Pharmacokinetics of topical ocular phenylephrine HCl.

abstract：PURPOSE:To compare psychophysical Naka-Rushton parameters in retinitis pigmentosa (RP) patients and healthy controls using a flash-on-flash increment threshold paradigm, and to measure changes of these parameters with RP progression. METHODS:Sixty-six RP patients and 10 normal subjects were tested, and their maximum r...

journal_title：Investigative ophthalmology & visual science

authors： Dagnelie G,Massof RW

更新日期：1993-01-01 00:00:00

abstract：Purpose:To investigate the roles and pathways of microRNAs 143 and 145 in transforming growth factor (TGF)-β1-induced human subconjunctival fibrosis. Methods:Human tenon's capsule fibroblasts (HTFs) were obtained from a healthy eye. After treating cultured HTFs with TGF-β1, the expression of microRNAs 143 and 145 was ...

journal_title：Investigative ophthalmology & visual science

authors： Hwang YH,Jung SA,Lyu J,Kim YY,Lee JH

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To evaluate the glaucoma progression in patients with a history of refractive corneal surgery (RCS). METHODS:A total of 313 eyes of 313 glaucoma patients (RCS group, 34 eyes; non-RCS group, 279 eyes) with a mean follow-up period of 2.7 years were included. Glaucoma progression was determined either by experts'...

journal_title：Investigative ophthalmology & visual science

authors： Kim YJ,Yun SC,Na JH,Tchah HW,Jung JJ,Sung KR

更新日期：2012-07-03 00:00:00

abstract：PURPOSE:Glaucoma is an optic neuropathy commonly associated with elevated intraocular pressure (IOP), leading to optic nerve head (ONH) cupping, axon loss, and apoptosis of retinal ganglion cells (RGCs), which could ultimately result in blindness. Brn3b is a class-4 POU domain transcription factor that plays a key role...

journal_title：Investigative ophthalmology & visual science

authors： Stankowska DL,Minton AZ,Rutledge MA,Mueller BH 2nd,Phatak NR,He S,Ma HY,Forster MJ,Yorio T,Krishnamoorthy RR

更新日期：2015-01-13 00:00:00

abstract：:Linear nonperforating incisions were made in the corneas of 2-week-old and 2-year-old rabbits. The resulting wounds were examined by light microscopy and transmission and scanning electron microscopy. A corneal incision of a 2-week-old rabbit produced a wide gaping wound caused by retraction of the cut stromal lamella...

journal_title：Investigative ophthalmology & visual science

authors： Lee RE,Davison PF,Cintron C

更新日期：1982-11-01 00:00:00

abstract：PURPOSE:Endotoxin-induced uveitis (EIU) is a model that mimics human acute anterior uveitis. Cyclooxygenase (COX)-2 is an enzyme that initiates the conversion of arachidonic acid (AA) into prostaglandins (PGs), whereas 5-lipoxygenase (5-LO) generates leukotrienes (LT). The purpose of this study was to delineate the rol...

journal_title：Investigative ophthalmology & visual science

authors： Tuo J,Tuaillon N,Shen D,Chan CC

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:To determine the disease course of retinal dystrophy caused by recessive variants in the DRAM2 (damage-regulated autophagy modulator 2) gene. METHODS:Sixteen individuals with DRAM2-retinopathy were examined (six families; age range, 19-56 years, includes one pre-symptomatic case). The change in visual acuity o...

journal_title：Investigative ophthalmology & visual science

authors： Sergouniotis PI,McKibbin M,Robson AG,Bolz HJ,De Baere E,Müller PL,Heller R,El-Asrag ME,Van Schil K,Plagnol V,Toomes C,Uk Inherited Retinal Disease Consortium.,Ali M,Holder GE,Charbel Issa P,Leroy BP,Inglehearn CF,Webste

更新日期：2015-12-01 00:00:00

abstract：:Liposomes 0.5 to 5 micron in diameter and of various phospholipid compositions were used as a simplified model of rod outer segment membranes to examine the phagocytic mechanism of cultured explants of retinal dystrophic Royal College of Surgeons (RCS) and normal Long-Evans (LE) rat pigment epithelium. RCS pigment epi...

journal_title：Investigative ophthalmology & visual science

authors： Effron JT,Szamier RB,Edwards RB

更新日期：1981-10-01 00:00:00

abstract：PURPOSE:Age-related cataract (ARC) is one of the most common causes of severe visual impairment among the elderly worldwide with four subtypes, such as cortical, nuclear, subcapsular, and mixed types. DNA damage and malfunction of DNA repair are believed to contribute to the pathogenesis of ARC. This study examined the...

journal_title：Investigative ophthalmology & visual science

authors： Su S,Yao Y,Zhu R,Liang C,Jiang S,Hu N,Zhou J,Yang M,Xing Q,Guan H

更新日期：2013-02-01 00:00:00

abstract：:This study was undertaken to observe the effect on the differential light sensitivity in glaucoma suspects produced by a long-term reduction in intraocular pressure (IOP) with timolol maleate. The results are taken from an ongoing 6 year follow-up study of glaucoma suspects randomly selected for treatment and nontreat...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Drance SM,Douglas GR

更新日期：1988-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the changes in tumor burden and hypoxia in the LH(BETA)T(AG) retinal tumors after treatment with a focal, single-modality, and combination therapy using periocular carboplatin and 2-deoxy-d-glucose (2-DG). METHODS:Seventeen-week-old LH(BETA)T(AG) transgenic mice (n = 25) w...

journal_title：Investigative ophthalmology & visual science

authors： Piña Y,Houston SK,Murray TG,Boutrid H,Celdran M,Feuer W,Shi W,Hernandez E,Lampidis TJ

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:China has among the lowest cataract surgical rates in Asia. This study was conducted to identify barriers to cataract surgery in rural China. METHODS:All subjects having undergone cataract surgery and persons with presenting visual acuity or=1 eye due to nons...

journal_title：Investigative ophthalmology & visual science

authors： Yin Q,Hu A,Liang Y,Zhang J,He M,Lam DS,Ge J,Wang N,Friedman DS,Zhao J,Congdon N

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:We assessed the association between complement pathway genes and age-related macular degeneration (AMD) in a Chinese population. METHODS:In a case-control study, 165 AMD patients and 216 unrelated controls were recruited from two hospitals in central China. We selected and genotyped six single nucleotide poly...

journal_title：Investigative ophthalmology & visual science

authors： Wu L,Tao Q,Chen W,Wang Z,Song Y,Sheng S,Li P,Zhou J

更新日期：2013-01-07 00:00:00

abstract：PURPOSE:To assess the effect of cataract on the evaluation of macular pigment optical density (MPOD) in aged patients. METHODS:MPOD was prospectively measured using autofluorescence spectrometry before and after cataract surgery. The Lens Opacities Classification System III was used to grade the cataracts at baseline....

journal_title：Investigative ophthalmology & visual science

authors： Sasamoto Y,Gomi F,Sawa M,Sakaguchi H,Tsujikawa M,Nishida K

更新日期：2011-02-16 00:00:00

abstract：PURPOSE:Amblyopia is the commonest visual disorder of childhood. Yet the contributions of the two principal treatments (spectacle wear and occlusion) to outcome are unknown. This study was undertaken to investigate the dose-response relationship of amblyopia therapy. METHODS:The study comprised three distinct phases: ...

journal_title：Investigative ophthalmology & visual science

authors： Stewart CE,Moseley MJ,Stephens DA,Fielder AR

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:To identify pathogenic mutations in the guanylate cyclase-activating protein 1 (GCAP1) and GCAP2 genes and to characterize the biochemical effect of mutation on guanylate cyclase (GC) stimulation. METHODS:The GCAP1 and GCAP2 genes were screened by direct sequencing for mutations in 216 patients and 421 patient...

journal_title：Investigative ophthalmology & visual science

authors： Nishiguchi KM,Sokal I,Yang L,Roychowdhury N,Palczewski K,Berson EL,Dryja TP,Baehr W

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To determine whether integrin-linked kinase (ILK) controls the organization of the actin cytoskeleton in the trabecular meshwork (TM) by regulating integrin co-signaling. METHODS:The cell binding domain and the Heparin II (Hep II) domain of fibronectin were used to activate α5β1 and α4β1 integrin signaling, re...

journal_title：Investigative ophthalmology & visual science

authors： Faralli JA,Newman JR,Sheibani N,Dedhar S,Peters DM

更新日期：2011-03-25 00:00:00

abstract：PURPOSE:To investigate the capacity for rapid saccade adaptation in Williams-Beuren Syndrome (WBS), a genetic neurodevelopmental disorder, in which it has been observed that saccadic accuracy is severely reduced. METHODS:Saccade amplitude modification was elicited by backward steps (30% of target eccentricity) during ...

journal_title：Investigative ophthalmology & visual science

authors： van der Geest JN,Haselen GC,Frens MA

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:Subretinal fibrosis causes damage to visual acuity, especially if the lesion is in the macula, as is frequently observed in advanced age-related macular degeneration. Exudate leukocytes form abnormal vessels that initiate regional inflammation accompanied with local glial proliferation and matrix production. Th...

journal_title：Investigative ophthalmology & visual science

authors： Jo YJ,Sonoda KH,Oshima Y,Takeda A,Kohno R,Yamada J,Hamuro J,Yang Y,Notomi S,Hisatomi T,Ishibashi T

更新日期：2011-08-01 00:00:00

abstract：Purpose:To investigate the optimal procedures for multichannel visually evoked potentials (VEPs) to detect misrouting in albinism subjects. Methods:Investigations were done in a phenotypically heterogeneous group of 180 albinism subjects and 187 controls with and without ocular pathology. We retrospectively compared s...

journal_title：Investigative ophthalmology & visual science

authors： Kruijt CC,de Wit GC,Talsma HE,Schalij-Delfos NE,van Genderen MM

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:To evaluate a fully automated local fractal dimension method to quantify vessel density and foveal avascular zone (FAZ) area in optical coherence tomography angiography (OCTA) images. METHODS:Fifty-two healthy Asian Indian eyes underwent imaging prospectively with OCTA system. Superficial and deep retinal vasc...

journal_title：Investigative ophthalmology & visual science

authors： Gadde SG,Anegondi N,Bhanushali D,Chidambara L,Yadav NK,Khurana A,Sinha Roy A

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Patients with typical clinical features of retinitis pigmentosa were found to have the atypical electroretinographic finding of a negative waveform to a bright flash in the dark-adapted state. The full-field electroretinogram (ERG) was studied in seven such patients to understand better the pathophysiology. ME...

journal_title：Investigative ophthalmology & visual science

authors： Cideciyan AV,Jacobson SG

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:High concentrations of unconjugated bilirubin are neurotoxic and cause brain damage in newborn infants. However, the exact level of bilirubin that may be neurotoxic in a given infant is unknown. The aim of this study was to use a quantitative measure of neural activity, the swept parameter visual evoked potenti...

journal_title：Investigative ophthalmology & visual science

authors： Hou C,Norcia AM,Madan A,Good WV

更新日期：2014-09-02 00:00:00

abstract：:Recently protease inhibitors were used to treat corneal ulceration and persistent epithelial defect. An organ culture system was used in this study to examine the effect of four protease inhibitors on rat corneal epithelial migration and on incorporation of 3H-leucine into trichloroacetic acid-precipitable material as...

journal_title：Investigative ophthalmology & visual science

authors： Zieske JD,Bukusoglu G

更新日期：1991-06-01 00:00:00

abstract：PURPOSE:Our previous work indicated that a larger circumferential Young's modulus (E) of trabecular meshwork (TM) correlated with a higher outflow facility (C) in normal human donor eyes. The current study investigated the influence of glaucomatous TM stiffness and cellularity on C. METHODS:Eight left eyes from glauco...

journal_title：Investigative ophthalmology & visual science

authors： Camras LJ,Stamer WD,Epstein D,Gonzalez P,Yuan F

更新日期：2014-02-10 00:00:00

abstract：PURPOSE:Recent studies have shown that a decrease of regulatory T (Treg) cells may contribute to the activity of acute anterior uveitis (AAU) and ankylosing spondylitis (AS). A number of immunogenetic factors including IL2RA, miR-27a, miR-182, and FoxO1 are associated with Treg cell function. In this study, we investig...

journal_title：Investigative ophthalmology & visual science

authors： Yu H,Liu Y,Zhang L,Wu L,Zheng M,Cheng L,Luo L,Kijlstra A,Yang P

更新日期：2014-11-20 00:00:00

abstract：PURPOSE:To analyze the roles of vitreal macrophages and circulating leukocytes in retinal vascular growth. METHODS:Bone marrow (BM) cells from green fluorescent protein (GFP) transgenic mice were transplanted into postnatal day (P)1 mice after irradiation. The mice were exposed to 76% to 78% oxygen (P7-P12), to initia...

journal_title：Investigative ophthalmology & visual science

authors： Kataoka K,Nishiguchi KM,Kaneko H,van Rooijen N,Kachi S,Terasaki H

更新日期：2011-03-14 00:00:00

abstract：PURPOSE:Corneal crystallins are lost from resident cells of the corneal stroma during wound repair, and this is associated with a loss of cell transparency. The goal of this study was to identify factors inducing loss of the corneal crystallin transketolase (TKT). METHODS:A cell culture model of freshly isolated rabbi...

journal_title：Investigative ophthalmology & visual science

authors： Stramer BM,Fini ME

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:Angioscotomas are scotomata caused by vessel shadows. Their extent may be influenced by physiological and pharmacologic conditions and disease. In this study, the authors quantified angioscotomas in normal subjects using a fundus perimetry technique with a scanning laser ophthalmoscope. They further investigate...

journal_title：Investigative ophthalmology & visual science

authors： Remky A,Beausencourt E,Elsner AE

更新日期：1996-10-01 00:00:00

abstract：Purpose:Mutations in CACNA2D4, encoding the α2δ4 subunit of retinal voltage-gated calcium channels (Cav), cause a rare type of retinal dysfunction in human, mainly affecting cone vision. Here, we investigate the role of CACNA2D4 in targeting of Cav, its influence on cone-mediated signal transmission, and the cellular a...

journal_title：Investigative ophthalmology & visual science

authors： Schlegel DK,Glasauer SMK,Mateos JM,Barmettler G,Ziegler U,Neuhauss SCF

更新日期：2019-12-02 00:00:00