Correlation of histologic and clinical images to determine the diagnostic value of fluorescein angiography for studying retinal capillary detail.

abstract：:A method for assessing the inward permeability of the blood-retinal barrier by fluorophotometry is presented. The permeability value is calculated with the fluorophotometer computer from fluorophotometric scan values in vitreous and non-protein-bound fluorescein concentration values in plasma. No diffusion coefficient...

journal_title：Investigative ophthalmology & visual science

authors： Kappelhof JP,van Best JA,van Valenberg PL,Oosterhuis JA

更新日期：1987-04-01 00:00:00

abstract：:This study used primary cultures of conjunctival and corneal epithelial cells from rabbit, monkey and humans to investigate the infection process and host interactions of chlamydia. The epithelial cells were isolated from bulbar and palpebral conjunctivae and the cornea following incubation with EDTA or dispase and mi...

journal_title：Investigative ophthalmology & visual science

authors： Patton DL,Chan KY,Kuo CC,Cosgrove YT,Langley L

更新日期：1988-07-01 00:00:00

abstract：PURPOSE:Lectin studies have shown that in the rabbit corneal epithelium, alpha-2,3 sialylation of O-linked glycans differentiates limbal and corneal epithelial cell phenotypes. Because sialic acid can be regulated at the level of the expression of sialyltransferases (STs), the purpose of the present study was to analyz...

journal_title：Investigative ophthalmology & visual science

authors： Matic M,Petrov I,Stegman Z,Buku A,Wolosin JM

更新日期：1998-05-01 00:00:00

abstract：PURPOSE:To determine the role of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the response of the human retinal pigment epithelial cell line ARPE-19 to oxidative stress. METHODS:ARPE-19 cells were treated with the chemical oxidant tert-butyl hydroperoxide (t-BOOH), and cell viability was ...

journal_title：Investigative ophthalmology & visual science

authors： Hutnik CM,Pocrnich CE,Liu H,Laird DW,Shao Q

更新日期：2008-02-01 00:00:00

abstract：Purpose:To evaluate the nature and extent of functional abnormality in X-linked retinoschisis (XLRS) by comparing three dark-adapted, full-field measures: the electroretinogram (ERG), pupillary light reflex (PLR), and luminance threshold. Methods:ERGs, PLRs (pupil constriction due to light stimulation), and luminance ...

journal_title：Investigative ophthalmology & visual science

authors： McAnany JJ,Park JC,Fishman GA,Collison FT

更新日期：2020-06-03 00:00:00

abstract：PURPOSE:The expression of the lens fiber cell integral membrane proteins MP20, the alpha 3 gap junction protein (connexin 46), and MP26 (MIP) was determined both during development of the bovine fetal lens and in different animal species. METHODS:The relative levels of the mRNA species coding for these proteins was de...

journal_title：Investigative ophthalmology & visual science

authors： Jarvis LJ,Kumar NM,Louis CF

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:As efforts to noninvasively measure intracranial pressure (ICP) increase, we thought it important to investigate the timing of retinal venous pulsation in relation to the intraocular and intracranial pressure pulses. METHODS:Neurosurgical patients undergoing continuous direct ICP monitoring had video recording...

journal_title：Investigative ophthalmology & visual science

authors： Morgan WH,Lind CR,Kain S,Fatehee N,Bala A,Yu DY

更新日期：2012-07-10 00:00:00

abstract：:Vanadate, an inhibitor of (Na+ + K+)ATPase, also inhibits active transepithelial Na+ and Cl- transport (measured as short-circuit current) in the isolated cornea in concentrations of 10(-4)M to 10(-3)M. The disulfonic stilbene, DIDS, does not affect the short-circuit current per se, but it prevents the inhibitory effe...

journal_title：Investigative ophthalmology & visual science

authors： Candia OA,Podos SM

更新日期：1981-06-01 00:00:00

abstract：:Light and electron microscopic studies were done on 11 cynomolgus monkey eyes which had undergone total iris removal followed by surgical disinsertion of the ciliary muscle from the scleral spur 4.7 to 14.4 months earlier. Anterior chamber perfusion to measure gross outflow facility had been performed one to nine time...

journal_title：Investigative ophthalmology & visual science

authors： Lütjen-Drecoll E,Kaufman PL,Bárány EH

更新日期：1977-03-01 00:00:00

abstract：PURPOSE:To study the topography of photoreceptor loss early in the course of Leber congenital amaurosis (LCA) caused by RPE65 mutations. METHODS:Young patients with RPE65-LCA (n = 9; ages, 6-17 years) were studied with optical coherence tomography (OCT) in a wide region of central retina. Outer nuclear layer (ONL) thi...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Cideciyan AV,Aleman TS,Sumaroka A,Windsor EA,Schwartz SB,Heon E,Stone EM

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:A preferential loss of ERG b-wave was detected in a substrain of C57BL/10 mice. Electroretinographic and histologic techniques were used to investigate this hitherto unknown retinopathy. METHODS:ERGs were obtained from normal and affected C57BL/10. C57BL/6 mice served also as controls. a-Wave and c-wave analys...

journal_title：Investigative ophthalmology & visual science

authors： Ruether K,Grosse J,Matthiessen E,Hoffmann K,Hartmann C

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:In uveal melanoma, both tumor size and an inflammatory phenotype have been shown to correlate with a poor clinical prognosis. The purpose of this study was to identify whether inflammatory cytokines were present in the vitreous of eyes with uveal melanoma and to determine whether the vitreal concentration of cy...

journal_title：Investigative ophthalmology & visual science

authors： Nagarkatti-Gude N,Bronkhorst IH,van Duinen SG,Luyten GP,Jager MJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:To study the effect of aminoguanidine (AMG), an inhibitor of nitric oxide production, on the ocular infection of Balb/c mice with herpes simplex virus (HSV) type 1 strain F and HSV-2 strain G. METHODS:Animals were treated with different amounts of AMG (0.5, 0.1, and 0.05 mg/mouse) by topical application in the...

journal_title：Investigative ophthalmology & visual science

authors： Benencia F,Courrèges MC,Gamba G,Cavalieri H,Massouh EJ

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:The selective degeneration of pericytes and the proliferation of endothelial cells (ECs) appear to be associated with microaneurysm formation, an initial deficit in the early stage of diabetic retinopathy. The preventive effect of aldose reductase (AR) inhibitor (ARI) for high glucose-induced pericyte loss and ...

journal_title：Investigative ophthalmology & visual science

authors： Takamura Y,Tomomatsu T,Kubo E,Tsuzuki S,Akagi Y

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the changes in tumor burden and hypoxia in the LH(BETA)T(AG) retinal tumors after treatment with a focal, single-modality, and combination therapy using periocular carboplatin and 2-deoxy-d-glucose (2-DG). METHODS:Seventeen-week-old LH(BETA)T(AG) transgenic mice (n = 25) w...

journal_title：Investigative ophthalmology & visual science

authors： Piña Y,Houston SK,Murray TG,Boutrid H,Celdran M,Feuer W,Shi W,Hernandez E,Lampidis TJ

更新日期：2010-12-01 00:00:00

abstract：Purpose:To characterize inheritance, penetrance, and trinucleotide repeat expansion stability in Fuchs endothelial corneal dystrophy (FECD). Methods:One thousand unrelated and related subjects with and without FECD were prospectively recruited. CTG18.1 repeat length (CTG18.1L) was determined via short tandem repeat as...

journal_title：Investigative ophthalmology & visual science

authors： Xu TT,Li YJ,Afshari NA,Aleff RA,Rinkoski TA,Patel SV,Maguire LJ,Edwards AO,Brown WL,Fautsch MP,Wieben ED,Baratz KH

更新日期：2021-01-04 00:00:00

abstract：Purpose:To determine whether combining quantitative optical coherence tomography angiography (OCTA) parameters can achieve high sensitivity and specificity to distinguish eyes with nonproliferative diabetic retinopathy (NPDR) from those with proliferative diabetic retinopathy (PDR) as well as eyes with diabetes and no ...

journal_title：Investigative ophthalmology & visual science

authors： Ashraf M,Nesper PL,Jampol LM,Yu F,Fawzi AA

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:To determine the prevalence of presbyopia in the state of Andhra Pradesh in south India. METHODS:Comprehensive ocular examinations including logMAR (logarithm of the minimum angle of resolution) distance and near (presenting and best corrected) visual acuity, slit lamp biomicroscopy of the anterior segment, an...

journal_title：Investigative ophthalmology & visual science

authors： Nirmalan PK,Krishnaiah S,Shamanna BR,Rao GN,Thomas R

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To investigate the role of epoxyeicosatrienoic acids (EETs) and prostaglandins (PGs) in retinal blood vessel calibers and vasodilation during flicker light stimulation in humans. METHODS:Twelve healthy nonsmokers participated in a balanced crossover study. Oral fluconazole 400 mg and dispersible aspirin 600 mg...

journal_title：Investigative ophthalmology & visual science

authors： Noonan JE,Dusting GJ,Nguyen TT,Jenkins AJ,Man RE,Best WJ,Dias DA,Jayasinghe NS,Roessner U,Lamoureux EL

更新日期：2014-10-08 00:00:00

abstract：PURPOSE:The authors' previous study showed that the expression of a Rho-associated serine/threonine kinase (ROCK) is regulated during cell cycle progression in corneal epithelial cells. The present study was conducted to determine whether and how Rho/ROCK signaling regulates cell cycle progression. METHODS:Rabbit corn...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,Guerriero E,Lathrop K,SundarRaj N

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate tumor control efficacy of paclitaxel in the treatment of retinal tumors harbored by the LH beta-Tag murine transgenic model of retinoblastoma. METHODS:LH beta-Tag-positive mice (n = 5) 10 weeks of age received two 20-microL subconjunctival injections delivered with ...

journal_title：Investigative ophthalmology & visual science

authors： Suárez F,Jockovich ME,Hernandez E,Feuer W,Parel JM,Murray TG

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Somatostatin (SST) analogues have been used to treat proliferative diabetic retinopathy, pseudotumor cerebri, thyroid orbitopathy, and cystoid macular edema. There is a paucity of published data in regards to cell-specific distribution of SST receptors (SSTR) in normal human eye tissues. Gene expression for all...

journal_title：Investigative ophthalmology & visual science

authors： Klisovic DD,O'Dorisio MS,Katz SE,Sall JW,Balster D,O'Dorisio TM,Craig E,Lubow M

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:In MRL/Mp-lpr/lpr (MRL/lpr) and MRL/Mp-+/+ (MRL/+) mice, a T-cell-driven lacrimal gland inflammation spontaneously develops that is a model for Sjögren's syndrome. The lacrimal gland lesions in these mice were evaluated by immunohistochemistry for the relative contributions of T-helper (Th)1 versus Th2 immune r...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Lee B,Whittum-Hudson JA,Prendergast RA

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To study pathologic changes in the photoreceptors in eyes with idiopathic macular telangiectasia (MacTel) type 2 using adaptive optics scanning laser ophthalmoscopy (AO-SLO). METHODS:Thirteen eyes with nonproliferative MacTel type 2 and 10 normal eyes underwent a full ophthalmologic examination, spectral-domai...

journal_title：Investigative ophthalmology & visual science

authors： Ooto S,Hangai M,Takayama K,Arakawa N,Tsujikawa A,Koizumi H,Oshima S,Yoshimura N

更新日期：2011-07-25 00:00:00

abstract：PURPOSE:To evaluate a fully automated local fractal dimension method to quantify vessel density and foveal avascular zone (FAZ) area in optical coherence tomography angiography (OCTA) images. METHODS:Fifty-two healthy Asian Indian eyes underwent imaging prospectively with OCTA system. Superficial and deep retinal vasc...

journal_title：Investigative ophthalmology & visual science

authors： Gadde SG,Anegondi N,Bhanushali D,Chidambara L,Yadav NK,Khurana A,Sinha Roy A

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Retinal injury induces Müller cell dedifferentiation by activating extracellular signal-regulated kinase (ERK) signaling. Stimulation of α2-adrenergic receptors protects against injury but also activates ERK in Müller cells. The purpose of this work was to study the effect of α2-adrenergic signaling on injury-i...

journal_title：Investigative ophthalmology & visual science

authors： Harun-Or-Rashid M,Díaz-DelCastillo M,Galindo-Romero C,Hallböök F

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To investigate the relationship between photopic open-loop accommodation and vergence and the effect of mental effort on these positions. METHODS:Twenty subjects (11 men and 9 women) viewed monocularly a photopic (25 cdm-2), high-contrast (90%) Maltese cross-target for 3 minutes, through a 0.5-mm pinhole drill...

journal_title：Investigative ophthalmology & visual science

authors： Gray LS,Winn B,Gilmartin B,Eadie AS

更新日期：1993-09-01 00:00:00

abstract：:The uveal absorption of aqueous humor at two different intraocular pressures was measured in rhesus monkeys by sampling vortex vein blood during anterior chamber perfusion of Ringer's solution containing both fluorescein and 125I albumin. At 20 mm. Hg, an excess of fluorescein equivalent in amount to 0.45 microliter/m...

journal_title：Investigative ophthalmology & visual science

authors： Pederson JE,Gaasterland DE,MacLellan HM

更新日期：1977-11-01 00:00:00

abstract：:The short-term fluctuation in regular grid threshold static fields is commonly determined from repeated observations of a number of threshold points. In this study we estimated the short-term fluctuation from a single determination of the field. Sixty-two eyes of 62 patients were tested, using three consecutive repeti...

journal_title：Investigative ophthalmology & visual science

authors： Schulzer M,Mills RP,Hopp RH,Lau W,Drance SM

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:To determine whether intraocular pressure (IOP) elevation alters OPA1 expression and triggers OPA1 release, as well as whether the uncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist memantine blocks OPA1 release and subsequent apoptotic cell death in glaucomatous DBA/2J mouse retina. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Ju WK,Kim KY,Angert M,Duong-Polk KX,Lindsey JD,Ellisman MH,Weinreb RN

更新日期：2009-02-01 00:00:00