Binocular coordination of saccades during reading in strabismic children.

abstract：:Dopamine, cis-flupenthixol, and dibutyryl cAMP affected the standing potential and light-evoked responses of the perfused cat eye in vitro. At micromolar concentrations, dopamine, a retinal neurotransmitter, increased the standing potential of the eye. At slightly higher concentrations, dopamine abolished the "light p...

journal_title：Investigative ophthalmology & visual science

authors： Dawis SM,Niemeyer G

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:In the studies of spatial integration an increase in the spatial extent of the stimulus usually results in a decrease in the spatial frequency bandwidth of the stimulus. The authors investigated separately the effects of these two factors on contrast detectability. METHODS:Efficiencies were measured for a circ...

journal_title：Investigative ophthalmology & visual science

authors： Kukkonen H,Näsänen R,Rovamo J

更新日期：1994-06-01 00:00:00

abstract：PURPOSE:Skeletal and craniofacial muscles are frequently composed of multiple neuromuscular compartments that serve different physiological functions. Evidence of possible regional selectivity in LR intramuscular innervation was sought in a study of the anatomic potential of lateral rectus (LR) muscle compartmentalizat...

journal_title：Investigative ophthalmology & visual science

authors： Peng M,Poukens V,da Silva Costa RM,Yoo L,Tychsen L,Demer JL

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To test the hypothesis that overexpression of genes coding for the anti-apoptotic proteins Bcl-2 or Bcl-XL in photoreceptor cells may prevent or delay photoreceptor degenerations. METHODS:Transgenic mice were generated in which the bcl-2 or bcl-XL transgenes were expressed in photoreceptor cells under the tran...

journal_title：Investigative ophthalmology & visual science

authors： Joseph RM,Li T

更新日期：1996-11-01 00:00:00

abstract：PURPOSE:To investigate the effect of hydrogen peroxide on the epithelial cells of cultured rabbit lenses. METHODS:Lenses were cultured in minimum essential medium containing a single dose of 0.03, 0.1, or 0.2 mM H2O2. Three hours later the medium was replaced with peroxide-free minimum essential medium. Lenses were al...

journal_title：Investigative ophthalmology & visual science

authors： Reddan JR,Giblin FJ,Dziedzic DC,Wirebaugh BM,Peters JL

更新日期：1995-02-01 00:00:00

abstract：PURPOSE:The virulence of any given strain of herpes simplex virus (HSV) is probably due to the effects of the constellation of genes in that strain and how they act in concert to promote disease. The goal of this work was to develop a system to identify and study the role of multiple genes in HSV disease. METHODS:Mixe...

journal_title：Investigative ophthalmology & visual science

authors： Brandt CR,Kolb AW,Shah DD,Pumfery AM,Kintner RL,Jaehnig E,Van Gompel JJ

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:Overloading of unfolded or misfolded proteins in the endoplasmic reticulum (ER) can cause ER stress and activate the unfolded protein response (UPR) in the cell. The authors tested whether transgene overexpression in the mouse lens would activate the UPR. METHODS:Transgenic mice expressing proteins that either...

journal_title：Investigative ophthalmology & visual science

authors： Reneker LW,Chen H,Overbeek PA

更新日期：2011-04-04 00:00:00

abstract：PURPOSE:To determine whether the Ganzfeld ERG photopic negative response (PhNR), an assay of inner retinal activity, is altered in childhood optic glioma (OPG). METHODS:Seventeen pediatric patients with a diagnosis of OPG, established on neuro-ophthalmologic and brain/orbit magnetic resonance imaging (MRI) criteria, w...

journal_title：Investigative ophthalmology & visual science

authors： Abed E,Piccardi M,Rizzo D,Chiaretti A,Ambrosio L,Petroni S,Parrilla R,Dickmann A,Riccardi R,Falsini B

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Recovery of photoreceptor cells after light damage is thought to involve the physiologic process of disk renewal. However, only indirect evidence is available to support this hypothesis. The present study sought to examine more directly the mechanisms of photoreceptor cell recovery by quantitatively assessing t...

journal_title：Investigative ophthalmology & visual science

authors： Rapp LM,Fisher PL,Dhindsa HS

更新日期：1994-08-01 00:00:00

abstract：PURPOSE:Retinal ganglion cells die by apoptosis during development and after trauma such as axonal damage and exposure to excitotoxins. Apoptosis is associated with changes in the expression of genes that regulate this process. The genes that regulate apoptosis in retinal ganglion cells have not been characterized prim...

journal_title：Investigative ophthalmology & visual science

authors： Li Y,Schlamp CL,Nickells RW

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:To develop a method to isolate human iris microvascular endothelial cells (HIECs) for exploring their constitutive and inflammatory agent-modulated expression of intercellular adhesion molecules (ICAM)-1 and -2, vascular cell adhesion molecule (VCAM)-1, and E-selectin. METHODS:Endothelial cells from collagenas...

journal_title：Investigative ophthalmology & visual science

authors： Silverman MD,Zamora DO,Pan Y,Texeira PV,Planck SR,Rosenbaum JT

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:To evaluate the effects of 5-fluorouracil (5-FU) on ocular cells in vitro and the effects of degradable 5-FU-loaded poly(DL-lactide-co-glycolide; PDLGA) 50:50 implant in the rabbit eye in vivo. METHODS:Cytotoxicity was assessed with a tetrazolium salt WST-1 cell proliferation/viability test and a lactate dehyd...

journal_title：Investigative ophthalmology & visual science

authors： Huhtala A,Rönkkö S,Teräsvirta M,Puustjärvi T,Sihvola R,Vehanen K,Laukkanen A,Anttila J,Urtti A,Pohjonen T,Uusitalo H

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Tests for ocular Chlamydia trachomatis have not been well characterized, because there is no gold standard test. Latent class analysis (LCA) was performed to estimate the sensitivity and specificity of laboratory and clinical tests for trachoma in the absence of a gold standard. METHODS:Individual data from pr...

journal_title：Investigative ophthalmology & visual science

authors： See CW,Alemayehu W,Melese M,Zhou Z,Porco TC,Shiboski S,Gaynor BD,Eng J,Keenan JD,Lietman TM

更新日期：2011-08-03 00:00:00

abstract：PURPOSE:To determine the size variation of the X-chromosomal human red and green visual pigment gene array in the general population using pulsed field gel electrophoresis and Southern blotting. METHODS:Peripheral blood lymphocytes were prepared from 67 anonymous males. The cells were embedded in agarose and the genom...

journal_title：Investigative ophthalmology & visual science

authors： Macke JP,Nathans J

更新日期：1997-04-01 00:00:00

abstract：:The rates of corneal penetration and efflux of phenylephrine (PE) and its metabolites were found to be limited by the epithelium. The rate constant for corneal penetration as measured in a lucite block perfusion system was 1.06 X 10(-3) hr-1 when the epithelium was present and 1.25 X 10(-2) hr-1 when the epithelium wa...

journal_title：Investigative ophthalmology & visual science

authors： Antoine ME,Edelhauser HF,O'Brien WJ

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The authors conducted a morphology analysis of filtering blebs with anterior segment optical coherence tomography (AS-OCT) in patients shortly after trabeculectomy to find further criteria for success or failure of a filtering bleb. METHODS:Thirty-seven patients (43 eyes) who had recently (<2 years) undergone ...

journal_title：Investigative ophthalmology & visual science

authors： Pfenninger L,Schneider F,Funk J

更新日期：2011-04-14 00:00:00

abstract：PURPOSE:In the Gbeta5(-/-) mouse, the electroretinogram (ERG) b-wave is absent, and the R7 subfamily of regulators of G protein signaling (RGS), which includes RGS6, -7, -9, and -11, is downregulated. Mutant mouse strains deficient in RGS7 or -11 were characterized, and the SG711 strain which is deficient in both prote...

journal_title：Investigative ophthalmology & visual science

authors： Chen FS,Shim H,Morhardt D,Dallman R,Krahn E,McWhinney L,Rao A,Gold SJ,Chen CK

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To investigate the protective effect of pioglitazone on the rat retina after ischemia/reperfusion (I/R) injury and to explore its possible mechanisms. METHODS:Retinal ischemia was induced by increasing the intraocular pressure to 110 mm Hg for 60 minutes, and pioglitazone was delivered 3 hours before the I/R. ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang XY,Xiao YQ,Zhang Y,Ye W

更新日期：2013-06-06 00:00:00

abstract：:Although intravitreal injection of antibiotics is being used more widely in treatment of bacterial endophthalmitis, the pharmacokinetic principles that underlie such therapy have been derived exclusively from experiments in the rabbit. Therefore, we studied several representative antibiotics in normal eyes of rhesus m...

journal_title：Investigative ophthalmology & visual science

authors： Barza M,Kane A,Baum J

更新日期：1983-12-01 00:00:00

abstract：PURPOSE:Changes in blood vessel barrier properties contribute to retinal edema in diabetic retinopathy (DR). However, limited data are available to describe the routes of transport for fluids and solutes across the inner blood-retinal barrier (iBRB). In this study, a three-pore model was developed to characterize such ...

journal_title：Investigative ophthalmology & visual science

authors： Lopez-Quintero SV,Ji XY,Antonetti DA,Tarbell JM

更新日期：2011-02-28 00:00:00

abstract：PURPOSE:To determine the effects of silicone hydrogel lens wear and lens-solution interactions on ocular surface sensitivity. METHODS:Forty-eight adapted lens wearers completed the study, which comprised two phases. Phase 1 included habitual lens wear, no lens wear (7 ± 3 days), and balafilcon A lenses (PV; PureVision...

journal_title：Investigative ophthalmology & visual science

authors： Situ P,Simpson TL,Jones LW,Fonn D

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To unravel the molecular genetic background in families with congenital cataract in association with microcornea (CCMC, OMIM 116150). METHODS:CCMC families were recruited from a national database on hereditary eye diseases; DNA was procured from a national gene bank on hereditary eye diseases and by blood samp...

journal_title：Investigative ophthalmology & visual science

authors： Hansen L,Yao W,Eiberg H,Kjaer KW,Baggesen K,Hejtmancik JF,Rosenberg T

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To analyze whether insulin receptor substrate (IRS-1) is involved in lymphatic vessel development and whether IRS-1 blockade can inhibit lymphangiogenesis in vivo. METHODS:The impact of IRS-1 blockade by GS-101 (Aganirsen), an antisense oligonucleotide against IRS-1, on lymphatic endothelial cell (LEC) prolife...

journal_title：Investigative ophthalmology & visual science

authors： Hos D,Regenfuss B,Bock F,Onderka J,Cursiefen C

更新日期：2011-07-29 00:00:00

abstract：:Recently protease inhibitors were used to treat corneal ulceration and persistent epithelial defect. An organ culture system was used in this study to examine the effect of four protease inhibitors on rat corneal epithelial migration and on incorporation of 3H-leucine into trichloroacetic acid-precipitable material as...

journal_title：Investigative ophthalmology & visual science

authors： Zieske JD,Bukusoglu G

更新日期：1991-06-01 00:00:00

abstract：:This paper investigates the amplitude of accommodation of early onset myopes, late onset myopes, emmetropes, and hyperopes. Eighty subjects were used, 41 women and 39 men, with an age range of 18-22 yr (mean = 19.82). All subjects wore an optimum refractive correction, giving visual acuities of 20/20 or better. Signif...

journal_title：Investigative ophthalmology & visual science

authors： McBrien NA,Millodot M

更新日期：1986-07-01 00:00:00

abstract：Purpose:Aging is a risk factor for dry eye disease. The aim of this study was to investigate if aging is associated with a range of signs of dry eye disease, including tear hyperosmolarity, reduced nerve density, and increased dendritic cell number, in mice. Method:Healthy C57BL/6 female mice, aged 2 months (young, n ...

journal_title：Investigative ophthalmology & visual science

authors： De Silva MEH,Hill LJ,Downie LE,Chinnery HR

更新日期：2019-06-03 00:00:00

abstract：:We describe an instrument called a scanning ocular spectrofluorophotometer (SOSF) that measures fluorescence in a two-dimensional cross-section through the anterior chamber and cornea and provides the ability to change excitation and emission wavelengths rapidly. The output of a xenon arc lamp is filtered by a diffrac...

journal_title：Investigative ophthalmology & visual science

authors： McLaren JW,Brubaker RF

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:Extremely low gestational age neonates (ELGANs) requiring oxygen therapy often experience frequent episodes of intermittent hypoxia (IH) and are at high risk for severe retinopathy of prematurity (ROP). Using an established model for oxygen-induced retinopathy (OIR), we examined the hypothesis that there is a c...

journal_title：Investigative ophthalmology & visual science

authors： Beharry KD,Cai CL,Sharma P,Bronshtein V,Valencia GB,Lazzaro DR,Aranda JV

更新日期：2013-11-19 00:00:00

abstract：PURPOSE:To identify the mutation leading to syndromic choroideremia (CHM) in two families and to define fundus autofluorescence (FAF) in CHM carriers. METHODS:The ophthalmic and clinical phenotype was investigated including FAF, neuropediatric, otorhinolaryngologic, cardiologic, and nephrologic examinations of three m...

journal_title：Investigative ophthalmology & visual science

authors： Poloschek CM,Kloeckener-Gruissem B,Hansen LL,Bach M,Berger W

更新日期：2008-09-01 00:00:00

abstract：:The color matches of 46 retinitis pigmentosa (RP) patients were found to differ significantly from those of 55 unaffected observers. The color matches of group I (trichromatic) RP observers were more protanomalous (i.e., required a greater red/green mixture ratio) than those of unaffected observers. The matches of gro...

journal_title：Investigative ophthalmology & visual science

authors： Young RS,Fishman GA

更新日期：1980-08-01 00:00:00