The decline in attentional visual fields over time among older participants in the Salisbury Eye Evaluation Driving Study.

Abstract:

PURPOSE:The loss of attentional visual field (AVF) has been linked to poor mobility and car crashes. We investigated the risk factors associated with a decrease in AVF over time among participants in the Salisbury Eye Evaluation Driving Study (SEEDS). METHODS:In a longitudinal cohort of 968 individuals ages 67 to 87, demographic, medical, visual, and cognitive factors were obtained at baseline (2005-2006) and follow-up (2007-2008) using structured medical questionnaires and onsite examinations. Using the standard deviation for the difference in AVF over 2 years of 4.3°, two subgroups were created: Those who lost 5° or more in two years and those who had no loss (i.e., loss of 5° or less, or no loss). Age-adjusted and multivariate odds ratios (OR) with 95% confidence intervals (95% CI) for each explanatory factor were determined using logistic regression. RESULTS:The overall change in AVF was -0.34° (SD = 4.32), which was a significant decline from baseline. of the population, 14% lost 5° or more of AVF. The following determinants were associated with a minimum loss of 5° over 2 years: female sex (OR = 1.59, P = 0.03), history of stroke (OR = 1.90, P = 0.03), depression (OR = 1.07, P = 0.02), a lower baseline Trails A and B scores (OR = 1.09, P = 0.003 and OR = 1.02, P = 0.02, respectively), and lower baseline visual acuity (OR = 1.21, P = 0.03). In addition, decline was related to a lower baseline measure of auditory attention (OR = 1.14, P = 0.007) and lower baseline visual fields in the central 20° (OR = 1.24, P = 0.01). CONCLUSIONS:Loss in AVF over time is related independently to decrements in cognition and vision. The higher odds of loss in female subjects, independent of these factors, deserves further research.

authors

Rao P,Munoz B,Turano K,Munro C,West SK

doi

10.1167/iovs.11-8874

subject

Has Abstract

pub_date

2013-03-13 00:00:00

pages

1839-44

issue

3

eissn

0146-0404

issn

1552-5783

pii

iovs.11-8874

journal_volume

54

pub_type

杂志文章
  • Retinal ischemia/reperfusion injury is mediated by Toll-like receptor 4 activation of NLRP3 inflammasomes.

    abstract:PURPOSE:Retinal ischemia/reperfusion (IR) is common in eye disorders. Pattern-recognition receptors (PRRs) are reported to initiate sterile inflammatory response. The role of PRRs in retinal IR injury is currently unknown. Thus, we investigated the expression and function of membrane and cytoplasmic PRRs during retinal...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.14-14380

    authors: Qi Y,Zhao M,Bai Y,Huang L,Yu W,Bian Z,Zhao M,Li X

    更新日期:2014-08-05 00:00:00

  • The effect of prednisolone on antibody-dependent cell-mediated cytotoxicity and the growth of type I herpes simplex virus in human cells.

    abstract::Treatment of human skin and corneal fibroblasts with prednisolone-21-phosphate did not increase the capacity of these cells to replicate type I herpes simplex virus (HSV). The steroid however was found to (1) inhibit human lymphocytes from mediating antibody-dependent cell-mediated cytotoxicity (ADCC) against HSV-infe...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Cooper JA Jr,Daniels CA,Trofatter EF Jr

    更新日期:1978-04-01 00:00:00

  • Preservation of visual sensitivity of older subjects: association with macular pigment density.

    abstract:PURPOSE:The authors investigated how individual differences in macular pigment (MP) density are related to loss of visual sensitivity with age. METHODS:Macular pigment and visual sensitivity of 27 healthy older subjects (aged 60-84 years) were compared with data from 10 younger subjects (aged 24-36 years). Macular pig...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Hammond BR Jr,Wooten BR,Snodderly DM

    更新日期:1998-02-01 00:00:00

  • Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line.

    abstract:PURPOSE:To investigate whether signaling pathways that incorporate protein tyrosine kinases and phosphatases regulate PKC-sensitive, volume-sensitive Cl(-) currents (I(Cl,vol)) in cultured rabbit nonpigmented ciliary epithelial cells. METHODS:Activation of I(Cl,vol) in response to hyposmotic stimulation was recorded w...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Shi C,Barnes S,Coca-Prados M,Kelly ME

    更新日期:2002-05-01 00:00:00

  • Inhibition of DNA and RNA synthesis in lymphocyte cultures by rod outer segments and its counteraction by vitamin E and other antioxidants.

    abstract::Bovine rod outer segments (ROS) specifically stimulate DNA synthesis in lymphocyte cultures from guinea pigs preimmunized with ROS. At doses above 10 microgram/ml protein, however, preparations of ROS inhibit DNA and RNA synthesis by the sensitized lymphocytes or by normal lymphocytes reacting to mitogens. The inhibti...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Gery I

    更新日期:1980-07-01 00:00:00

  • Retinal function and structure in the hypotransferrinemic mouse.

    abstract:PURPOSE:The iron carrier transferrin is expressed at remarkably high levels in normal retinas and is upregulated during retinal degeneration. The authors characterized the consequences of genetically reduced retinal transferrin production on retinal structure and function. METHODS:Hypotransferrinemic (HPX⁻/⁻) mice tre...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.11-7436

    authors: Lederman M,Obolensky A,Grunin M,Banin E,Chowers I

    更新日期:2012-02-02 00:00:00

  • Corneal sensitivity following lacrimal gland excision in the rat.

    abstract:PURPOSE:Dry eye disease (DED) produces ocular pain and irritation, yet a detailed characterization of ocular sensitivity in a preclinical model of DED is lacking. The aim of the present study was to assess nociceptive behaviors in an aqueous tear deficiency model of DED in the rat. METHODS:Spontaneous blinking, cornea...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.15-16717

    authors: Meng ID,Barton ST,Mecum NE,Kurose M

    更新日期:2015-05-01 00:00:00

  • Upper eyelid movements measured with a search coil during blinks and vertical saccades.

    abstract::Upper eyelid movements were recorded in nine human subjects by mounting a miniature coil of wire directly on the eyelid and subjecting the search coil to a vertically directed alternating magnetic field. The metrics of blinks and lid movements accompanying saccades were described by "main sequence" relationships, link...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Guitton D,Simard R,Codère F

    更新日期:1991-12-01 00:00:00

  • ADAM17 transactivates EGFR signaling during embryonic eyelid closure.

    abstract:PURPOSE:During mammalian embryonic eyelid closure ADAM17 has been proposed to play a role as a transactivator of epidermal growth factor receptor (EGFR) signaling by shedding membrane bound EGFR ligands. However, ADAM17 also sheds numerous other ligands, thus implicating ADAM17 in additional molecular pathways. The goa...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.12-11130

    authors: Hassemer EL,Endres B,Toonen JA,Ronchetti A,Dubielzig R,Sidjanin DJ

    更新日期:2013-01-07 00:00:00

  • Recharacterization of the RGC-5 retinal ganglion cell line.

    abstract:PURPOSE:The transformed RGC-5 retinal ganglion cell line is used widely in glaucoma research. Increased resistance to glutamate was noted in published literature and led to the recharacterization of the RGC-5 cell line. METHODS:Characterization of the RGC-5 cell line was performed by sequencing of a region of the nucl...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.09-3484

    authors: Van Bergen NJ,Wood JP,Chidlow G,Trounce IA,Casson RJ,Ju WK,Weinreb RN,Crowston JG

    更新日期:2009-09-01 00:00:00

  • Critical role of TNF-α-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization.

    abstract:PURPOSE:We evaluated the roles of tumor necrosis factor (TNF)-α in alkali-induced corneal neovascularization (CNV). METHODS:CNV was induced by alkali injury and compared in wild-type (WT) BALB/c mice, and TNF receptor 1-deficient (TNF-Rp55 KO) counterparts, or in mice treated with TNF-α antagonist and recombinant TNF-...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.10-5548

    authors: Lu P,Li L,Liu G,Baba T,Ishida Y,Nosaka M,Kondo T,Zhang X,Mukaida N

    更新日期:2012-06-14 00:00:00

  • Cataracts in patients heterozygous for galactokinase deficiency.

    abstract::The role of heterozygous galactokinase deficiency in the development of presenile cataracts is presently undetermined. Erythrocyte galactokinase activity was measured from 95 normal Caucasian subjects and from 39 Caucasian patients who had developed idiopathic bilateral cataracts between ages 20 and 55. The diagnosis ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Stambolian D,Scarpino-Myers V,Eagle RC Jr,Hodes B,Harris H

    更新日期:1986-03-01 00:00:00

  • Plasma docosahexaenoic acid levels in various genetic forms of retinitis pigmentosa.

    abstract::In 188 patients from separate families with various forms of retinitis pigmentosa (RP) and 91 normal subjects, plasma fatty acids were measured as a percentage of total plasma fatty acids, and their concentrations were determined using capillary-column gas-liquid chromatography. After controlling for the effects of ag...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Gong J,Rosner B,Rees DG,Berson EL,Weigel-DiFranco CA,Schaefer EJ

    更新日期:1992-08-01 00:00:00

  • Eye-specific IOP-induced displacements and deformations of human lamina cribrosa.

    abstract:PURPOSE:To measure high-resolution eye-specific displacements and deformations induced within the human LC microstructure by an acute increase in IOP. METHODS:Six eyes from donors aged 23 to 82 were scanned using second harmonic-generated (SHG) imaging at various levels of IOP from 10 to 50 mm Hg. An image registratio...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.13-12724

    authors: Sigal IA,Grimm JL,Jan NJ,Reid K,Minckler DS,Brown DJ

    更新日期:2014-01-02 00:00:00

  • Classification of human senile cataractous change by the American Cooperative Cataract Research Group (CCRG) method: III. The association of nuclear color (sclerosis) with extent of cataract formation, age, and visual acuity.

    abstract::Nineteen hundred and seventy-six immature human cataracts extracted intracapsularly were classified according to the Cooperative Cataract Research Group (CCRG) method of cataract classification. Data on cataract location and extent, nuclear color, preoperative visual acuity, age, and sex were organized and stored in t...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Chylack LT Jr,Ransil BJ,White O

    更新日期:1984-02-01 00:00:00

  • A murine model for retinopathy of prematurity identifies endothelial cell proliferation as a potential mechanism for plus disease.

    abstract:PURPOSE:To characterize the features and possible mechanism of plus disease in the mouse oxygen-induced retinopathy (OIR) model for retinopathy of prematurity. METHODS:Wild-type and Adam (A Disintegrin And Metalloproteinase) knockout mice were exposed to 75% oxygen from postnatal day 7 to 12 (P7 to P12) (hyperoxia), t...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.12-11492

    authors: Guaiquil VH,Hewing NJ,Chiang MF,Rosenblatt MI,Chan RV,Blobel CP

    更新日期:2013-08-07 00:00:00

  • Scanning electron microscopy of human drusen.

    abstract::Drusen are small, yellowish deposits that form under the retinal pigment epithelium (RPE) with senescence or under certain pathological conditions. The present study examined these structures under the scanning electron microscope. Tissue came from four eyes of 66- and 75-year-old donors who demonstrated widespread dr...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Ulshafer RJ,Allen CB,Nicolaissen B Jr,Rubin ML

    更新日期:1987-04-01 00:00:00

  • Angiography and multifocal electroretinography show that blood supply to the pig retina may be both ipsilateral and contralateral.

    abstract:PURPOSE:We recently presented a transfemoral endovascular coiling technique for inducing experimental retinal ischemia in pigs. Substantial variation was seen in the degree of ischemia. It was hypothesized that the blood supply to the retina may originate from both the ipsilateral and contralateral ophthalmic arteries ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.13-12376

    authors: Morén H,Gesslein B,Undrén P,Andreasson S,Malmsjö M

    更新日期:2013-09-09 00:00:00

  • Diclofenac protects cultured human corneal epithelial cells against hyperosmolarity and ameliorates corneal surface damage in a rat model of dry eye.

    abstract:PURPOSE:Dry eye syndrome (DES) is characterized by an increase in tear osmolarity and induction of the expression and nuclear localization of an osmoprotective transcription factor (nuclear factor of activated T-cells 5 [NFAT5]) that plays an important role in providing protection against hyperosmotic tears. In this st...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.13-13850

    authors: Sawazaki R,Ishihara T,Usui S,Hayashi E,Tahara K,Hoshino T,Higuchi A,Nakamura S,Tsubota K,Mizushima T

    更新日期:2014-04-21 00:00:00

  • Myeloid suppressor cells induced by retinal pigment epithelial cells inhibit autoreactive T-cell responses that lead to experimental autoimmune uveitis.

    abstract:PURPOSE:To test whether retinal pigment epithelial (RPE) cells are able to induce myeloid-derived suppressor cell (MDSC) differentiation from bone marrow (BM) progenitors. METHODS:BM cells were cocultured with or without RPE cells in the presence of GM-CSF and IL-4. Numbers of resultant MDSCs were assessed by flow cyt...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.11-8377

    authors: Tu Z,Li Y,Smith D,Doller C,Sugita S,Chan CC,Qian S,Fung J,Caspi RR,Lu L,Lin F

    更新日期:2012-02-23 00:00:00

  • Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma.

    abstract:PURPOSE:Primary intraocular lymphoma (PIOL) is a diffuse large B cell lymphoma that initially infiltrates the retina, vitreous, or optic nerve head, with or without central nervous system involvement. This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 m...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.05-1312

    authors: Wallace DJ,Shen D,Reed GF,Miyanaga M,Mochizuki M,Sen HN,Dahr SS,Buggage RR,Nussenblatt RB,Chan CC

    更新日期:2006-07-01 00:00:00

  • The acute effect of topical epinephrine on macular blood flow in humans.

    abstract::The acute effect of topical epinephrine HCl 2% on macular capillary blood flow was studied in 18 healthy human volunteers using the blue-field simulation technique. This technique provides a method for quantifying the velocity of leukocytes flowing in macular capillaries. Subjects adjusted the velocity of simulated le...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Robinson F,Chen S,Petrig BL,Grunwald JE,Riva CE

    更新日期:1992-01-01 00:00:00

  • Heritability of macular pigment: a twin study.

    abstract:PURPOSE:Several studies have reported higher levels of macular pigment (MP) in association with reduced risk for age-related macular degeneration (ARMD), a disease to which there is a genetic predisposition. A classic twin study was performed to determine the heritability of MP in the healthy eye. METHODS:One hundred ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.05-0519

    authors: Liew SH,Gilbert CE,Spector TD,Mellerio J,Marshall J,van Kuijk FJ,Beatty S,Fitzke F,Hammond CJ

    更新日期:2005-12-01 00:00:00

  • Analysis of macrophage phenotype in rejected corneal allografts.

    abstract:PURPOSE:We investigated the phenotype of macrophages infiltrating rejected corneal allografts. METHODS:We performed allogeneic or syngeneic corneal transplantation in mice, and humanely killed animals at day 28 during allograft rejection when 60% of corneal allografts were rejected. We divided allografts into two grou...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.13-12650

    authors: Oh JY,Lee HJ,Ko AY,Ko JH,Kim MK,Wee WR

    更新日期:2013-11-21 00:00:00

  • Molecular cloning of a new angiopoietinlike factor from the human cornea.

    abstract:PURPOSE:To isolate tissue-specific gene products that contribute to corneal integrity. METHODS:A cDNA library was constructed and differentially hybridized. Cornea-specific clones were purified and further characterized. RESULTS:In this study cornea-specific gene products were isolated by differential cDNA hybridizat...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Peek R,van Gelderen BE,Bruinenberg M,Kijlstra A

    更新日期:1998-09-01 00:00:00

  • A fungal pH-responsive signaling pathway regulating Aspergillus adaptation and invasion into the cornea.

    abstract:PURPOSE:To investigate the role of PalB and PacC, two components of a pH-responsive signal-transduction pathway of Aspergillus nidulans, during the pathogenesis of fungal infection of the cornea. METHODS:Fungal strains included an A. nidulans wild-type isolate (A83), loss-of-function A. nidulans mutants of the palB (B...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.09-4348

    authors: Hua X,Yuan X,Wilhelmus KR

    更新日期:2010-03-01 00:00:00

  • Suprathreshold spatial frequency detection and binocular interaction in strabismic and anisometropic amblyopia.

    abstract::We have investigated suprathreshold contrast sensitivity and binocular interactions in strabismic and anisometropic amblyopes using a reaction time paradigm. For every spatial frequency, reaction time increased as the grating contrast decreased. At all spatial frequencies and contrast values the reaction times using t...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Levi DM,Harwerth RS,Manny RE

    更新日期:1979-07-01 00:00:00

  • Naturally occurring vitreous chamber-based myopia in the Labrador retriever.

    abstract:PURPOSE:To investigate whether myopia is present in a breed of domestic dog, the Labrador retriever, and how the ocular components are related to refractive error in this breed. METHODS:Cycloplegic refractive error was measured in 75 Labrador retrievers by retinoscopy. Corneal and crystalline lens radii of curvature w...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Mutti DO,Zadnik K,Murphy CJ

    更新日期:1999-06-01 00:00:00

  • Reduction of inner retinal thickness in patients with autosomal dominant optic atrophy associated with OPA1 mutations.

    abstract:PURPOSE:To determine the morphologic changes in the retina in the macula and around the optic disc in patients with autosomal dominant optic atrophy (ADOA) associated with a mutation in the OPA1 gene. METHODS:Cross-sectional images of the macular area of the retina were obtained by optical coherence tomography (OCT) i...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.07-0024

    authors: Ito Y,Nakamura M,Yamakoshi T,Lin J,Yatsuya H,Terasaki H

    更新日期:2007-09-01 00:00:00

  • Intraocular Vascular Endothelial Growth Factor Levels in Pachychoroid Neovasculopathy and Neovascular Age-Related Macular Degeneration.

    abstract:Purpose:To investigate the difference in intraocular vascular endothelial growth factor (VEGF) concentration between pachychoroid neovasculopathy and neovascular age-related macular degeneration (nAMD) and its associations with responses to three monthly anti-VEGF injections as an initial treatment for the two conditio...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.16-20967

    authors: Hata M,Yamashiro K,Ooto S,Oishi A,Tamura H,Miyata M,Ueda-Arakawa N,Takahashi A,Tsujikawa A,Yoshimura N

    更新日期:2017-01-01 00:00:00