VIP and VIP gene silencing modulation of differentiation marker N-cadherin and cell shape of corneal endothelium in human corneas ex vivo.

abstract：:The existence of wide-band, phase-specific channels in the human visual system has been suggested in recent investigations. We used a number of adapting gratings to test for phase-specific adaptation effects. Observers were asked to discriminate between a simple 3 cpd sine-wave grating, (3), and a complex grating comp...

journal_title：Investigative ophthalmology & visual science

authors： Sansbury RV,Distelhorst J,Moore S

更新日期：1978-05-01 00:00:00

abstract：PURPOSE:To determine the mechanism of reattachment of harvested human retinal pigment epithelium (RPE) to RPE-derived extracellular matrix and Bruch's membrane. METHODS:Confluent first-to third-passage human RPE were harvested from tissue culture and plated onto RPE-derived extracellular matrix or human Bruch's membra...

journal_title：Investigative ophthalmology & visual science

authors： Ho TC,Del Priore LV

更新日期：1997-05-01 00:00:00

abstract：:Bovine corneal endothelial cells in culture synthesize predominantly type III collagen, unlike rabbit corneal endothelial cultures which synthesize type IV collagen. In an attempt to document whether this type III collagen synthesis by bovine cells is a tissue culture-specific phenomenon, collagens synthesized by orga...

journal_title：Investigative ophthalmology & visual science

authors： Kay EP,Oh S

更新日期：1988-02-01 00:00:00

abstract：PURPOSE:Ca(2+) is a major regulator of cell function. In the retinal pigment epithelium (RPE), intracellular free Ca(2+) concentration ([Ca(2+)](i)) is essential for the maintenance of normal retinal function. Therefore, accurate control of [Ca(2+)](i) is vital in these cells. Because Ca(2+) is permanently extruded fro...

journal_title：Investigative ophthalmology & visual science

authors： Wimmers S,Strauss O

更新日期：2007-12-01 00:00:00

abstract：:Lymphocyte cultures were employed to assess the degree of spontaneous and induced chromosomal fragility in retinoblastoma. Sister chromatid exchange (SCEs) were scored in metaphases. Three unilateral, three bilateral, eleven family members and controls were studied. Retinoblastoma (RB) lymphocytes did not exhibit incr...

journal_title：Investigative ophthalmology & visual science

authors： Abramovsky-Kaplan I,Jones IS

更新日期：1984-06-01 00:00:00

abstract：Purpose:To develop deep learning (DL) models for the automatic detection of optical coherence tomography (OCT) measures of diabetic macular thickening (MT) from color fundus photographs (CFPs). Methods:Retrospective analysis on 17,997 CFPs and their associated OCT measurements from the phase 3 RIDE/RISE diabetic macul...

journal_title：Investigative ophthalmology & visual science

authors： Arcadu F,Benmansour F,Maunz A,Michon J,Haskova Z,McClintock D,Adamis AP,Willis JR,Prunotto M

更新日期：2019-03-01 00:00:00

abstract：:The visual effects of carbon disulfide exposure were studied in macaque monkeys with measurements of visual thresholds, fluorescein angiography and fundus photography. Five monkeys were exposed by inhalation for 6 hr a day, 5 days a week to 256 ppm carbon disulfide (CS2). The motor dysfunction observed in these monkey...

journal_title：Investigative ophthalmology & visual science

authors： Merigan WH,Wood RW,Zehl D,Eskin TA

更新日期：1988-04-01 00:00:00

abstract：PURPOSE:The purpose of the present study was to examine the roles of signaling pathways potentially activated by TGFbeta (i.e., Smad and p38 mitogen-activated kinase [MAPK]) in regulation of cell migration and proliferation of healing mouse corneal epithelium. METHODS:Activation of Smads or p38MAPK was evaluated by im...

journal_title：Investigative ophthalmology & visual science

authors： Saika S,Okada Y,Miyamoto T,Yamanaka O,Ohnishi Y,Ooshima A,Liu CY,Weng D,Kao WW

更新日期：2004-01-01 00:00:00

abstract：:Docosapentaenoic acid (22:5 omega 6), a minor constituent (less than 4%) of photoreceptor outer segment membranes in all vertebrate species examined to date, comprises 23% of the fatty acids in total lipids from rabbit outer segment membranes. This fatty acid is a significant constituent of each of the three major pho...

journal_title：Investigative ophthalmology & visual science

authors： Nielsen JC,Maude MB,Hughes H,Anderson RE

更新日期：1986-02-01 00:00:00

abstract：:We have investigated the involvement of cell-mediated immune responses to Herpes simplex virus type 1 (HSV-1) in the pathogenesis of HSV-1 induced corneal stromal lesions in mice. Topical corneal (TC) HSV-1 infection induced a vigorous delayed hypersensitivity response, as well as lymphoproliferative and cytotoxic res...

journal_title：Investigative ophthalmology & visual science

authors： Ksander BR,Hendricks RL

更新日期：1987-12-01 00:00:00

abstract：PURPOSE:To assess alterations in allergic ocular responses to nonparasite antigens in an experimental system in which mice were skewed toward a Th2 cytokine profile by helminth infection. METHODS:Mice were inoculated with Ascaris suum (A. suum) eggs concurrent with ragweed (RW) sensitization (RW/acute) or by repeated ...

journal_title：Investigative ophthalmology & visual science

authors： Schopf L,Luccioli S,Bundoc V,Justice P,Chan CC,Wetzel BJ,Norris HH,Urban JF Jr,Keane-Myers A

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:The mouse has become an important wound healing model with which to study corneal fibrosis, a frequent complication of refractive surgery. The aim of the current study was to quantify changes in stromal ultrastructure and light scatter that characterize fibrosis in mouse corneal debridement wounds. METHODS:Epi...

journal_title：Investigative ophthalmology & visual science

authors： Boote C,Du Y,Morgan S,Harris J,Kamma-Lorger CS,Hayes S,Lathrop KL,Roh DS,Burrow MK,Hiller J,Terrill NJ,Funderburgh JL,Meek KM

更新日期：2012-05-14 00:00:00

abstract：Purpose:To test the hypothesis that emmetropization buffers against genetic and environmental risk factors for myopia by investigating whether risk factor effect sizes vary depending on children's position in the refractive error distribution. Methods:Refractive error was assessed in participants from two birth cohort...

journal_title：Investigative ophthalmology & visual science

authors： Pozarickij A,Enthoven CA,Ghorbani Mojarrad N,Plotnikov D,Tedja MS,Haarman AEG,Tideman JWL,Polling JR,Northstone K,Williams C,Klaver CCW,Guggenheim JA

更新日期：2020-02-07 00:00:00

abstract：PURPOSE:The growth of ocular neovascularization is regulated by a balance between stimulating and inhibiting growth factors. Somatostatin affects angiogenesis by inhibiting the growth hormone-insulin-like growth factor axis and also has a direct antiproliferative effect on human retinal endothelial cells. The purpose o...

journal_title：Investigative ophthalmology & visual science

authors： Lambooij AC,Kuijpers RW,van Lichtenauer-Kaligis EG,Kliffen M,Baarsma GS,van Hagen PM,Mooy CM

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:To investigate whether polymorphisms in the gene encoding the chemokine receptor CX3CR1, which has been linked to changes in functional ligand-binding activity, are associated with retinal vasculitis (RV) in a cohort of patients in the United Kingdom. METHODS:DNA was prepared from whole blood of 126 patients w...

journal_title：Investigative ophthalmology & visual science

authors： Wallace GR,Vaughan RW,Kondeatis E,Mathew R,Chen Y,Graham EM,Stanford MR

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To isolate and characterize bovine lens endopeptidase activity that cleaves the Phe-Ser bond in peptide substrates. METHODS:The protease activity in young bovine lens homogenate was measured using the Mca-(Ala(7),Lys(Dnp)(9))-bradykinin substrate. Degradation of bradykinin and other unlabeled peptide substrate...

journal_title：Investigative ophthalmology & visual science

authors： Chaerkady R,Sharma KK

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:Glucocorticoid sensitivity in glaucoma has been attributed to differences in the expression of the two glucocorticoid receptors, GRalpha and GRbeta. GRalpha undergoes steroid-dependent nuclear translocation by associating with a heat shock protein (Hsp)90 multiprotein heterocomplex. The nuclear transport of the...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Clark AF,Yorio T

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Slow oscillatory eye movements (SOMs) occur simultaneously with tremor, drifts, and microsaccades during visual fixation. In a previous study, the amplitude of SOM was found to be affected by the visual characteristics of the stimuli. This indicates a perceptual influence on the control of the movement. However...

journal_title：Investigative ophthalmology & visual science

authors： Zhang B,Bolzani R,Öqvist Seimyr G,Ygge J,Pansell T

更新日期：2013-12-11 00:00:00

abstract：Purpose:Effective intravitreal gene delivery to cells of the central retina (i.e., photoreceptors) would be of substantial benefit for treating patients with retinal diseases, such as achromatopsia, where retinal detachment from a subretinal may be harmful. Previous studies demonstrated that mutation of the recombinant...

journal_title：Investigative ophthalmology & visual science

authors： Reid CA,Ertel KJ,Lipinski DM

更新日期：2017-12-01 00:00:00

abstract：Purpose:Ocular rigidity (OR) is an important biomechanical property, thought to be relevant in the pathophysiology of open-angle glaucoma (OAG). This study aims to evaluate the relationship between OR and neuroretinal damage caused by glaucoma. Methods:One hundred eight subjects (22 with healthy eyes, 23 with suspect ...

journal_title：Investigative ophthalmology & visual science

authors： Sayah DN,Mazzaferri J,Descovich D,Costantino S,Lesk MR

更新日期：2020-11-02 00:00:00

abstract：PURPOSE:To test whether eliprodil (SL 82.0715), a unique antagonist for the N-methyl-D-aspartate (NMDA) receptor, is protective in the glutamate-induced cytotoxicity model in cultured rat retinal ganglion cells (RGCs). METHODS:Two to four days after a fluorescent dye, Di-I, was injected near the superior colliculi, ne...

journal_title：Investigative ophthalmology & visual science

authors： Pang IH,Wexler EM,Nawy S,DeSantis L,Kapin MA

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:Viral conjunctivitis is a highly contagious infection often causing major epidemics. A safe broad-spectrum antiviral agent is needed to treat this unmet medical need. The purpose of this study is to demonstrate that in vitro NVC-422 is a safe, broad-spectrum topical virucidal agent with activity against ophthal...

journal_title：Investigative ophthalmology & visual science

authors： Jekle A,Abdul Rani S,Celeri C,Zuck M,Xu P,Wang L,Najafi-Tagol K,Anderson M,Stroman D,Debabov D

更新日期：2013-02-19 00:00:00

abstract：PURPOSE:Acute optic neuritis (ON) is often followed by recovery of visual function. Although this recovery is mainly attributable to resolution of the acute inflammation, the redistribution of ion channels along the demyelinated membrane, and subsequent remyelination, part of it may be the result of neural plasticity. ...

journal_title：Investigative ophthalmology & visual science

authors： Klistorner A,Arvind H,Garrick R,Graham SL,Paine M,Yiannikas C

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To investigate the effects of retinoic acid, retinol, and 11-cis retinaldehyde on proliferation, differentiation, and survival of cultured embryonic chick neural retina cells; to describe the metabolic transformations of these retinoids by the cultured cells. METHODS:Retinoids were added to glia-free, low-dens...

journal_title：Investigative ophthalmology & visual science

authors： Stenkamp DL,Gregory JK,Adler R

更新日期：1993-07-01 00:00:00

abstract：Purpose:To radiologically examine for the presence of bony remodeling of the orbit in thyroid eye disease (TED). Methods:Computed tomography (CT) scans of 248 orbits of 124 patients with TED and 185 orbits of 138 controls were retrospectively reviewed, and the following parameters measured: the angle of the inferomedi...

journal_title：Investigative ophthalmology & visual science

authors： Tan NYQ,Leong YY,Lang SS,Htoon ZM,Young SM,Sundar G

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To evaluate symptoms, signs, and the levels of 16 tears inflammatory mediators of dry eye (DE) patients exposed to an environment simulating an in-flight air cabin in an environmental chamber. METHODS:Twenty DE patients were exposed to controlled environment simulating an in-flight airplane cabin (simulated in...

journal_title：Investigative ophthalmology & visual science

authors： Tesón M,González-García MJ,López-Miguel A,Enríquez-de-Salamanca A,Martín-Montañez V,Benito MJ,Mateo ME,Stern ME,Calonge M

更新日期：2013-03-01 00:00:00

abstract：Purpose:Dry eye disease (DED) is a multifactorial disease associated with ocular surface inflammation. Toll-like receptors (TLRs) are integral in the initiation of inflammatory signaling. Therefore, we evaluated the effect of TLR-deficiency on dry eye-related ocular surface damage and inflammation using a mouse model o...

journal_title：Investigative ophthalmology & visual science

authors： Reins RY,Lema C,Courson J,Kunnen CME,Redfern RL

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To assess the safety of a possible substitute treatment for intraocular steroid injections, intraocular injections of ketorolac tromethamine, one of the nonsteroidal anti-inflammatory drugs, were performed in rabbits. METHODS:Either 0.5% or 0.25% preservative-free ketorolac tromethamine ophthalmic solution (0....

journal_title：Investigative ophthalmology & visual science

authors： Margalit E,Kugler LJ,Brumm MV,Meza JL,Kompella UB,Escobar ER,Christensen GR

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:Myopia (short sightedness) is a complex trait influenced by as yet unidentified genetic factors. To date, there have been four myopia susceptibility loci (MYP7 to -10) identified in twin studies, but these are yet to be independently verified. In an independent yet ethnically and phenotypically similar twin coh...

journal_title：Investigative ophthalmology & visual science

authors： Schäche M,Richardson AJ,Pertile KK,Dirani M,Scurrah K,Baird PN

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To identify if whole-body hydration plays an important role in dry eye (DE). We hypothesized that individuals classified as DE have higher plasma osmolality (Posm), indicating suboptimal hydration, compared with those classified as non-DE. METHODS:Using a hospital-based observational cross-sectional design, as...

journal_title：Investigative ophthalmology & visual science

authors： Walsh NP,Fortes MB,Raymond-Barker P,Bishop C,Owen J,Tye E,Esmaeelpour M,Purslow C,Elghenzai S

更新日期：2012-09-25 00:00:00