Porous poly(ε-caprolactone) scaffolds for retinal pigment epithelium transplantation.

abstract：:This paper investigates the amplitude of accommodation of early onset myopes, late onset myopes, emmetropes, and hyperopes. Eighty subjects were used, 41 women and 39 men, with an age range of 18-22 yr (mean = 19.82). All subjects wore an optimum refractive correction, giving visual acuities of 20/20 or better. Signif...

journal_title：Investigative ophthalmology & visual science

authors： McBrien NA,Millodot M

更新日期：1986-07-01 00:00:00

abstract：PURPOSE:To determine the effects of blocking substance P (SP) interactions with its major receptor (NK1-R) using the antagonist spantide I in susceptible mice infected with Pseudomonas aeruginosa. METHODS:Immunohistochemistry and enzyme immunosorbent assay (EIA) tested levels of SP in the cornea of B6 and BALB/c mice....

journal_title：Investigative ophthalmology & visual science

authors： Hazlett LD,McClellan SA,Barrett RP,Liu J,Zhang Y,Lighvani S

更新日期：2007-02-01 00:00:00

abstract：:Although intravitreal injection of antibiotics is being used more widely in treatment of bacterial endophthalmitis, the pharmacokinetic principles that underlie such therapy have been derived exclusively from experiments in the rabbit. Therefore, we studied several representative antibiotics in normal eyes of rhesus m...

journal_title：Investigative ophthalmology & visual science

authors： Barza M,Kane A,Baum J

更新日期：1983-12-01 00:00:00

abstract：Purpose:Understanding the role of mitochondria in retinal ganglion cells (RGCs) is relevant to human disease as studies have shown mitochondrial abnormalities in primary open-angle glaucoma patients. This study seeks to determine the effects of the sigma-1 receptor (σ-1r) and its agonists on mitochondrial function in o...

journal_title：Investigative ophthalmology & visual science

authors： Ellis DZ,Li L,Park Y,He S,Mueller B,Yorio T

更新日期：2017-05-01 00:00:00

abstract：Purpose:The purpose of this study was to measure change in anterior lamina cribrosa depth (ALD) globally and regionally in glaucoma eyes at different intraocular pressures (IOP). Methods:Twenty-seven glaucoma patients were imaged before and after IOP-lowering procedures using optical coherence tomography. The anterior...

journal_title：Investigative ophthalmology & visual science

authors： Quigley H,Arora K,Idrees S,Solano F,Bedrood S,Lee C,Jefferys J,Nguyen TD

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To assess the retinal macrophage response to cannulation of the anterior chamber (AC) and acute elevation of intraocular pressure (IOP) in adult mice. METHODS:Eyes from 12-month-old C57BL/6J WT mice were subject to IOP increase (50 mm Hg for 30 minutes) by direct cannulation of the AC. Fellow eyes were either ...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chrysostomou V,Trounce IA,McMenamin PG,Crowston JG

更新日期：2013-04-30 00:00:00

abstract：PURPOSE:To investigate regional differences in Ca(2+) mobilization kinetics in the intact human lens produced by exposure to agonists of tyrosine-kinase and G-protein-coupled receptors and to characterize the major receptor subtypes involved in Ca(2+) signaling in the different regions. METHODS:Whole human lenses were...

journal_title：Investigative ophthalmology & visual science

authors： Collison DJ,Duncan G

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:As the number of cases of Acanthamoeba spp. keratitis (AK) is constantly growing, new diagnostic tools are needed to confirm and guide ophthalmologists in this clinically problematic diagnosis. Molecular diagnosis is particularly well adapted, although only a few real-time PCR techniques have been described rec...

journal_title：Investigative ophthalmology & visual science

authors： Maubon D,Dubosson M,Chiquet C,Yera H,Brenier-Pinchart MP,Cornet M,Savy O,Renard E,Pelloux H

更新日期：2012-05-14 00:00:00

abstract：PURPOSE:To determine whether people with central visual field loss (CFL) show a smaller visual contribution to posture stabilization than people with normal vision and to determine the visual factors that predict the magnitude of visual stabilization in people with central visual field loss. METHODS:Posture informatio...

journal_title：Investigative ophthalmology & visual science

authors： Turano KA,Dagnelie G,Herdman SJ

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:A preferential loss of ERG b-wave was detected in a substrain of C57BL/10 mice. Electroretinographic and histologic techniques were used to investigate this hitherto unknown retinopathy. METHODS:ERGs were obtained from normal and affected C57BL/10. C57BL/6 mice served also as controls. a-Wave and c-wave analys...

journal_title：Investigative ophthalmology & visual science

authors： Ruether K,Grosse J,Matthiessen E,Hoffmann K,Hartmann C

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:In situ 2-photon excitation fluorescence (TPEF) of the human trabecular meshwork (TM) reveals beams of heterogeneous autofluorescence (AF) comprising high intensity fluorescent fibers (AF-high) on a background of lower intensity fluorescence (AF-low). To determine the sources of this AF heterogeneity, we imaged...

journal_title：Investigative ophthalmology & visual science

authors： Huang AS,Gonzalez JM Jr,Le PV,Heur M,Tan JC

更新日期：2013-07-18 00:00:00

abstract：PURPOSE:Bacillus cereus causes one of the most rapidly blinding forms of bacterial endophthalmitis. Migration of B. cereus throughout the eye during endophthalmitis is a unique aspect of this disease that may contribute to intraocular virulence. This study was conducted to analyze the contribution of swarming and intra...

journal_title：Investigative ophthalmology & visual science

authors： Callegan MC,Novosad BD,Ramirez R,Ghelardi E,Senesi S

更新日期：2006-10-01 00:00:00

abstract：:This volume presents articles based on a workshop held June 14 to 16, 2013 in Rancho Palos Verde, CA sponsored by the Ocular Research Symposia Foundation (ORSF). The mission of the ORSF is to focus attention on unmet needs and current research opportunities in eye research with the objective of accelerating translatio...

journal_title：Investigative ophthalmology & visual science

authors： Chader GJ,Taylor A

更新日期：2013-12-13 00:00:00

abstract：PURPOSE:Sildenafil (Viagra), a cGMP-specific phosphodiesterase type 5 inhibitor, is widely used for the treatment of erectile dysfunction and pulmonary hypertension. Clinical studies have reported transient visual impairments in patients after single-dose sildenafil use, suggesting neural involvement in several retinal...

journal_title：Investigative ophthalmology & visual science

authors： Martins J,Kolomiets B,Caplette R,Sahel JA,Castelo-Branco M,Ambrósio AF,Picaud S

更新日期：2015-04-01 00:00:00

abstract：:Chronic blepharitis has been a difficult disease to define either microbiologically or biochemically. Sterols from meibomian secretions of normal subjects and patients were analyzed, and important differences were observed. Based on analyses of these secretions, two significantly different (P less than 0.001) types of...

journal_title：Investigative ophthalmology & visual science

authors： Shine WE,McCulley JP

更新日期：1991-07-01 00:00:00

abstract：PURPOSE:To examine the potential of a broad-spectrum kinase inhibitor as a means of neutralizing the effects of contraction promoters on ocular cells. METHODS:The inhibitory effects of a broad-spectrum kinase inhibitor were examined and characterized using an in vitro assay of extracellular matrix contraction by choro...

journal_title：Investigative ophthalmology & visual science

authors： Guidry C,Hardwick C

更新日期：1994-02-01 00:00:00

abstract：:Membrane-bound proteins in plasma membrane enriched fractions from cultured rat RPE were analyzed by two-dimensional gel electrophoresis. Membrane proteins were characterized on three increasingly specific levels. Total protein was visualized by silver staining. A maximum of 102 separate proteins were counted in silve...

journal_title：Investigative ophthalmology & visual science

authors： Clark VM,Hall MO

更新日期：1986-02-01 00:00:00

abstract：PURPOSE:To investigate whether visual deficits in children with infantile spasm (IS) are the result of seizure activity or of treatment with the anticonvulsant drug vigabatrin (VGB). METHODS:Vision function was determined in three experiments by determining peak contrast sensitivity (CS) and grating acuity (GA) with t...

journal_title：Investigative ophthalmology & visual science

authors： Mirabella G,Morong S,Buncic JR,Snead OC,Logan WJ,Weiss SK,Abdolell M,Westall CA

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:We recently presented a transfemoral endovascular coiling technique for inducing experimental retinal ischemia in pigs. Substantial variation was seen in the degree of ischemia. It was hypothesized that the blood supply to the retina may originate from both the ipsilateral and contralateral ophthalmic arteries ...

journal_title：Investigative ophthalmology & visual science

authors： Morén H,Gesslein B,Undrén P,Andreasson S,Malmsjö M

更新日期：2013-09-09 00:00:00

abstract：PURPOSE:Vascular endothelial growth factor (VEGF)-A and placental growth factor (PlGF) are members of a large group of homologous peptides identified as the VEGF family. Although VEGF-A is known to act as a potent angiogenic peptide in the retina, the vasoactive function of PlGF in this tissue is less well defined. Thi...

journal_title：Investigative ophthalmology & visual science

authors： Feeney SA,Simpson DA,Gardiner TA,Boyle C,Jamison P,Stitt AW

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:The loss of attentional visual field (AVF) has been linked to poor mobility and car crashes. We investigated the risk factors associated with a decrease in AVF over time among participants in the Salisbury Eye Evaluation Driving Study (SEEDS). METHODS:In a longitudinal cohort of 968 individuals ages 67 to 87, ...

journal_title：Investigative ophthalmology & visual science

authors： Rao P,Munoz B,Turano K,Munro C,West SK

更新日期：2013-03-13 00:00:00

abstract：:To determine whether glaucoma selectively injures a particular size of optic nerve fiber (and its cell body), we induced chronic experimental glaucoma in one eye each of ten monkeys. With automated image analysis, the number and diameter of optic nerve fibers were compared between each glaucomatous eye and its normal ...

journal_title：Investigative ophthalmology & visual science

authors： Quigley HA,Sanchez RM,Dunkelberger GR,L'Hernault NL,Baginski TA

更新日期：1987-06-01 00:00:00

abstract：PURPOSE:To investigate the choroidal thickness (CT) in children with amblyopia through spectral-domain optical coherence tomography (SD-OCT). METHODS:Thirty-seven children with unilateral amblyopia and 22 children with normal vision participated in the study. Cross-sectional images of the choroid of evaluated eyes wer...

journal_title：Investigative ophthalmology & visual science

authors： Xu J,Zheng J,Yu S,Sun Z,Zheng W,Qu P,Chen Y,Chen W,Yu X

更新日期：2014-10-14 00:00:00

abstract：PURPOSE:The authors used and validated a recently developed method, mRNA differential display, to detect and clone genes that are differentially expressed in healing compared to stationary corneal epithelium. METHODS:RNAs from unwounded and 18-hour postwound corneal epithelia were isolated and subjected to mRNA differ...

journal_title：Investigative ophthalmology & visual science

authors： Yu FX,Gipson IK,Guo Y

更新日期：1995-09-01 00:00:00

abstract：PURPOSE:To test the hypothesis that longitudinal differences between retinal nerve fiber layer (RNFL) birefringence, measured by scanning laser polarimetry (SLP), and RNFL thickness, measured by optical coherence tomography (OCT), are informative about the state of axonal degeneration. METHODS:Colchicine was injected ...

journal_title：Investigative ophthalmology & visual science

authors： Fortune B,Wang L,Cull G,Cioffi GA

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:This study examined the association between peripapillary choroidal thickness (PCT) with age and race in a group of African descent (AD) and European descent (ED) subjects with normal eyes. METHODS:Optic nerve head images from enhanced depth imaging spectral-domain optical coherence tomography of 166 normal ey...

journal_title：Investigative ophthalmology & visual science

authors： Rhodes LA,Huisingh C,Johnstone J,Fazio MA,Smith B,Wang L,Clark M,Downs JC,Owsley C,Girard MJ,Mari JM,Girkin CA

更新日期：2015-02-24 00:00:00

abstract：PURPOSE:Platelet-derived growth factor (PDGF) is an important stimulatory factor for proliferative retinopathies. Expression of PDGF-B in the retinas of transgenic mice (hemizygous rho/PDGF-B mice) results in rapid-onset retinal detachment caused by proliferation of glial cells, endothelial cells, and pericytes, wherea...

journal_title：Investigative ophthalmology & visual science

authors： Saishin Y,Saishin Y,Takahashi K,Seo MS,Melia M,Campochiaro PA

更新日期：2003-08-01 00:00:00

abstract：:Pattern ERGs in response to pattern-reversal stimuli varying in spatial frequency (range: 0.2-9.03 cycles/deg) and contrast (range: 0.03-0.93) were recorded from two normal male subjects. At most spatial frequencies the response amplitude increased linearly up to the highest contrast without saturation. From the ampli...

journal_title：Investigative ophthalmology & visual science

authors： Korth M,Rix R,Sembritzki O

更新日期：1985-03-01 00:00:00

abstract：:The level of oxygen at the anterior corneal surface beneath the closed eyelid is shown to be equivalent to an atmosphere of 7.7% oxygen. This finding is in good agreement with assumptions which have been based on the oxygen level at the palpebral conjunctiva. However, in some instances a significant amount of oxygen i...

journal_title：Investigative ophthalmology & visual science

authors： Efron N,Carney LG

更新日期：1979-01-01 00:00:00

abstract：PURPOSE:To determine whether complement-derived SC5b-9, the soluble nonlytic-fluid phase of the membrane attack complex, can be generated in normal human corneas when they are injured with lipopolysaccharide (LPS), ribitol teichoic acid (RTA) immune complexes, acid, or alkali. METHODS:The experimental cornea of each d...

journal_title：Investigative ophthalmology & visual science

authors： Mondino BJ,Chou HJ,Sumner HL

更新日期：1996-07-01 00:00:00