Influence of thyroid hormone on thyroid hormone receptor beta-1 expression and lacrimal gland and ocular surface morphology.

abstract：:To investigate the accumulation of tear proteins on disposable extended-wear contact lenses (42% Etafilcon A and 58% hydration), a technique involving sodium dodecyl sulfate-polyacrylamide minigel electrophoresis combined with a sensitive silver-staining method was used. Besides the binding of large amounts of tear ly...

journal_title：Investigative ophthalmology & visual science

authors： Cheng KH,Kok JH,van Mil C,Kijlstra A

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:This retrospective observational study was designed to evaluate the frequency of, and the factors associated with, optic disc swelling in Vogt-Koyanagi-Harada disease (VKH). METHODS:A retrospective observational study was conducted. We analyzed 116 eyes of 58 patients with VKH. Demographic and clinical differe...

journal_title：Investigative ophthalmology & visual science

authors： Nakao K,Abematsu N,Mizushima Y,Sakamoto T

更新日期：2012-04-18 00:00:00

abstract：PURPOSE:Angioscotomas are scotomata caused by vessel shadows. Their extent may be influenced by physiological and pharmacologic conditions and disease. In this study, the authors quantified angioscotomas in normal subjects using a fundus perimetry technique with a scanning laser ophthalmoscope. They further investigate...

journal_title：Investigative ophthalmology & visual science

authors： Remky A,Beausencourt E,Elsner AE

更新日期：1996-10-01 00:00:00

abstract：PURPOSE:To determine the effect of taxol and etoposide, hydrophobic drugs with antifibrosis activity, on the outcome of filtration surgery in glaucomatous monkeys. METHODS:Elevated intraocular pressure was produced bilaterally in eight cynomolgus monkeys by laser treatment of the trabecular meshwork. Four animals subc...

journal_title：Investigative ophthalmology & visual science

authors： Jampel HD,Thibault D,Leong KW,Uppal P,Quigley HA

更新日期：1993-10-01 00:00:00

abstract：PURPOSE:We compared the anti-fibrotic effects of single versus multiple postoperative injections of saratin following glaucoma filtration surgery (GFS) in the rabbit model. METHODS:The experiment was in two parts. To determine the optimal frequency for postoperative therapy, seven New Zealand White (NZW) rabbits recei...

journal_title：Investigative ophthalmology & visual science

authors： Min J,Lukowski ZL,Levine MA,Meyers CA,Beattie AR,Schultz GS,Samuelson DA,Sherwood MB

更新日期：2012-11-19 00:00:00

abstract：PURPOSE:Reading a text requires vergence angle adjustments, so that the images in the two eyes fall on corresponding retinal areas. Vergence adjustments bring the two retinal images into Panum's fusional area and therefore, small remaining errors or regulations do not lead to double vision. The present study evaluated ...

journal_title：Investigative ophthalmology & visual science

authors： Jainta S,Dehnert A,Heinrich SP,Jaschinski W

更新日期：2011-12-09 00:00:00

abstract：:We tested the state of retinal correspondence at different positions in the visual field of ten observers with strabismic and/or anisometropic amblyopia, four strabismic subjects with alternating fixation and three normal controls. Correspondence was evaluated by the subjective displacement of dichoptic stimuli; to es...

journal_title：Investigative ophthalmology & visual science

authors： Sireteanu R,Fronius M

更新日期：1989-09-01 00:00:00

abstract：PURPOSE:To further characterize a subpopulation of choroidal ganglion cells associated with the ciliary nerves. METHODS:Isolated long ciliary nerves of porcine and human eyes containing ciliary nerve-associated ganglion cells (CNGCs) were embedded in Epon for ultrastructural investigation, or wholemounts were stained ...

journal_title：Investigative ophthalmology & visual science

authors： May CA,Fuchs AV,Scheib M,Lütjen-Drecoll E

更新日期：2002-03-01 00:00:00

abstract：Purpose:Endophthalmitis models have reported the virulent role of Panton-Valentine leucocidin (PVL) secreted by Staphylococcus aureus on the retina. PVL targets retinal ganglion cells (RGCs), expressing PVL membrane receptor C5aR. Interactions between PVL and retinal cells lead to glial activation, retinal inflammation...

journal_title：Investigative ophthalmology & visual science

authors： Wurtz M,Ruhland E,Liu X,Namer IJ,Mazzoleni V,Lipsker D,Keller D,Prévost G,Gaucher D

更新日期：2021-01-04 00:00:00

abstract：PURPOSE:To assess the impact on visual function of community glaucoma screening in an African American population using spectral-domain optical coherence tomography (SD-OCT). METHODS:Using a Monte Carlo microsimulation model with a 10-year time horizon, we analyzed the efficacy of SD-OCT screening on visual field outc...

journal_title：Investigative ophthalmology & visual science

authors： Blumberg DM,Vaswani R,Nong E,Al-Aswad L,Cioffi GA

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:We investigated the response of retinal vessel diameters and oxygen saturation to flicker light stimulation of neuronal activity in patients with diabetic retinopathy. METHODS:We included 18 patients with nonproliferative diabetic retinopathy (mean age 62.2 ± 8.3 years, diabetes type 1 in 4 patients and type 2...

journal_title：Investigative ophthalmology & visual science

authors： Hammer M,Heller T,Jentsch S,Dawczynski J,Schweitzer D,Peters S,Schmidtke KU,Müller UA

更新日期：2012-06-26 00:00:00

abstract：:Extracellular matrix (ECM) turnover and remodeling are initiated, at least in part, by the regulated secretion of members of a family of matrix metalloproteinases. Human and bovine trabecular mesh-work in culture secrete interstitial collagenase, both the 72- and the 92-kD forms of type IV collagenase (gelatinases) an...

journal_title：Investigative ophthalmology & visual science

authors： Alexander JP,Samples JR,Van Buskirk EM,Acott TS

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age- and sex-matched controls using ultra-high field 7.0-T magnetic resonance imaging (MRI). METHODS:The study included 18 patients with POAG and 18 age- and sex-matched healthy volunteers. All s...

journal_title：Investigative ophthalmology & visual science

authors： Lee JY,Jeong HJ,Lee JH,Kim YJ,Kim EY,Kim YY,Ryu T,Cho ZH,Kim YB

更新日期：2014-04-10 00:00:00

abstract：PURPOSE:To assess the comparative accuracy of potential screening tests for open angle glaucoma (OAG). METHODS:Medline, Embase, Biosis (to November 2005), Science Citation Index (to December 2005), and The Cochrane Library (Issue 4, 2005) were searched. Studies assessing candidate screening tests for detecting OAG in ...

journal_title：Investigative ophthalmology & visual science

authors： Mowatt G,Burr JM,Cook JA,Siddiqui MA,Ramsay C,Fraser C,Azuara-Blanco A,Deeks JJ,OAG Screening Project.

更新日期：2008-12-01 00:00:00

abstract：Purpose:Candida remains the leading cause of fungal endophthalmitis. However, the pathobiology and innate immune responses in this disease are not well characterized. Here, we developed two murine models of candida endophthalmitis and evaluated their disease susceptibility and differential immune response. Methods:End...

journal_title：Investigative ophthalmology & visual science

authors： Rottmann BG,Singh PK,Singh S,Revankar SG,Chandrasekar PH,Kumar A

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. METHODS:72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related ac...

journal_title：Investigative ophthalmology & visual science

authors： Balaskas K,Ballabeni P,Guex-Crosier Y

更新日期：2012-09-14 00:00:00

abstract：Purpose:We describe the spatial distribution and cross-sectional associations with physical and lifestyle attributes. Methods:The participants of the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular and HEarT) study underwent an exhaustive ophthalmologic examination, including optical coherence tomography,...

journal_title：Investigative ophthalmology & visual science

authors： Alassane S,Binquet C,Arnould L,Fleck O,Acar N,Delcourt C,Bretillon L,Bron AM,Creuzot-Garcher C

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Since central corneal thickness may inversely influence the amount and rate of progression of glaucomatous optic nerve damage and because lamina cribrosa thickness may be of importance in susceptibility to glaucoma, it was the purpose of the present study to evaluate whether central corneal thickness is related...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Holbach L

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:To determine the accuracy of a history of cataract and cataract surgery (self-report and for a sibling), and to determine which demographic, cognitive, and medical factors are predictive of an accurate history. METHODS:All participants in the Salisbury Eye Evaluation (SEE) project and their locally resident si...

journal_title：Investigative ophthalmology & visual science

authors： Bowie H,Congdon NG,Lai H,West SK

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:In uveal melanoma, both tumor size and an inflammatory phenotype have been shown to correlate with a poor clinical prognosis. The purpose of this study was to identify whether inflammatory cytokines were present in the vitreous of eyes with uveal melanoma and to determine whether the vitreal concentration of cy...

journal_title：Investigative ophthalmology & visual science

authors： Nagarkatti-Gude N,Bronkhorst IH,van Duinen SG,Luyten GP,Jager MJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Cigarette smoking is the most consistent risk factor for age-related macular degeneration (AMD), especially the choroidal neovascularization (CNV)-mediated exudative type. Dioxins and dioxin-like compounds have various effects on living organisms and are also contained in cigarette smoke. However, the effects o...

journal_title：Investigative ophthalmology & visual science

authors： Takeuchi A,Takeuchi M,Oikawa K,Sonoda KH,Usui Y,Okunuki Y,Takeda A,Oshima Y,Yoshida K,Usui M,Goto H,Kuroda M

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To examine the association between central corneal thickness (CCT) and glaucoma. METHODS:This was a nested case-control study using 1090 subjects from an eye disease population survey in Singapore and 243 participants from a hospital glaucoma surgery clinical trial in Singapore. RESULTS:Mean CCT in 938 commun...

journal_title：Investigative ophthalmology & visual science

authors： Day AC,Machin D,Aung T,Gazzard G,Husain R,Chew PT,Khaw PT,Seah SK,Foster PJ

更新日期：2011-10-28 00:00:00

abstract：:Cataracts were produced in cultured rat lenses by either 10 microM calcium ionophore A23187, 25 microM sodium selenite, or 30 mM xylose. E64, an inhibitor of cysteine proteases, such as calpain (EC, 3.4.22.17), reduced severity of cataract and proteolysis of crystallins when included at a 500 microM concentration in t...

journal_title：Investigative ophthalmology & visual science

authors： Shearer TR,Azuma M,David LL,Murachi T

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To compare the effectiveness of upper punctal occlusion versus that of lower punctal occlusion in dry eye patients. METHODS:One eye's upper punctum and the contralateral eye's lower punctum were occluded with collagen plugs in 20 dry eye patients. The same procedure was performed in 20 normal subjects. The upp...

journal_title：Investigative ophthalmology & visual science

authors： Chen F,Wang J,Chen W,Shen M,Xu S,Lu F

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:Recent studies on ocular shape have raised increased interest in the peripheral characteristics of the eye, as it potentially triggers changes in the central vision. Current techniques are, however, not capable of accurately measuring the three-dimensional shape of the retina. We describe a new magnetic resonan...

journal_title：Investigative ophthalmology & visual science

authors： Beenakker JW,Shamonin DP,Webb AG,Luyten GP,Stoel BC

更新日期：2015-01-15 00:00:00

abstract：PURPOSE:To test whether a diet supplemented with coenzyme Q10 (CoQ10) ameliorates glutamate excitotoxicity and oxidative stress-mediated retinal ganglion cell (RGC) degeneration by preventing mitochondrial alterations in the retina of glaucomatous DBA/2J mice. METHODS:Preglaucomatous DBA/2J and age-matched control DBA...

journal_title：Investigative ophthalmology & visual science

authors： Lee D,Shim MS,Kim KY,Noh YH,Kim H,Kim SY,Weinreb RN,Ju WK

更新日期：2014-02-18 00:00:00

abstract：:The microvascular permeability response of the guinea pig conjunctiva to sulfidopeptide leukotrienes (LTs) was quantified as extravasation of radiolabeled bovine serum albumin. The LTs were potent inducers of increased microvascular permeability, with relative potencies LTE4 greater than or equal to LTD4 greater than ...

journal_title：Investigative ophthalmology & visual science

authors： Gary RK Jr,Woodward DF,Nieves AL,Williams LS,Gleason JG,Wasserman MA

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To investigate mechanical properties of the human posterior lens capsule. METHODS:Twenty-five human donor eyes were obtained from an eye bank. The age of the donors ranged from 1 to 94 years. Test specimens were prepared as tissue rings from posterior lens capsules by means of excimer laser. Capsular thickness...

journal_title：Investigative ophthalmology & visual science

authors： Krag S,Andreassen TT

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:To determine the effect of treatment with latanoprost on the tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in cultured human ciliary muscle (HCM) cells. METHODS:Confluent serum-starved HCM cells were exposed to increasing concentrations of latanoprost acid (LA, 1 nM to 10 micro M) for 6, 18, and 24 ho...

journal_title：Investigative ophthalmology & visual science

authors： Anthony TL,Lindsey JD,Weinreb RN

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:Transforming growth factor beta-induced (TGFBI)-related dystrophies constitute the most common heritable forms of corneal dystrophy worldwide. However, other than the underlying genotypes of these conditions, a limited knowledge exists of the exact pathomechanisms of these disorders. This study expands on our p...

journal_title：Investigative ophthalmology & visual science

authors： Courtney DG,Poulsen ET,Kennedy S,Moore JE,Atkinson SD,Maurizi E,Nesbit MA,Moore CB,Enghild JJ

更新日期：2015-07-01 00:00:00