Secreted Mucins on the Ocular Surface.

abstract：Purpose:To compare in vivo lamina cribrosa (LC) strains (deformations) following acute IOP elevation in healthy, glaucoma, and ocular hypertensive subjects. Methods:There were 20 healthy, 20 high-tension primary open-angle glaucoma (POAG), 16 primary angle-closure glaucoma (PACG), and 20 ocular hypertensive (OHT; with...

journal_title：Investigative ophthalmology & visual science

authors： Beotra MR,Wang X,Tun TA,Zhang L,Baskaran M,Aung T,Strouthidis NG,Girard MJA

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:This study was conducted to investigate metabolic changes in aqueous humor from rabbit eyes exposed to either UV-A or -B radiation, by using (1)H nuclear magnetic resonance (NMR) spectroscopy and unsupervised pattern recognition METHODS:methods. Both eyes of adult albino rabbits were irradiated with UV-A (366 ...

journal_title：Investigative ophthalmology & visual science

authors： Tessem MB,Bathen TF,Cejková J,Midelfart A

更新日期：2005-03-01 00:00:00

abstract：:To determine whether glaucoma selectively injures a particular size of optic nerve fiber (and its cell body), we induced chronic experimental glaucoma in one eye each of ten monkeys. With automated image analysis, the number and diameter of optic nerve fibers were compared between each glaucomatous eye and its normal ...

journal_title：Investigative ophthalmology & visual science

authors： Quigley HA,Sanchez RM,Dunkelberger GR,L'Hernault NL,Baginski TA

更新日期：1987-06-01 00:00:00

abstract：PURPOSE:Elevated levels of extracellular glutamate have been implicated in the pathophysiology of neuronal loss in both central nervous system and ophthalmic disorders, including glaucoma. This increase in glutamate may result from a failure of glutamate transporters, which are molecules that ordinarily regulate extrac...

journal_title：Investigative ophthalmology & visual science

authors： Naskar R,Vorwerk CK,Dreyer EB

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:To test the effect of valacyclovir alone and with aspirin on the asymptomatic shedding of HSV-1 DNA in tears and saliva of healthy individuals. METHOD. The subjects (n = 45) were randomized into three groups without regard to age, sex, or race. Group 1 (n = 14) received the placebo, group 2 (n = 15) received a ...

journal_title：Investigative ophthalmology & visual science

authors： Kumar M,Hill JM,Clement C,Varnell ED,Thompson HW,Kaufman HE

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Glaucoma is a distinct neuropathy characterized by the chronic and progressive death of retinal ganglion cells (RGCs). The etiology of RGC death remains unknown. Risk factors for glaucomatous RGC death are elevated intraocular pressure and glial production of tumor necrosis factor-alpha (TNF-α). Previously, the...

journal_title：Investigative ophthalmology & visual science

authors： Bai Y,Shi Z,Zhuo Y,Liu J,Malakhov A,Ko E,Burgess K,Schaefer H,Esteban PF,Tessarollo L,Saragovi HU

更新日期：2010-12-01 00:00:00

abstract：Purpose:Although retinal dopamine (DA) has been long implicated in myopia development, current studies demonstrate that retinal DA levels are unaltered in C57BL/6 mice with form-deprivation myopia. This work was undertaken to explore whether and how refractive development is perturbed in this mouse strain when retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Wu XH,Qian KW,Xu GZ,Li YY,Ma YY,Huang F,Wang YQ,Zhou X,Qu J,Yang XL,Zhong YM,Weng SJ

更新日期：2016-10-01 00:00:00

abstract：Purpose:To evaluate the contribution of fixational saccades toward fixation instability in strabismic monkeys. Methods:Binocular eye movements were measured as six experimental monkeys (five strabismic monkeys and one monkey with downbeat nystagmus) and one normal monkey fixated targets of two shapes (Optotype, Disk) ...

journal_title：Investigative ophthalmology & visual science

authors： Upadhyaya S,Pullela M,Ramachandran S,Adade S,Joshi AC,Das VE

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:To demonstrate the presence of corneal stromal precursors that express neural markers in vitro. METHODS:To isolate sphere-forming cells, human corneal stromal cells were subjected to a reaggregation-free neurosphere assay in medium containing methylcellulose gel matrix. To promote differentiation, the isolated...

journal_title：Investigative ophthalmology & visual science

authors： Uchida S,Yokoo S,Yanagi Y,Usui T,Yokota C,Mimura T,Araie M,Yamagami S,Amano S

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To determine whether tonometric readings of increases in intraocular pressure (IOP) during the water-drinking test (WDT) are affected by variations in central corneal thickness (CCT) induced by photorefractive keratectomy (PRK). METHODS:Data from 30 randomly selected eyes of 30 patients (18 men and 12 women; m...

journal_title：Investigative ophthalmology & visual science

authors： Tamburrelli C,Giudiceandrea A,Vaiano AS,Caputo CG,Gullà F,Salgarello T

更新日期：2005-09-01 00:00:00

abstract：:Although the lens has been shown to have the capacity to respond to insulin in vitro, little is known concerning the biochemical relationships of insulin to the lens in vivo. Therefore we have measured insulin in the aqueous humor of rabbits by a sensitive radioimmunoassay after paracentesis and feeding. The insulin c...

journal_title：Investigative ophthalmology & visual science

authors： Coulter JB 3rd,Engelke JA,Eaton DK

更新日期：1980-12-01 00:00:00

abstract：:The glycosaminoglycans (GAGs) extractable from the trabecular meshworks (TM) of human and non-human primate eye have been analyzed by sequential enzymatic degradation and cellulose acetate electrophoresis. For comparison, similar extracts of the cornea, sclera, iris, and ciliary body have also been analyzed. The distr...

journal_title：Investigative ophthalmology & visual science

authors： Acott TS,Westcott M,Passo MS,Van Buskirk EM

更新日期：1985-10-01 00:00:00

abstract：PURPOSE:To evaluate the kinetics, receptor specificity, molecular basis, and site selectivity of the endocrine and neural regulation of secretory component (SC) synthesis by rat lacrimal gland acinar cells. METHODS:Acinar cells from the rat lacrimal and submandibular glands, as well as epithelial cells (IEC-6) from th...

journal_title：Investigative ophthalmology & visual science

authors： Lambert RW,Kelleher RS,Wickham LA,Vaerman JP,Sullivan DA

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:To evaluate the performance of an automated retinal image quality assessment system for use in automated diabetic retinopathy grading. METHODS:Algorithmic methods have been developed for assessing the quality of 45 degrees single field retinal images for use in diabetic retinopathy screening. For this purpose,...

journal_title：Investigative ophthalmology & visual science

authors： Fleming AD,Philip S,Goatman KA,Olson JA,Sharp PF

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:As the number of cases of Acanthamoeba spp. keratitis (AK) is constantly growing, new diagnostic tools are needed to confirm and guide ophthalmologists in this clinically problematic diagnosis. Molecular diagnosis is particularly well adapted, although only a few real-time PCR techniques have been described rec...

journal_title：Investigative ophthalmology & visual science

authors： Maubon D,Dubosson M,Chiquet C,Yera H,Brenier-Pinchart MP,Cornet M,Savy O,Renard E,Pelloux H

更新日期：2012-05-14 00:00:00

abstract：PURPOSE:Recent studies have suggested the involvement of nerve growth factor (NGF) in the conjunctival inflammatory process and in corneal epithelium proliferation and differentiation. To verify the hypothesis that NGF could locally modulate the inflammatory and reparative processes, the authors evaluated the expressio...

journal_title：Investigative ophthalmology & visual science

authors： Lambiase A,Bonini S,Micera A,Rama P,Bonini S,Aloe L

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:To evaluate the efficiency of mitomycin C (MMC) in limiting the postoperative inflammatory response and scarring after strabismus surgery. METHODS:A prospective, two-stage, masked, controlled trial was conducted. In the first stage, the inflammatory response at the extraocular muscle reattachment site was incr...

journal_title：Investigative ophthalmology & visual science

authors： Minguini N,Monteiro de Carvalho KM,Akaishi PM,De Luca IM

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of coulomb-controlled iontophoresis (CCI) for delivery of riboflavin prior to corneal collagen cross-linking (CXL). METHODS:The eyes of 20 8-week-old Lewis rats, subject to epithelium-ON (epi-ON, n = 20 eyes) or epithelium-OFF (epi-OFF, n = 20 eyes) conditions, were used to evaluate th...

journal_title：Investigative ophthalmology & visual science

authors： Arboleda A,Kowalczuk L,Savoldelli M,Klein C,Ladraa S,Naud MC,Aguilar MC,Parel JM,Behar-Cohen F

更新日期：2014-04-28 00:00:00

abstract：PURPOSE:The secreted Ly6/uPAR-related protein-1 (Slurp1), associated with the hyperkeratotic disorder mal de Meleda, is abundantly expressed in corneas. Here, we examine its corneal expression and functions. METHODS:Gene expression was quantified by quantitative PCR (qPCR), immunoblots, and immunofluorescent staining....

journal_title：Investigative ophthalmology & visual science

authors： Swamynathan S,Buela KA,Kinchington P,Lathrop KL,Misawa H,Hendricks RL,Swamynathan SK

更新日期：2012-12-19 00:00:00

abstract：PURPOSE:To measure changes in nuclear gene expression resulting from mitochondrial dysfunction in retinal pigment epithelial cells. METHODS:ARPE-19 retinal pigment epithelial cells were depleted of their mitochondrial (mt)DNA by passaging in a low concentration of ethidium bromide. Loss of mitochondrial DNA was determ...

journal_title：Investigative ophthalmology & visual science

authors： Miceli MV,Jazwinski SM

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To examine the accommodative accuracy and amplitude in children with Down syndrome. Accommodation is usually assumed to be good in children and is rarely measured. METHODS:A dynamic retinoscopy technique was developed that allows rapid and reliable measures of accuracy and amplitude of accommodation in infants...

journal_title：Investigative ophthalmology & visual science

authors： Woodhouse JM,Meades JS,Leat SJ,Saunders KJ

更新日期：1993-06-01 00:00:00

abstract：Purpose:Although normal function of the lacrimal gland is essential for vision (and thus for human well-being), the lacrimal gland remains rather poorly understood at a molecular level. The purpose of this study was to identify new genes and signaling cascades involved in lacrimal gland development. Methods:To identif...

journal_title：Investigative ophthalmology & visual science

authors： Dvoriantchikova G,Tao W,Pappas S,Gaidosh G,Tse DT,Ivanov D,Pelaez D

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To evaluate the refractive status and optical components in school age children born prematurely and to examine the risk factors associated with refractive errors. METHODS:The participants were a cohort of children aged 7 to 9 years with gestational age less than 35 weeks or birth weight less than 1500 g. The ...

journal_title：Investigative ophthalmology & visual science

authors： Chen TC,Tsai TH,Shih YF,Yeh PT,Yang CH,Hu FC,Lin LL,Yang CM

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Currently, the test for useful field of view (UFOV) typically relies on subjective feedback for detecting peripheral targets while attending to a central target. Steady-state visual evoked potential (SSVEP) recorded from the occipital region of the brain has been frequently used as an objective alternative to r...

journal_title：Investigative ophthalmology & visual science

authors： Lin ST,Tey LK

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:The goal was to establish an accurate method for measuring intraocular pressure (IOP) in living adult zebrafish and to determine the average IOPs of genetically different strains and mutants. The overall purpose was to develop the zebrafish system for studies of IOP and glaucoma. Elevated IOP and anterior segme...

journal_title：Investigative ophthalmology & visual science

authors： Link BA,Gray MP,Smith RS,John SW

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:This was a pilot study conducted to examine the expression of osteopontin in uveal melanoma and to determine whether serum osteopontin can be used in detecting metastatic uveal melanoma. METHODS:Osteopontin mRNA was measured in three uveal melanoma cell lines of various invasive potential by real-time PCR. Tis...

journal_title：Investigative ophthalmology & visual science

authors： Kadkol SS,Lin AY,Barak V,Kalickman I,Leach L,Valyi-Nagy K,Majumdar D,Setty S,Maniotis AJ,Folberg R,Pe'er J

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:To determine the involvement of rat kallikrein-binding protein (RKBP) in the development of diabetic retinopathy. METHODS:Diabetes was induced by streptozotocin (STZ) (55 mg/kg body weight in 0.05 M citrate buffer, pH 4.5) in male Sprague-Dawley rats (150 to 175 g, 6 weeks old) as confirmed by hyperglycemia an...

journal_title：Investigative ophthalmology & visual science

authors： Hatcher HC,Ma JX,Chao J,Chao L,Ottlecz A

更新日期：1997-03-01 00:00:00

abstract：Purpose:Rose bengal (RB)-photosensitized protein crosslinking has been proposed for several applications in the eye. This study identifies oxygen-dependent and oxygen-independent mechanistic pathways in cornea for RB-photosensitized crosslinking to enhance its efficiency for ocular treatments. Methods:Rabbit corneas e...

journal_title：Investigative ophthalmology & visual science

authors： Wertheimer CM,Elhardt C,Kaminsky SM,Pham L,Pei Q,Mendes B,Afshar S,Kochevar IE

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To document the cyclovertical ocular motor mechanism used for vertical fusion in healthy subjects, and to explore whether vertical vergence training in healthy individuals can produce objectively confirmed vertical deviations that change with head tilt, revealing a basic mechanism that can produce a pattern of ...

journal_title：Investigative ophthalmology & visual science

authors： Irsch K,Guyton DL,Ramey NA,Adyanthaya RS,Ying HS

更新日期：2013-05-03 00:00:00

abstract：Purpose:To investigate factors associated with visual field (VF) progression in treated myopic normal-tension glaucoma (NTG) using a novel posterior sclera reconstruction method involving swept-source optical coherence tomography (OCT). Methods:Fifty-six myopic patients on ocular hypotensive therapy with the diagnose ...

journal_title：Investigative ophthalmology & visual science

authors： Kim YC,Koo YH,Jung KI,Park CK

更新日期：2019-05-01 00:00:00