Lipid Emulsion-Based OCT Angiography for Ex Vivo Imaging of the Aqueous Outflow Tract.

abstract：PURPOSE:To examine the prognostic relevance of expression of the chemokine receptors CCR7 and CXCR4 and its ligand CXCL12 in uveal melanoma in nonmetastatic and metastatic patients with correlation to liver metastasis and overall survival. METHODS:Primary uveal melanoma specimens from 19 patients with correlating live...

journal_title：Investigative ophthalmology & visual science

authors： van den Bosch T,Koopmans AE,Vaarwater J,van den Berg M,de Klein A,Verdijk RM

更新日期：2013-11-08 00:00:00

abstract：PURPOSE:The virulence of any given strain of herpes simplex virus (HSV) is probably due to the effects of the constellation of genes in that strain and how they act in concert to promote disease. The goal of this work was to develop a system to identify and study the role of multiple genes in HSV disease. METHODS:Mixe...

journal_title：Investigative ophthalmology & visual science

authors： Brandt CR,Kolb AW,Shah DD,Pumfery AM,Kintner RL,Jaehnig E,Van Gompel JJ

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:Classically, acute and chronic inflammations are characterized by fibrin deposition and a dynamic influx of leukocytes. This leukocyte recruitment, and associated activation, is thought to be dependent on the generation of leukocyte chemotactic factors (LCF). Although the functional existence of LCF in ocular t...

journal_title：Investigative ophthalmology & visual science

authors： Ramsby ML,Kreutzer DL

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:Photodynamic therapy (PDT) and the administration of compounds acting against vascular endothelial growth factor (anti-VEGF) are approved for the treatment of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Experimental evidence that the combined use of both treatment opt...

journal_title：Investigative ophthalmology & visual science

authors： Zuluaga MF,Mailhos C,Robinson G,Shima DT,Gurny R,Lange N

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:Polypoidal choroidal vasculopathy (PCV) is a major cause of serosanguinous maculopathy in Chinese patients with age-related macular degeneration (AMD). Variants in the CFH and HTRA1/LOC387715 genes are strongly associated with AMD in Caucasians and Chinese. Variants in the C2 and BF genes have been found to con...

journal_title：Investigative ophthalmology & visual science

authors： Lee KY,Vithana EN,Mathur R,Yong VH,Yeo IY,Thalamuthu A,Lee MW,Koh AH,Lim MC,How AC,Wong DW,Aung T

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Vision restoration is a fast-approaching reality for some people with profound vision loss. In order to reliably determine treatment efficacy, accurate assessment of baseline residual visual function is critical. The purpose of this study was to compare residual function as detected on Goldman visual field (GVF...

journal_title：Investigative ophthalmology & visual science

authors： Ayton LN,Apollo NV,Varsamidis M,Dimitrov PN,Guymer RH,Luu CD

更新日期：2014-03-06 00:00:00

abstract：:Advanced macular degeneration is an important cause of vision loss in the United States with over 2 million people affected by the disease. Despite substantial progress in the development of new therapies for wet AMD, the severe visual impairment associated with geographic atrophy in dry AMD or Stargardt disease remai...

journal_title：Investigative ophthalmology & visual science

authors： Schwartz SD,Tan G,Hosseini H,Nagiel A

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:To investigate the role of macrophages in the development of laser-induced choroidal neovascularization (CNV) by selective depletion with liposomal clodronate (Cl(2)MDP-LIP). METHODS:Laser photocoagulation was used to induce CNV in wild-type C57BL/6J mice. Animals were treated with intravenous (IV) and/or su...

journal_title：Investigative ophthalmology & visual science

authors： Sakurai E,Anand A,Ambati BK,van Rooijen N,Ambati J

更新日期：2003-08-01 00:00:00

abstract：Purpose:To refine the Minnesota Grading System (MGS) using definitions from the Age-Related Eye Disease Studies (AREDS) into a nine-step grading scale (MGS-9). Methods:A nine-step grading scale descriptive analysis using three key phenotypic features (total drusen area, increased, and decreased pigmentation) of human ...

journal_title：Investigative ophthalmology & visual science

authors： Olsen TW,Liao A,Robinson HS,Palejwala NV,Sprehe N

更新日期：2017-10-01 00:00:00

abstract：:The role of heterozygous galactokinase deficiency in the development of presenile cataracts is presently undetermined. Erythrocyte galactokinase activity was measured from 95 normal Caucasian subjects and from 39 Caucasian patients who had developed idiopathic bilateral cataracts between ages 20 and 55. The diagnosis ...

journal_title：Investigative ophthalmology & visual science

authors： Stambolian D,Scarpino-Myers V,Eagle RC Jr,Hodes B,Harris H

更新日期：1986-03-01 00:00:00

abstract：:Three congenic Royal College of Surgeons (RCS) strains of rats have been developed: the RCS-p+ strain, which is a black-eyed dystrophic strain; the pink-eyed RCS-rdy+ strain, which is wild-type (+/+) at the retinal dystrophy (rdy) genetic locus and serves as the control for the inbred, pink-eyed RCS strain; and the bl...

journal_title：Investigative ophthalmology & visual science

authors： LaVail MM

更新日期：1981-05-01 00:00:00

abstract：PURPOSE:To test the hypothesis that retinal hypoxia is present during vascular development in normal rat pups and in a newborn rat model of retinopathy of prematurity (ROP). METHODS:Preretinal vitreous PO(2) measurements were made during room air breathing using (19)F magnetic resonance spectroscopy (MRS) and a perflu...

journal_title：Investigative ophthalmology & visual science

authors： Zhang W,Ito Y,Berlin E,Roberts R,Berkowitz BA

更新日期：2003-07-01 00:00:00

abstract：Purpose:To investigate the molecular pathways that drive thyroid stimulating hormone receptor (TSHR)-induced cellular proliferation in orbital fibroblasts (OFs) from thyroid eye disease (TED) patients. Methods:Orbital fibroblasts from TED and non-TED patients were treated with TSH and changes in gene expression and pr...

journal_title：Investigative ophthalmology & visual science

authors： Woeller CF,Roztocil E,Hammond C,Feldon SE

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:To identify the disease locus associated with autosomal dominant Fuchs corneal dystrophy (FCD) in a large family and to compare the progression of severity in families mapped to the FCD1 and FCD2 loci. METHODS:Seventeen individuals in a large family were examined by slit lamp biomicroscopy. Blood samples were ...

journal_title：Investigative ophthalmology & visual science

authors： Riazuddin SA,Eghrari AO,Al-Saif A,Davey L,Meadows DN,Katsanis N,Gottsch JD

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Advanced glycation end products (AGEs) form irreversible cross-links with many macromolecules and have been shown to accumulate in tissues at an accelerated rate in diabetes. In the present study, AGE formation in vitreous was examined in patients of various ages and in patients with diabetes. Ex vivo investiga...

journal_title：Investigative ophthalmology & visual science

authors： Stitt AW,Moore JE,Sharkey JA,Murphy G,Simpson DA,Bucala R,Vlassara H,Archer DB

更新日期：1998-12-01 00:00:00

abstract：PURPOSE:To explore the susceptibilities of adult retinal neurons in dissociated culture to treatments with excitotoxic agonists and the mechanisms of the resultant retinal cell death. METHODS:C57B6 mice were used. Retinas were removed, dissociated, plated on a polylysine/laminin substrate, and maintained in vitro for ...

journal_title：Investigative ophthalmology & visual science

authors： Luo X,Baba A,Matsuda T,Romano C

更新日期：2004-12-01 00:00:00

abstract：:Extraocular muscle represents a distinctive class among mammalian skeletal musculature in exhibiting the full range of muscle fiber type variability found in vertebrate species. To better understand the basis for the unique structural/functional diversity of extraocular muscle, the ontogeny of lateral rectus muscles w...

journal_title：Investigative ophthalmology & visual science

authors： Porter JD,Baker RS

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:The anterior surface of the eye is covered by several physically contiguous but histologically distinguishable epithelial overlying the cornea, limbus, bulbar conjunctiva, fornix conjunctiva, and palpebral conjunctiva. It is important to determine whether the different phenotypes of these epithelia are the resu...

journal_title：Investigative ophthalmology & visual science

authors： Wei ZG,Wu RL,Lavker RM,Sun TT

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of a biodegradable scleral plug containing ganciclovir (GCV) in a rabbit model of human cytomegalovirus (HCMV) retinitis. METHODS:To develop a rabbit model for HCMV retinitis, HCMV solution was injected once into the vitreous cavity of pigmented rabbits. The treated animals were divide...

journal_title：Investigative ophthalmology & visual science

authors： Sakurai E,Matsuda Y,Ozeki H,Kunou N,Nakajima K,Ogura Y

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:This study explores the order of assembly of the lens fiber cell plasma membrane. Because the lens must synthesize most of its membrane components, our approach was to map directly the spatial distribution of cholesterol, fatty acid (reflecting phospholipid), and the main intrinsic protein, MP26, synthesis in t...

journal_title：Investigative ophthalmology & visual science

authors： Cenedella RJ

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:To characterize retinal functional consequences of elevated intraocular pressure (IOP) in a rat model of experimental glaucoma. METHODS:Unilateral elevation of IOP was produced by hypertonic saline injection into an episcleral vein in 20 adult male Brown-Norway rats. IOP was measured in both eyes of awake anim...

journal_title：Investigative ophthalmology & visual science

authors： Fortune B,Bui BV,Morrison JC,Johnson EC,Dong J,Cepurna WO,Jia L,Barber S,Cioffi GA

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:This study evaluated the role for poly(ADP-ribose) polymerase (PARP) in diabetes-induced cataractogenesis and early retinal changes. METHODS:Control and streptozotocin (STZ)-diabetic rats were treated with or without the PARP inhibitors 1,5-isoquinolinediol (ISO; 3 mg kg(-1) d(-1) intraperitoneally) and 10-(4-...

journal_title：Investigative ophthalmology & visual science

authors： Drel VR,Xu W,Zhang J,Kador PF,Ali TK,Shin J,Julius U,Slusher B,El-Remessy AB,Obrosova IG

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:To quantitate in vivo retinal ganglion cell (RGC) survival after transient periods of pressure-induced ischemia of the rat retina and after different survival intervals. METHODS:In adult rats, RGCs were labeled with fluorogold applied to their main targets in the brain. Seven days later, in several groups of r...

journal_title：Investigative ophthalmology & visual science

authors： Sellés-Navarro I,Villegas-Pérez MP,Salvador-Silva M,Ruiz-Gómez JM,Vidal-Sanz M

更新日期：1996-09-01 00:00:00

abstract：Purpose:To enumerate the ocular surface fungal microbiome of healthy human eyes by using next-generation sequencing (NGS). Methods:Tarsal and fornix conjunctiva from the lower and upper lids of both eyes of healthy individuals were swabbed in duplicate separately. A total of 34 samples were collected from both the eye...

journal_title：Investigative ophthalmology & visual science

authors： Shivaji S,Jayasudha R,Sai Prashanthi G,Kalyana Chakravarthy S,Sharma S

更新日期：2019-01-02 00:00:00

abstract：Purpose:Ocular lens fiber cell elongation, differentiation, and compaction are associated with extensive reorganization of cell adhesive interactions and cytoskeleton; however, our knowledge of proteins critical to these events is still evolving. This study characterizes the distribution pattern of neuronal-specific α-...

journal_title：Investigative ophthalmology & visual science

authors： Maddala R,Rao PV

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:To characterize photoreceptor cell apoptosis and cell loss in a mouse model of experimental retinal detachment (RD), and to use the technology of mouse genetics to study the molecular mechanisms underlying RD-associated photoreceptor degeneration. METHODS:Retinal detachments were created in adult wild-type and...

journal_title：Investigative ophthalmology & visual science

authors： Yang L,Bula D,Arroyo JG,Chen DF

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:To study the antineoplastic effect of vitamin D analogues in a xenograft model of human retinoblastoma. METHODS:Athymic mice were injected subcutaneously with Y79 cells and treated 5 days a week with either mineral oil (control group) or the vitamin D analogues calcitriol or 1,25-dihydroxy-16-ene-23-yne vitami...

journal_title：Investigative ophthalmology & visual science

authors： Audo I,Darjatmoko SR,Schlamp CL,Lokken JM,Lindstrom MJ,Albert DM,Nickells RW

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:The purpose of the study was to assess vision-related quality of life (QoL) in patients with visual field loss (VFL) after lesions of the postchiasmatic visual pathway and to investigate the influence of VFL and reduced visual acuity (VA) on vision-related QoL. METHODS:In 312 patients with postchiasmatic damag...

journal_title：Investigative ophthalmology & visual science

authors： Gall C,Lucklum J,Sabel BA,Franke GH

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:To describe the dark-adaptation (DA) functions in subjects with molecularly proven achromatopsia (ACHM) using refined testing conditions with a view to guiding assessment in forthcoming gene therapy trials. METHODS:The DA functions of nine subjects with ACHM were measured and compared with those of normal obse...

journal_title：Investigative ophthalmology & visual science

authors： Aboshiha J,Luong V,Cowing J,Dubis AM,Bainbridge JW,Ali RR,Webster AR,Moore AT,Fitzke FW,Michaelides M

更新日期：2014-08-28 00:00:00

abstract：PURPOSE:To compare the pharmacokinetics and tissue response between intravitreal and microcannulation injections into the suprachoroidal space using bevacizumab. METHODS:Sixty-two pigs were studied. Either a pars plana intravitreal bevacizumab or a viscoelastic-enhanced microcannula suprachoroidal injection was perfor...

journal_title：Investigative ophthalmology & visual science

authors： Olsen TW,Feng X,Wabner K,Csaky K,Pambuccian S,Cameron JD

更新日期：2011-07-01 00:00:00