Mapping canonical Wnt signaling in the developing and adult retina.

abstract：:The uveal absorption of aqueous humor at two different intraocular pressures was measured in rhesus monkeys by sampling vortex vein blood during anterior chamber perfusion of Ringer's solution containing both fluorescein and 125I albumin. At 20 mm. Hg, an excess of fluorescein equivalent in amount to 0.45 microliter/m...

journal_title：Investigative ophthalmology & visual science

authors： Pederson JE,Gaasterland DE,MacLellan HM

更新日期：1977-11-01 00:00:00

abstract：PURPOSE:Bayesian estimators allow the frequency of visual field progression rates in the population (the prior distribution) to constrain rate estimates for individuals. We examined the benefits of a prior distribution accounting for one of progression's major risk factors--whether intraocular pressure is treated--to g...

journal_title：Investigative ophthalmology & visual science

authors： Anderson AJ,Johnson CA

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:To investigate the effect of Fas and Fas ligand (FasL) deficiency on the development of herpes stromal keratitis and on the von Szily model of herpes retinitis in C57BL/6 mice, which are ordinarily resistant to development of both of these herpetic diseases. METHODS:Anterior chamber inoculation of the right ey...

journal_title：Investigative ophthalmology & visual science

authors： Nguyen QD,Uy HS,Merchant A,Medina CA,Baltatzis S,Zhao T,Zhao ZS,Cantor H,Foster CS

更新日期：2001-10-01 00:00:00

abstract：:Freshly enucleated monkey, calf, and human eyes were quantitatively perfused with mock aqueous humor through the anterior chamber by a constant pressure technique. After baseline perfusion at 15 mm Hg, intraocular pressure was raised to 45 mm Hg and later reduced back to 15 mm Hg. Calf and human (both adult and infant...

journal_title：Investigative ophthalmology & visual science

authors： Hashimoto JM,Epstein DL

更新日期：1980-12-01 00:00:00

abstract：Purpose:To investigate factors associated with visual field (VF) progression in treated myopic normal-tension glaucoma (NTG) using a novel posterior sclera reconstruction method involving swept-source optical coherence tomography (OCT). Methods:Fifty-six myopic patients on ocular hypotensive therapy with the diagnose ...

journal_title：Investigative ophthalmology & visual science

authors： Kim YC,Koo YH,Jung KI,Park CK

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To determine whether dexamethasone (DEX)-induced ocular hypertension (OHT) in mice mimics the hallmarks of steroid-induced glaucoma (SIG) in humans, including reduced conventional outflow facility (C), increased extracellular matrix (ECM), and myofibroblasts within the outflow pathway. METHODS:Osmotic mini-pum...

journal_title：Investigative ophthalmology & visual science

authors： Overby DR,Bertrand J,Tektas OY,Boussommier-Calleja A,Schicht M,Ethier CR,Woodward DF,Stamer WD,Lütjen-Drecoll E

更新日期：2014-07-15 00:00:00

abstract：Purpose:To examine the early glial reactivity and neuron damage in response to short-term cerebrospinal fluid pressure (CSFp) reduction, as compared with intraocular pressure (IOP) elevation. Methods:The experiment included 54 male Sprague-Dawley rats with elevated translaminar cribrosa pressure difference (TLPD), def...

journal_title：Investigative ophthalmology & visual science

authors： Li XX,Zhang Z,Zeng HY,Wu S,Liu L,Zhang JX,Liu Q,Yang DY,Wang NL

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:Leber congenital amaurosis (LCA) is a group of childhood-onset retinal diseases characterized by severe visual impairment or blindness. One form is caused by mutations in the RPE65 gene, which encodes the retinal pigment epithelium (RPE) isomerase. In this study, the retinal structure and expression of molecula...

journal_title：Investigative ophthalmology & visual science

authors： Hernández M,Pearce-Kelling SE,Rodriguez FD,Aguirre GD,Vecino E

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine the possibility that all-trans-retinoic acid (RA) in the eye is a signal related to changes in scleral extracellular matrix in a primate model of postnatal eye growth. METHODS:Juvenile marmosets (Callithrix jacchus) were divided into two experimental groups based on the...

journal_title：Investigative ophthalmology & visual science

authors： Troilo D,Nickla DL,Mertz JR,Summers Rada JA

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:This study evaluated the role for poly(ADP-ribose) polymerase (PARP) in diabetes-induced cataractogenesis and early retinal changes. METHODS:Control and streptozotocin (STZ)-diabetic rats were treated with or without the PARP inhibitors 1,5-isoquinolinediol (ISO; 3 mg kg(-1) d(-1) intraperitoneally) and 10-(4-...

journal_title：Investigative ophthalmology & visual science

authors： Drel VR,Xu W,Zhang J,Kador PF,Ali TK,Shin J,Julius U,Slusher B,El-Remessy AB,Obrosova IG

更新日期：2009-04-01 00:00:00

abstract：:Intact rod photoreceptors were dissociated from pronase-treated whole retinas of adult mice by repeated passage through a plastic pipette tip. Hemocytometer counts of the cell suspensions indicate that, during a series of ten dissociation steps, a total of about 1-2 million intact photoreceptor cells are dissociated f...

journal_title：Investigative ophthalmology & visual science

authors： Lolley RN,Lee RH,Chase DG,Racz E

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:To identify the defective gene in the sex-linked, recessively inherited retinal dysplasia and degeneration (rdd) chicken and to search for the human equivalent disease. METHODS:Microsatellites from chicken chromosome Z were genotyped in 77 progeny of a carrier male (rdd/+) and an affected female (rdd/W), and c...

journal_title：Investigative ophthalmology & visual science

authors： Ali M,Hocking PM,McKibbin M,Finnegan S,Shires M,Poulter JA,Prescott K,Booth A,Raashid Y,Jafri H,Ruddle JB,Mackey DA,Jacobson SG,Toomes C,Lester DH,Burt DW,Curry WJ,Inglehearn CF

更新日期：2011-09-27 00:00:00

abstract：PURPOSE:To assess the prevalence, distribution, and demographic associations of refractive error in an urban population in southern India. METHODS:Two thousand five hundred twenty-two subjects of all ages, representative of the Hyderabad population, were examined in the population-based Andhra Pradesh Eye Disease Stud...

journal_title：Investigative ophthalmology & visual science

authors： Dandona R,Dandona L,Naduvilath TJ,Srinivas M,McCarty CA,Rao GN

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:Estimates of the incidences of severe visual impairment and blindness (SVI/B) and their causes are key to good health service planning. Thus, the database of Germany's largest state's blind registry was used to estimate current incidence rates (IR) and to project rates for Germany in 2010 and 2030. METHODS:The...

journal_title：Investigative ophthalmology & visual science

authors： Finger RP,Fimmers R,Holz FG,Scholl HP

更新日期：2011-06-21 00:00:00

abstract：PURPOSE:The link between nasal-temporal motion asymmetries and anomalous binocular sensory function in infantile esotropia (ET) has led to the idea that visual evoked potential responses to horizontal motion (mVE) is an alternative measure of sensory binocularity to stereopsis. A second hypothesis is that the mVEP resp...

journal_title：Investigative ophthalmology & visual science

authors： Fawcett SL,Birch EE

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:To examine the retinotoxic effect of naphthalene, a powerful oxidative agent and a well-known cataractogenic agent. METHODS:A 10% solution of naphthalene dissolved in paraffin oil was given every other day by gavage to 31 pigmented rabbits for 5 weeks, at a dose of 1 g/kg body weight. Four rabbits who received...

journal_title：Investigative ophthalmology & visual science

authors： Orzalesi N,Migliavacca L,Miglior S

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:To evaluate the performance and potential clinical role of three-dimensional (3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality. METHODS:...

journal_title：Investigative ophthalmology & visual science

authors： Esmaeelpour M,Povazay B,Hermann B,Hofer B,Kajic V,Kapoor K,Sheen NJ,North RV,Drexler W

更新日期：2010-10-01 00:00:00

abstract：Purpose:Neovascularization (NV) and retinal vascular leakage are major causes of impaired vision in ocular diseases. The purpose of this study was to identify novel phenylphthalimide analogs with therapeutic effects on NV and vascular leakage and to explore the mechanism of action. Methods:Antiangiogenic activities of...

journal_title：Investigative ophthalmology & visual science

authors： Wang B,Li PK,Ma JX,Chen D

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:Corneas with scars and certain chronic pathologic conditions contain highly sulfated dermatan sulfate, but little is known of the core proteins that carry these atypical glycosaminoglycans. In this study the proteoglycan proteins attached to dermatan sulfate in normal and pathologic human corneas were examined ...

journal_title：Investigative ophthalmology & visual science

authors： Funderburgh JL,Hevelone ND,Roth MR,Funderburgh ML,Rodrigues MR,Nirankari VS,Conrad GW

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:To quantitate in vivo retinal ganglion cell (RGC) survival after transient periods of pressure-induced ischemia of the rat retina and after different survival intervals. METHODS:In adult rats, RGCs were labeled with fluorogold applied to their main targets in the brain. Seven days later, in several groups of r...

journal_title：Investigative ophthalmology & visual science

authors： Sellés-Navarro I,Villegas-Pérez MP,Salvador-Silva M,Ruiz-Gómez JM,Vidal-Sanz M

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration (AMD), the most common cause of incurable blindness in the western world, is characterized by the dysfunction and eventual death of choroidal endothelial (CECs), RPE, and photoreceptor cells. Stem cell-based treatment strategies designed to replace photoreceptor and RPE cells cu...

journal_title：Investigative ophthalmology & visual science

authors： Songstad AE,Wiley LA,Duong K,Kaalberg E,Flamme-Wiese MJ,Cranston CM,Riker MJ,Levasseur D,Stone EM,Mullins RF,Tucker BA

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To compare two spectral domain optical coherence tomography (SD-OCT) devices for the identification of angle structures and the presence of angle closure. METHODS:This was a prospective comparative study. Consecutive patients underwent gonioscopy and anterior segment imaging using two SD-OCT devices (iVue and ...

journal_title：Investigative ophthalmology & visual science

authors： Quek DT,Narayanaswamy AK,Tun TA,Htoon HM,Baskaran M,Perera SA,Aung T

更新日期：2012-08-03 00:00:00

abstract：PURPOSE:Trefoil factor family (TFF) peptides, and in particular TFF3, are characteristic secretory products of mucous epithelia that promote antiapoptosis, epithelial migration, restitution, and wound healing. For a long time, a receptor for TFF3 had not yet been identified. However, the chemokine receptor CXCR4 has be...

journal_title：Investigative ophthalmology & visual science

authors： Dieckow J,Brandt W,Hattermann K,Schob S,Schulze U,Mentlein R,Ackermann P,Sel S,Paulsen FP

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Children with idiopathic infantile nystagmus (IIN) exhibit visual acuity deficits that have been modeled in terms of foveation characteristics of the nystagmus waveform. Here we present evidence for an additional component of acuity loss associated with the deprivation experienced during the sensitive period of...

journal_title：Investigative ophthalmology & visual science

authors： Felius J,Muhanna ZA

更新日期：2013-05-01 00:00:00

abstract：:The ability of human and rabbit ocular tissues to degrade prostaglandins (PGs) was compared by following the metabolic fate of PGF2 alpha. No metabolism was observed in vitro after 5.0 hr incubation with human cornea, iris/ciliary body, or sclera, as indicated by the absence of a decrease in [3H]-PGF2 alpha concentrat...

journal_title：Investigative ophthalmology & visual science

authors： Cheng-Bennett A,Poyer J,Weinkam RJ,Woodward DF

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:To investigate the role of intralysosomal redox-active iron in oxidative stress-induced damage in trabecular meshwork (TM) cells. METHODS:Chronic oxidative stress was applied using the hyperoxic model; acute oxidative stress was applied with H(2)O(2). Microarray analysis was performed using microarrays. mRNA a...

journal_title：Investigative ophthalmology & visual science

authors： Lin Y,Epstein DL,Liton PB

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To assess vascular endothelial function in patients with normal pressure glaucoma using forearm blood flow responses to intra-arterial infusions of endothelial-dependent and -independent vasoactive agents. METHODS:Eight patients with newly diagnosed and untreated normal pressure glaucoma and eight healthy age-...

journal_title：Investigative ophthalmology & visual science

authors： Henry E,Newby DE,Webb DJ,O'Brien C

更新日期：1999-07-01 00:00:00

abstract：Purpose:Although retinal dopamine (DA) has been long implicated in myopia development, current studies demonstrate that retinal DA levels are unaltered in C57BL/6 mice with form-deprivation myopia. This work was undertaken to explore whether and how refractive development is perturbed in this mouse strain when retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Wu XH,Qian KW,Xu GZ,Li YY,Ma YY,Huang F,Wang YQ,Zhou X,Qu J,Yang XL,Zhong YM,Weng SJ

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To determine whether messenger RNA coding for fibroblast growth factor receptor-1, interleukin-1 receptor, and glucocorticoid receptor messenger RNA are produced in human lacrimal tissue. METHODS:Total cellular RNA was isolated from three specimens of normal human lacrimal tissue and complementary DNA was synt...

journal_title：Investigative ophthalmology & visual science

authors： Wilson SE,Lloyd SA,Kennedy RH

更新日期：1993-05-01 00:00:00

abstract：Purpose:The purpose of this study was to evaluate the effect of gravity acceleration on choroidal and retinal nerve fiber layer (RNFL) thickness using swept-source optical coherence tomography (SS-OCT). Methods:Thirteen healthy volunteers who planned to participate in human centrifuge training as part of the flight su...

journal_title：Investigative ophthalmology & visual science

authors： Kim DY,Song J,Kim JY,Choi K,Hyung S,Chae JB

更新日期：2017-12-01 00:00:00