Homocysteine levels in the vitreous of proliferative diabetic retinopathy and rhegmatogenous retinal detachment: its modulating role on lysyl oxidase.

abstract：:The corneas of 12 eye donors with maturity-onset diabetes were obtained, and the corneal epithelial basement membranes were studied by transmission electron microscopy. Similar tissue was obtained from 12 nondiabetic eye donors who were matched for age (within 2 years) and race. The mean thickness of the corneal epith...

journal_title：Investigative ophthalmology & visual science

authors： Taylor HR,Kimsey RA

更新日期：1981-04-01 00:00:00

abstract：PURPOSE:Orbital eye position and vestibular sensitivity have both been postulated to influence vestibulo-ocular reflex (VOR) axis direction. The interaction of these factors in unilateral vestibular deafferentation (UVD) was examined. METHODS:Initial VOR direction and magnitude were examined in six normal human subjec...

journal_title：Investigative ophthalmology & visual science

authors： Crane BT,Tian J,Ishiyama A,Demer JL

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:T cells play an important role in the pathogenesis of uveitis. Recent studies have indicated that the TNFSF15 gene that encodes the TL1A protein can regulate the differentiation and activation of T cells. TNFSF15 gene polymorphisms have been found to be associated with several autoimmune disorders. A possible a...

journal_title：Investigative ophthalmology & visual science

authors： Li H,Hou S,Yu H,Zheng M,Zhang L,Zhang J,Zhang Q,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Migration of Müller glial cells is enhanced in proliferative retinopathies, but the mechanisms involved are ill defined. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid synthesized by sphingosine kinase (SphK), which promotes proliferation, migration, and inflammation, acting as an intracellular media...

journal_title：Investigative ophthalmology & visual science

authors： Simón MV,Prado Spalm FH,Politi LE,Rotstein NP

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Lenses from selenite-treated animals develop reversible "cold cataract" at a lower temperature than is required for lenses from age-matched control animals. This unexplained, stabilized phase transition is readily observed in intact lenses 36 to 48 hours after treatment and occurs in lenses before the appearanc...

journal_title：Investigative ophthalmology & visual science

authors： Mitton KP,Hess JL,Bunce GE

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:We identified a topographic relation of localized reticular pseudodrusen (RPD) to choroidal watershed zones (CWZ) and to changes in choroidal volumes (CV). METHODS:We included 30 eyes of 30 patients with RPD in an area <10 mm(2) and no other retinal alteration (76.7 ± 6.9 years). Patients underwent spectral-do...

journal_title：Investigative ophthalmology & visual science

authors： Alten F,Clemens CR,Heiduschka P,Eter N

更新日期：2013-05-07 00:00:00

abstract：PURPOSE:We measured the aqueous humor levels of matrix metalloproteinases (MMP) MMP-1, MMP-2, MMP-3, and tissue inhibitors of matrix metalloproteinases (TIMP) TIMP-1, TIMP-2, and TIMP-3 in patients with myopia or cataract, and investigated the relationship between their levels and axial length (AL). METHODS:We measure...

journal_title：Investigative ophthalmology & visual science

authors： Jia Y,Hu DN,Zhu D,Zhang L,Gu P,Fan X,Zhou J

更新日期：2014-05-29 00:00:00

abstract：PURPOSE:To compare the ability of several machine learning classifiers to predict development of abnormal fields at follow-up in ocular hypertensive (OHT) eyes that had normal visual fields in baseline examination. METHODS:The visual fields of 114 eyes of 114 patients with OHT with four or more visual field tests with...

journal_title：Investigative ophthalmology & visual science

authors： Sample PA,Goldbaum MH,Chan K,Boden C,Lee TW,Vasile C,Boehm AG,Sejnowski T,Johnson CA,Weinreb RN

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:One of the methods used in macular translocation (MT) surgery for subfoveal neovascularization is to create a temporary total retinal detachment followed by a 360 degrees retinotomy. The whole retina is then shifted from the original surface of the retinal pigment epithelium (RPE), resulting in an unusual retin...

journal_title：Investigative ophthalmology & visual science

authors： Terasaki H,Miyake Y,Suzuki T,Niwa T,Piao CH,Suzuki S,Nakamura M,Kondo M

更新日期：2002-02-01 00:00:00

abstract：:Vitrectomy has been shown to halt diabetic retinal neovascularization, but the mechanism of this process is unknown. We propose that vitrectomy improves the oxygen supply to ischemic inner retina by way of fluid currents in the vitreous cavity. In order to test this hypothesis, we induced branch retinal vein occlusion...

journal_title：Investigative ophthalmology & visual science

authors： Stefánsson E,Novack RL,Hatchell DL

更新日期：1990-02-01 00:00:00

abstract：PURPOSE:Corneal allografts placed in human eyes at high risk often fail, and immune rejection is thought to be a major pathogenic factor. To understand the immunologic factors responsible for rejection in this instance, the authors have created "high-risk" eyes in mice by inducing corneal neovascularization. The author...

journal_title：Investigative ophthalmology & visual science

authors： Sano Y,Ksander BR,Streilein JW

更新日期：1995-10-01 00:00:00

abstract：Purpose:We examined the pattern and extent of connective tissue distribution in the extraocular muscles (EOMs) and determined the ability of the interconnected connective tissues to disseminate force laterally. Methods:Human EOMs were examined for collagens I, III, IV, and VI; fibronectin; laminin; and elastin using i...

journal_title：Investigative ophthalmology & visual science

authors： McLoon LK,Vicente A,Fitzpatrick KR,Lindström M,Pedrosa Domellöf F

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To examine changes in spherical equivalent over a 5-year period in persons 43 to 84 years of age. METHODS:All people 43 to 84 years of age and living in Beaver Dam, Wisconsin, in 1988 were invited for a baseline examination (1988-1990) and a 5-year follow-up examination (1993-1995). Refractions were determined...

journal_title：Investigative ophthalmology & visual science

authors： Lee KE,Klein BE,Klein R

更新日期：1999-07-01 00:00:00

abstract：Purpose:Diabetic retinopathy (DR) is a leading cause of vision impairment and blindness worldwide in the working-age population, and the incidence is rising. Until now it has been difficult to define initiating events and disease progression at the molecular level, as available diabetic rodent models do not present the...

journal_title：Investigative ophthalmology & visual science

authors： Ali Z,Zang J,Lagali N,Schmitner N,Salvenmoser W,Mukwaya A,Neuhauss SCF,Jensen LD,Kimmel RA

更新日期：2020-02-07 00:00:00

abstract：PURPOSE:Diabetic complications are associated with hypoglycemia and hyperglycemia. The purpose of this study was to investigate the effect of both glucose deprivation and hyperglycemia on the induction of endoplasmic reticulum (ER) stress and the subsequent activation of the unfolded protein response (UPR) that results...

journal_title：Investigative ophthalmology & visual science

authors： Mulhern ML,Madson CJ,Danford A,Ikesugi K,Kador PF,Shinohara T

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:Previous studies have shown that insulin-like growth factor-binding protein (IGFBP)-2 is markedly upregulated in senescent RPE cells in vitro, and might therefore be a marker of senescent cells in vivo. This study was conducted to determine whether IGFBP-2 expression in human RPE cells from the macula and perip...

journal_title：Investigative ophthalmology & visual science

authors： Miyamura N,Mishima K,Honda S,Aotaki-Keen AE,Morse LS,Handa JT,Hjelmeland LM

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration is a common form of vision loss affecting older adults. The etiology of AMD is multifactorial and is influenced by environmental and genetic risk factors. In this study, we examine how 19 common risk variants contribute to drusen progression, a hallmark of AMD pathogenesis. MET...

journal_title：Investigative ophthalmology & visual science

authors： Hoffman JD,van Grinsven MJ,Li C,Brantley M Jr,McGrath J,Agarwal A,Scott WK,Schwartz SG,Kovach J,Pericak-Vance M,Sanchez CI,Haines JL

更新日期：2016-04-01 00:00:00

abstract：Purpose:Dry eye disease (DED) is a multifactorial disease associated with ocular surface inflammation. Toll-like receptors (TLRs) are integral in the initiation of inflammatory signaling. Therefore, we evaluated the effect of TLR-deficiency on dry eye-related ocular surface damage and inflammation using a mouse model o...

journal_title：Investigative ophthalmology & visual science

authors： Reins RY,Lema C,Courson J,Kunnen CME,Redfern RL

更新日期：2018-06-01 00:00:00

abstract：:The authors sought S-100 protein in sections cut from formalin- or glutaraldehyde-fixed, paraffin-embedded tumors from the eye and other sites by an immunoperoxidase technique, using rabbit antibovine S-100 protein antiserum, swine antirabbit serum, a peroxidase-antiperoxidase preparation, and amino-ethylcarbizole as ...

journal_title：Investigative ophthalmology & visual science

authors： Cochran AJ,Holland GN,Wen DR,Herschman HR,Lee WR,Foos RY,Straatsma BR

更新日期：1983-08-01 00:00:00

abstract：PURPOSE:Our previous work indicated that a larger circumferential Young's modulus (E) of trabecular meshwork (TM) correlated with a higher outflow facility (C) in normal human donor eyes. The current study investigated the influence of glaucomatous TM stiffness and cellularity on C. METHODS:Eight left eyes from glauco...

journal_title：Investigative ophthalmology & visual science

authors： Camras LJ,Stamer WD,Epstein D,Gonzalez P,Yuan F

更新日期：2014-02-10 00:00:00

abstract：PURPOSE:To evaluate the dynamic changes in refraction during the accommodative facility test in myopes and emmetropes. METHODS:Ten myopes and 10 emmetropes participated in the study. All were young adults, and refractive error in the myopes was corrected with soft contact lenses. Monocular accommodative facility measu...

journal_title：Investigative ophthalmology & visual science

authors： Radhakrishnan H,Allen PM,Charman WN

更新日期：2007-09-01 00:00:00

abstract：:In an anisotonic medium the tendency of the lens to swell or shrink in response to the osmotic gradient is countered by a change in the content of lens solute, so that the change in the volume of lens water is minimal. This phenomenon is known as volume regulation. The rapid phase of volume regulation occurs in less t...

journal_title：Investigative ophthalmology & visual science

authors： Patterson JW

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:To determine the influence of eye pigmentation on transscleral retinal delivery of celecoxib. METHODS:Melanin content in ocular tissues of both the strains was determined by sodium hydroxide solubilization METHOD:The affinity of celecoxib to synthetic and natural melanin was estimated by co-incubating celecox...

journal_title：Investigative ophthalmology & visual science

authors： Cheruvu NP,Amrite AC,Kompella UB

更新日期：2008-01-01 00:00:00

abstract：Purpose:Adult central nervous system (CNS) neurons are unable to regenerate their axons after injury. Krüppel-like transcription factor (KLF) family members regulate intrinsic axon growth ability in vitro and in vivo, but mechanisms downstream of these transcription factors are not known. Methods:Purified retinal gang...

journal_title：Investigative ophthalmology & visual science

authors： Galvao J,Iwao K,Apara A,Wang Y,Ashouri M,Shah TN,Blackmore M,Kunzevitzky NJ,Moore DL,Goldberg JL

更新日期：2018-06-01 00:00:00

abstract：:Visual acuity of infants and young children with ophthalmologic disorders was assessed by adapting a transformed up-down staircase to preferential looking (PL) procedures. Eighty-five percent of pediatric patients between 11 days and 5 years of age were tested successfully. Acuity of infants and young children with no...

journal_title：Investigative ophthalmology & visual science

authors： Mayer DL,Fulton AB,Hansen RM

更新日期：1982-10-01 00:00:00

abstract：PURPOSE:To investigate whether polymorphisms in the gene encoding the chemokine receptor CX3CR1, which has been linked to changes in functional ligand-binding activity, are associated with retinal vasculitis (RV) in a cohort of patients in the United Kingdom. METHODS:DNA was prepared from whole blood of 126 patients w...

journal_title：Investigative ophthalmology & visual science

authors： Wallace GR,Vaughan RW,Kondeatis E,Mathew R,Chen Y,Graham EM,Stanford MR

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To evaluate diurnal intraocular pressure (DIOP) among individuals with primary angle closure (PAC) or primary angle-closure suspect (PACS). Additionally, the hypothesis that greater DIOP fluctuation is related to smaller angle parameters was investigated. METHODS:Forty Caucasian newly referred untreated patien...

journal_title：Investigative ophthalmology & visual science

authors： Sanchez-Parra L,Pardhan S,Buckley RJ,Parker M,Bourne RR

更新日期：2015-05-01 00:00:00

abstract：:An analysis of size, shape, vacuole and cell counts of Schlemm's canal was undertaken in 20 human eyes that had undergone conventional immersion fixation. A reduction in vacuole count with age was shown to be associated with a decreased canal cell count. The decrease in cell count with age was closely linked to an age...

journal_title：Investigative ophthalmology & visual science

authors： Ainsworth JR,Lee WR

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:Adeno-associated viral (AAV) vectors have been used to express several different proteins in the eye. The purpose of this study was to determine whether AAV-mediated intraocular gene transfer of pigment epithelium-derived factor (PEDF) inhibits the development of choroidal neovascularization (CNV) in a murine m...

journal_title：Investigative ophthalmology & visual science

authors： Mori K,Gehlbach P,Yamamoto S,Duh E,Zack DJ,Li Q,Berns KI,Raisler BJ,Hauswirth WW,Campochiaro PA

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:Acute optic neuritis (ON) is often followed by recovery of visual function. Although this recovery is mainly attributable to resolution of the acute inflammation, the redistribution of ion channels along the demyelinated membrane, and subsequent remyelination, part of it may be the result of neural plasticity. ...

journal_title：Investigative ophthalmology & visual science

authors： Klistorner A,Arvind H,Garrick R,Graham SL,Paine M,Yiannikas C

更新日期：2010-05-01 00:00:00