Epigenetic Modifications Compromise Mitochondrial DNA Quality Control in the Development of Diabetic Retinopathy.

abstract：PURPOSE:Dietary deficiency in the retinoid precursors of the visual pigment chromophore 11-cis retinal eventually results in selective degeneration of the photoreceptor cells of the vertebrate retina. An early effect of retinoid deficiency is depletion of chromophore from the photoreceptor outer segments. Experiments w...

journal_title：Investigative ophthalmology & visual science

authors： Katz ML,Stientjes HJ,Gao CL,Norberg M

更新日期：1993-05-01 00:00:00

abstract：PURPOSE:To compare the mydriatic effect and the short-term corneal endothelial safety of intracamerally injected N-methyl-3,4-dihydroxyphenylamine (epinine) to phenylephrine in a porcine eye model. METHODS:One hundred twelve eyes from newly slaughtered pigs were used in this study. After pretreatment with 20 mg intrac...

journal_title：Investigative ophthalmology & visual science

authors： Lundberg B,Behndig A

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To assess the reactive changes of the corneal epithelial thickness (ET) profile induced by small incision lenticule extraction (SMILE) for treatment of myopia. METHODS:This prospective observational study included 46 eyes of 23 patients that were scheduled for myopic SMILE. High-resolution spectral-domain opti...

journal_title：Investigative ophthalmology & visual science

authors： Luft N,Ring MH,Dirisamer M,Mursch-Edlmayr AS,Kreutzer TC,Pretzl J,Bolz M,Priglinger SG

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:To describe the variation in ocular biometry and its association with refraction in adult Mongolians. METHODS:The study included 1800 subjects, aged 40 years or more, who were selected in two Mongolian provinces-Hövsgöl and Omnögobi-to participate in this population survey. Axial length (AL) and its componen...

journal_title：Investigative ophthalmology & visual science

authors： Wickremasinghe S,Foster PJ,Uranchimeg D,Lee PS,Devereux JG,Alsbirk PH,Machin D,Johnson GJ,Baasanhu J

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:Experimental autoimmune uveoretinitis (EAU) in mice is an important model for elucidating basic mechanisms in autoimmune eye disease. The need for pertussis toxin (PTX) as an additional adjuvant to elicit EAU has limited the usefulness of this model in some types of studies by introducing a pleiotropic factor w...

journal_title：Investigative ophthalmology & visual science

authors： Silver PB,Chan CC,Wiggert B,Caspi RR

更新日期：1999-11-01 00:00:00

abstract：:The existence of wide-band, phase-specific channels in the human visual system has been suggested in recent investigations. We used a number of adapting gratings to test for phase-specific adaptation effects. Observers were asked to discriminate between a simple 3 cpd sine-wave grating, (3), and a complex grating comp...

journal_title：Investigative ophthalmology & visual science

authors： Sansbury RV,Distelhorst J,Moore S

更新日期：1978-05-01 00:00:00

abstract：PURPOSE:To localize and identify the gene and mutations causing autosomal dominant retinitis pigmentosa in a Chinese Family. METHODS:Families were ascertained and patients underwent complete ophthalmic examinations. Blood samples were collected and DNA was extracted. A linkage scan of genomic regions containing known ...

journal_title：Investigative ophthalmology & visual science

authors： Li N,Mei H,MacDonald IM,Jiao X,Hejtmancik JF

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To evaluate age-related Meibomian gland (MG) changes by in vivo laser scanning confocal microscopy (LSCM). METHODS:Asymptomatic healthy subjects (n=100, age range 20-83 years) with an Ocular Surface Disease Index score of less than 13 were consecutively enrolled. Two additional groups, one composed of subjects...

journal_title：Investigative ophthalmology & visual science

authors： Villani E,Canton V,Magnani F,Viola F,Nucci P,Ratiglia R

更新日期：2013-07-16 00:00:00

abstract：PURPOSE:Mammalian central nervous system neurons fail to regenerate after injury or disease, in part due to a progressive loss in intrinsic axon growth ability after birth. Whether lost axon growth ability is due to limited growth resources or to changes in the axonal growth cone is unknown. METHODS:Static and time-la...

journal_title：Investigative ophthalmology & visual science

authors： Steketee MB,Oboudiyat C,Daneman R,Trakhtenberg E,Lamoureux P,Weinstein JE,Heidemann S,Barres BA,Goldberg JL

更新日期：2014-06-06 00:00:00

abstract：:The relative importance of the anterior ciliary arteries to blood flow to the anterior segment and the quadrant distribution of blood to the iris, ciliary body, and ciliary processes were determined in canines with the use of 15 +/- 3 mum 103Ru microspheres with the reference blood flow method. Recti muscles were isol...

journal_title：Investigative ophthalmology & visual science

authors： Keough EM,Wilcox LM,Connolly RJ,Hotte CE

更新日期：1980-11-01 00:00:00

abstract：PURPOSE:To compare structural properties from spectral-domain optical coherence tomography (SDOCT) and psychophysical measures from a subset of patients enrolled in a larger multicenter natural history study of X-linked retinoschisis (XLRS). METHODS:A subset of males (n = 24) participating in a larger natural history ...

journal_title：Investigative ophthalmology & visual science

authors： Bennett LD,Wang YZ,Klein M,Pennesi ME,Jayasundera T,Birch DG

更新日期：2016-02-01 00:00:00

abstract：:Two-dimensional electrophoretic maps of extracts from eleven normal and eleven keratoconus corneas were compared. Of the eleven corneas analyzed, eight were pooled and the remaining three were analyzed individually. Several differences were demonstrated between electrophoretic patterns of normal and keratoconus cornea...

journal_title：Investigative ophthalmology & visual science

authors： Panjwani N,Drysdale J,Clark B,Alberta J,Baum J

更新日期：1989-12-01 00:00:00

abstract：PURPOSE:Disruption of the normally antiangiogenic environment of the retina leads to aberrant angiogenesis, the major cause of vision loss throughout the world. Prolactin (PRL), the hormone originally associated with milk production, can be proteolytically processed to 16K-PRL, a 16 kDa N-terminal PRL fragment with pot...

journal_title：Investigative ophthalmology & visual science

authors： Aranda J,Rivera JC,Jeziorski MC,Riesgo-Escovar J,Nava G,López-Barrera F,Quiróz-Mercado H,Berger P,Martínez de la Escalera G,Clapp C

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:To analyze the roles of vitreal macrophages and circulating leukocytes in retinal vascular growth. METHODS:Bone marrow (BM) cells from green fluorescent protein (GFP) transgenic mice were transplanted into postnatal day (P)1 mice after irradiation. The mice were exposed to 76% to 78% oxygen (P7-P12), to initia...

journal_title：Investigative ophthalmology & visual science

authors： Kataoka K,Nishiguchi KM,Kaneko H,van Rooijen N,Kachi S,Terasaki H

更新日期：2011-03-14 00:00:00

abstract：PURPOSE:The incidence of blindness is increasing, in part, because of abnormal ocular neovascularization. Anti-VEGF therapies have yielded impressive results; however, they are not a cure for blindness. Recently, metallothioneins (MTs) 1 and 2 have been implicated in the process of angiogenesis. Therefore, we investiga...

journal_title：Investigative ophthalmology & visual science

authors： Nakamura S,Shimazawa M,Inoue Y,Takata S,Ito Y,Tsuruma K,Ikeda T,Honda A,Satoh M,Hara H

更新日期：2014-09-23 00:00:00

abstract：PURPOSE:To determine the site of highest resistance to the movement of water across Bruch's membrane in humans. METHODS:A hydraulic conductivity chamber was designed that enabled us to measure flow across Bruch's membrane while ablating its subepithelial aspect using an excimer laser (193 nm). When resistance was lost...

journal_title：Investigative ophthalmology & visual science

authors： Starita C,Hussain AA,Patmore A,Marshall J

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:The degeneration of retinal pigment epithelial (RPE) cells is considered to be a crucial event in the pathophysiology of age-related macular degeneration (AMD). Cumulative oxidative damage has been implicated in the development of the changes seen in AMD. The present study was undertaken to evaluate the express...

journal_title：Investigative ophthalmology & visual science

authors： Alge CS,Priglinger SG,Neubauer AS,Kampik A,Zillig M,Bloemendal H,Welge-Lussen U

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:Overloading of unfolded or misfolded proteins in the endoplasmic reticulum (ER) can cause ER stress and activate the unfolded protein response (UPR) in the cell. The authors tested whether transgene overexpression in the mouse lens would activate the UPR. METHODS:Transgenic mice expressing proteins that either...

journal_title：Investigative ophthalmology & visual science

authors： Reneker LW,Chen H,Overbeek PA

更新日期：2011-04-04 00:00:00

abstract：Purpose:To assess interocular delays in amblyopes with stereopsis and to evaluate the relationship between interocular delays and the clinical characteristics. Methods:Twenty amblyopes with stereopsis (median, 400 arcseconds) and 20 controls with normal or corrected to normal visual acuity (≤0 logMAR) and normal stere...

journal_title：Investigative ophthalmology & visual science

authors： Wu Y,Reynaud A,Tao C,Mao Y,He Z,Zhou J,Hess RF

更新日期：2020-03-09 00:00:00

abstract：:The purpose of the current study was to investigate the relationship between systemic blood pressure (BP) and long posterior ciliary arterial (LPCA) blood flow (BF) in response to autonomic drugs, and to determine the types of receptors involved. LPCA BF was measured in anesthetized rabbits at the retrobulbar region u...

journal_title：Investigative ophthalmology & visual science

authors： Okubo H,Gherezhiher T,Koss MC

更新日期：1990-05-01 00:00:00

abstract：:A method for denuding Descemet's membrane by dissection of all overlying stroma, while preserving the corneal endothelial layer, was developed and evaluated. The technique consists in treating the stroma with trypsin and surgically removing the softened stromal layers. With an automated thickness-measuring technique, ...

journal_title：Investigative ophthalmology & visual science

authors： Soong H,Fischbarg J,Iwamoto T

更新日期：1978-11-01 00:00:00

abstract：:The level of oxygen at the anterior corneal surface beneath the closed eyelid is shown to be equivalent to an atmosphere of 7.7% oxygen. This finding is in good agreement with assumptions which have been based on the oxygen level at the palpebral conjunctiva. However, in some instances a significant amount of oxygen i...

journal_title：Investigative ophthalmology & visual science

authors： Efron N,Carney LG

更新日期：1979-01-01 00:00:00

abstract：PURPOSE:To examine the association between central corneal thickness (CCT) and glaucoma. METHODS:This was a nested case-control study using 1090 subjects from an eye disease population survey in Singapore and 243 participants from a hospital glaucoma surgery clinical trial in Singapore. RESULTS:Mean CCT in 938 commun...

journal_title：Investigative ophthalmology & visual science

authors： Day AC,Machin D,Aung T,Gazzard G,Husain R,Chew PT,Khaw PT,Seah SK,Foster PJ

更新日期：2011-10-28 00:00:00

abstract：PURPOSE:Reading a text requires vergence angle adjustments, so that the images in the two eyes fall on corresponding retinal areas. Vergence adjustments bring the two retinal images into Panum's fusional area and therefore, small remaining errors or regulations do not lead to double vision. The present study evaluated ...

journal_title：Investigative ophthalmology & visual science

authors： Jainta S,Dehnert A,Heinrich SP,Jaschinski W

更新日期：2011-12-09 00:00:00

abstract：PURPOSE:To isolate and characterize ciliary body epithelial antigens reactive with a monoclonal antibody, 2B4.14.1. METHODS:A mouse monoclonal antibody generated against human corneal endothelium, 2B4.14.1 reacts with nonpigmented epithelium of human and guinea pig ciliary bodies. The ciliary body proteins reactive wi...

journal_title：Investigative ophthalmology & visual science

authors： Howell DN,Ross JR,Miller SE,Sanfilippo FP

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:A human biovar of Chlamydia trachomatis was used to develop a murine model of ocular chlamydial infection. The inbred mouse model will allow detailed immunologic studies during ocular infection, and use of a human biovar for infection may aid in identification of appropriate vaccine strategies against chlamydia...

journal_title：Investigative ophthalmology & visual science

authors： Whittum-Hudson JA,O'Brien TP,Prendergast RA

更新日期：1995-09-01 00:00:00

abstract：PURPOSE:To investigate the role of anti-vascular endothelial growth factor (VEGF)-C therapy in corneal graft survival and concomitant suppression of hem- and lymph-angiogenesis. METHODS:Corneal suture model in BALB/c mice was placed and immunohistochemical staining was performed with CD31/PECAM-1 and LYVE-1 to quantif...

journal_title：Investigative ophthalmology & visual science

authors： Hajrasouliha AR,Funaki T,Sadrai Z,Hattori T,Chauhan SK,Dana R

更新日期：2012-03-09 00:00:00

abstract：:We tested the state of retinal correspondence at different positions in the visual field of ten observers with strabismic and/or anisometropic amblyopia, four strabismic subjects with alternating fixation and three normal controls. Correspondence was evaluated by the subjective displacement of dichoptic stimuli; to es...

journal_title：Investigative ophthalmology & visual science

authors： Sireteanu R,Fronius M

更新日期：1989-09-01 00:00:00

abstract：PURPOSE:To determine the roles of glial fibrillary acidic protein (GFAP) and vimentin in Müller cell reactivity. METHODS:Retinal detachments were created in mice deficient for GFAP and vimentin (GFAP(-/-)vim(-/-)) and age-matched wild-type (wt) mice. The reactivity of the retina was studied by immunofluorescence and e...

journal_title：Investigative ophthalmology & visual science

authors： Verardo MR,Lewis GP,Takeda M,Linberg KA,Byun J,Luna G,Wilhelmsson U,Pekny M,Chen DF,Fisher SK

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To determine whether the size and configuration of the optic chiasm in humans with albinism is different from that in normal control subjects. METHODS:Seventeen patients and 15 control subjects underwent magnetic resonance imaging of the entire head. Images were reformatted to the chiasm region and analyzed wi...

journal_title：Investigative ophthalmology & visual science

authors： Schmitz B,Schaefer T,Krick CM,Reith W,Backens M,Käsmann-Kellner B

更新日期：2003-01-01 00:00:00