Association of genetic variation on chromosome 9p21 with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration.

abstract：:Specimens for chlamydial isolation culture and direct fluorescent antibody cytology (DFA) were collected from 1671 women and children from a trachoma-endemic area in Central Tanzania. Trachoma was graded using the new World Health Organization grading scheme, and 54% of the children and 9% of the women had inflammator...

journal_title：Investigative ophthalmology & visual science

authors： Taylor HR,Rapoza PA,West S,Johnson S,Munoz B,Katala S,Mmbaga BB

更新日期：1989-08-01 00:00:00

abstract：PURPOSE:To test the effects of genistein on choriocapillaris regeneration and retinal pigment epithelial (RPE) wound healing in a surgical model in the rabbit. METHODS:Intravitreal injections of either 0.1 ml of a 90-microM concentration of genistein, dimethyl sulfoxide (DMSO; negative control), or 2 microg cyclohexim...

journal_title：Investigative ophthalmology & visual science

authors： Majji AB,Hayashi A,Kim HC,Grebe RR,de Juan E Jr

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:To assess the range of macular pigment optical density (MPOD) in a healthy group of young adults of South Asian origin; to investigate whether any dietary factors or personal characteristics were related to intersubject variations in MPOD; and to compare the mean MPOD of the South Asian group with the mean MPOD...

journal_title：Investigative ophthalmology & visual science

authors： Howells O,Eperjesi F,Bartlett H

更新日期：2013-04-17 00:00:00

abstract：PURPOSE:To identify genes and molecular mechanisms associated with photoreceptor degeneration in a canine model of XLRP caused by an RPGR exon ORF15 microdeletion. Methods. Expression profiles of mutant and normal retinas were compared by using canine retinal custom cDNA microarrays. qRT-PCR, Western blot analysis, and...

journal_title：Investigative ophthalmology & visual science

authors： Genini S,Zangerl B,Slavik J,Acland GM,Beltran WA,Aguirre GD

更新日期：2010-11-01 00:00:00

abstract：Purpose:To compare blood pressure and urine albumin-creatinine ratio over time for participants receiving aflibercept, bevacizumab, or ranibizumab. Methods:Preplanned secondary analyses from a randomized trial comparing aflibercept, bevacizumab, and ranibizumab for diabetic macular edema (DME). The Diabetic Retinopath...

journal_title：Investigative ophthalmology & visual science

authors： Glassman AR,Liu D,Jampol LM,Sun JK,Diabetic Retinopathy Clinical Research Network.

更新日期：2018-03-01 00:00:00

abstract：:Nonenzymatic glycated lens alpha-crystallin, isolated from human diabetic cataract lenses, does not differ in subunit size and secondary structure from nonglycated alpha-crystallin. The tertiary structure, however, has undergone a significant change as reflected in the changes of near-ultraviolet (UV) circular dichroi...

journal_title：Investigative ophthalmology & visual science

authors： Liang JN,Chylack LT Jr

更新日期：1987-05-01 00:00:00

abstract：:Visual thresholds and rhodopsin levels were determined in nine subjects with autosomal dominant retinitis pigmentosa. The subjects fell into two groups, corresponding to two subtypes of the disease revealed by two-color, dark-adapted static perimetry. In the first of these subtypes, rod-mediated function was variably ...

journal_title：Investigative ophthalmology & visual science

authors： Kemp CM,Jacobson SG,Faulkner DJ

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:Previous studies have shown that insulin-like growth factor-binding protein (IGFBP)-2 is markedly upregulated in senescent RPE cells in vitro, and might therefore be a marker of senescent cells in vivo. This study was conducted to determine whether IGFBP-2 expression in human RPE cells from the macula and perip...

journal_title：Investigative ophthalmology & visual science

authors： Miyamura N,Mishima K,Honda S,Aotaki-Keen AE,Morse LS,Handa JT,Hjelmeland LM

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:To investigate the characteristics of the mononuclear cell infiltrate in murine experimental autoimmune uveoretinitis (EAU). METHODS:EAU was induced by immunization with bovine interphotoreceptor retinal binding protein (IRBP) in Freund's complete adjuvant (subcutaneous injection) and pertussis toxin (intraper...

journal_title：Investigative ophthalmology & visual science

authors： Jiang HR,Lumsden L,Forrester JV

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:This study was conducted to investigate metabolic changes in aqueous humor from rabbit eyes exposed to either UV-A or -B radiation, by using (1)H nuclear magnetic resonance (NMR) spectroscopy and unsupervised pattern recognition METHODS:methods. Both eyes of adult albino rabbits were irradiated with UV-A (366 ...

journal_title：Investigative ophthalmology & visual science

authors： Tessem MB,Bathen TF,Cejková J,Midelfart A

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:Lenses from selenite-treated animals develop reversible "cold cataract" at a lower temperature than is required for lenses from age-matched control animals. This unexplained, stabilized phase transition is readily observed in intact lenses 36 to 48 hours after treatment and occurs in lenses before the appearanc...

journal_title：Investigative ophthalmology & visual science

authors： Mitton KP,Hess JL,Bunce GE

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:The relative effect of simultaneously administered oxygen and carbon dioxide on the retinal and cerebral vessels is still controversial. The purpose of this study was to quantify and compare the superior-temporal retinal arteriole (RA) and middle cerebral artery (MCA) responses to hypercarbic and combined hyper...

journal_title：Investigative ophthalmology & visual science

authors： Kisilevsky M,Mardimae A,Slessarev M,Han J,Fisher J,Hudson C

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Oxidative stress seems to be an important factor in the development of age-related macular degeneration (AMD). The role of DNA repair mechanisms has also received attention recently in AMD pathogenesis. This case-control study was conducted to determine the frequency of polymorphisms in two DNA repair enzyme ge...

journal_title：Investigative ophthalmology & visual science

authors： Görgün E,Güven M,Unal M,Batar B,Güven GS,Yenerel M,Tatlipinar S,Seven M,Yüksel A

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Neovascularization of the avascular cornea is a significant problem associated with many corneal diseases. Because Fas ligand (FasL) is highly expressed in the cornea, the role of this molecule in controlling corneal neovascularization was examined in this study. METHODS:C57BL/6(B6), FasL (CD95L)-deficient B6-...

journal_title：Investigative ophthalmology & visual science

authors： Stuart PM,Pan F,Plambeck S,Ferguson TA

更新日期：2003-01-01 00:00:00

abstract：:The neutrophilic response in the alkali-injured rabbit cornea can be separated into two peaks: the first from 12-24 hr and the second at 21 days. In the experiments detailed here, alkali-injured rabbit eyes were treated for 0-7 days (early peak), 6-35 days (late peak), or 0-35 days (both peaks) with 6.5% or 10% topica...

journal_title：Investigative ophthalmology & visual science

authors： Haddox JL,Pfister RR,Yuille-Barr D

更新日期：1989-06-01 00:00:00

abstract：PURPOSE:Folic acid is essential for DNA, RNA, and protein synthesis, and deficiencies in folate can lead to nutritional amblyopia and optic neuropathy. The transport of folate from the choroidal blood supply to the retina is only now beginning to be understood. The reduced-folate transporter was reported recently to be...

journal_title：Investigative ophthalmology & visual science

authors： Smith SB,Kekuda R,Gu X,Chancy C,Conway SJ,Ganapathy V

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:By their control of membrane potential and intracellular free Ca(2+) ([Ca(2+)](i)), K(+) currents are pivotal in the regulation of arterial smooth muscle tone. The goal of the present study was to identify and characterize the A-type K(+) current in retinal microvascular smooth muscle (MVSM) and to examine its ...

journal_title：Investigative ophthalmology & visual science

authors： McGahon MK,Dawicki JM,Scholfield CN,McGeown JG,Curtis TM

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To investigate the effect of nerve growth factor (NGF) in combination with docosahexaenoic acid (DHA) on corneal nerve regeneration in a rabbit model after PRK and correlate the findings with functional tear test. METHODS:Unilateral PRK was performed on 21 New Zealand albino rabbits. Three groups, each consist...

journal_title：Investigative ophthalmology & visual science

authors： Esquenazi S,Bazan HE,Bui V,He J,Kim DB,Bazan NG

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To evaluate the potential role that FoxO transcription factors play in modulating resveratrol's protective effects against oxidative stress in lens epithelial cells. METHODS:Primary human or porcine lens epithelial cells (LECs) were treated with resveratrol (RES) 25 μM and incubated under either physiologic (5...

journal_title：Investigative ophthalmology & visual science

authors： Li G,Luna C,Navarro ID,Epstein DL,Huang W,Gonzalez P,Challa P

更新日期：2011-06-21 00:00:00

abstract：PURPOSE:To test the association between TCF4, a gene recently found to confer susceptibility to Fuchs' corneal dystrophy (FCD) in Caucasian populations, and Chinese patients with FCD. METHODS:Fifty-seven Chinese subjects with clinically diagnosed FCD and 121 normal control subjects were recruited. Genomic DNA was extr...

journal_title：Investigative ophthalmology & visual science

authors： Thalamuthu A,Khor CC,Venkataraman D,Koh LW,Tan DT,Aung T,Mehta JS,Vithana EN

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:To examine the behavior of fibroblasts and retinal pigment epithelial cells after attachment to the retinal surface in vitro to elucidate the pathobiology of the early stages of epiretinal membrane formation. METHODS:Human retinal pigment epithelial (HRPE) cells and bovine Tenon's capsule fibroblasts (BTFs) we...

journal_title：Investigative ophthalmology & visual science

authors： Allamby D,Foreman D,Carrington L,McLeod D,Boulton M

更新日期：1997-09-01 00:00:00

abstract：:Failure of corneal grafts is thought to involve the development and activation of specifically sensitized T-cells. One method which might be used to circumvent the development of such cells is the phenomenon of anterior chamber-associated immune deviation (ACAID). Injection of antigen into the anterior chamber of the ...

journal_title：Investigative ophthalmology & visual science

authors： She SC,Steahly LP,Moticka EJ

更新日期：1990-10-01 00:00:00

abstract：:In tear fluid, a large number of proteins can be detected with electrophoretic or immunologic techniques. The composition of serum proteins in tears resembles that of whole serum. By comparison of the protein patterns resulting from different sampling methods, it was shown that serum albumin is not present in the secr...

journal_title：Investigative ophthalmology & visual science

authors： Janssen PT,van Bijsterveld OP

更新日期：1983-05-01 00:00:00

abstract：PURPOSE:Neovascular age-related macular degeneration (AMD) resulting in decreased central vision severely impairs affected individuals. Current standard treatment is an intravitreal anti-VEGF therapy (ranibizumab), but responses to treatment show large variability. Genetic factors that influence AMD and that affect the...

journal_title：Investigative ophthalmology & visual science

authors： Kloeckener-Gruissem B,Barthelmes D,Labs S,Schindler C,Kurz-Levin M,Michels S,Fleischhauer J,Berger W,Sutter F,Menghini M

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:We determined the causes and five-year incidence of blindness and visual impairment (VI) in an adult, urban Chinese population. METHODS:Participants underwent a comprehensive eye examination at baseline in 2003 and then five years later. The World Health Organization (WHO) and United States (US) definitions we...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Huang W,He M,Zheng Y,Huang S,Liu B,Jin L,Congdon NG,He M

更新日期：2013-06-14 00:00:00

abstract：PURPOSE:The fibrotic lens disorder posterior capsule opacification (PCO) develops in millions of patients following cataract surgery. PCO characteristics are extensive extracellular matrix (ECM) production and contraction of the posterior lens capsule, resulting in light-scattering ECM modification (wrinkling). The pro...

journal_title：Investigative ophthalmology & visual science

authors： Eldred JA,Hodgkinson LM,Dawes LJ,Reddan JR,Edwards DR,Wormstone IM

更新日期：2012-06-26 00:00:00

abstract：:Recombinant human interferon alpha subtype D (RIFN alpha D) was effective in reducing the shedding of herpes simplex virus type-1 (HSV-1) induced by 6-hydroxydopamine iontophoresis followed by topical epinephrine application in previously infected rabbit corneas. A treatment schedule of RIFN alpha D, two drops QID was...

journal_title：Investigative ophthalmology & visual science

authors： Mayers M,Matli M,Okumoto M,Samy M,Smolin G

更新日期：1985-02-01 00:00:00

abstract：PURPOSE:Previous studies have demonstrated a role for the retinal pigment epithelium (RPE) in the development and maintenance of the choroidal vasculature, suggesting that RPE serves a trophic role for the choroidal vessels. The goal of this study was to determine the expression pattern of vascular endothelial growth f...

journal_title：Investigative ophthalmology & visual science

authors： Saint-Geniez M,Maldonado AE,D'Amore PA

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:In normal eyes and in diseases such as age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR), retinal pigment epithelial (RPE) cell survival is critically important. Bcl-x(L) has been shown to be among the most highly expressed survival factors in cultured human RPE cells. In the curr...

journal_title：Investigative ophthalmology & visual science

authors： Zhang N,Peairs JJ,Yang P,Tyrrell J,Roberts J,Kole R,Jaffe GJ

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Angiotensin II (AII) has been shown to play a role in many vascular diseases. In the study described, the effect of AII on vascular endothelial growth factor (VEGF) expression and related intracellular signaling mechanism was investigated in bovine retinal microcapillary pericytes. METHODS:Cultured bovine reti...

journal_title：Investigative ophthalmology & visual science

authors： Otani A,Takagi H,Oh H,Suzuma K,Matsumura M,Ikeda E,Honda Y

更新日期：2000-04-01 00:00:00