Scene perception in age-related macular degeneration.


PURPOSE:To assess the scene gist recognition in eyes with age-related macular degeneration (AMD) and to study the relationship between scene recognition and macular function. METHODS:Twenty-seven patients with age-related macular degeneration with a visual acuity lower than 20/50 and 17 age-matched controls were included. All patients underwent a visual field test, fundus autofluorescence, and fluorescein angiography to assess the visual field defect and the lesion size. The stimuli were colored photographs of natural scenes displayed on a 30-inch screen. Two scene categorization tasks were performed: natural versus urban and indoor versus outdoor scenes. Participants were given a target (e.g., indoor scenes) and asked to press a key when they saw a picture corresponding to that target. Accuracy and response times were recorded. RESULTS:Patients with AMD were able to accomplish both categorization tasks with a high correct detection rate (above 75% correct), though performance was lower than in controls for both natural/urban scenes and indoor/outdoor scenes. Patients with AMD were more accurate and faster for natural/urban scenes than for indoor/outdoor scenes, but performance did not differ between the two categories in controls. No significant correlation was found between performance for scene categorization and clinical variables such as visual acuity, type of AMD, size of the scotoma, and size of the lesion. CONCLUSIONS:Scene gist recognition can be accomplished with the low spatial resolution of peripheral vision. These results support the "scene-centered approach" that initial scene recognition is based on the global scene properties and not on the objects it contains.


Tran TH,Rambaud C,Despretz P,Boucart M




Has Abstract


2010-12-01 00:00:00














  • The effects of citrate on the adherence of neutrophils to nylon fibers in vitro.

    abstract::The therapeutic effect of citrate on alkali-burned eyes is thought to be the result of inhibition of PMN activities while ascorbate apparently stimulates the production of new collagen by scorbutic fibroblasts. Attachment of PMNs to the vascular endothelium is the initial PMN response to mediators and must occur befor...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Pfister RR,Haddox JL,Snyder TL

    更新日期:1988-06-01 00:00:00

  • Relationship between retinal vascular geometry with retinal nerve fiber layer and ganglion cell-inner plexiform layer in nonglaucomatous eyes.

    abstract:PURPOSE:To examine the relationship between retinal vascular geometric parameters with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) parameters in nonglaucomatous subjects. METHODS:Study subjects were identified from the Singapore Chinese Eye Study (SCES), a population-based survey ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Tham YC,Cheng CY,Zheng Y,Aung T,Wong TY,Cheung CY

    更新日期:2013-11-05 00:00:00

  • Neural network classification of corneal topography. Preliminary demonstration.

    abstract:PURPOSE:Videokeratography is a powerful tool for the diagnosis of corneal shape abnormalities. However, interpretation of the topographic map is sometimes difficult, especially when pathologies with similar topographic patterns are suspected. The neural networks model, an artificial intelligence approach, was applied f...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Maeda N,Klyce SD,Smolek MK

    更新日期:1995-06-01 00:00:00

  • IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis.

    abstract:PURPOSE:To determine the role of IL-33 in resistance to Pseudomonas aeruginosa keratitis. METHODS:Corneal IL-33 mRNA and protein levels were tested in susceptible C57BL/6 (B6) and resistant BALB/c mice. B6 mice were injected with recombinant mouse IL-33 (rmIL-33) and disease severity, bacterial load, polymorphonuclear...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Hazlett LD,McClellan SA,Barrett RP,Huang X,Zhang Y,Wu M,van Rooijen N,Szliter E

    更新日期:2010-03-01 00:00:00

  • Molecular cloning of a new angiopoietinlike factor from the human cornea.

    abstract:PURPOSE:To isolate tissue-specific gene products that contribute to corneal integrity. METHODS:A cDNA library was constructed and differentially hybridized. Cornea-specific clones were purified and further characterized. RESULTS:In this study cornea-specific gene products were isolated by differential cDNA hybridizat...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Peek R,van Gelderen BE,Bruinenberg M,Kijlstra A

    更新日期:1998-09-01 00:00:00

  • Expression of the Opa1 mitochondrial protein in retinal ganglion cells: its downregulation causes aggregation of the mitochondrial network.

    abstract:PURPOSE:Mutations in the mitochondrial dynamin-related GTPase OPA1 cause autosomal dominant optic atrophy (ADOA), but the pathophysiology of this disease is unknown. As a first step in functional studies, this study was conducted to evaluate the expression of Opa1 in whole retina and in isolated retinal ganglion cells ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Kamei S,Chen-Kuo-Chang M,Cazevieille C,Lenaers G,Olichon A,Bélenguer P,Roussignol G,Renard N,Eybalin M,Michelin A,Delettre C,Brabet P,Hamel CP

    更新日期:2005-11-01 00:00:00

  • Visible-Light Optical Coherence Tomography Angiography for Monitoring Laser-Induced Choroidal Neovascularization in Mice.

    abstract:PURPOSE:This study sought to determine the earliest time-point at which evidence of choroidal neovascularization (CNV) could be detected with visible-light optical coherence tomography angiography (vis-OCTA) in a mouse model of laser-induced CNV. METHODS:Visible light-OCTA was used to study laser-induced CNV at differ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Shah RS,Soetikno BT,Yi J,Liu W,Skondra D,Zhang HF,Fawzi AA

    更新日期:2016-07-01 00:00:00

  • Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS).

    abstract:PURPOSE:We tested variants in genes related to lutein and zeaxanthin status for association with age-related macular degeneration (AMD) in the Carotenoids in Age-Related Eye Disease Study (CAREDS). METHODS:Of 2005 CAREDS participants, 1663 were graded for AMD from fundus photography and genotyped for 424 single nucleo...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章,多中心研究


    authors: Meyers KJ,Mares JA,Igo RP Jr,Truitt B,Liu Z,Millen AE,Klein M,Johnson EJ,Engelman CD,Karki CK,Blodi B,Gehrs K,Tinker L,Wallace R,Robinson J,LeBlanc ES,Sarto G,Bernstein PS,SanGiovanni JP,Iyengar SK

    更新日期:2014-01-29 00:00:00

  • Endogenic regulation of proliferation and zinc transporters by pigment epithelial cells nonvirally transfected with PEDF.

    abstract:PURPOSE:Genetic modification of cells before transplantation may allow the delivery of neuroprotective and other functional molecules to patients with neurodegenerative diseases. To avoid complications associated with virally transfected cells, we have explored the use of nonviral methods to insert genetic material int...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Johnen S,Kazanskaya O,Armogan N,Stickelmann C,Stöcker M,Walter P,Thumann G

    更新日期:2011-07-23 00:00:00

  • Mechanisms of mitotic inhibition in corneal endothelium: contact inhibition and TGF-beta2.

    abstract:PURPOSE:Contact inhibition has been implicated as an important antiproliferative mechanism in developing and mature corneal endothelium. Although exogenous TGF-beta2 and TGF-beta2 in aqueous humor suppress S-phase entry in cultured rat corneal endothelial cells, it is not known whether TGF-beta2 contributes to the mito...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Joyce NC,Harris DL,Mello DM

    更新日期:2002-07-01 00:00:00

  • Anti-retinal antibodies in serum of laser-treated rabbits.

    abstract:PURPOSE:Retinal injuries that affect the photoreceptors and/or the retinal pigment epithelium (RPE) may result in the leakage of retinal proteins into the systemic circulation. This study was designed to determine whether an immune response is elicited after an acute retinal injury resulting in circulating anti-retinal...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Scott SE,Bouhenni RA,Chomyk AM,Dunmire JJ,Patil J,Nakamura H,Deepak P

    更新日期:2012-04-06 00:00:00

  • Tunicamycin-induced dysgenesis of retinal rod outer segment membranes. II. Quantitative freeze-fracture analysis.

    abstract::Tunicamycin (TM), a selective inhibitor of dolichylphosphate-dependent oligosaccharide biosynthesis, effectively blocks glycosylation, but not synthesis, of opsin, the rod visual pigment apoglycoprotein. In parallel with this inhibition, vesicular membrane material accumulates in the compartment between rod inner and ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Defoe DM,Besharse JC,Fliesler SJ

    更新日期:1986-11-01 00:00:00

  • Quantitative Analysis of the Displacement of the Anterior Visual Pathway by Pituitary Lesions and the Associated Visual Field Loss.

    abstract:PURPOSE:To evaluate quantitatively the relationship between the displacement of anterior visual pathway structures by pituitary tumors and visual field damage with the goal of improving diagnosis and management. METHODS:Subjects had pituitary macroadenomas and both magnetic resonance imaging (MRI) and static perimetry...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Boland MV,Lee IH,Zan E,Yousem DM,Miller NR

    更新日期:2016-07-01 00:00:00

  • Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity.

    abstract:PURPOSE:To explore the maximum retinal vasodilation in response to repeated flicker light stimulation in relation to vasospastic propensity in healthy subjects. METHODS:Twenty-four young healthy women were grouped as vasospastic and nonvasospastic, based on their history of cold extremities and on the results of nailf...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Gugleta K,Zawinka C,Rickenbacher I,Kochkorov A,Katamay R,Flammer J,Orgul S

    更新日期:2006-09-01 00:00:00

  • Measuring In Vivo Free Radical Production by the Outer Retina.

    abstract:PURPOSE:Excessive and continuously produced free radicals in the outer retina are implicated in retinal aging and the pathogenesis of sight-threatening retinopathies, yet measuring outer retinal oxidative stress in vivo remains a challenge. Here, we test the hypothesis that continuously produced paramagnetic free radic...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Berkowitz BA,Bredell BX,Davis C,Samardzija M,Grimm C,Roberts R

    更新日期:2015-12-01 00:00:00

  • Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia.

    abstract:PURPOSE:Methylenetetrahydrofolate reductase (Mthfr) is a key enzyme in homocysteine-methionine metabolism. We investigated Mthfr expression in retina and asked whether mild hyperhomocysteinemia, due to Mthfr deficiency, alters retinal neurovascular structure and function. METHODS:Expression of Mthfr was investigated a...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Markand S,Saul A,Roon P,Prasad P,Martin P,Rozen R,Ganapathy V,Smith SB

    更新日期:2015-04-01 00:00:00

  • Corneal epithelial cell cultures on stromal carriers.

    abstract::Exposure of denuded rabbit corneal stromal carriers for 24 hr at 37 degrees C to suspensions of rabbit corneal epithelial cells grown in tissue culture resulted in the establishment of a cell layer on the carriers. The cell layers persisted for at least 1 week of incubation and were one to three cells thick. They cons...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Friend J,Kinoshita S,Thoft RA,Eliason JA

    更新日期:1982-07-01 00:00:00

  • Optical coherence tomography of the swollen optic nerve head: deformation of the peripapillary retinal pigment epithelium layer in papilledema.

    abstract::PURPOSE. To examine the biomechanical deformation of load bearing structures of the optic nerve head (ONH) resulting from raised intracranial pressure, using high definition optical coherence tomography (HD-OCT). The authors postulate that elevated intracranial pressure induces forces in the retrolaminar subarachnoid ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Kupersmith MJ,Sibony P,Mandel G,Durbin M,Kardon RH

    更新日期:2011-08-22 00:00:00

  • Oxygen levels beneath the closed eyelid.

    abstract::The level of oxygen at the anterior corneal surface beneath the closed eyelid is shown to be equivalent to an atmosphere of 7.7% oxygen. This finding is in good agreement with assumptions which have been based on the oxygen level at the palpebral conjunctiva. However, in some instances a significant amount of oxygen i...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Efron N,Carney LG

    更新日期:1979-01-01 00:00:00

  • Visual acuity is related to parafoveal retinal thickness in patients with retinitis pigmentosa and macular cysts.

    abstract:PURPOSE:To quantify the prevalence and effect on visual acuity of macular cysts in a large cohort of patients with retinitis pigmentosa. METHODS:In 316 patients with typical forms of retinitis pigmentosa, visual acuity was measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts, macular cysts were dete...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Sandberg MA,Brockhurst RJ,Gaudio AR,Berson EL

    更新日期:2008-10-01 00:00:00

  • Phakic iris-fixated intraocular lens placement in the anterior chamber: effects on aqueous flow.

    abstract:PURPOSE:Phakic intraocular lenses (pIOLs) are used for correcting vision; in this paper we investigate the fluid dynamical effects of an iris-fixated lens in the anterior chamber. In particular, we focus on changes in the wall shear stress (WSS) on the cornea and iris, which could be responsible for endothelial and pig...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Repetto R,Pralits JO,Siggers JH,Soleri P

    更新日期:2015-05-01 00:00:00

  • Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.

    abstract:Purpose:Although normal function of the lacrimal gland is essential for vision (and thus for human well-being), the lacrimal gland remains rather poorly understood at a molecular level. The purpose of this study was to identify new genes and signaling cascades involved in lacrimal gland development. Methods:To identif...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Dvoriantchikova G,Tao W,Pappas S,Gaidosh G,Tse DT,Ivanov D,Pelaez D

    更新日期:2017-02-01 00:00:00

  • Preoperative Aqueous Cytokine Levels are Associated With Endothelial Cell Loss After Descemet's Stripping Automated Endothelial Keratoplasty.

    abstract:Purpose:To evaluate the association between endothelial cell density (ECD) after Descemet's stripping automated endothelial keratoplasty (DSAEK) and preoperative cytokine levels in the aqueous humor (AqH). Methods:This prospective consecutive case series included 97 consecutive patients who underwent DSAEK (64 eyes) o...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Yazu H,Yamaguchi T,Aketa N,Higa K,Suzuki T,Yagi-Yaguchi Y,Satake Y,Abe T,Tsubota K,Shimazaki J

    更新日期:2018-02-01 00:00:00

  • Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model.

    abstract:Purpose:To investigate autophagy in the outflow pathway and ganglion cell layer in the aging and ocular hypertensive mouse. Methods:Both 4-month-old and 18-month-old C57BL/6J and GFP-LC3 mice were subjected to unilateral injection of hypertonic saline into a limbal vein, causing sclerosis of the outflow pathway and su...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Nettesheim A,Dixon A,Shim MS,Coyne A,Walsh M,Liton PB

    更新日期:2020-08-03 00:00:00

  • Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery.

    abstract:Purpose:Lens epithelial cell (LEC) conversion to myofibroblast is responsible for fibrotic cataract surgery complications including posterior capsular opacification. While transforming growth factor beta (TGFβ) signaling is important, the mechanisms by which the TGFβ pathway is activated post cataract surgery (PCS) are...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Jiang J,Shihan MH,Wang Y,Duncan MK

    更新日期:2018-10-01 00:00:00

  • A practical method for measuring macular pigment optical density.

    abstract:PURPOSE:Increasing evidence indicates that the macular pigments (MP) protect the central retina and may retard macular disease. For that reason, a practical method for measuring MP that does not require elaborate optics and can be applied to diverse populations by operators with a modest amount of experience was develo...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Wooten BR,Hammond BR Jr,Land RI,Snodderly DM

    更新日期:1999-10-01 00:00:00

  • The influence of SRC-family tyrosine kinases on Na,K-ATPase activity in lens epithelium.

    abstract:PURPOSE:Na,K-adenosine triphosphatase (ATPase) is essential for the regulation of cytoplasmic ion concentrations in lens cells. Earlier studies demonstrated that tyrosine phosphorylation by Lyn kinase, a Src-family member, inhibits Na,K-ATPase activity in porcine lens epithelium. In the present study, experiments were ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Bozulic LD,Dean WL,Delamere NA

    更新日期:2005-02-01 00:00:00

  • Stretch to see: lateral tension strongly determines cell survival in long-term cultures of adult porcine retina.

    abstract:PURPOSE:To explore the effect of lateral tension as a survival factor for retinal explants in vitro. The central nervous system (CNS) resides in a highly mechanical milieu. However, the importance of biomechanical homeostasis for normal CNS function has not been extensively explored. Diseases in which normal mechanical...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Taylor L,Moran D,Arnér K,Warrant E,Ghosh F

    更新日期:2013-03-13 00:00:00

  • Altered gene expression in the eye of a mouse model for batten disease.

    abstract:PURPOSE:Juvenile neuronal ceroid lipofuscinosis (JNCL or Batten Disease) is one of the most common progressive neurodegenerative disorders of childhood, resulting from autosomal recessive inheritance of mutations in the CLN3 gene. Pathologically, Batten disease is characterized by lysosomal storage of autofluorescent m...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Chattopadhyay S,Kingsley E,Serour A,Curran TM,Brooks AI,Pearce DA

    更新日期:2004-09-01 00:00:00

  • The effect of platelet-activating factor (PAF), histamine, and ethanol on vascular permeability of the guinea pig conjunctiva.

    abstract::Increased vascular permeability, one of the characteristic features of immediate hypersensitivity (Type I), is mediated through a variety of compounds, including histamine and platelet-activating factor (PAF), a phospholipid inflammatory mediator. The effects on vascular permeability of histamine, PAF, and ethanol, th...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章


    authors: Stock EL,Roth SI,Kim ED,Walsh MK,Thamman R

    更新日期:1990-05-01 00:00:00