Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage.

abstract：PURPOSE:The lipid layer of the tear film forms a barrier to evaporation. Evaporation is a major cause of tear thinning between blinks and tear breakup. The purpose of this study was to investigate the relation between tear film thinning and lipid layer thickness before and after instillation of an emulsion eye drop. M...

journal_title：Investigative ophthalmology & visual science

authors： King-Smith PE,Hinel EA,Nichols JJ

更新日期：2010-05-01 00:00:00

abstract：Purpose:RPE65-associated Leber congenital amaurosis (RPE65-LCA) is a progressive severe retinal dystrophy with early profound dysfunction of rod photoreceptors followed by progressive cone photoreceptor degeneration. We aim to provide detailed information about how cone dysfunction affects color discrimination. Method...

journal_title：Investigative ophthalmology & visual science

authors： Kumaran N,Ripamonti C,Kalitzeos A,Rubin GS,Bainbridge JWB,Michaelides M

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic. One such ligand, TCDD, was found to exert potent immunosuppressive capacities in mice developing pathogenic autoimmune processes, including EAU, but its toxicity makes it unusable for humans. A recently identified endogenous AHR lig...

journal_title：Investigative ophthalmology & visual science

authors： Nugent LF,Shi G,Vistica BP,Ogbeifun O,Hinshaw SJ,Gery I

更新日期：2013-11-13 00:00:00

abstract：PURPOSE:To examine the effect of combining angiostatin with photodynamic therapy (PDT) using Lutetium Texaphyrin (Lu-Tex; Alcon, Fort Worth, TX) as a photosensitizer in bovine retinal capillary endothelial (BRCE) and retinal pigment epithelial (RPE) cells and to determine the mode of PDT-induced cell death in these cel...

journal_title：Investigative ophthalmology & visual science

authors： Renno RZ,Delori FC,Holzer RA,Gragoudas ES,Miller JW

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:Primary intraocular lymphoma (PIOL) is a diffuse large B cell lymphoma that initially infiltrates the retina, vitreous, or optic nerve head, with or without central nervous system involvement. This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 m...

journal_title：Investigative ophthalmology & visual science

authors： Wallace DJ,Shen D,Reed GF,Miyanaga M,Mochizuki M,Sen HN,Dahr SS,Buggage RR,Nussenblatt RB,Chan CC

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To describe the dark-adaptation (DA) functions in subjects with molecularly proven achromatopsia (ACHM) using refined testing conditions with a view to guiding assessment in forthcoming gene therapy trials. METHODS:The DA functions of nine subjects with ACHM were measured and compared with those of normal obse...

journal_title：Investigative ophthalmology & visual science

authors： Aboshiha J,Luong V,Cowing J,Dubis AM,Bainbridge JW,Ali RR,Webster AR,Moore AT,Fitzke FW,Michaelides M

更新日期：2014-08-28 00:00:00

abstract：PURPOSE:To clarify the functions of a specific subtype of thyroid hormone receptor (TR), TRbeta2, and photoreceptor cell-specific nuclear receptor (PNR) in the development of cone photoreceptors. METHODS:The expression of short (S)- and medium (M)-wavelength cone opsins was analyzed by reverse transcription polymerase...

journal_title：Investigative ophthalmology & visual science

authors： Yanagi Y,Takezawa S,Kato S

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:To investigate the relationship between ornithine-delta-aminotransferase (OAT) deficiency and ornithine accumulation and the specific degeneration of retinal pigment epithelial (RPE) cells in gyrate atrophy. METHODS:Human RPE cells, human hepatoma cells, and human fibroblast cells were treated with 5-fluoromet...

journal_title：Investigative ophthalmology & visual science

authors： Ueda M,Masu Y,Ando A,Maeda H,Del Monte MA,Uyama M,Ito S

更新日期：1998-04-01 00:00:00

abstract：PURPOSE:Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in transducing inner retinal neurons after intravitreal injection in several species. However, results in nonprimates may not be predictive of transduction in the human inner retina, because of differences in eye size and the specialized mo...

journal_title：Investigative ophthalmology & visual science

authors： Yin L,Greenberg K,Hunter JJ,Dalkara D,Kolstad KD,Masella BD,Wolfe R,Visel M,Stone D,Libby RT,Diloreto D Jr,Schaffer D,Flannery J,Williams DR,Merigan WH

更新日期：2011-04-25 00:00:00

abstract：PURPOSE:To assess alterations in allergic ocular responses to nonparasite antigens in an experimental system in which mice were skewed toward a Th2 cytokine profile by helminth infection. METHODS:Mice were inoculated with Ascaris suum (A. suum) eggs concurrent with ragweed (RW) sensitization (RW/acute) or by repeated ...

journal_title：Investigative ophthalmology & visual science

authors： Schopf L,Luccioli S,Bundoc V,Justice P,Chan CC,Wetzel BJ,Norris HH,Urban JF Jr,Keane-Myers A

更新日期：2005-08-01 00:00:00

abstract：Purpose:A recent proposal for why glaucomatous perimetric sensitivities of approximately 15 to 19 dB or less are unreliable involves the idea that the neural response of normal retinal ganglion cells saturates for intense perimetric stimuli. A predicted consequence of this saturation is that the neural response for two...

journal_title：Investigative ophthalmology & visual science

authors： Anderson AJ,McKendrick AM,Turpin A

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Because immune rejection is likely to be a major barrier to successful retinal transplantation, it is important to determine whether immune privilege for allogeneic retinal grafts is a feature of the subretinal space and vitreous cavity. METHODS:Newborn neural retinas of C57BL/6 mice were implanted into the su...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Jorquera M,Streilein JW

更新日期：1993-11-01 00:00:00

abstract：:Primary cultures of retinal pigment epithelial (RPE) cells from cats with mucopolysaccharidosis VI (MPS VI) have been initiated from mixed populations of cells (ie, derived from the entire eyecup and represented by both pigmented and nonpigmented RPE cells). The cells were enzymatically dissociated from the eyecup and...

journal_title：Investigative ophthalmology & visual science

authors： Stramm L,Haskins M,Desnick RJ,Aguirre G

更新日期：1985-02-01 00:00:00

abstract：:Flicker contrast sensitivity was tested in the "good" eyes of 13 patients with monocular exudative age-related maculopathy (ARM). The stimulus was a foveal, long-wavelength, low spatial frequency 2.8 degrees circle in an equiluminant (photopic) surround. Two of these ARM-risk eyes have since developed exudative ARM. C...

journal_title：Investigative ophthalmology & visual science

authors： Mayer MJ,Spiegler SJ,Ward B,Glucs A,Kim CB

更新日期：1992-10-01 00:00:00

abstract：:An arterial connection between the two internal ophthalmic arteries in the rabbit was confirmed. The consensual response to ocular injury and its relationship to this interconnecting artery was examined by transecting the interconnecting vessel and creating a monocular injury by anterior chamber paracentesis. In the r...

journal_title：Investigative ophthalmology & visual science

authors： Forster S,Mead A,Sears M

更新日期：1979-02-01 00:00:00

abstract：PURPOSE:To evaluate whether β-zone parapapillary atrophy (PPA) is associated with the rate of retinal nerve fiber layer (RNFL) thickness change as assessed by trend-based analysis using time-domain optical coherence tomography (OCT). METHODS:This retrospective cohort study included 202 glaucomatous eyes that were obse...

journal_title：Investigative ophthalmology & visual science

authors： Lee EJ,Kim TW,Weinreb RN,Park KH,Kim SH,Kim DM

更新日期：2011-06-22 00:00:00

abstract：PURPOSE:To isolate and characterize ciliary body epithelial antigens reactive with a monoclonal antibody, 2B4.14.1. METHODS:A mouse monoclonal antibody generated against human corneal endothelium, 2B4.14.1 reacts with nonpigmented epithelium of human and guinea pig ciliary bodies. The ciliary body proteins reactive wi...

journal_title：Investigative ophthalmology & visual science

authors： Howell DN,Ross JR,Miller SE,Sanfilippo FP

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:We identified a topographic relation of localized reticular pseudodrusen (RPD) to choroidal watershed zones (CWZ) and to changes in choroidal volumes (CV). METHODS:We included 30 eyes of 30 patients with RPD in an area <10 mm(2) and no other retinal alteration (76.7 ± 6.9 years). Patients underwent spectral-do...

journal_title：Investigative ophthalmology & visual science

authors： Alten F,Clemens CR,Heiduschka P,Eter N

更新日期：2013-05-07 00:00:00

abstract：PURPOSE:To determine whether the native basement membrane left behind after manual débridement wounding is retained throughout healing in the Balb/c mouse. METHODS:Mouse corneas were subjected to either 1.5 mm (small) or limbus-to-limbus (large) epithelial débridement wounds and allowed to heal for times ranging from ...

journal_title：Investigative ophthalmology & visual science

authors： Sta Iglesia DD,Stepp MA

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:To determine whether the atmospheric pressure (ATM) change experienced during diving can induce changes in the intraocular pressure (IOP) of eyes in a normal population. METHODS:The IOP of 27 healthy volunteers (ages, 23.8 +/- 4.9 years; range, 18-44) was measured with a Perkins applanation tonometer by two in...

journal_title：Investigative ophthalmology & visual science

authors： Van de Veire S,Germonpre P,Renier C,Stalmans I,Zeyen T

更新日期：2008-12-01 00:00:00

abstract：Purpose:To review the usefulness of local and systemic inflammatory biomarkers of diabetic retinopathy (DR) to implement a more personalized treatment. Methods:An integrated research (from ophthalmologist and diabetologist point of view) of most significant literature on serum, vitreous, and aqueous humor (AH) biochem...

journal_title：Investigative ophthalmology & visual science

authors： Vujosevic S,Simó R

更新日期：2017-05-01 00:00:00

abstract：:PURPOSE. To investigate the characteristics of a spectral-domain optical coherence tomography (SD-OCT) image phenomenon known as the mirror artifact, calculate its prevalence, analyze potential risk factors, measure severity, and correlate it to spherical equivalent and central visual acuity (VA). METHODS. OCT macular...

journal_title：Investigative ophthalmology & visual science

authors： Ho J,Castro DP,Castro LC,Chen Y,Liu J,Mattox C,Krishnan C,Fujimoto JG,Schuman JS,Duker JS

更新日期：2010-07-01 00:00:00

abstract：:Vitrectomy has been shown to halt diabetic retinal neovascularization, but the mechanism of this process is unknown. We propose that vitrectomy improves the oxygen supply to ischemic inner retina by way of fluid currents in the vitreous cavity. In order to test this hypothesis, we induced branch retinal vein occlusion...

journal_title：Investigative ophthalmology & visual science

authors： Stefánsson E,Novack RL,Hatchell DL

更新日期：1990-02-01 00:00:00

abstract：PURPOSE:A recent study identified single nucleotide polymorphisms (SNPs) within the IL-1 gene cluster at chromosomal locus 2q13 that were associated with reduced risk for primary open-angle glaucoma (POAG) in whites. The purpose of this study was to investigate the association between IL-1 SNPs and glaucoma in Chinese ...

journal_title：Investigative ophthalmology & visual science

authors： How AC,Aung T,Chew X,Yong VH,Lim MC,Lee KY,Toh JY,Li Y,Liu J,Vithana EN

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:To investigate the effect of retinal eccentricity on the phenomenon of dichoptic suppression of the mfVEP amplitude and to examine the relationship between the degree of simulated unilateral visual impairment and the possible release of dichoptic suppression in the contralateral eye. METHOD:Eight subjects with...

journal_title：Investigative ophthalmology & visual science

authors： Leaney J,Klistorner A,Arvind H,Graham SL

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:The increase in intraocular pressure in primary open-angle glaucoma (POAG) may involve transforming growth factor (TGF)-beta2 signaling, as TGF-beta2 is found in higher amounts than normal in the aqueous humor of patients with POAG. In vitro, TGF-beta2 causes an accumulation of extracellular matrix (ECM) in the...

journal_title：Investigative ophthalmology & visual science

authors： Fuchshofer R,Yu AH,Welge-Lüssen U,Tamm ER

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:Macular drusen are hallmarks of age-related maculopathy (ARM), but these focal extracellular lesions also appear with age in the peripheral retina. The present study was conducted to determine regional differences in morphology that contribute to the higher vulnerability of the macula to advanced disease. METH...

journal_title：Investigative ophthalmology & visual science

authors： Rudolf M,Clark ME,Chimento MF,Li CM,Medeiros NE,Curcio CA

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:To examine the effects of modification of immune effector cells, including macrophages, in the pathogenesis of herpes simplex virus retinitis in BALB/c mice. METHODS:Two intravitreal injections (2 microliters each) of anti-CD11b monoclonal antibody (mAb) [13 micrograms/microliters] were administered to the con...

journal_title：Investigative ophthalmology & visual science

authors： Berra A,Rodriguez A,Heiligenhaus A,Pazos B,Van Rooijen N,Foster CS

更新日期：1994-06-01 00:00:00

abstract：PURPOSE:To compare structural properties from spectral-domain optical coherence tomography (SDOCT) and psychophysical measures from a subset of patients enrolled in a larger multicenter natural history study of X-linked retinoschisis (XLRS). METHODS:A subset of males (n = 24) participating in a larger natural history ...

journal_title：Investigative ophthalmology & visual science

authors： Bennett LD,Wang YZ,Klein M,Pennesi ME,Jayasundera T,Birch DG

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:To test the effects of subconjunctival topotecan (TPT) in fibrin sealant (FS) in transgenic murine retinoblastoma (RB). METHODS:Growth inhibitory, apoptotic, and cell cycle effects of TPT were assayed in human RB cell lines. In a dose-escalation study, eight groups of three 10- to 14-week-old wild-type mice we...

journal_title：Investigative ophthalmology & visual science

authors： Tsui JY,Dalgard C,Van Quill KR,Lee L,Grossniklaus HE,Edelhauser HF,O'Brien JM

更新日期：2008-02-01 00:00:00