Ocular biometry and refraction in Mongolian adults.

abstract：PURPOSE:Defensins are naturally occurring antimicrobial peptides. Recently the authors published evidence of defensin production by the human ocular surface. A study was undertaken to look for intraocular defensins that may account for unexplained antimicrobial activity of intraocular fluids. METHODS:Reverse transcrip...

journal_title：Investigative ophthalmology & visual science

authors： Haynes RJ,McElveen JE,Dua HS,Tighe PJ,Liversidge J

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To investigate the topographic relationship between ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) defects in open-angle glaucoma patients with localized RNFL defects, using spectral-domain optical coherence tomography (SD-OCT). METHODS:We analyzed 140 eyes of 1...

journal_title：Investigative ophthalmology & visual science

authors： Kim KE,Park KH,Yoo BW,Jeoung JW,Kim DM,Kim HC

更新日期：2014-05-06 00:00:00

abstract：PURPOSE:To estimate the critical duration of temporal summation for achromatic Goldmann III stimuli under the conditions of standard automated perimetry (SAP) and quantify response variability for short-duration stimuli. METHODS:Contrast thresholds were gathered using the method of constant stimuli for seven circular ...

journal_title：Investigative ophthalmology & visual science

authors： Mulholland PJ,Redmond T,Garway-Heath DF,Zlatkova MB,Anderson RS

更新日期：2014-12-16 00:00:00

abstract：PURPOSE:To explore the roles of ZO-1 in corneal fibroblasts and myofibroblasts in a model of wounding. METHODS:Antibodies were used to identify ZO-1 in cultured rabbit corneal fibroblasts by immunocytochemistry, Western blot analysis, and immunoprecipitation. For colocalization studies, antibodies to beta-catenin, cad...

journal_title：Investigative ophthalmology & visual science

authors： Taliana L,Benezra M,Greenberg RS,Masur SK,Bernstein AM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To evaluate the expression of lumican and decorin, the major proteoglycans of the adult corneal stroma, during the acquisition of corneal transparency in developing chick embryos. METHODS:mRNA levels of decorin and lumican were measured in total RNA extracted from corneas of days 9 to 18 of development by Nort...

journal_title：Investigative ophthalmology & visual science

authors： Cornuet PK,Blochberger TC,Hassell JR

更新日期：1994-03-01 00:00:00

abstract：:A single injection of an aqueous suspension of group A streptococcal peptidoglycan-polysaccharide complexes (PG-PS) when injected intraperitoneally into Lewis rats induced a self-limiting bilateral uveitis with associated perpetuating polyarthritis. The uveitis was characterized clinically during the first 72 h by iri...

journal_title：Investigative ophthalmology & visual science

authors： Wells A,Pararajasegaram G,Baldwin M,Yang CH,Hammer M,Fox A

更新日期：1986-06-01 00:00:00

abstract：PURPOSE:To evaluate immunohistochemical staining of the endothelia of corneas from patients with clinical diagnoses of iridocorneal endothelial (ICE) syndrome. METHODS:Corneas diagnosed with ICE syndrome and removed during corneal transplantation were freshly frozen, sectioned, and stained with monoclonal antibodies t...

journal_title：Investigative ophthalmology & visual science

authors： Hirst LW,Bancroft J,Yamauchi K,Green WR

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:One of the methods used in macular translocation (MT) surgery for subfoveal neovascularization is to create a temporary total retinal detachment followed by a 360 degrees retinotomy. The whole retina is then shifted from the original surface of the retinal pigment epithelium (RPE), resulting in an unusual retin...

journal_title：Investigative ophthalmology & visual science

authors： Terasaki H,Miyake Y,Suzuki T,Niwa T,Piao CH,Suzuki S,Nakamura M,Kondo M

更新日期：2002-02-01 00:00:00

abstract：:The metabolic disorder in diabetics often results in progressive retinopathy with severe visual impairment. Changes in metabolism can influence corneal autofluorescence. This has led to speculation that diabetic retinopathy might be associated with changes in corneal autofluorescence. Corneal autofluorescence of both ...

journal_title：Investigative ophthalmology & visual science

authors： Stolwijk TR,van Best JA,Oosterhuis JA,Swart W

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Retinitis pigmentosa is a clinically and genetically heterogeneous disorder. It is characterized by progressive degeneration of the peripheral retina, leading to night blindness and loss of the peripheral visual field. PRPF31 is one of four pre-mRNA splicing factors identified as causing autosomal dominant reti...

journal_title：Investigative ophthalmology & visual science

authors： Waseem NH,Vaclavik V,Webster A,Jenkins SA,Bird AC,Bhattacharya SS

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to compare the accommodative performance of the amblyopic eye of children with unilateral amblyopia to that of their nonamblyopic eye, and also to that of children without amblyopia, during both monocular and binocular viewing. METHODS:Modified Nott retinoscopy was used to measure...

journal_title：Investigative ophthalmology & visual science

authors： Manh V,Chen AM,Tarczy-Hornoch K,Cotter SA,Candy TR

更新日期：2015-01-27 00:00:00

abstract：PURPOSE:To determine whether the atmospheric pressure (ATM) change experienced during diving can induce changes in the intraocular pressure (IOP) of eyes in a normal population. METHODS:The IOP of 27 healthy volunteers (ages, 23.8 +/- 4.9 years; range, 18-44) was measured with a Perkins applanation tonometer by two in...

journal_title：Investigative ophthalmology & visual science

authors： Van de Veire S,Germonpre P,Renier C,Stalmans I,Zeyen T

更新日期：2008-12-01 00:00:00

abstract：Purpose:Although retinal dopamine (DA) has been long implicated in myopia development, current studies demonstrate that retinal DA levels are unaltered in C57BL/6 mice with form-deprivation myopia. This work was undertaken to explore whether and how refractive development is perturbed in this mouse strain when retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Wu XH,Qian KW,Xu GZ,Li YY,Ma YY,Huang F,Wang YQ,Zhou X,Qu J,Yang XL,Zhong YM,Weng SJ

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Retinal pigment epithelial (RPE) cells are known to play important roles in maintaining the homeostasis of the retina and in controlling choroidal neovascularization. The purpose of this study was to identify a factor or factors that would stimulate RPE cells to proliferate. METHODS:To isolate such a factor, 1...

journal_title：Investigative ophthalmology & visual science

authors： Tanaka Y,Utsumi J,Matsui M,Sudo T,Nakamura N,Mutoh M,Kajita A,Sone S,Kigasawa K,Shibuya M,Reddy VN,Zhang Q,Iwata T

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To investigate the dynamic effect of tear lipocalins (TLs), the major lipid-binding protein in tears, at aqueous-cornea and lipid-aqueous interfaces, and their potential contribution to surface tension in the tear film. METHODS:Human apo- and holo-TLs were applied to the aqueous subphase in a Langmuir trough, ...

journal_title：Investigative ophthalmology & visual science

authors： Glasgow BJ,Marshall G,Gasymov OK,Abduragimov AR,Yusifov TN,Knobler CM

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:To develop structural markers of early glaucomatous optic nerve damage with confocal scanning laser ophthalmoscopy. METHODS:Custom software was developed to analyze the images of 53 patients with open-angle glaucoma and 43 healthy subjects (matched for age, race, and refractive error), with images acquired wit...

journal_title：Investigative ophthalmology & visual science

authors： Caprioli J,Park HJ,Ugurlu S,Hoffman D

更新日期：1998-11-01 00:00:00

abstract：:The authors have put quantitation of human lens fluorescence on a rational basis by using the accompanying Raman signal from lens protein as a normalization factor. The intensity ratio, Fluorescence/Raman (F/R), may be used to compare lenses of different ages when the exciting wavelength is long enough to give a measu...

journal_title：Investigative ophthalmology & visual science

authors： Yu NT,Bando M,Kuck JF Jr

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:We sought to determine whether conjunctival ultraviolet autofluorescence (UVAF), a biomarker of outdoor light exposure, is associated with myopia. METHODS:We performed a cross-sectional study on Norfolk Island and recruited individuals aged ≥ 15 years. Participants completed a sun-exposure questionnaire and un...

journal_title：Investigative ophthalmology & visual science

authors： Sherwin JC,Hewitt AW,Coroneo MT,Kearns LS,Griffiths LR,Mackey DA

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:We studied the correlation between outer nuclear layer (ONL) thickness and cone density in normal eyes and eyes with retinitis pigmentosa (RP). METHODS:Spectral-domain optical coherence tomography (SD-OCT) scans were acquired using a displaced pupil entry position of the scanning beam to distinguish Henle's fi...

journal_title：Investigative ophthalmology & visual science

authors： Menghini M,Lujan BJ,Zayit-Soudry S,Syed R,Porco TC,Bayabo K,Carroll J,Roorda A,Duncan JL

更新日期：2014-12-16 00:00:00

abstract：PURPOSE:To identify the chromosomal location of the gene causing snowflake vitreoretinal degeneration (SVD), an autosomal dominant retinal degeneration characterized by small yellow-white dots in the retina, fibrillar anomaly of the vitreous humor, and retinal detachment. METHODS:Clinical data were collected on 31 fam...

journal_title：Investigative ophthalmology & visual science

authors： Jiao X,Ritter R 3rd,Hejtmancik JF,Edwards AO

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:Ischemic preconditioning (IPC) protects the rat retina against the injury that ordinarily follows prolonged ischemia. It has been shown that release of adenosine, de novo protein synthesis, and mediators, such as protein kinase C and K(ATP) channels, is required for IPC protection. However, the molecular mechan...

journal_title：Investigative ophthalmology & visual science

authors： Zhang C,Rosenbaum DM,Shaikh AR,Li Q,Rosenbaum PS,Pelham DJ,Roth S

更新日期：2002-09-01 00:00:00

abstract：:Long-term S-antigen (S-Ag) specific T lymphocyte lines can induce experimental autoimmune uveoretinitis (EAU) when transferred into naive rats systemically or intravitreally. The uveitogenic lymphocyte line (ThS) stains positively for the ART 18 (IL-2 receptor) and W3/25 (T helper/inducer); negatively for OX6 (RT1B) a...

journal_title：Investigative ophthalmology & visual science

authors： Chan CC,Caspi RR,Roberge FG,Nussenblatt RB

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:EGF-induced activation of the epigenetic CCCTC binding factor (CTCF) plays an important role in corneal epithelial cell proliferation by suppressing the Pax6 gene. The present study focused on further understanding the role of CTCF in mediating EGF-induced migration of immortalized human corneal epithelial cell...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Deng SX,Lu L

更新日期：2012-02-23 00:00:00

abstract：PURPOSE:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Evidence suggests oxidative stress plays a role in the disease. To assess the potential contribution of epigenetic regulation of antioxidant genes relevant to AMD pathogenesis, we evaluated DNA methylation, a tissue-specifi...

journal_title：Investigative ophthalmology & visual science

authors： Hunter A,Spechler PA,Cwanger A,Song Y,Zhang Z,Ying GS,Hunter AK,Dezoeten E,Dunaief JL

更新日期：2012-04-24 00:00:00

abstract：PURPOSE:To report the impact of intravitreous bevacizumab therapy on contrast sensitivity in patients with neovascular age-related macular degeneration (nAMD). METHODS:This was a prospective, multicenter, double-masked, randomized, controlled trial of 131 patients with nAMD. The patients with nAMD had received intravi...

journal_title：Investigative ophthalmology & visual science

authors： Patel PJ,Chen FK,Da Cruz L,Rubin GS,Tufail A,ABC Trial Study Group.

更新日期：2011-05-11 00:00:00

abstract：PURPOSE:Several studies have reported higher levels of macular pigment (MP) in association with reduced risk for age-related macular degeneration (ARMD), a disease to which there is a genetic predisposition. A classic twin study was performed to determine the heritability of MP in the healthy eye. METHODS:One hundred ...

journal_title：Investigative ophthalmology & visual science

authors： Liew SH,Gilbert CE,Spector TD,Mellerio J,Marshall J,van Kuijk FJ,Beatty S,Fitzke F,Hammond CJ

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:Human blood contains low levels of protoporphyrin IX (PP IX), a photoactive compound that produces reactive oxygen species when exposed to light. It has been proposed that photoactivation of PP IX and subsequent generation of potentially tissue-damaging reactive oxygen may be a mechanism of retinal injury in re...

journal_title：Investigative ophthalmology & visual science

authors： Bynoe LA,Gottsch JD,Sadda SR,Panton RW,Haller EM,Gleason CA

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:To determine whether the uniform field and pattern ERGs that are reduced in macaque eyes with experimental glaucoma have the same inner-retinal origins. METHODS:ERGs were recorded from 14 anesthetized adult macaques using DTL electrodes. Six monkeys had laser-induced experimental glaucoma, and two others recei...

journal_title：Investigative ophthalmology & visual science

authors： Viswanathan S,Frishman LJ,Robson JG

更新日期：2000-08-01 00:00:00

abstract：:Two-dimensional electrophoretic maps of extracts from eleven normal and eleven keratoconus corneas were compared. Of the eleven corneas analyzed, eight were pooled and the remaining three were analyzed individually. Several differences were demonstrated between electrophoretic patterns of normal and keratoconus cornea...

journal_title：Investigative ophthalmology & visual science

authors： Panjwani N,Drysdale J,Clark B,Alberta J,Baum J

更新日期：1989-12-01 00:00:00

abstract：PURPOSE:Nerve growth factor (NGF) is a neuropeptide essential for the development, survival, growth, and differentiation of corneal cells. Its effects are mediated by both TrkA and p75 receptors. Clinically relevant use of NGF was introduced to treat neurotrophic ulcerations in patients. Herein, we examine the mechanis...

journal_title：Investigative ophthalmology & visual science

authors： Blanco-Mezquita T,Martinez-Garcia C,Proença R,Zieske JD,Bonini S,Lambiase A,Merayo-Lloves J

更新日期：2013-06-04 00:00:00