Scene perception in age-related macular degeneration.

Abstract:

PURPOSE:To assess the scene gist recognition in eyes with age-related macular degeneration (AMD) and to study the relationship between scene recognition and macular function. METHODS:Twenty-seven patients with age-related macular degeneration with a visual acuity lower than 20/50 and 17 age-matched controls were included. All patients underwent a visual field test, fundus autofluorescence, and fluorescein angiography to assess the visual field defect and the lesion size. The stimuli were colored photographs of natural scenes displayed on a 30-inch screen. Two scene categorization tasks were performed: natural versus urban and indoor versus outdoor scenes. Participants were given a target (e.g., indoor scenes) and asked to press a key when they saw a picture corresponding to that target. Accuracy and response times were recorded. RESULTS:Patients with AMD were able to accomplish both categorization tasks with a high correct detection rate (above 75% correct), though performance was lower than in controls for both natural/urban scenes and indoor/outdoor scenes. Patients with AMD were more accurate and faster for natural/urban scenes than for indoor/outdoor scenes, but performance did not differ between the two categories in controls. No significant correlation was found between performance for scene categorization and clinical variables such as visual acuity, type of AMD, size of the scotoma, and size of the lesion. CONCLUSIONS:Scene gist recognition can be accomplished with the low spatial resolution of peripheral vision. These results support the "scene-centered approach" that initial scene recognition is based on the global scene properties and not on the objects it contains.

authors

Tran TH,Rambaud C,Despretz P,Boucart M

doi

10.1167/iovs.10-5517

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

6868-74

issue

12

eissn

0146-0404

issn

1552-5783

pii

51/12/6868

journal_volume

51

pub_type

杂志文章
  • Subconjunctival Versus Intrascleral Application Of Mitomycin C During Trabeculectomy.

    abstract::Purpose: To compare efficacy and safety between subconjunctival and intrascleral methods of mitomycin C (MMC) application during trabeculectomy Methods: This retrospective study included 165 eyes treated by trabeculectomy and compared clinical outcomes between eyes that received subconjunctival MMC (Group 1, 80 eyes, ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.14-14159

    authors: Zhang M,Li B,Wang J,Liu W,Wu X

    更新日期:2014-07-21 00:00:00

  • Decrease in rate of myopia progression with a contact lens designed to reduce relative peripheral hyperopia: one-year results.

    abstract:PURPOSE:To determine whether a novel optical treatment using contact lenses to reduce relative peripheral hyperopia can slow the rate of progress of myopia. METHODS:Chinese children, aged 7 to 14 years, with baseline myopia from sphere -0.75 to -3.50 D and cylinder ≤1.00 D, were fitted with novel contact lenses (n = 4...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章,随机对照试验

    doi:10.1167/iovs.11-7260

    authors: Sankaridurg P,Holden B,Smith E 3rd,Naduvilath T,Chen X,de la Jara PL,Martinez A,Kwan J,Ho A,Frick K,Ge J

    更新日期:2011-12-09 00:00:00

  • Oscillatory eye movements resembling pendular nystagmus in normal juvenile macaques.

    abstract:PURPOSE:Juvenile monkeys being trained on smooth-pursuit tasks exhibit ocular oscillations resembling pendular nystagmus. The purpose of this study was to analyze these oscillations, the effects of gabapentin on them, and responses of cerebellar floccular neurons to understand possible neuronal mechanisms. METHODS:Fou...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.10-5903

    authors: Shichinohe N,Barnes G,Akao T,Kurkin S,Fukushima J,Kase M,Leigh RJ,Belton T,Fukushima K

    更新日期:2011-06-01 00:00:00

  • Fundus Autofluorescence Lifetime Patterns in Retinitis Pigmentosa.

    abstract:Purpose:We investigated whether fundus autofluorescence (FAF) lifetimes in patients with retinitis pigmentosa display a disease-specific lifetime pattern. Methods:Fundus autofluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in two spectral channels (498-560 and 560-720 nm) after excitation with a 473 n...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.17-23336

    authors: Dysli C,Schuerch K,Escher P,Wolf S,Zinkernagel MS

    更新日期:2018-04-01 00:00:00

  • Free epsilon amino groups and 5-hydroxymethylfurfural contents in clear and cataractous human lenses.

    abstract::The free epsilon-amino groups and 5-hydroxymethylfurfural (5-HMF) contents were determined in soluble and insoluble proteins of clear human lenses and diabetic and nondiabetic senile cataractous lenses. The free epsilon-amino group content of soluble proteins in diabetic cataracts was decreased by 37% (P less than 0.0...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Rao GN,Cotlier E

    更新日期:1986-01-01 00:00:00

  • Prior binocular dissociation reduces monocular form deprivation amblyopia in monkeys.

    abstract::The profound visual deficits associated with early monocular form deprivation (MD) are caused largely by competitive binocular interactions in the visual cortex. We tested the hypothesis that disrupting normal cortical binocularity prior to the onset of MD would reduce the degree of form deprivation amblyopia compared...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Smith EL 3rd,Harwerth RS,Siderov J,Wingard M,Crawford ML,von Noorden GK

    更新日期:1992-04-01 00:00:00

  • Effect of UV-A light on the chaperone-like properties of young and old lens alpha-crystallin.

    abstract:PURPOSE:To study the damaging effect of UV-A irradiation on the chaperone-like properties of alpha-crystallin and the subsequent recovery process of young and old bovine lenses. METHODS:Young and old bovine lenses were kept in organ culture. After 24 hours of incubation they were irradiated with UV-A at 365 nm, and op...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Weinreb O,van Boekel MA,Dovrat A,Bloemendal H

    更新日期:2000-01-01 00:00:00

  • Gender-related differences in the morphology of the lacrimal gland.

    abstract::Previous research has demonstrated that distinct, gender-related differences exist in the morphology of the rat lacrimal gland. The purpose of the present study was to determine whether this sexual dimorphism is unique to the rat, or extends as well to other species. Lacrimal glands were collected from adult male and ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Cornell-Bell AH,Sullivan DA,Allansmith MR

    更新日期:1985-08-01 00:00:00

  • Anterior segment optical coherence tomography parameters in subtypes of primary angle closure.

    abstract:PURPOSE:To compare anterior segment parameters, assessed by anterior segment optical coherence tomography (ASOCT), in subjects categorized as primary angle closure suspect (PACS), primary angle closure (PAC), primary angle closure glaucoma (PACG), and previous acute PAC (APAC); and to identify factors associated with A...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.13-12285

    authors: Guzman CP,Gong T,Nongpiur ME,Perera SA,How AC,Lee HK,Cheng L,He M,Baskaran M,Aung T

    更新日期:2013-08-07 00:00:00

  • The Potential Inhibitory Effects of miR-19b on Ocular Inflammation are Mediated Upstream of the JAK/STAT Pathway in a Murine Model of Allergic Conjunctivitis.

    abstract:Purpose:Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine that initiates allergic inflammatory reaction between epithelial and dendritic cells (DCs). miR-19b was reported to suppress TSLP expression. The present study aimed to examine miR-19b expression, regulation, and function in allergic conjunctivitis ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.61.3.8

    authors: Guo C,Liu J,Hao P,Wang Y,Sui S,Li L,Ying M,Han R,Wang L,Li X

    更新日期:2020-03-09 00:00:00

  • Human Parafoveal Capillary Vascular Anatomy and Connectivity Revealed by Optical Coherence Tomography Angiography.

    abstract:Purpose:To assess the connection among arterioles, venules, and capillaries in three retinal capillary plexuses using optical coherence tomography angiography (OCTA). Methods:This was a prospective, cross-sectional, observational study including 20 eyes of 10 healthy subjects. En face and cross-sectional OCTA images w...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.18-24710

    authors: Nesper PL,Fawzi AA

    更新日期:2018-08-01 00:00:00

  • Human diabetic neovascular membranes contain high levels of urokinase and metalloproteinase enzymes.

    abstract:PURPOSE:Retinal neovascularization is one of the leading causes of blindness. A crucial event in this process is the remodeling and penetration of the capillary basement membrane by migrating endothelial cells. This process requires proteolysis of basement membrane components by a variety of proteinases. The objective ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Das A,McGuire PG,Eriqat C,Ober RR,DeJuan E Jr,Williams GA,McLamore A,Biswas J,Johnson DW

    更新日期:1999-03-01 00:00:00

  • Oxidative Stress-Induced Dysfunction of Müller Cells During Starvation.

    abstract:PURPOSE:Müller cells support retinal neurons with essential functions. Here, we aim to examine the impact of starvation and oxidative stress on glutamate uptake and mitochondrial function in Müller cells. METHODS:Cultured human retinal Müller cells (MIO-M1) were exposed to H2O2 and additional starvation for 24 hours. ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.16-19275

    authors: Toft-Kehler AK,Gurubaran IS,Desler C,Rasmussen LJ,Skytt DM,Kolko M

    更新日期:2016-05-01 00:00:00

  • Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal.

    abstract:PURPOSE:To assess changes in rod and cone visual functions in a mouse model of Fundus albipunctatus with disrupted 11-cis-retinol dehydrogenase (RDH) genes after pharmacologic treatment with an artificial retinal chromophore. METHODS:Retinoid levels and photoreceptor functions of Rdh5-/-Rdh11-/- mice at a variety of l...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.06-0215

    authors: Maeda A,Maeda T,Palczewski K

    更新日期:2006-10-01 00:00:00

  • Human trabecular cells. I. Establishment in tissue culture and growth characteristics.

    abstract::After a careful dissection of trabecular tissue from recent postmortem specimens, human trabecular cells were established in tissue culture with 250 ng/ml fibroblast growth factor (FGF), Dulbecco's modified Eagle's medium (DME), and 10% human serum. These conditions have allowed propagation of human trabecular cells f...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Polansky JR,Weinreb RN,Baxter JD,Alvarado J

    更新日期:1979-10-01 00:00:00

  • Parstatin suppresses ocular neovascularization and inflammation.

    abstract:PURPOSE:Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the PAR1 receptor. The authors recently showed that parstatin is a potent inhibitor of angiogenesis. The purpose of the present study was to evaluate the therapeutic effect of parstatin on ocular neovascularization. METHODS:Choroidal...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.10-5576

    authors: Huang H,Vasilakis P,Zhong X,Shen JK,Geronatsiou K,Papadaki H,Maragoudakis ME,Gartaganis SP,Vinores SA,Tsopanoglou NE

    更新日期:2010-11-01 00:00:00

  • Myopic refractive error in adult Latinos: the Los Angeles Latino Eye Study.

    abstract:PURPOSE:To estimate gender- and age-specific prevalence of myopia and identify risk indicators for myopia in a population-based sample of Latino adults aged 40 years and older in La Puente, California. METHODS:Noncycloplegic automated refraction with supplemental standardized subjective refraction was performed for pr...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.05-1153

    authors: Tarczy-Hornoch K,Ying-Lai M,Varma R,Los Angeles Latino Eye Study Group.

    更新日期:2006-05-01 00:00:00

  • Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice.

    abstract:PURPOSE:Optic neuritis (ON) is a condition involving primary inflammation, demyelination, and axonal injury in the optic nerve and leads to apoptotic retinal ganglion cell (RGC) death, which contributes to the persistence of visual loss. Currently, ON has no effective treatment. The goal was to determine the effectiven...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.11-8419

    authors: Adamus G,Brown L,Andrew S,Meza-Romero R,Burrows GG,Vandenbark AA

    更新日期:2012-01-25 00:00:00

  • The role of macrophages in the pathogenesis of HSV-1 induced chorioretinitis in BALB/c mice.

    abstract:PURPOSE:To examine the effects of modification of immune effector cells, including macrophages, in the pathogenesis of herpes simplex virus retinitis in BALB/c mice. METHODS:Two intravitreal injections (2 microliters each) of anti-CD11b monoclonal antibody (mAb) [13 micrograms/microliters] were administered to the con...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Berra A,Rodriguez A,Heiligenhaus A,Pazos B,Van Rooijen N,Foster CS

    更新日期:1994-06-01 00:00:00

  • Accommodative facility in eyes with and without myopia.

    abstract:PURPOSE:To compare accommodative facility in eyes with myopia to that in eyes with emmetropia or hyperopia and to determine whether accommodative facility can be used to predict an association with myopia. METHODS:In the Sydney Myopia Study, year-1 school children (6.7 +/- 0.4 years) were assessed for accommodative fa...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章,多中心研究

    doi:10.1167/iovs.05-1078

    authors: Pandian A,Sankaridurg PR,Naduvilath T,O'Leary D,Sweeney DF,Rose K,Mitchell P

    更新日期:2006-11-01 00:00:00

  • Expression of MMPs and TIMPs in human pterygia and cultured pterygium epithelial cells.

    abstract:PURPOSE:Pterygia are a common, benign, fibrovascular, and infiltrative process of the corneal-conjunctival junction of unknown pathogenesis. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes active against all components of the extracellular matrix, whose activity is specifically neutralized by tissu...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Di Girolamo N,McCluskey P,Lloyd A,Coroneo MT,Wakefield D

    更新日期:2000-03-01 00:00:00

  • The shape of posterior corneal surface in normal, post-LASIK, and post-epi-LASIK eyes.

    abstract::PURPOSE. To evaluate the shape of the posterior corneal surface in eyes with normal myopia or myopic astigmatism and the changes after LASIK and epi-LASIK. METHODS. A total of 152 eyes were included in the study. The posterior corneal elevation was measured with Scheimpflug imaging (Pentacam; Oculus, Wetzlar, Germany)...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.09-4811

    authors: Zhang L,Wang Y

    更新日期:2010-07-01 00:00:00

  • The association between copy number variations in glutathione S-transferase M1 and T1 and age-related cataract in a Han Chinese population.

    abstract:PURPOSE:To determine the contribution of copy number variation (CNV) in glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) to the susceptibility to age-related cataract (ARC) and its subtypes in a Han Chinese population. METHODS:ARC cases (n = 279) and controls (n = 145) were included from a...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.10-5240

    authors: Zhou J,Hu J,Guan H

    更新日期:2010-08-01 00:00:00

  • Evidence for a major gene for cortical cataract.

    abstract:PURPOSE:To examine the possible presence of a major gene determining susceptibility to cortical cataract. METHODS:The percentage of the lens area involved with cortical opacity, summed over both eyes, was evaluated in 1275 individuals from the Beaver Dam Eye Study. After adjusting for the effects of age and sex, these...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Heiba IM,Elston RC,Klein BE,Klein R

    更新日期:1995-01-01 00:00:00

  • Clinical Characteristics, Mutation Spectrum, and Prevalence of Åland Eye Disease/Incomplete Congenital Stationary Night Blindness in Denmark.

    abstract:Purpose:To assess clinical characteristics, foveal structure, mutation spectrum, and prevalence rate of Åland eye disease (AED)/incomplete congenital stationary night blindness (iCSNB). Methods:A retrospective survey included individuals diagnosed with AED at a national low-vision center from 1980 to 2014. A subset of...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.16-19445

    authors: Hove MN,Kilic-Biyik KZ,Trotter A,Grønskov K,Sander B,Larsen M,Carroll J,Bech-Hansen T,Rosenberg T

    更新日期:2016-12-01 00:00:00

  • Unilateral gonadectomy does not alter contralateral intraocular pressure in rabbit eyes.

    abstract::The purpose of this study was to determine whether unilateral gonadectomy caused any change in intraocular pressure. Repeated measurements in 22 male and nine female rabbits after unilateral gonadectomy were made by three different methods of determining intraocular pressure. We were unable to find a decrease in intra...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: van den Pol A,Maul E,Sears M

    更新日期:1977-03-01 00:00:00

  • Corneal autofluorescence: an indicator of diabetic retinopathy.

    abstract::The metabolic disorder in diabetics often results in progressive retinopathy with severe visual impairment. Changes in metabolism can influence corneal autofluorescence. This has led to speculation that diabetic retinopathy might be associated with changes in corneal autofluorescence. Corneal autofluorescence of both ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Stolwijk TR,van Best JA,Oosterhuis JA,Swart W

    更新日期:1992-01-01 00:00:00

  • Normal square wave jerks.

    abstract::Fixation stability of the saccadic system was investigated by infrared reflection oculography in 29 normal subjects, young and elderly. Square wave jerks consisting of spontaneous horizontal saccadic excursions of 0.5 degree and over, followed some 200 msec later by corrective saccades, were recorded in 24% of subject...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Herishanu YO,Sharpe JA

    更新日期:1981-02-01 00:00:00

  • A murine model for retinopathy of prematurity identifies endothelial cell proliferation as a potential mechanism for plus disease.

    abstract:PURPOSE:To characterize the features and possible mechanism of plus disease in the mouse oxygen-induced retinopathy (OIR) model for retinopathy of prematurity. METHODS:Wild-type and Adam (A Disintegrin And Metalloproteinase) knockout mice were exposed to 75% oxygen from postnatal day 7 to 12 (P7 to P12) (hyperoxia), t...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.12-11492

    authors: Guaiquil VH,Hewing NJ,Chiang MF,Rosenblatt MI,Chan RV,Blobel CP

    更新日期:2013-08-07 00:00:00

  • Identification of a novel secreted protease from Pseudomonas aeruginosa that causes corneal erosions.

    abstract:PURPOSE:The purpose of this study was to identify a new Pseudomonas protease and determine its possible role in keratitis. METHODS:Concentrated culture supernatants of the Pseudomonas aeruginosa strains PA103 and ATCC 19660 were analyzed by zymography. P. aeruginosa small protease (PASP) was purified from strain PA103...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.04-1483

    authors: Marquart ME,Caballero AR,Chomnawang M,Thibodeaux BA,Twining SS,O'Callaghan RJ

    更新日期:2005-10-01 00:00:00