma. METHODS:Athymic mice were injected subcutaneously with Y79 cells and treated 5 days a week with either mineral oil (control group) or the vitamin D analogues calcitriol or 1,25-dihydroxy-16-ene-23-yne vitami...

journal_title：Investigative ophthalmology & visual science

authors： Audo I,Darjatmoko SR,Schlamp CL,Lokken JM,Lindstrom MJ,Albert DM,Nickells RW

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Glaucoma is the second most frequent cause of visual impairment worldwide. Elevated intraocular pressure (IOP) causes glaucomatous optic nerve damage, especially in the primary open-angle glaucoma (POAG) subtype. As most previous studies on IOP genetics were analyses of glaucomatous families, a study of general...

journal_title：Investigative ophthalmology & visual science

authors： Lee MK,Woo SJ,Kim JI,Cho SI,Kim H,Sung J,Seo JS,Kim DM

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Endocannabinoids are important modulators of synaptic transmission and plasticity throughout the central nervous system. The cannabinoid receptor type 1 (CB1R) is extensively expressed in the adult retina of rodents, while CB2R mRNA and protein expression have been only recently demonstrated in retinal tissue. ...

journal_title：Investigative ophthalmology & visual science

authors： Cécyre B,Zabouri N,Huppé-Gourgues F,Bouchard JF,Casanova C

更新日期：2013-12-11 00:00:00

abstract：:The capacities of porcine choroidal fibroblasts, retinal glial cells, and retinal pigment epithelial cells to contract collagen gels in vitro were compared. Experiments with varied cell numbers indicated that glial cells are the most effective, followed by choroidal fibroblasts and retinal pigment epithelial cells. An...

journal_title：Investigative ophthalmology & visual science

authors： Guidry C,McFarland RJ,Morris R,Witherspoon CD,Hook M

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:To determine the role of small GTPase Rho and its relation with epidermal growth factor receptor (EGFR) in mediating corneal epithelial wound healing. METHODS:Rho activity in THCE cells, an SV40-immortalized human corneal epithelial cell (HCEC) line, and primary HCECs was assessed by pull-down assay followed b...

journal_title：Investigative ophthalmology & visual science

authors： Yin J,Lu J,Yu FS

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:Corneal crystallins are lost from resident cells of the corneal stroma during wound repair, and this is associated with a loss of cell transparency. The goal of this study was to identify factors inducing loss of the corneal crystallin transketolase (TKT). METHODS:A cell culture model of freshly isolated rabbi...

journal_title：Investigative ophthalmology & visual science

authors： Stramer BM,Fini ME

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the repeatability of manual measurements of choroidal thickness in healthy subjects imaged on spectral domain optical coherence tomography (OCT) using the enhanced depth imaging (EDI) technique. METHODS:Fifty consecutive, healthy, young, adult volunteers with no known e...

journal_title：Investigative ophthalmology & visual science

authors： Rahman W,Chen FK,Yeoh J,Patel P,Tufail A,Da Cruz L

更新日期：2011-04-08 00:00:00

abstract：Purpose:Synthesis of keratan sulfate (KS) relies on coordinated action of multiple enzymes, including the N-acetylglucosamine-transferring enzyme, β-1,3-N-acetylglucosaminyltransferase-7 (β3GnT7). A mouse model deficient in β3GnT7 was developed to explore structural changes in KS and the extracellular matrix (ECM; i.e....

journal_title：Investigative ophthalmology & visual science

authors： Littlechild SL,Young RD,Caterson B,Yoshida H,Yamazaki M,Sakimura K,Quantock AJ,Akama TO

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To investigate whether tissue plasminogen activator (tPA) can prevent and/or reverse steroid-induced IOP elevation in an ovine model. METHODS:Three animal groups were subjected to bilateral steroid-induced IOP elevation using thrice daily topical ocular prednisolone administration. In the first group (N = 8), ...

journal_title：Investigative ophthalmology & visual science

authors： Gerometta R,Kumar S,Shah S,Alvarez L,Candia O,Danias J

更新日期：2013-12-03 00:00:00

abstract：:One eye of each of eight subjects was exposed to gases containing oxygen concentrations of 1.0%, 2.5%, 4.9%, 7.5%, 10.1%, and 21.4% (oxygen partial pressures ranging from 8 to 158 mmHg) for 8 hr. The precorneal oxygen concentration required to avoid corneal edema for the group as a whole was 10.1% (an oxygen tension o...

journal_title：Investigative ophthalmology & visual science

authors： Holden BA,Sweeney DF,Sanderson G

更新日期：1984-04-01 00:00:00

abstract：PURPOSE:Nystagmus, head nodding, and anomalous head position are symptoms of spasmus nutans. This disorder appears in early childhood and is thought to be self-limited. However, the visual outcome of patients with spasmus nutans is unclear. The resolution of nystagmus has not been proven with quantitative eye movement ...

journal_title：Investigative ophthalmology & visual science

authors： Gottlob I,Wizov SS,Reinecke RD

更新日期：1995-12-01 00:00:00

abstract：PURPOSE:To determine the efficacy of the M1-selective muscarinic antagonist, pirenzepine, in preventing experimentally induced myopia in a mammalian model, the tree shrew. METHODS:Tree shrews were monocularly deprived (MD) using translucent goggles or negative lenses for a period of 12 days. In two of the MD groups, t...

journal_title：Investigative ophthalmology & visual science

authors： Cottriall CL,McBrien NA

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:To study the survival of adult retinal grafts prepared in a physiologically optimized way. METHODS:Twenty-three rabbits received an adult full-thickness rabbit retinal transplant positioned under the host retina, using a vitrectomy technique. The transplants were prepared using a procedure based on a previousl...

journal_title：Investigative ophthalmology & visual science

authors： Wassélius J,Ghosh F

更新日期：2001-10-01 00:00:00

abstract：:Tissue culture of retinal vessels from fetal calf eyes produced colonies of endothelium, pericytes, and smooth muscle. Identification of endothelial cells was based upon culture morphology, [3H]thymidine labeling of isolated vessels, and factor VIII immunofluorescence. Thimerosal added to the culture medium destroyed ...

journal_title：Investigative ophthalmology & visual science

authors： Buzney SM,Massicotte SJ

更新日期：1979-11-01 00:00:00

abstract：PURPOSE:To determine whether caspase or cathepsin pathways are activated in human retinal pigment epithelial cells (ARPE-19) after exposure to 7-ketocholesterol (7kCh). METHODS:ARPE-19 cells were exposed to 7kCh with or without z-VAD-fmk, a pan-caspase inhibitor. Caspase-3, -8, and -9 activities were measured by a flu...

journal_title：Investigative ophthalmology & visual science

authors： Luthra S,Fardin B,Dong J,Hertzog D,Kamjoo S,Gebremariam S,Butani V,Narayanan R,Mungcal JK,Kuppermann BD,Kenney MC

更新日期：2006-12-01 00:00:00

abstract：:Photoreceptors can segregate inner segment proteins from outer segment proteins. It is uncertain whether such a sorting process occurs during disc morphogenesis in rods, thereby resulting in an outer segment plasma membrane which differs compositionally from the discs. In this study, the plasma membranes of intact, pu...

journal_title：Investigative ophthalmology & visual science

authors： Polans AS,Burton MD

更新日期：1988-10-01 00:00:00