Biosynthetic human EGF accelerates healing of Neodecadron-treated primate corneas.

abstract：PURPOSE:Oxidative stress and cellular senescence are known to contribute to the development of AMD; however, the mechanism is not fully understood. This study investigated the role of TGF-β-activated kinase 1 (TAK1) in the senescence of RPE cells as a model for the development of dry AMD. METHODS:Cultured human RPE ce...

journal_title：Investigative ophthalmology & visual science

authors： Dvashi Z,Green Y,Pollack A

更新日期：2014-08-12 00:00:00

abstract：PURPOSE:Children with cortical or cerebral visual impairment (CVI) often experience photophobia. In a study conducted to test whether this clinical phenomenon affects visual function, the sweep visual evoked potential (VEP) was used to evaluate cortical responses to grating stimuli in two luminance conditions: low and ...

journal_title：Investigative ophthalmology & visual science

authors： Good WV,Hou C

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:Recently, RAP1 (Telomeric Repeat Binding Factor 2, Interacting Protein [TERF2IP]) was discovered as a modulator that selectively regulates nuclear factor light chain kappa enhancer of activated B cells (NFκB) signaling. The roles of RAP1 in regulation of inflammation and angiogenesis for corneal recovery follow...

journal_title：Investigative ophthalmology & visual science

authors： Poon MW,Yan L,Jiang D,Qin P,Tse HF,Wong IY,Wong DS,Tergaonkar V,Lian Q

更新日期：2015-01-08 00:00:00

abstract：PURPOSE:This study investigated a novel motion-on-color paradigm to functionally isolate the magnocellular pathway and evaluate its diagnostic value in preperimetric glaucoma patients. METHODS:Thirty patients with preperimetric primary open-angle glaucoma and 30 controls participated in this study. They were tested in...

journal_title：Investigative ophthalmology & visual science

authors： Wen W,Zhang P,Liu T,Zhang T,Gao J,Sun X,He S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To study retinal microstructure in Usher Syndrome type 1B (USH1B) caused by MYO7A mutations as a prelude to treatment initiatives. METHODS:Patients with MYO7A-USH1B (n=17; ages 5-61) were studied with optical coherence tomography. Retinal laminae across horizontal and vertical meridians were measured. Colocali...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Aleman TS,Sumaroka A,Cideciyan AV,Roman AJ,Windsor EA,Schwartz SB,Rehm HL,Kimberling WJ

更新日期：2009-04-01 00:00:00

abstract：Purpose:To assess the connection among arterioles, venules, and capillaries in three retinal capillary plexuses using optical coherence tomography angiography (OCTA). Methods:This was a prospective, cross-sectional, observational study including 20 eyes of 10 healthy subjects. En face and cross-sectional OCTA images w...

journal_title：Investigative ophthalmology & visual science

authors： Nesper PL,Fawzi AA

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:To determine the fate of donor epithelial, stromal, and endothelial cells after corneal transplantation in humans. METHODS:Fifty-two transplanted corneal buttons were explanted over a 2-year period from patients who required regrafting and had received corneas from donors of opposite sex. Fluorescence in situ ...

journal_title：Investigative ophthalmology & visual science

authors： Lagali N,Stenevi U,Claesson M,Fagerholm P,Hanson C,Weijdegård B,Swedish Society of Corneal Surgeons.

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:To assess corneal epithelial cell survival after keratoplasty. METHODS:Corneal impression cytology (CIC) was performed on sex-mismatched corneal transplants. Fluorescent in situ hybridization (FISH) with sex chromosome-specific probes was performed to identify epithelial cell mosaicism and therefore allocate t...

journal_title：Investigative ophthalmology & visual science

authors： Catanese M,Popovici C,Proust H,Hoffart L,Matonti F,Cochereau I,Conrath J,Gabison EE

更新日期：2011-02-22 00:00:00

abstract：PURPOSE:Stereoscopic displays challenge the neural cross-coupling between accommodation and vergence by inducing a constant accommodative demand and a varying vergence demand. Stereoscopic viewing calls for a decrease in the gain of vergence accommodation, which is the accommodation caused by vergence, quantified by us...

journal_title：Investigative ophthalmology & visual science

authors： Neveu P,Roumes C,Philippe M,Fuchs P,Priot AE

更新日期：2016-08-01 00:00:00

abstract：Purpose:To investigate diabetic optic neuropathy (DON) prevalence and risk factors in Chinese diabetic retinopathy (DR) patients. Methods:This retrospective study included 1067 eyes (550 patients) that underwent ocular imaging. The diabetes duration, systolic blood pressure (SBP), hemoglobin A1c (HbA1c), and high-dens...

journal_title：Investigative ophthalmology & visual science

authors： Hua R,Qu L,Ma B,Yang P,Sun H,Liu L

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:The RAS association domain family 1 (RASSF1) gene is a tumor-suppressor gene located on chromosome 3p21.3. The alternative transcript (RASSF1a) has been shown to be inactivated by hypermethylation in several human malignancies, including breast, prostate, and lung cancer, and in cutaneous melanoma. The purpose ...

journal_title：Investigative ophthalmology & visual science

authors： Maat W,van der Velden PA,Out-Luiting C,Plug M,Dirks-Mulder A,Jager MJ,Gruis NA

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:The role of the Wnt[b]/beta-catenin-dependent pathway (canonical Wnt pathway) in the context of retinal development and homeostasis is largely unknown. This study was undertaken to characterize activation of the Wnt canonical pathway and its relevance to cell type populations in the developing and adult retina....

journal_title：Investigative ophthalmology & visual science

authors： Liu H,Thurig S,Mohamed O,Dufort D,Wallace VA

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:To investigate the relationship between photopic open-loop accommodation and vergence and the effect of mental effort on these positions. METHODS:Twenty subjects (11 men and 9 women) viewed monocularly a photopic (25 cdm-2), high-contrast (90%) Maltese cross-target for 3 minutes, through a 0.5-mm pinhole drill...

journal_title：Investigative ophthalmology & visual science

authors： Gray LS,Winn B,Gilmartin B,Eadie AS

更新日期：1993-09-01 00:00:00

abstract：:We studied the effect of topical timolol maleate 0.5% on the retinal circulation of eyes with ocular hypertension using laser Doppler velocimetry and monochromatic fundus photography. Patients with ocular hypertension had normal eye examinations and had documented elevated intraocular pressures of 23 mmHg or higher on...

journal_title：Investigative ophthalmology & visual science

authors： Grunwald JE

更新日期：1990-03-01 00:00:00

abstract：:Exposure of adult male and female albino rats to high-intensity illumination for 17.5 hr results in a marked, transient exophthalmos, which persists for approximately 48 hr after the light exposure. Upon examination of the Harderian glands in these rats, a significant glandular weight increase was observed up to 2 day...

journal_title：Investigative ophthalmology & visual science

authors： Johnson DD,Rudeen PK,O'Steen WK

更新日期：1979-12-01 00:00:00

abstract：PURPOSE:To report neural rim dimensions for South Indians and examine rim shape with relevance to clinical evaluation. METHODS:Healthy phakic participants (n = 623) of the Chennai Glaucoma Study with normal frequency-doubling perimetry underwent complete eye examinations including optic disc digital stereophotography....

journal_title：Investigative ophthalmology & visual science

authors： Arvind H,George R,Raju P,Ve RS,Mani B,Kannan P,Vijaya L

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To determine the intergrader reproducibility for computer-assisted grading of optical coherence tomography (OCT) images in eyes with neovascular age-related macular degeneration (AMD), by using a standardized grading procedure. METHODS:Sixty OCT image sets (of six radial lines each) were independently analyzed...

journal_title：Investigative ophthalmology & visual science

authors： Joeres S,Tsong JW,Updike PG,Collins AT,Dustin L,Walsh AC,Romano PW,Sadda SR

更新日期：2007-09-01 00:00:00

abstract：:Lateral heterophoria at distance often is cited as an index of tonic vergence, yet recent research has shown that vergence in darkness is more convergent than most measures of phoria. Two experiments were conducted to investigate the possible role of accommodation in this discrepancy. Experiment I compared measures of...

journal_title：Investigative ophthalmology & visual science

authors： Owens DA,Tyrrell RA

更新日期：1992-08-01 00:00:00

abstract：:Male albino rats, injected intravenously or intracerebroventricularly with delta 1-tetrahydrocannabinol (THC), develop mudriasis. The median effective dose of the intravenous administration group was 5 mg/kg THC, whereas that for the intracerebroventricular route was 150 microgram/kg THC. Sympathectomy significantly d...

journal_title：Investigative ophthalmology & visual science

authors： Korczyn AD,Eshel Y

更新日期：1982-03-01 00:00:00

abstract：PURPOSE:To investigate the effect of amino acids on ornithine cytotoxicity in ornithine-delta-aminotransferase (OAT)-deficient human retinal pigment epithelial (RPE) cells as an in vitro model of gyrate atrophy (GA) of the choroid and retina. METHODS:RPE cells were treated with 0.5 mM 5-fluoromethylornithine (5-FMOrn)...

journal_title：Investigative ophthalmology & visual science

authors： Nakauchi T,Ando A,Ueda-Yamada M,Yamazaki Y,Uyama M,Matsumura M,Ito S

更新日期：2003-11-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) can infect the cornea and achieve ganglionic latency. HSV-1 can later be activated by a variety of effectors although the exact mechanism of reactivation is unknown. Rabbits harboring latent HSV-1 strain McKrae can be induced to shed virus by ocular iontophoresis of epinephrine to t...

journal_title：Investigative ophthalmology & visual science

authors： Rootman DS,Haruta Y,Hill JM,Kaufman HE

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:To investigate the application of anterior corneal and ocular aberrations in detecting mildly ectatic corneas. METHODS:This study retrospectively reviewed the data of 220 eyes separated into three groups by the NIDEK Corneal Navigator System automated corneal classification software: normal (N) (n = 123); form...

journal_title：Investigative ophthalmology & visual science

authors： Saad A,Gatinel D

更新日期：2012-05-17 00:00:00

abstract：:Chronic blepharitis has been a difficult disease to define either microbiologically or biochemically. Sterols from meibomian secretions of normal subjects and patients were analyzed, and important differences were observed. Based on analyses of these secretions, two significantly different (P less than 0.001) types of...

journal_title：Investigative ophthalmology & visual science

authors： Shine WE,McCulley JP

更新日期：1991-07-01 00:00:00

abstract：PURPOSE:To investigate the role of nitric oxide synthase (NOS) in photoreceptor degeneration associated with photodynamic therapy (PDT) in a laser-induced model of choroidal neovascularization (CNV). METHODS:PDT was performed in monkey and Brown Norway rats with laser-induced CNV. L-NAME, a NOS inhibitor, or saline wa...

journal_title：Investigative ophthalmology & visual science

authors： She H,Nakazawa T,Matsubara A,Hisatomi T,Young TA,Michaud N,Connolly E,Hafezi-Moghadam A,Gragoudas ES,Miller JW

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:To test the hypothesis that the robust expansion of bovine corneal endothelial cells (BCECs) in vitro is due to the presence of individual endothelial cells with various levels of proliferative potential. METHODS:BCECs and bovine vascular endothelial cells (ECs) derived from aorta, coronary artery, and pulmona...

journal_title：Investigative ophthalmology & visual science

authors： Huang L,Harkenrider M,Thompson M,Zeng P,Tanaka H,Gilley D,Ingram DA,Bonanno JA,Yoder MC

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Varicella zoster virus (VZV) is a common cause of infectious uveitis associated with an intraocular inflammatory response involving virus-specific T cells. In the current study, the functional characteristics and the antigen specificity of VZV-reactive T cells recovered from intraocular fluid (IOF) samples of f...

journal_title：Investigative ophthalmology & visual science

authors： Milikan JC,Kinchington PR,Baarsma GS,Kuijpers RW,Osterhaus AD,Verjans GM

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:To determine the involvement of calpain in ovine cataractogenesis by measuring calcium, calpain activity, proteolysis, and the effect of calpain inhibition. METHODS:Sheep with genetic cataracts were examined for cataract severity. Calcium in normal and cataract lenses was measured. The presence of calpain was ...

journal_title：Investigative ophthalmology & visual science

authors： Robertson LJ,Morton JD,Yamaguchi M,Bickerstaffe R,Shearer TR,Azuma M

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:To determine the effects of overexpression of mutated BIGH3 in HeLa and human corneal epithelial (HCE) cells. METHODS:Six mutations known to be responsible for autosomal dominant corneal dystrophies linked to chromosome 5 were generated in a BIGH3 expression vector and transfected in HeLa and HCE cells. The ex...

journal_title：Investigative ophthalmology & visual science

authors： Morand S,Buchillier V,Maurer F,Bonny C,Arsenijevic Y,Munier FL,Schorderet DF

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:To assess the reproducibility of the ocular response analyzer (ORA) in nonoperated eyes and the impact of corneal biomechanical properties on intraocular pressure (IOP) measurements in normal and glaucomatous eyes. METHODS:In the reliability study, two independent examiners obtained repeated ORA measurements i...

journal_title：Investigative ophthalmology & visual science

authors： Moreno-Montañés J,Maldonado MJ,García N,Mendiluce L,García-Gómez PJ,Seguí-Gómez M

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine the relationship between objectively measured ambient light exposure and longitudinal changes in axial eye growth in childhood. METHODS:A total of 101 children (41 myopes and 60 nonmyopes), 10 to 15 years of age participated in this prospective longitudinal observationa...

journal_title：Investigative ophthalmology & visual science

authors： Read SA,Collins MJ,Vincent SJ

更新日期：2015-10-01 00:00:00