Hsp27 upregulation by HIF-1 signaling offers protection against retinal ischemia in rats.

abstract：PURPOSE:Elevated levels of C-reactive protein (CRP), a proinflammatory marker, are associated with systemic vascular disorders. In addition, clinical studies have implicated that elevated CRP is an independent risk factor for diabetic retinopathy and age-related macular degeneration. However, the direct effect of CRP o...

journal_title：Investigative ophthalmology & visual science

authors： Nagaoka T,Kuo L,Ren Y,Yoshida A,Hein TW

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:In a group of humans with strabismic amblyopia, the relationship was examined between the structure and function of different brain regions. Three question were addressed: (1) Is the lateral geniculate nucleus (LGN) in humans with amblyopia structurally as well as functionally abnormal? (2) Do structural anomal...

journal_title：Investigative ophthalmology & visual science

authors： Barnes GR,Li X,Thompson B,Singh KD,Dumoulin SO,Hess RF

更新日期：2010-03-01 00:00:00

abstract：Purpose:To examine the associations between nighttime driving performance of older drivers and photopic, mesopic, and glare-based tests of visual function. Methods:Participants included 26 older drivers (71.8 ± 6.3 years), with minimal or no eye disease, but who reported vision-related nighttime driving difficulties. ...

journal_title：Investigative ophthalmology & visual science

authors： Kimlin JA,Black AA,Wood JM

更新日期：2017-05-01 00:00:00

abstract：Purpose:Activation of proteolytic enzymes, calpains and caspases, have been observed in many models of retinal disease. We previously demonstrated calpain activation in monkey retinal explants cultured under hypoxia. However, cellular responses are often species-specific. The purpose of the present study was to determi...

journal_title：Investigative ophthalmology & visual science

authors： Kobayashi-Otsugu M,Orihara K,Nakajima E,Shearer TR,Azuma M

更新日期：2020-11-02 00:00:00

abstract：:The comparison of intracellular pH (pHi) regulation between fresh (FBCE) and cultured (CBCE) bovine corneal endothelium was extended to HCO3- transport mechanisms. Upon introduction of CO2/HCO3- Ringer's solution, there was a small, sharp acidification followed by an alkalinization .09 and .18 pH U above the HCO3- fre...

journal_title：Investigative ophthalmology & visual science

authors： Bonanno JA,Giasson C

更新日期：1992-10-01 00:00:00

abstract：:A sensitive fluorometric assay for measuring permeability of liposomes containing bovine lens MIP26 has been developed and characterized. Lens membrane proteins were isolated and incorporated into artificial membranes composed of bovine brain phospholipids, sphingomyelin and the fluorescent probe, N-4-nitrobenzo-2-oxa...

journal_title：Investigative ophthalmology & visual science

authors： Scaglione BA,Rintoul DA

更新日期：1989-05-01 00:00:00

abstract：PURPOSE:To study the antineoplastic effect of vitamin D analogues in a xenograft model of human retinoblastoma. METHODS:Athymic mice were injected subcutaneously with Y79 cells and treated 5 days a week with either mineral oil (control group) or the vitamin D analogues calcitriol or 1,25-dihydroxy-16-ene-23-yne vitami...

journal_title：Investigative ophthalmology & visual science

authors： Audo I,Darjatmoko SR,Schlamp CL,Lokken JM,Lindstrom MJ,Albert DM,Nickells RW

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Mutations in the coding region of the OPTN gene are associated with certain glaucomas. Although the function of the optineurin protein is yet to be elucidated, the most common mutation, E50K, is associated with a severe phenotype. This study explores some functional features of optineurin and its mutants. METH...

journal_title：Investigative ophthalmology & visual science

authors： Chalasani ML,Radha V,Gupta V,Agarwal N,Balasubramanian D,Swarup G

更新日期：2007-04-01 00:00:00

abstract：Purpose:Rose bengal (RB)-photosensitized protein crosslinking has been proposed for several applications in the eye. This study identifies oxygen-dependent and oxygen-independent mechanistic pathways in cornea for RB-photosensitized crosslinking to enhance its efficiency for ocular treatments. Methods:Rabbit corneas e...

journal_title：Investigative ophthalmology & visual science

authors： Wertheimer CM,Elhardt C,Kaminsky SM,Pham L,Pei Q,Mendes B,Afshar S,Kochevar IE

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Changes in gene expression were investigated after treatment of cultured human retinal pigment epithelial (RPE) cells with vitreous. This may have implications for proliferative diseases such as proliferative vitreoretinopathy. METHODS:Cells were cultured in the presence or absence of human vitreous, and gene ...

journal_title：Investigative ophthalmology & visual science

authors： Hunt DM,Chen WH,Hunt RC

更新日期：1998-10-01 00:00:00

abstract：PURPOSE:We evaluated the roles of tumor necrosis factor (TNF)-α in alkali-induced corneal neovascularization (CNV). METHODS:CNV was induced by alkali injury and compared in wild-type (WT) BALB/c mice, and TNF receptor 1-deficient (TNF-Rp55 KO) counterparts, or in mice treated with TNF-α antagonist and recombinant TNF-...

journal_title：Investigative ophthalmology & visual science

authors： Lu P,Li L,Liu G,Baba T,Ishida Y,Nosaka M,Kondo T,Zhang X,Mukaida N

更新日期：2012-06-14 00:00:00

abstract：PURPOSE:To isolate all constituent mucins from human conjunctival mucus. METHODS:Mucins were extracted from human conjunctiva in guanidine hydrochloride and protease inhibitors. The mucins were isolated by density gradient centrifugation, gel filtration, and ion exchange chromatography. Throughout purification, the mu...

journal_title：Investigative ophthalmology & visual science

authors： Berry M,Ellingham RB,Corfield AP

更新日期：1996-12-01 00:00:00

abstract：PURPOSE:To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. METHODS:72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related ac...

journal_title：Investigative ophthalmology & visual science

authors： Balaskas K,Ballabeni P,Guex-Crosier Y

更新日期：2012-09-14 00:00:00

abstract：PURPOSE:To assess changes in rod and cone visual functions in a mouse model of Fundus albipunctatus with disrupted 11-cis-retinol dehydrogenase (RDH) genes after pharmacologic treatment with an artificial retinal chromophore. METHODS:Retinoid levels and photoreceptor functions of Rdh5-/-Rdh11-/- mice at a variety of l...

journal_title：Investigative ophthalmology & visual science

authors： Maeda A,Maeda T,Palczewski K

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To assess the effect of group B streptococcal (GBS) meningitis on retinal blood flow (RetBF) and choroidal blood flow (ChBF) autoregulation in sedated newborn piglets (1 to 5 days of age). METHODS:Fourteen study animals injected with 0.5 ml heat-killed GBS (10(9)) were compared to 10 control animals injected w...

journal_title：Investigative ophthalmology & visual science

authors： Bottoli I,Beharry K,Modanlou HD,Norris K,Ling E,Noya F,Amato MM,Aranda JV

更新日期：1995-06-01 00:00:00

abstract：PURPOSE:To estimate the relative importance of genes and environment in peripapillary atrophy type beta (beta-PPA) in a classic twin study. METHODS:Female twin pairs (n = 506) aged 49 to 79 years were recruited from the St. Thomas' UK Adult Twin Registry. Peripapillary atrophy was identified from masked grading of ste...

journal_title：Investigative ophthalmology & visual science

authors： Healey PR,Mitchell P,Gilbert CE,Lee AJ,Ge D,Snieder H,Spector TD,Hammond CJ

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:Intramuscular innervation of horizontal rectus extraocular muscles (EOMs) is segregated into superior and inferior (transverse) compartments, while all EOMs are also divided into global (GL) and orbital (OL) layers with scleral and pulley insertions, respectively. We sought evidence of potential independent act...

journal_title：Investigative ophthalmology & visual science

authors： Shin A,Yoo L,Chaudhuri Z,Demer JL

更新日期：2012-12-19 00:00:00

abstract：PURPOSE:To characterize the chemokines and chemokine receptors that mediate the effect of proinflammatory cytokines, interleukin (IL)-1 and tumor necrosis factor (TNF)-alpha, on the recruitment of MHC class II(+) Langerhans cells (LCs) in the corneal epithelium. METHODS:A standard model for corneal LC recruitment, app...

journal_title：Investigative ophthalmology & visual science

authors： Yamagami S,Hamrah P,Miyamoto K,Miyazaki D,Dekaris I,Dawson T,Lu B,Gerard C,Dana MR

更新日期：2005-04-01 00:00:00

abstract：:The activities of Mg(2+)-dependent and Na(+)-K(+)-stimulated ATPase in homogenates of rat retina were measured in the presence of increasing concentrations of oxidized glutathione (GSSG). The Mg(2+)-ATPase was not inhibited by GSSG at any of the concentrations tested. The Na(+)-K(+)-stimulated ATPase was not inhibited...

journal_title：Investigative ophthalmology & visual science

authors： Winkler BS,Solomon FJ,Orselli SM

更新日期：1991-09-01 00:00:00

abstract：PURPOSE:To evaluate the relationship between retinal vascular caliber (RVC), iris color, and age-related macular degeneration (AMD) in elderly Irish nuns. METHODS:Data from 1233 participants in the cross-sectional observational Irish Nun Eye Study were assessed from digital photographs with a standardized protocol usi...

journal_title：Investigative ophthalmology & visual science

authors： McGowan A,Silvestri G,Moore E,Silvestri V,Patterson CC,Maxwell AP,McKay GJ

更新日期：2014-12-18 00:00:00

abstract：Purpose:To investigate the association of microRNA (miRNA) copy number variants (CNVs) with acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS) and to assess underlying disease mechanisms. Methods:This study included 768 patients with AAU+AS+ or AAU+AS- and 660 controls from a Chinese Han populati...

journal_title：Investigative ophthalmology & visual science

authors： Yang L,Du L,Yue Y,Huang Y,Zhou Q,Cao S,Qi J,Liang L,Wu L,Wang C,Ye Z,Tian Y,Kijlstra A,Hou S,Yang P

更新日期：2017-04-01 00:00:00

abstract：:The authors investigated the mechanisms underlying the head shaking shown by some patients with congenital nystagmus (CN). In order to improve visual function by head shaking, a patient with CN must have some visual acuity loss due to retinal image motion created by the nystagmus; an abnormal vestibulo-ocular reflex (...

journal_title：Investigative ophthalmology & visual science

authors： Carl JR,Optican LM,Chu FC,Zee DS

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:To determine the metrics of vertical saccades in elderly subjects for comparison in neurologic disease. METHODS:Sixteen elderly subjects, ten middle-aged subjects, and thirteen young subjects were examined using a magnetic search coil technique. Saccades were measured to predictable vertical target steps and m...

journal_title：Investigative ophthalmology & visual science

authors： Huaman AG,Sharpe JA

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:Invasion of tumor cells into blood vessels is essential for metastasis of uveal melanoma. The occurrence of ingrowth of tumor cells in blood vessels in uveal melanoma was analyzed, and this parameter was compared with the survival of the patients. METHODS:Between 1972 and 2007, 643 eyes primarily enucleated fo...

journal_title：Investigative ophthalmology & visual science

authors： Ly LV,Odish OF,Wolff-Rouendaal Dd,Missotten GS,Luyten GP,Jager MJ

更新日期：2010-02-01 00:00:00

abstract：:The basal laminae of capillaries, glomeruli, and nerves are thickened in diabetes. Previous studies have shown that diabetic tissues produce increased levels of basal lamina collagen and reduced levels of proteoglycans. Since heparan sulfate and chondroitin sulfate proteoglycans are thought to act as anionic barriers ...

journal_title：Investigative ophthalmology & visual science

authors： Caldwell RB,Slapnick SM,McLaughlin BJ

更新日期：1986-12-01 00:00:00

abstract：:Extraocular muscle represents a distinctive class among mammalian skeletal musculature in exhibiting the full range of muscle fiber type variability found in vertebrate species. To better understand the basis for the unique structural/functional diversity of extraocular muscle, the ontogeny of lateral rectus muscles w...

journal_title：Investigative ophthalmology & visual science

authors： Porter JD,Baker RS

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:Activation of complement has been implicated as one of the major causes of age-related macular degeneration (AMD). Evidence is accumulating for a role of complement in other retinal diseases, such as diabetic retinopathy and proliferative vitreoretinopathy. Because of the paucity of animal models that directly ...

journal_title：Investigative ophthalmology & visual science

authors： Cashman SM,Desai A,Ramo K,Kumar-Singh R

更新日期：2011-05-18 00:00:00

abstract：PURPOSE:The organization of scleral collagen helps to determine the eye's biomechanical response to intraocular pressure (IOP), and may therefore be important in glaucoma. This study provides a quantitative assessment of changes in scleral collagen fibril organization in bead-induced murine experimental glaucoma. METH...

journal_title：Investigative ophthalmology & visual science

authors： Pijanka JK,Kimball EC,Pease ME,Abass A,Sorensen T,Nguyen TD,Quigley HA,Boote C

更新日期：2014-09-16 00:00:00

abstract：PURPOSE:Tubby-like proteins (TULPs) are a family of four proteins, two of which have been linked to neurosensory disease phenotypes. TULP1 is a photoreceptor-specific protein that is mutated in retinitis pigmentosa, an inherited retinal disease characterized by the degeneration of rod and cone photoreceptor cells. To i...

journal_title：Investigative ophthalmology & visual science

authors： Xi Q,Pauer GJ,Ball SL,Rayborn M,Hollyfield JG,Peachey NS,Crabb JW,Hagstrom SA

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To enhance drug uptake in RPE cells, improve efficacy for choroidal neovascularization (CNV), and reduce drug toxicity, an EphA2-targeted nanocarrier loaded with doxorubicin (DOX) was developed by conjugation with a homing peptide YSA. METHODS:The YSA was coupled to PEGylated lipid. Then, YSA-modified DOX stea...

journal_title：Investigative ophthalmology & visual science

authors： Wang JL,Liu YL,Li Y,Dai WB,Guo ZM,Wang ZH,Zhang Q

更新日期：2012-10-23 00:00:00