Prophylactic effect of intravenous moxifloxacin in a rabbit model of Staphylococcus epidermidis endophthalmitis.

abstract：:Congenic mice of the MRL/Mp strain spontaneously develop an autoimmune connective tissue disease that shares immunologic and histopathologic features with the human disorders systemic lupus erythematosus, rheumatoid arthritis, and systemic vasculitis. The autoimmune disorder in these mice is markedly accelerated by th...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Alexander EL,Green WR

更新日期：1985-09-01 00:00:00

abstract：Purpose:Evidence from animals and blind humans suggests that early visual experience influences the developmental calibration of auditory localization. Hypothesizing that unilateral amblyopia may involve cross-modal deficits in spatial hearing, we measured the precision and accuracy of sound localization in humans with...

journal_title：Investigative ophthalmology & visual science

authors： Richards MD,Goltz HC,Wong AMF

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Injury to the adult optic nerve, caused mechanically or by diseases, is still not reparable because the retinal ganglion cells (RGCs) are not allowed to regrow their axons and die retrogradely, although they possess the intrinsic propensity to regenerate axons in experimental conditions. METHODS:In vitro propa...

journal_title：Investigative ophthalmology & visual science

authors： Charalambous P,Hurst LA,Thanos S

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To investigate the biometric characteristics of eyes with idiopathic central serous chorioretinopathy (CSC). METHODS:Medical records of 52 consecutive patients with unilateral CSC were reviewed. Central serous chorioretinopathy was diagnosed using spectral-domain optical coherence tomography (SD-OCT) and fluor...

journal_title：Investigative ophthalmology & visual science

authors： Oh JH,Oh J,Togloom A,Kim SW,Huh K

更新日期：2014-03-13 00:00:00

abstract：PURPOSE:To map the gene for autosomal dominant cataracts (ADC) in an American white family of European descent. METHODS:Ophthalmic examinations and linkage analyses using a variety of polymorphisms were performed; two-point lod scores calculated. RESULTS:Affected individuals (14 studied) exhibited variable expressivi...

journal_title：Investigative ophthalmology & visual science

authors： Bateman JB,Johannes M,Flodman P,Geyer DD,Clancy KP,Heinzmann C,Kojis T,Berry R,Sparkes RS,Spence MA

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:Alkali burning of the rabbit cornea is a well-established model for the study of anterior surface inflammation, neovascularization, and wound-healing processes. 12-hydroxyeicosanoids have been implicated as mediators of such responses. 12(S)-hydroxyeicosatetraenoic acid (12[S]-HETE) is a lipoxygenase-derived ar...

journal_title：Investigative ophthalmology & visual science

authors： Conners MS,Urbano F,Vafeas C,Stoltz RA,Dunn MW,Schwartzman ML

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:To investigate the effects of lomerizine, a Ca2+ antagonist, on the ocular tissue circulation in rabbits and on the circulation in the optic nerve head (ONH) and choroid in healthy volunteers. METHODS:Lomerizine (0.1 [n=10] or 0.3 [n=11] mg/kg) or vehicle solution (n=11) was injected intravenously in urethane-...

journal_title：Investigative ophthalmology & visual science

authors： Tamaki Y,Araie M,Fukaya Y,Nagahara M,Imamura A,Honda M,Obata R,Tomita K

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age- and sex-matched controls using ultra-high field 7.0-T magnetic resonance imaging (MRI). METHODS:The study included 18 patients with POAG and 18 age- and sex-matched healthy volunteers. All s...

journal_title：Investigative ophthalmology & visual science

authors： Lee JY,Jeong HJ,Lee JH,Kim YJ,Kim EY,Kim YY,Ryu T,Cho ZH,Kim YB

更新日期：2014-04-10 00:00:00

abstract：Purpose:Ocular neovascularization (NV) is a pathologic process characterized by the proliferation and infiltration of various types of cells such as RPE, glial, and endothelial cells, which interact with proangiogenic factors and inflammatory cytokines. Endocan is known to be enriched in retinal endothelial tip cells u...

journal_title：Investigative ophthalmology & visual science

authors： Su T,Zhong Y,Demetriades AM,Shen J,Sui A,Yao Y,Gao Y,Zhu Y,Shen X,Xie B

更新日期：2018-02-01 00:00:00

abstract：:Intracameral perfusion with 4 to 6 mM Na2EDTA or 4 mM EGTA for 40 to 80 min caused a very large increase in gross outflow facility. This effect was partly reversible when followed by perfusion with mock aqueous humor. Eyes perfused with Na2EDTA were studied morphologically. In the trabecular meshwork the cells separat...

journal_title：Investigative ophthalmology & visual science

authors： Bill A,Lütjen-Drecoll E,Svedbergh B

更新日期：1980-05-01 00:00:00

abstract：PURPOSE:The objective of this systematic review was to examine the evidence on zinc intake from foods and supplements in the primary prevention and treatment of AMD. METHODS:Randomized controlled trials (RCTs), prospective cohort, retrospective cohort, and case-control studies that investigated zinc intake from foods ...

journal_title：Investigative ophthalmology & visual science

authors： Vishwanathan R,Chung M,Johnson EJ

更新日期：2013-06-12 00:00:00

abstract：Purpose:To clarify the distinct molecular pathogenesis of central serous chorioretinopathy (CSC) and pachychoroid neovasculopathy (PNV). Methods:Aqueous humor (AH) was collected from 18 acute CSC, 20 chronic CSC, and 20 PNV patients. Concentrations of 30 cytokines in the AH were analyzed using a multiplex bead immunoa...

journal_title：Investigative ophthalmology & visual science

authors： Terao N,Koizumi H,Kojima K,Yamagishi T,Nagata K,Kitazawa K,Yamamoto Y,Yoshii K,Hiraga A,Toda M,Kinoshita S,Sotozono C,Hamuro J

更新日期：2018-12-03 00:00:00

abstract：Purpose:Primary open angle glaucoma (POAG) is the most prevalent form of glaucoma, accounting for approximately 90% of all cases. The aqueous humor (AH), a biological fluid in the anterior and posterior chambers of the eye, is involved in a multitude of functions including the maintenance of IOP and ocular homeostasis....

journal_title：Investigative ophthalmology & visual science

authors： Sharma S,Bollinger KE,Kodeboyina SK,Zhi W,Patton J,Bai S,Edwards B,Ulrich L,Bogorad D,Sharma A

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:This study focuses on the identification of regulatory elements that contribute to lens-specific expression of the human CP49 gene within the 5'-flanking DNA sequences. METHODS:The DNA sequence upstream of the human CP49 coding region was subcloned as a set of 5' and 3' deletion series. The constructs were tra...

journal_title：Investigative ophthalmology & visual science

authors： DePianto DJ,Hess JF,Blankenship TN,FitzGerald PG

更新日期：2003-01-01 00:00:00

abstract：:PURPOSE. To investigate morphologic photoreceptor layer abnormalities and their correlation with visual function in occult macular dystrophy (OMD), by using spectral-domain optical coherence tomography (SD-OCT). METHODS. This observational case series included 18 eyes of 9 patients with OMD. All patients underwent an ...

journal_title：Investigative ophthalmology & visual science

authors： Park SJ,Woo SJ,Park KH,Hwang JM,Chung H

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To investigate the effect of ABCA4 mutation status on lipofuscin-related quantitative autofluorescence (qAF) in humans and on bisretinoid accumulation in mice. METHODS:Genotyped parents (n = 26; age 37-64 years) of patients with biallelic ABCA4-related retinopathy underwent in-depth retinal phenotyping includi...

journal_title：Investigative ophthalmology & visual science

authors： Müller PL,Gliem M,Mangold E,Bolz HJ,Finger RP,McGuinness M,Betz C,Jiang Z,Weber BH,MacLaren RE,Holz FG,Radu RA,Charbel Issa P

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To determine the influence of specific regions within Lp82 calpain on protein stability, enzymatic activity, and localization within lens and to test the influence of an Lp82 knockout mouse on normal maturational proteolysis in lens. METHODS:DNA constructs for Lp82 and Lp82-related proteins were subcloned into...

journal_title：Investigative ophthalmology & visual science

authors： Ma H,Shih M,Fukiage C,Azuma M,Duncan MK,Reed NA,Richard I,Beckmann JS,Shearer TR

更新日期：2000-12-01 00:00:00

abstract：Purpose:Treatment success in clinical trials for AMD would ideally be aligned to measurable performance in visual tasks rather than imperceptible changes on clinical charts. We test the hypothesis that patients with dry AMD perform worse than visually healthy peers on computer-based surrogates of "real-world" visual se...

journal_title：Investigative ophthalmology & visual science

authors： Taylor DJ,Smith ND,Crabb DP

更新日期：2017-03-01 00:00:00

abstract：Purpose:Suppression in amblyopia may be an unequal form of normal interocular suppression or a distinct pathophysiology. To explore this issue, we examined the orientation tuning and contrast dependence of continuous flash suppression (CFS) in adults with amblyopia and visually normal controls. Methods:Nine patients (...

journal_title：Investigative ophthalmology & visual science

authors： Gao TY,Ledgeway T,Lie AL,Anstice N,Black J,McGraw PV,Thompson B

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:To investigate effects of aging on endothelial nitric oxide synthase (eNOS) expression and signaling in angular aqueous plexus (AAP) (functional equivalent to human Schlemm's canal) cells subjected to shear stress. METHODS:The AAP cells were isolated differentially from porcine outflow tissues using puromycin ...

journal_title：Investigative ophthalmology & visual science

authors： Lei Y,Stamer WD,Wu J,Sun X

更新日期：2014-11-06 00:00:00

abstract：PURPOSE:Sorsby fundus dystrophy (SFD) is a rare, late-onset macular dystrophy caused by mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) gene. The known mutations introduce potentially unpaired cysteine residues in the C terminus of the protein and result in the formation of higher-molecular-weight pro...

journal_title：Investigative ophthalmology & visual science

authors： Weber BH,Lin B,White K,Kohler K,Soboleva G,Herterich S,Seeliger MW,Jaissle GB,Grimm C,Reme C,Wenzel A,Asan E,Schrewe H

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:This study examined the association between peripapillary choroidal thickness (PCT) with age and race in a group of African descent (AD) and European descent (ED) subjects with normal eyes. METHODS:Optic nerve head images from enhanced depth imaging spectral-domain optical coherence tomography of 166 normal ey...

journal_title：Investigative ophthalmology & visual science

authors： Rhodes LA,Huisingh C,Johnstone J,Fazio MA,Smith B,Wang L,Clark M,Downs JC,Owsley C,Girard MJ,Mari JM,Girkin CA

更新日期：2015-02-24 00:00:00

abstract：PURPOSE:To evaluate immunohistochemical staining of the endothelia of corneas from patients with clinical diagnoses of iridocorneal endothelial (ICE) syndrome. METHODS:Corneas diagnosed with ICE syndrome and removed during corneal transplantation were freshly frozen, sectioned, and stained with monoclonal antibodies t...

journal_title：Investigative ophthalmology & visual science

authors： Hirst LW,Bancroft J,Yamauchi K,Green WR

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:To examine the signal transduction pathways involved in the activation of orbital fibroblast effector functions relevant to the pathogenesis of Graves' ophthalmopathy (GO). To determine, using antisense technology, whether the c-myc protooncogene is involved in cell proliferation and glycosaminoglycan (GAG) syn...

journal_title：Investigative ophthalmology & visual science

authors： Heufelder AE,Bahn RS

更新日期：1995-06-01 00:00:00

abstract：PURPOSE:To characterize the potential for neuropeptide Y (NPY) signaling in the retinal pigment epithelium (RPE) by identifying the NPY receptor subtypes present, determining the effect of NPY on second-messenger production and membrane conductance, and establishing the neural retina as a site of NPY gene expression. ...

journal_title：Investigative ophthalmology & visual science

authors： Ammar DA,Hughes BA,Thompson DA

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:In the rabbit iris sphincter muscle, sodium nitroprusside (SNP), a nitric oxide (NO) donor, inhibits cholinergic contraction but does not affect tachykinergic contraction in vitro. The objectives of the current study were to clarify the mechanism for the different responsiveness to NO in cholinergic and tachyki...

journal_title：Investigative ophthalmology & visual science

authors： Chuman H,Chuman T,Nao-i N,Sawada A,Yamamoto R,Kobayashi H,Wada A

更新日期：1997-08-01 00:00:00

abstract：Purpose:We previously reported that a specific treadmill running exercise regimen protects against light-induced retinal degeneration (LIRD) in mice. We hypothesized that this protective effect varies with running intensity. To test this, mice undergoing LIRD were run at different treadmill speeds and retinal function ...

journal_title：Investigative ophthalmology & visual science

authors： Mees LM,Coulter MM,Chrenek MA,Motz CT,Landis EG,Boatright JH,Pardue MT

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:Lens epithelial tissue does not normally express major histocompatibility complex (MHC) class I molecules. In addition, the mechanism of self-tolerance to intraocular antigens is unknown. To study the effect of class I expression in the lens, transgenic mice were produced that express an allo-MHC class I molecu...

journal_title：Investigative ophthalmology & visual science

authors： Martin WD,Egan RM,Stevens JL,Woodward JG

更新日期：1995-05-01 00:00:00

abstract：:Three monoclonal antibodies against lens crystallin have been used to study the accumulation of specific polypeptides during development of the human lens. One antibody which recognizes an antigen common to three polypeptides with molecular weights close to 31,000 reacted equally well to the human lens cortex and nucl...

journal_title：Investigative ophthalmology & visual science

authors： Russell P,Carper DA,Chiogioji A,Reddy V

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:To delineate morphometric and quantitative features of the capillary image derived from high-resolution fundus fluorescein angiography (FFA) and consequently determine the diagnostic value of FFA for studying the retinal capillary circulation. METHODS:Retinal capillary images obtained from healthy young subjec...

journal_title：Investigative ophthalmology & visual science

authors： Mendis KR,Balaratnasingam C,Yu P,Barry CJ,McAllister IL,Cringle SJ,Yu DY

更新日期：2010-11-01 00:00:00