Abstract:
PURPOSE:In a group of humans with strabismic amblyopia, the relationship was examined between the structure and function of different brain regions. Three question were addressed: (1) Is the lateral geniculate nucleus (LGN) in humans with amblyopia structurally as well as functionally abnormal? (2) Do structural anomalies in the visual cortex correlate with the previously reported cortical functional losses? (3) Is there a link between the functional anomalies in the visual cortex and any structural anomalies in the geniculate? METHODS:The structure was compared by using voxel-based morphometry (VBM) and the function by functional magnetic resonance imaging (fMRI). RESULTS:The results showed that the geniculate is structurally abnormal in humans with strabismic amblyopia. CONCLUSIONS:These findings add further weight to the role of the LGN in the cortical deficits exhibited in human strabismic amblyopes.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Barnes GR,Li X,Thompson B,Singh KD,Dumoulin SO,Hess RFdoi
10.1167/iovs.09-3931subject
Has Abstractpub_date
2010-03-01 00:00:00pages
1432-8issue
3eissn
0146-0404issn
1552-5783pii
iovs.09-3931journal_volume
51pub_type
杂志文章abstract:PURPOSE:To investigate thickness profile changes of the corneal epithelium and Bowman's layer at the vertical and horizontal meridians with overnight myopia orthokeratology (OK) lenses. METHODS:Twenty subjects (age range: 19-33 years) wore reverse-geometry rigid gas-permeable OK lenses in both eyes for 30 days. Before...
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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doi:
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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doi:
更新日期:2000-02-01 00:00:00
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