Sources of structural autofluorescence in the human trabecular meshwork.

abstract：PURPOSE:Currently, there are no definitive immunomarkers for epithelial stem cells (corneal and conjunctival) or their poorly understood niche microenvironment. The H2B-GFP/K5tTA mouse enables visualization of label-retaining cells (LRCs), which exhibit the functional marker of stem cell quiescence. We used immunofluor...

journal_title：Investigative ophthalmology & visual science

authors： Parfitt GJ,Kavianpour B,Wu KL,Xie Y,Brown DJ,Jester JV

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:Sensory imbalances in humans with amblyopia have been well documented using luminance-modulated (first-order) stimuli. However, little is known regarding whether there is a deficient binocular combination in amblyopes for stimuli defined by modulations in contrast (second-order stimuli). To address this, we ask...

journal_title：Investigative ophthalmology & visual science

authors： Zhou J,Liu R,Feng L,Zhou Y,Hess RF

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To investigate the role of epoxyeicosatrienoic acids (EETs) and prostaglandins (PGs) in retinal blood vessel calibers and vasodilation during flicker light stimulation in humans. METHODS:Twelve healthy nonsmokers participated in a balanced crossover study. Oral fluconazole 400 mg and dispersible aspirin 600 mg...

journal_title：Investigative ophthalmology & visual science

authors： Noonan JE,Dusting GJ,Nguyen TT,Jenkins AJ,Man RE,Best WJ,Dias DA,Jayasinghe NS,Roessner U,Lamoureux EL

更新日期：2014-10-08 00:00:00

abstract：PURPOSE:To determine whether the severity of glaucomatous damage in eyes with pseudoexfoliative (PEX) glaucoma is related to the amount of PEX material in the trabecular meshwork. METHODS:Trabecular meshwork and optic nerves from 19 eyes (11 donors) with PEX syndrome were studied. Eyes were chosen to represent all sta...

journal_title：Investigative ophthalmology & visual science

authors： Gottanka J,Flügel-Koch C,Martus P,Johnson DH,Lütjen-Drecoll E

更新日期：1997-11-01 00:00:00

abstract：:The mitotic rate and goblet cell content of conjunctival epithelium following total or central corneal epithelial removal using n-heptanol was measured to determine how the conjunctival epithelium responds to injury and whether conjuctiva responds to central corneal epithelial loss. One day following a wound that remo...

journal_title：Investigative ophthalmology & visual science

authors： Danjo S,Friend J,Thoft RA

更新日期：1987-09-01 00:00:00

abstract：Purpose:Primates and rodents are used widely as animal models of glaucoma, but each has significant limitations. Researchers need additional animal models that closely resemble the relevant anatomy and pathologic features of the human disease to more quickly advance research. We validate a novel glaucoma animal model i...

journal_title：Investigative ophthalmology & visual science

authors： Samuels BC,Siegwart JT,Zhan W,Hethcox L,Chimento M,Whitley R,Downs JC,Girkin CA

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Recovery of photoreceptor cells after light damage is thought to involve the physiologic process of disk renewal. However, only indirect evidence is available to support this hypothesis. The present study sought to examine more directly the mechanisms of photoreceptor cell recovery by quantitatively assessing t...

journal_title：Investigative ophthalmology & visual science

authors： Rapp LM,Fisher PL,Dhindsa HS

更新日期：1994-08-01 00:00:00

abstract：Purpose:This study is to investigate the corneal anomaly caused by excess transforming growth factor-α (TGF-α) during mouse development. Methods:Bitransgenic KeraRT/TGF-α mice, generated via cross-mating tetO-TGF-α and KeraRT mice, were induced to overexpress TGF-α by doxycycline commencing at embryonic day 0 or postn...

journal_title：Investigative ophthalmology & visual science

authors： Zhang L,Yuan Y,Yeh LK,Dong F,Zhang J,Okada Y,Kao WWY,Liu CY,Zhang Y

更新日期：2020-07-01 00:00:00

abstract：:Posterior eye cups of the frog Rana ridibunda were prefixed in the presence of tannic acid, osmicated and stained en bloc with uranyl acetate. Electron microscopy revealed the following features of membrane traffic in cells of the retinal pigment epithelium (RPE): (1) intracellular membranes with increased electron de...

journal_title：Investigative ophthalmology & visual science

authors： Rungger-Brändle E,Englert U,Leuenberger PM

更新日期：1987-12-01 00:00:00

abstract：PURPOSE:To evaluate the dynamic changes in refraction during the accommodative facility test in myopes and emmetropes. METHODS:Ten myopes and 10 emmetropes participated in the study. All were young adults, and refractive error in the myopes was corrected with soft contact lenses. Monocular accommodative facility measu...

journal_title：Investigative ophthalmology & visual science

authors： Radhakrishnan H,Allen PM,Charman WN

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To test the hypothesis that acute topical dorzolamide (DZ) decreases intraocular pressure (IOP) and increases retinal and choroidal blood flow in the DBA/2J mouse model of glaucoma. METHODS:Retinal and choroidal blood flow were measured in 4- and 9-month-old DBA/2J mice, and 4-month C57BL/6 (control) mice unde...

journal_title：Investigative ophthalmology & visual science

authors： Chandra S,Muir ER,Deo K,Kiel JW,Duong TQ

更新日期：2016-03-01 00:00:00

abstract：:Quantitative autoradiography was used to study the incorporation of 3H-thymidine into the retina of albino rats following in vivo exposure to 300-nm radiation. Relative to background labeling in unexposed eyes, there was 8-20 times as much label per unit area in the outer nuclear layer, inner nuclear layer, and gangli...

journal_title：Investigative ophthalmology & visual science

authors： Rapp LM,Jose JG,Pitts DG

更新日期：1985-03-01 00:00:00

abstract：Purpose:We previously reported that a specific treadmill running exercise regimen protects against light-induced retinal degeneration (LIRD) in mice. We hypothesized that this protective effect varies with running intensity. To test this, mice undergoing LIRD were run at different treadmill speeds and retinal function ...

journal_title：Investigative ophthalmology & visual science

authors： Mees LM,Coulter MM,Chrenek MA,Motz CT,Landis EG,Boatright JH,Pardue MT

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:To investigate the induction of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) gene expression by prostaglandin E2 (PGE2) in cultured rat Müller cells and to study the mechanism of the induction. METHODS:Müller cells were obtained from neonatal Sprague-Dawley rat retinas an...

journal_title：Investigative ophthalmology & visual science

authors： Cheng T,Cao W,Wen R,Steinberg RH,LaVail MM

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:To assess vascular endothelial function in patients with normal pressure glaucoma using forearm blood flow responses to intra-arterial infusions of endothelial-dependent and -independent vasoactive agents. METHODS:Eight patients with newly diagnosed and untreated normal pressure glaucoma and eight healthy age-...

journal_title：Investigative ophthalmology & visual science

authors： Henry E,Newby DE,Webb DJ,O'Brien C

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Retinopathy of prematurity (ROP) is a major cause of visual handicap in the pediatric population. To date, this disorder is thought to stem from deficient retinal vascularization. Intriguingly, functional electrophysiological studies in patients with mild or moderate ROP and in the oxygen-induced retinopathy (O...

journal_title：Investigative ophthalmology & visual science

authors： Shao Z,Dorfman AL,Seshadri S,Djavari M,Kermorvant-Duchemin E,Sennlaub F,Blais M,Polosa A,Varma DR,Joyal JS,Lachapelle P,Hardy P,Sitaras N,Picard E,Mancini J,Sapieha P,Chemtob S

更新日期：2011-08-05 00:00:00

abstract：PURPOSE:Amblyopia is the commonest visual disorder of childhood. Yet the contributions of the two principal treatments (spectacle wear and occlusion) to outcome are unknown. This study was undertaken to investigate the dose-response relationship of amblyopia therapy. METHODS:The study comprised three distinct phases: ...

journal_title：Investigative ophthalmology & visual science

authors： Stewart CE,Moseley MJ,Stephens DA,Fielder AR

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:To study retinal structure in choroideremia patients and carriers using high-resolution imaging techniques. METHODS:Subjects from four families (six female carriers and five affected males) with choroideremia (CHM) were characterized with best-corrected visual acuity (BCVA), kinetic and static perimetry, full-...

journal_title：Investigative ophthalmology & visual science

authors： Syed R,Sundquist SM,Ratnam K,Zayit-Soudry S,Zhang Y,Crawford JB,MacDonald IM,Godara P,Rha J,Carroll J,Roorda A,Stepien KE,Duncan JL

更新日期：2013-02-01 00:00:00

abstract：Purpose:To give a European regulatory overview of the requirements on and the use of biomarkers or surrogate endpoints in the development of drugs for ocular disease. Methods:Definitions, methods to validate new markers, and circumstances where surrogate endpoints can be appropriate are summarized. Results:The key en...

journal_title：Investigative ophthalmology & visual science

authors： Wickström K,Moseley J

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To identify the prognostic value of extraocular extension in enucleated uveal melanoma (UM) patients and to correlate extraocular extension to chromosomal aberrations, metastasis-free survival (MFS), and clinico-histopathological risk factors. METHODS:Retrospective study of patients with UM treated with enucle...

journal_title：Investigative ophthalmology & visual science

authors： van Beek JG,Koopmans AE,Vaarwater J,de Rooi JJ,Paridaens D,Naus NC,de Klein A,Verdijk RM,Kiliç E

更新日期：2014-03-04 00:00:00

abstract：:Extraocular muscle represents a distinctive class among mammalian skeletal musculature in exhibiting the full range of muscle fiber type variability found in vertebrate species. To better understand the basis for the unique structural/functional diversity of extraocular muscle, the ontogeny of lateral rectus muscles w...

journal_title：Investigative ophthalmology & visual science

authors： Porter JD,Baker RS

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:To develop an eye-motion-tracking optical coherence tomographic (OCT) method and assess its effect on image registration and nerve fiber layer (NFL) thickness measurement reproducibility. METHODS:A system capable of tracking common fundus features based on reflectance changes was integrated into a commercial O...

journal_title：Investigative ophthalmology & visual science

authors： Ishikawa H,Gabriele ML,Wollstein G,Ferguson RD,Hammer DX,Paunescu LA,Beaton SA,Schuman JS

更新日期：2006-03-01 00:00:00

abstract：Purpose:To evaluate the corneal endothelial characteristics across the primary angle closure (PAC) disease spectrum amongst patients diagnosed as PAC suspects (PACS), PAC, PAC glaucoma (PACG), and previous acute PAC (APAC). Methods:We analyzed a total of 529 subjects (51 PACS, 170 PAC, 234 PACG, and 74 with previous A...

journal_title：Investigative ophthalmology & visual science

authors： Verma S,Nongpiur ME,Husain R,Wong TT,Boey PY,Quek D,Perera SA,Aung T

更新日期：2018-09-04 00:00:00

abstract：PURPOSE:Migration of Müller glial cells is enhanced in proliferative retinopathies, but the mechanisms involved are ill defined. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid synthesized by sphingosine kinase (SphK), which promotes proliferation, migration, and inflammation, acting as an intracellular media...

journal_title：Investigative ophthalmology & visual science

authors： Simón MV,Prado Spalm FH,Politi LE,Rotstein NP

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To characterize the potential for neuropeptide Y (NPY) signaling in the retinal pigment epithelium (RPE) by identifying the NPY receptor subtypes present, determining the effect of NPY on second-messenger production and membrane conductance, and establishing the neural retina as a site of NPY gene expression. ...

journal_title：Investigative ophthalmology & visual science

authors： Ammar DA,Hughes BA,Thompson DA

更新日期：1998-09-01 00:00:00

abstract：Purpose:The lysozyme 2 (Lyz2 or LysM) cre mouse is extensively used to achieve genetic manipulation in myeloid cells and it has been widely employed in retinal research. However, LysM has been recently described to be expressed in brain neurons and there is a debate on whether it is also expressed by resident microglia...

journal_title：Investigative ophthalmology & visual science

authors： Fouda AY,Xu Z,Narayanan SP,Caldwell RW,Caldwell RB

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:To examine the distribution of anti-GQ1b, -GT1a, and -GD1b antibody binding in human extraocular muscles (EOMs), axial and limb muscles, and muscle spindles and thereby test the hypothesis that their distinctive ganglioside composition provides the molecular basis for selective involvement of EOMs and muscle sp...

journal_title：Investigative ophthalmology & visual science

authors： Liu JX,Willison HJ,Pedrosa-Domellöf F

更新日期：2009-07-01 00:00:00

abstract：:PURPOSE. To solve the shortage of donor corneas, a decellularizing method based on hypertonic saline treatment was introduced, and a favorable outcome was observed in pig-to-rabbit lamellar corneal transplantation. This study was an investigation of the efficacy of pig-to-nonhuman primate lamellar corneal transplantat...

journal_title：Investigative ophthalmology & visual science

authors： Choi HJ,Kim MK,Lee HJ,Ko JH,Jeong SH,Lee JI,Oh BC,Kang HJ,Wee WR

更新日期：2011-08-22 00:00:00

abstract：PURPOSE:Corneal confocal microscopy is a reiterative, rapid, noninvasive in vivo clinical examination technique capable of imaging corneal nerve fibers. Nerve fiber tortuosity may indicate a degenerative and attempted regenerative response of nerve fibers to diabetes. The purpose of this study was to define alterations...

journal_title：Investigative ophthalmology & visual science

authors： Kallinikos P,Berhanu M,O'Donnell C,Boulton AJ,Efron N,Malik RA

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic. One such ligand, TCDD, was found to exert potent immunosuppressive capacities in mice developing pathogenic autoimmune processes, including EAU, but its toxicity makes it unusable for humans. A recently identified endogenous AHR lig...

journal_title：Investigative ophthalmology & visual science

authors： Nugent LF,Shi G,Vistica BP,Ogbeifun O,Hinshaw SJ,Gery I

更新日期：2013-11-13 00:00:00