Aqueous humor flow during sleep.

abstract：PURPOSE:To explore the effect of dominance and laterality on refractive error and axial length. METHODS:Ocular dominance was assessed with the hole-in-the-card test in 543 children during their 2006 follow-up visits for the Singapore Cohort study Of the Risk factors for Myopia (SCORM). Data were compared to cycloplegi...

journal_title：Investigative ophthalmology & visual science

authors： Chia A,Jaurigue A,Gazzard G,Wang Y,Tan D,Stone RA,Saw SM

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:The aim of this study was to show the usefulness of three methods for measuring IOP: Goldmann applanation tonometry, rebound tonometry, and Ultra-High-Speed Scheimpflug technology. METHODS:The examined group consisted of 96 patients (192 eyes), including 63 women and 33 men with a mean age of 59.3 ± 19.9 years...

journal_title：Investigative ophthalmology & visual science

authors： Smedowski A,Weglarz B,Tarnawska D,Kaarniranta K,Wylegala E

更新日期：2014-02-04 00:00:00

abstract：PURPOSE:To examine the involvement of p27(KIP1) in the regulation of the proliferation of the developing corneal endothelium. METHODS:Central and peripheral corneas in C57Bl6 mice at postnatal day (P)1, P11, and 12 weeks after birth were analyzed by immunocytochemistry with anti-p27(KIP1), -p57(KIP2), and -proliferati...

journal_title：Investigative ophthalmology & visual science

authors： Yoshida K,Kase S,Nakayama K,Nagahama H,Harada T,Ikeda H,Harada C,Imaki J,Ohgami K,Shiratori K,Ilieva IB,Ohno S,Nishi S,Nakayama KI

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:A subset of patients with anterior uveitis express the marker, perinuclear anti-neutrophil cytoplasmic antibody (pANCA). In this study, recombinantly isolated pANCA monoclonal antibodies were used to search for ocular cells expressing the pANCA antigen. METHODS:Paraffin sections of human ocular tissues obtaine...

journal_title：Investigative ophthalmology & visual science

authors： Gordon LK,Eggena M,Targan SR,Braun J

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:Optical coherence tomography (OCT) can monitor for glaucoma by measuring dimensions of the optic nerve head (ONH) cup and disc. Multiple clinical studies have shown that different OCT devices yield different estimates of retinal dimensions. We developed phantoms mimicking ONH morphology as a new way to compare ...

journal_title：Investigative ophthalmology & visual science

authors： Agrawal A,Baxi J,Calhoun W,Chen CL,Ishikawa H,Schuman JS,Wollstein G,Hammer DX

更新日期：2016-07-01 00:00:00

abstract：:Interactions between direction-selective mechanisms for motion were examined in strabismic and anisometropic amblyopia. Amblyopes were found to have a marked reduction in sensitivity to flicker or movement when the amblyopic eye was presented with a combination of two gratings drifting in opposite directions at the sa...

journal_title：Investigative ophthalmology & visual science

authors： Schor CM,Levi DM

更新日期：1980-09-01 00:00:00

abstract：Purpose:To quantify and evaluate macular superficial capillaries and large vessels separately using an optical coherence tomographic angiography (OCTA)-based automatic segmentation algorithm. Methods:In this cross-sectional study, all eyes were scanned using an OCTA device with 3 × 3 mm cube centered on the fovea. Ret...

journal_title：Investigative ophthalmology & visual science

authors： Lei J,Yi E,Suo Y,Chen C,Xu X,Ding W,Abdelfattah NS,Fan X,Lu H

更新日期：2018-04-01 00:00:00

abstract：:The life history of melanin and lipofuscin granules of human retinal pigment epithelium (RPE) was studied in 30 human eyes spanning nine decades of life. Autofluorescent granules in the cytoplasm of eye over 30 years of age were shown, ultrastructurally and through lipid solvent extraction, to be lipofuscin granules. ...

journal_title：Investigative ophthalmology & visual science

authors： Feeney L

更新日期：1978-07-01 00:00:00

abstract：PURPOSE:To evaluate the short- and long-term changes of focal macular electroretinograms (fmERGs) after macular translocation with 360 degrees retinotomy. METHODS:This was a retrospective study. fmERGs were recorded in 19 eyes of 19 consecutive patients who underwent macular translocation with 360 degrees retinotomy f...

journal_title：Investigative ophthalmology & visual science

authors： Terasaki H,Ishikawa K,Niwa Y,Piao CH,Niwa T,Kondo M,Ito Y,Miyake Y

更新日期：2004-02-01 00:00:00

abstract：Purpose:To refine the Minnesota Grading System (MGS) using definitions from the Age-Related Eye Disease Studies (AREDS) into a nine-step grading scale (MGS-9). Methods:A nine-step grading scale descriptive analysis using three key phenotypic features (total drusen area, increased, and decreased pigmentation) of human ...

journal_title：Investigative ophthalmology & visual science

authors： Olsen TW,Liao A,Robinson HS,Palejwala NV,Sprehe N

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:To identify the prognostic value of extraocular extension in enucleated uveal melanoma (UM) patients and to correlate extraocular extension to chromosomal aberrations, metastasis-free survival (MFS), and clinico-histopathological risk factors. METHODS:Retrospective study of patients with UM treated with enucle...

journal_title：Investigative ophthalmology & visual science

authors： van Beek JG,Koopmans AE,Vaarwater J,de Rooi JJ,Paridaens D,Naus NC,de Klein A,Verdijk RM,Kiliç E

更新日期：2014-03-04 00:00:00

abstract：PURPOSE:Monkeys reared under conditions of alternating monocular occlusion during their first few months of life show large horizontal strabismus, "A" patterns, and dissociated vertical deviation. "A" patterns manifest as an inappropriate horizontal component in the deviated eye during vertical eye movements (cross-axi...

journal_title：Investigative ophthalmology & visual science

authors： Joshi AC,Das VE

更新日期：2011-08-24 00:00:00

abstract：:The irides of albino guinea pigs were photographed, and the iris arteriolar diameters were measured with the animal breathing room air, 10% O2/90% N2, or 100% O2. The iris arterioles constrict significantly in hyperoxia and dilate in hypoxia. The average constriction in 100% O2 was 27% +/- 8%, and the average dilatati...

journal_title：Investigative ophthalmology & visual science

authors： Stefansson E,Shelton RA,Landers MB 3rd,Walsh AW,Wolbarsht ML

更新日期：1983-06-01 00:00:00

abstract：PURPOSE:To examine sex- and race-associated differences in macular thickness and foveal pit morphology by using spectral-domain optical coherence tomography (SD-OCT). METHODS:One hundred eighty eyes of 90 healthy patients (43 women, 47 men) underwent retinal imaging with spectral-domain OCT. The lateral scale of each ...

journal_title：Investigative ophthalmology & visual science

authors： Wagner-Schuman M,Dubis AM,Nordgren RN,Lei Y,Odell D,Chiao H,Weh E,Fischer W,Sulai Y,Dubra A,Carroll J

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:To test the hypothesis that acute topical dorzolamide (DZ) decreases intraocular pressure (IOP) and increases retinal and choroidal blood flow in the DBA/2J mouse model of glaucoma. METHODS:Retinal and choroidal blood flow were measured in 4- and 9-month-old DBA/2J mice, and 4-month C57BL/6 (control) mice unde...

journal_title：Investigative ophthalmology & visual science

authors： Chandra S,Muir ER,Deo K,Kiel JW,Duong TQ

更新日期：2016-03-01 00:00:00

abstract：:The relationship of the ocular pressure to the anterior ciliary arterial pressure was studied by measuring the pressure of the anterior ciliary artery using a modified pressure chamber. Of the 40 subjects, 9 were normal, 16 were ocular hypertensive patients, and 15 were primary, open-angle, glaucoma patients. A signif...

journal_title：Investigative ophthalmology & visual science

authors： Sakimoto G,Schwartz B

更新日期：1984-08-01 00:00:00

abstract：PURPOSE:To demonstrate the effectiveness of Hierarchical Bayesian (HB) approach in a modeling framework for association effects that accounts for SEs of vision-specific latent traits assessed using Rasch analysis. METHODS:A systematic literature review was conducted in four major ophthalmic journals to evaluate Rasch ...

journal_title：Investigative ophthalmology & visual science

authors： Wong WL,Li X,Li J,Wong TY,Cheng CY,Lamoureux EL

更新日期：2014-07-11 00:00:00

abstract：PURPOSE:Glucocorticoid sensitivity in glaucoma has been attributed to differences in the expression of the two glucocorticoid receptors, GRalpha and GRbeta. GRalpha undergoes steroid-dependent nuclear translocation by associating with a heat shock protein (Hsp)90 multiprotein heterocomplex. The nuclear transport of the...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Clark AF,Yorio T

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To assess the repeatability and interoperator and intersession reproducibility of central corneal thickness (CCT) measurements made by a commercially available optical coherence tomography (OCT) system. METHODS:Intersession and interoperator reproducibility and repeatability were defined according to the guide...

journal_title：Investigative ophthalmology & visual science

authors： Muscat S,McKay N,Parks S,Kemp E,Keating D

更新日期：2002-06-01 00:00:00

abstract：:Vascular luminal castings of rabbit eyes were microdissected and studied with the scanning electron microscope to delineate the anatomy of the ciliary body microvasculature. We found regional microvascular differences corresponding to well known gross topographical and ultrastructural differences that may indicate reg...

journal_title：Investigative ophthalmology & visual science

authors： Morrison JC,DeFrank MP,Van Buskirk EM

更新日期：1987-08-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration (AMD), the most common cause of incurable blindness in the western world, is characterized by the dysfunction and eventual death of choroidal endothelial (CECs), RPE, and photoreceptor cells. Stem cell-based treatment strategies designed to replace photoreceptor and RPE cells cu...

journal_title：Investigative ophthalmology & visual science

authors： Songstad AE,Wiley LA,Duong K,Kaalberg E,Flamme-Wiese MJ,Cranston CM,Riker MJ,Levasseur D,Stone EM,Mullins RF,Tucker BA

更新日期：2015-12-01 00:00:00

abstract：:The characterization of beta-adrenergic receptors on cultured human trabecular cells and trabecular meshwork from human autopsy eyes was carried out by radioligand binding utilizing (125I)-iodopindolol. In cultured cells, the observed binding of (125I)-iodopindolol was of high affinity (Kd = 43 pM) and saturable. Scat...

journal_title：Investigative ophthalmology & visual science

authors： Wax MB,Molinoff PB,Alvarado J,Polansky J

更新日期：1989-01-01 00:00:00

abstract：:Chloroquine was administered intramuscularly 5 days a week to rhesus monkeys for as long as 4 1/2 years. No clinical, fluorescein angiographic, or electrophysiological evidence of retinal damage was observed. Yet chloroquine/chloroquine byproduct analysis of the ocular tissues revealed an enormous binding capacity of ...

journal_title：Investigative ophthalmology & visual science

authors： Rosenthal AR,Kolb H,Bergsma D,Huxsoll D,Hopkins JL

更新日期：1978-12-01 00:00:00

abstract：Purpose:The activation of the urokinase-type plasminogen activator and its receptor system is associated with retinal diseases. Among peptide inhibitors of this system, UPARANT acts by preventing the onset of pathologic signs of neovascular ocular diseases. We investigated whether systemic UPARANT may act in a therapeu...

journal_title：Investigative ophthalmology & visual science

authors： Cammalleri M,Locri F,Marsili S,Dal Monte M,Pisano C,Mancinelli A,Lista L,Rusciano D,De Rosa M,Pavone V,Bagnoli P

更新日期：2017-06-01 00:00:00

abstract：:Purpose. To establish a theoretical model to determine the relationship between retinal coverage and tamponade shape in relation to tamponade volume, for a variety of tamponades, and to test these relationships with a physical analogue of the human eye. Methods. The theoretical model was based on a static balance betw...

journal_title：Investigative ophthalmology & visual science

authors： Eames I,Angunawela RI,Aylward GW,Azarbadegan A

更新日期：2010-04-01 00:00:00

abstract：Purpose:Our goal was to generate and characterize a new mouse model in which only angiogenesis- and glaucoma-relevant tissues would be naturally fluorescent. The Matrix Gla (MGP) gene is highly expressed in vascular smooth muscle cells (VSMC) and trabecular meshwork (TM). We sought to direct our Mgp-Cre.KI mouse recomb...

journal_title：Investigative ophthalmology & visual science

authors： Asokan P,Mitra RN,Periasamy R,Han Z,Borrás T

更新日期：2018-02-01 00:00:00

abstract：:Cyclodestructive modalities in humans have been shown to be effective when applied 3.5 mm or more posterior to the limbus. Therefore, CW Nd:YAG contact transscleral laser and cryopexy were applied 6 mm posterior to the limbus of pigmented rabbits. The intraocular pressure (IOP), flare, iritis, cells and conjunctival h...

journal_title：Investigative ophthalmology & visual science

authors： Schubert HD,Federman JL

更新日期：1989-03-01 00:00:00

abstract：PURPOSE:To our knowledge, studies comparing binocular eye movements during reading task in strabismic children are scarce. The goal of our study was to examine binocular coordination of saccades during reading in strabismic children. METHODS:Binocular eye movements were recorded by an infrared system (mobile EBT) in 1...

journal_title：Investigative ophthalmology & visual science

authors： Lions C,Bui-Quoc E,Seassau M,Bucci MP

更新日期：2013-01-21 00:00:00

abstract：:The integrity of the RPE barrier function in retinal detachment was studied in vitro. The retinal pigment epithelium (RPE)-choroid tissue was isolated from cynomolgus monkey eyes with acute (less than 1 hr), subacute (1-2 weeks), and chronic (8-20 months) retinal detachments, and clamped between Ussing-type chambers. ...

journal_title：Investigative ophthalmology & visual science

authors： Tsuboi S,Pederson JE,Toris CB

更新日期：1987-11-01 00:00:00

abstract：:The autofluorescence of reduced pyridine nucleotides (NADH and NADPH) and oxidized flavoproteins within the rabbit cornea were noninvasively measured as a function of depth. This was accomplished by combining a corneal specular microscope with a time-shared spectrofluorometer. When either 8 mM sodium pentobarbital or ...

journal_title：Investigative ophthalmology & visual science

authors： Laing RA,Fischbarg J,Chance B

更新日期：1980-01-01 00:00:00