Lipoprotein particles of intraocular origin in human Bruch membrane: an unusual lipid profile.

abstract：PURPOSE:To determine and compare gene expression patterns in the whole retina and retinal ganglion cell layer (RGCL) in a rodent glaucoma model. METHODS:IOP was unilaterally elevated in Brown Norway rats (N = 26) by injection of hypertonic saline and monitored for 5 weeks. A cDNA microarray was used on whole retinas f...

journal_title：Investigative ophthalmology & visual science

authors： Guo Y,Cepurna WO,Dyck JA,Doser TA,Johnson EC,Morrison JC

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To elucidate the spatial distribution of inactivation of lactate dehydrogenase (LDH) in ultraviolet-B radiation (UVR-B)-exposed eyes. To determine the in vivo penetration depth of UVR-B in the lens. METHODS:LDH activity in cornea and lens was investigated with an enzyme histochemical technique. Thirty rats wer...

journal_title：Investigative ophthalmology & visual science

authors： Löfgren S,Söderberg PG

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:To evaluate the utility of baseline Stratus optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA) retinal nerve fiber layer (RNFL) normative classification in the prediction of future visual field (VF) loss. METHODS:Eighty-eight eyes with suspected glaucoma with abnormal RNFL classification by Str...

journal_title：Investigative ophthalmology & visual science

authors： Sung KR,Kim S,Lee Y,Yun SC,Na JH

更新日期：2011-04-22 00:00:00

abstract：PURPOSE:To compare conventional pattern-reversal visual evoked potentials (cVEPs) with multifocal VEPs (mfVEPs). METHODS:mfVEPs and cVEPs were recorded during the same session in 12 normal subjects with an active electrode at Oz referenced to the inion (Oz-In) or to a midfrontal position, Fz (Oz-Fz). The mfVEP stimulu...

journal_title：Investigative ophthalmology & visual science

authors： Fortune B,Hood DC

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:In humans, mutations in the gene encoding myosin VIIa can cause Usher syndrome type 1b (USH1B), a disease characterized by deafness and retinitis pigmentosa. Myosin VIIa is also the gene responsible for the inner ear abnormalities at the shaker1 (sh1) locus in mice. To date, none of the sh1 alleles examined hav...

journal_title：Investigative ophthalmology & visual science

authors： Libby RT,Steel KP

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:To test the effect of stimulators of activator protein (AP)-1, on expression of stromelysin (MMP-3) in human TM cells and on aqueous outflow in perfused human anterior segments. METHODS:Change in MMP-3 expression was determined by immunoassay of proMMP-3 levels in the media of cultured human TM cells. Anterior...

journal_title：Investigative ophthalmology & visual science

authors： Pang IH,Fleenor DL,Hellberg PE,Stropki K,McCartney MD,Clark AF

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:The prevalence of myopia shows a decline with age in cross-sectional studies. This pattern may represent an increase in the prevalence of myopia in younger generations, possibly through increased exposure to near work, or an intrinsic age-related decline in myopia prevalence. Data were analyzed from published s...

journal_title：Investigative ophthalmology & visual science

authors： Mutti DO,Zadnik K

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:Inflammatory status of RPE cells induced by A2E is essential in the development of AMD. Recent research indicated T-cell immunity was involved in the pathological progression of AMD. This study was designed to investigate how A2E suppresses immunoregulatory function of RPE cells in T-cell immunity in vitro. ME...

journal_title：Investigative ophthalmology & visual science

authors： Shi Q,Wang Q,Li J,Zhou X,Fan H,Wang F,Liu H,Sun X,Sun X

更新日期：2015-12-01 00:00:00

abstract：:This paper investigates the amplitude of accommodation of early onset myopes, late onset myopes, emmetropes, and hyperopes. Eighty subjects were used, 41 women and 39 men, with an age range of 18-22 yr (mean = 19.82). All subjects wore an optimum refractive correction, giving visual acuities of 20/20 or better. Signif...

journal_title：Investigative ophthalmology & visual science

authors： McBrien NA,Millodot M

更新日期：1986-07-01 00:00:00

abstract：PURPOSE:We evaluated the clinical use of segmented macular layer thickness measurement in terms of glaucoma diagnosis and the ability to detect progression, and to compare such outcomes to those by circumpapillary retinal nerve fiber layer (cRNFLT) and total macular thickness (TMT) measurements. METHODS:The study incl...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Kim YJ,Durbin MK,Lee HJ,Kim HK,Sohn YH

更新日期：2012-06-20 00:00:00

abstract：PURPOSE:To determine the contribution of copy number variation (CNV) in glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) to the susceptibility to age-related cataract (ARC) and its subtypes in a Han Chinese population. METHODS:ARC cases (n = 279) and controls (n = 145) were included from a...

journal_title：Investigative ophthalmology & visual science

authors： Zhou J,Hu J,Guan H

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:In uveal melanoma, both tumor size and an inflammatory phenotype have been shown to correlate with a poor clinical prognosis. The purpose of this study was to identify whether inflammatory cytokines were present in the vitreous of eyes with uveal melanoma and to determine whether the vitreal concentration of cy...

journal_title：Investigative ophthalmology & visual science

authors： Nagarkatti-Gude N,Bronkhorst IH,van Duinen SG,Luyten GP,Jager MJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:This study observed biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus in contact lens cases and investigated the inhibitory effects of 2,2'-dipyridyl (2DP) and 1,2,3,4,6-penta-O-galloyl-b-D-glucopyranose (PGG). METHODS:Biofilm formation of P. aeruginosa ATCC 9027 and S. aureus ATCC 25923 an...

journal_title：Investigative ophthalmology & visual science

authors： Cho P,Shi GS,Boost M

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in transducing inner retinal neurons after intravitreal injection in several species. However, results in nonprimates may not be predictive of transduction in the human inner retina, because of differences in eye size and the specialized mo...

journal_title：Investigative ophthalmology & visual science

authors： Yin L,Greenberg K,Hunter JJ,Dalkara D,Kolstad KD,Masella BD,Wolfe R,Visel M,Stone D,Libby RT,Diloreto D Jr,Schaffer D,Flannery J,Williams DR,Merigan WH

更新日期：2011-04-25 00:00:00

abstract：:Tissue culture of retinal vessels from fetal calf eyes produced colonies of endothelium, pericytes, and smooth muscle. Identification of endothelial cells was based upon culture morphology, [3H]thymidine labeling of isolated vessels, and factor VIII immunofluorescence. Thimerosal added to the culture medium destroyed ...

journal_title：Investigative ophthalmology & visual science

authors： Buzney SM,Massicotte SJ

更新日期：1979-11-01 00:00:00

abstract：PURPOSE:To determine the influence of specific regions within Lp82 calpain on protein stability, enzymatic activity, and localization within lens and to test the influence of an Lp82 knockout mouse on normal maturational proteolysis in lens. METHODS:DNA constructs for Lp82 and Lp82-related proteins were subcloned into...

journal_title：Investigative ophthalmology & visual science

authors： Ma H,Shih M,Fukiage C,Azuma M,Duncan MK,Reed NA,Richard I,Beckmann JS,Shearer TR

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:To determine the association between ocular dominance and spherical or astigmatic anisometropia, age, and sex. METHODS:Medical records of 10,264 myopic refractive surgery candidates were filtered. Ocular dominance was assessed with the hole-in-the-card test. Manifest refractive error was measured in each subje...

journal_title：Investigative ophthalmology & visual science

authors： Linke SJ,Baviera J,Munzer G,Steinberg J,Richard G,Katz T

更新日期：2011-11-25 00:00:00

abstract：PURPOSE:To evaluate the efficacy of a biodegradable scleral plug containing ganciclovir (GCV) in a rabbit model of human cytomegalovirus (HCMV) retinitis. METHODS:To develop a rabbit model for HCMV retinitis, HCMV solution was injected once into the vitreous cavity of pigmented rabbits. The treated animals were divide...

journal_title：Investigative ophthalmology & visual science

authors： Sakurai E,Matsuda Y,Ozeki H,Kunou N,Nakajima K,Ogura Y

更新日期：2001-08-01 00:00:00

abstract：:A group of 26 subjects with myotonic dystrophy were studied with fluorophotometry to evaluate the relationship between aqueous humor dynamics and the hypotony found in this disorder. All 26 received topical fluorescein to determine the anterior chamber elimination coefficient; five received systemic fluorescein to eva...

journal_title：Investigative ophthalmology & visual science

authors： Walker SD,Brubaker RF,Nagataki S

更新日期：1982-06-01 00:00:00

abstract：PURPOSE:A great deal of information about functionally significant domains of a protein may be obtained by comparison of primary sequences of gene homologues over a broad phylogenetic base. This study was designed to identify evolutionarily conserved domains of the photoreceptor disc membrane protein peripherin/rds by ...

journal_title：Investigative ophthalmology & visual science

authors： Li C,Ding XQ,O'Brien J,Al-Ubaidi MR,Naash MI

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:meso-Zeaxanthin is a carotenoid that is rarely encountered in nature outside of the vertebrate eye. It is not a constituent of a normal human diet, yet this carotenoid comprises one-third of the primate macular pigment. In the current study, we undertook a systematic approach to biochemically characterize the p...

journal_title：Investigative ophthalmology & visual science

authors： Gorusupudi A,Shyam R,Li B,Vachali P,Subhani YK,Nelson K,Bernstein PS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To investigate macular photoreceptor structure in patients with inherited retinal degeneration using high-resolution images and to correlate the findings with clinical phenotypes and genetic mutations. METHODS:Adaptive optics scanning laser ophthalmoscopy (AOSLO) images of photoreceptors were obtained in 16 ey...

journal_title：Investigative ophthalmology & visual science

authors： Duncan JL,Zhang Y,Gandhi J,Nakanishi C,Othman M,Branham KE,Swaroop A,Roorda A

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:To identify the prognostic value of extraocular extension in enucleated uveal melanoma (UM) patients and to correlate extraocular extension to chromosomal aberrations, metastasis-free survival (MFS), and clinico-histopathological risk factors. METHODS:Retrospective study of patients with UM treated with enucle...

journal_title：Investigative ophthalmology & visual science

authors： van Beek JG,Koopmans AE,Vaarwater J,de Rooi JJ,Paridaens D,Naus NC,de Klein A,Verdijk RM,Kiliç E

更新日期：2014-03-04 00:00:00

abstract：PURPOSE:We examined changes of the central nervous system in patients with advanced primary open-angle glaucoma (POAG). METHODS:The clinical observational study included 15 patients with bilateral advanced POAG and 15 healthy normal control subjects, matched for age and sex with the study group. Retinal nerve fiber l...

journal_title：Investigative ophthalmology & visual science

authors： Chen WW,Wang N,Cai S,Fang Z,Yu M,Wu Q,Tang L,Guo B,Feng Y,Jonas JB,Chen X,Liu X,Gong Q

更新日期：2013-01-17 00:00:00

abstract：PURPOSE:To compare confocal scanning laser tomography (CSLT) to optic disc photography for detecting progressive glaucomatous disc changes. METHODS:Four expert observers first examined a training set of 40 pairs of monoscopic disc photographs to help set a criterion for change. They then classified 44 pairs of monosco...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Hutchison DM,Artes PH,Caprioli J,Jonas JB,LeBlanc RP,Nicolela MT

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:StarGen is an equine infectious anemia virus (EIAV)-based lentiviral vector that expresses the photoreceptor-specific adenosine triphosphate (ATP)-binding cassette transporter (ABCA4) protein that is mutated in Stargardt disease (STGD1), a juvenile macular dystrophy. EIAV vectors are able to efficiently transdu...

journal_title：Investigative ophthalmology & visual science

authors： Binley K,Widdowson P,Loader J,Kelleher M,Iqball S,Ferrige G,de Belin J,Carlucci M,Angell-Manning D,Hurst F,Ellis S,Miskin J,Fernandes A,Wong P,Allikmets R,Bergstrom C,Aaberg T,Yan J,Kong J,Gouras P,Prefontaine A,

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:Diabetic retinopathy (DR) is a major cause of visual impairment in developed countries. While DR has been described classically as a microvascular disease, recent evidence suggests that changes to retinal microglia are an early feature of retinopathy. In our study, we assessed changes in microglial distribution...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chen X,Rakoczy EP,McMenamin PG

更新日期：2013-01-30 00:00:00

abstract：PURPOSE:This study investigated the relationship between amplitude and peak velocity of saccadic eye movements (the so-called main sequence) and the intra-individual variability of the main sequence. METHODS:Saccadic amplitudes and peak velocities were measured twice in 58 healthy subjects with an infrared reflection ...

journal_title：Investigative ophthalmology & visual science

authors： Bollen E,Bax J,van Dijk JG,Koning M,Bos JE,Kramer CG,van der Velde EA

更新日期：1993-12-01 00:00:00

abstract：:Sodium iodate and sodium iodoacetate were employed as biological probes to evaluate component forces contributing to the strength of retinal adhesion to the retinal pigment epithelium (RPE). Iodate treatment produced a rapid reduction in the strength of adhesion, which was complete within 1 hr without evidence of conc...

journal_title：Investigative ophthalmology & visual science

authors： Ashburn FS Jr,Pilkerton AR,Rao NA,Marak GE

更新日期：1980-12-01 00:00:00

abstract：:We present results from 64 glaucoma patients and glaucoma suspects followed up for a median period of 7.4 yr who had a median of seven examinations using Program 31 on the Octopus perimeter. The patients also had manual visual fields recorded on either the Tübinger or Goldmann perimeter during the same period. By exam...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Drance SM,Douglas GR

更新日期：1990-03-01 00:00:00