Myopic refractive error in adult Latinos: the Los Angeles Latino Eye Study.

abstract：Purpose:To quantify organelles impacting imaging in the cell body and intact apical processes of human retinal pigment epithelium (RPE), including melanosomes, lipofuscin-melanolipofuscin (LM), mitochondria, and nuclei. Methods:A normal perifovea of a 21-year-old white male was preserved after rapid organ recovery. An...

journal_title：Investigative ophthalmology & visual science

authors： Pollreisz A,Neschi M,Sloan KR,Pircher M,Mittermueller T,Dacey DM,Schmidt-Erfurth U,Curcio CA

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To understand the pathophysiology of human retinal degenerations caused by mutations in the peripherin/RDS gene. METHODS:Three families with autosomal dominant retinal degeneration were found to have mutations in the peripherin/RDS gene. There were two frameshift mutations: a 1-base pair (bp) insertion at codo...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Cideciyan AV,Kemp CM,Sheffield VC,Stone EM

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:This work examines the effects of cardiotrophin (CT)-1 on photoreceptor survival in transgenic rats that carry the rhodopsin mutation S334ter. METHODS:Recombinant CT-1 was injected intravitreally into eyes of heterozygous animals. Photoreceptor survival was analyzed by histology. Phosphorylation of signal tran...

journal_title：Investigative ophthalmology & visual science

authors： Song Y,Zhao L,Tao W,Laties AM,Luo Z,Wen R

更新日期：2003-09-01 00:00:00

abstract：Purpose:To evaluate the relationship between retinal vascular caliber and AMD in patients with AIDS. Methods:Participants enrolled in the Longitudinal Study of the Ocular Complications of AIDS had retinal photographs taken at enrollment. Retinal vascular caliber (central retinal artery equivalent [CRAE] and central re...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Van Natta ML,Pak JW,Danis RP,Hunt PW

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:The effects of adrenergic agonists and antagonists on Na+, K+, Cl- cotransport in fetal human nonpigmented ciliary epithelial (NPE) cells were investigated. METHODS:86Rb+ as a marker for K+ was used to study ouabain-insensitive, bumetanide-sensitive 86Rb+ uptake in cultured NPE monolayers. Cyclic adenosine mon...

journal_title：Investigative ophthalmology & visual science

authors： Crook RB,Riese K

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:The chaperone proteins, α-crystallins, also possess antiapoptotic properties. The purpose of the present study was to investigate whether 19 to 20-mer α-crystallin-derived mini-chaperone peptides (α-crystallin mini-chaperone) are antiapoptotic, and to identify their putative transporters in human fetal RPE (hfR...

journal_title：Investigative ophthalmology & visual science

authors： Sreekumar PG,Chothe P,Sharma KK,Baid R,Kompella U,Spee C,Kannan N,Manh C,Ryan SJ,Ganapathy V,Kannan R,Hinton DR

更新日期：2013-04-17 00:00:00

abstract：PURPOSE:In an earlier study it was reported that thrombin significantly reduces the rate of Na,K-adenosine triphosphatase (ATPase)-mediated ion transport by porcine lens. Because thrombin stimulates the release of endogenous endothelin (ET)-1 stores from some tissues, and because ET-1 can cause Na,K-ATPase inhibition, ...

journal_title：Investigative ophthalmology & visual science

authors： Okafor MC,Mukhopadhyay P,Delamere NA

更新日期：2002-03-01 00:00:00

abstract：:The microvascular permeability response of the guinea pig conjunctiva to sulfidopeptide leukotrienes (LTs) was quantified as extravasation of radiolabeled bovine serum albumin. The LTs were potent inducers of increased microvascular permeability, with relative potencies LTE4 greater than or equal to LTD4 greater than ...

journal_title：Investigative ophthalmology & visual science

authors： Gary RK Jr,Woodward DF,Nieves AL,Williams LS,Gleason JG,Wasserman MA

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To compare the diagnostic ability of the new spectral-domain optical coherence tomography (SD-OCT) algorithm for measuring circumpapillary retinal nerve fiber layer (RNFL) thickness centered on Bruch's membrane opening (BMO), with the conventional circumpapillary RNFL thickness measurement centered on the optic...

journal_title：Investigative ophthalmology & visual science

authors： Lee EJ,Lee KM,Kim H,Kim TW

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Tenascin (TN) is a large hexameric extracellular matrix glycoprotein that is expressed in developing organs and tumors. It has also been reported that TN is expressed in the embryonic cornea and during corneal wound healing. However, the role of TN in the cornea is not fully known. In this study, the role of TN...

journal_title：Investigative ophthalmology & visual science

authors： Matsuda A,Yoshiki A,Tagawa Y,Matsuda H,Kusakabe M

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:This study determined whether adenovirus-mediated transfer of the murine interferon-beta (AdCMVIFN-beta) gene protects against liver metastases arising from intraocular melanomas in mice. METHODS:A replication-deficient adenovirus vector (AdCMVIFN-beta) was used for the in vivo transfer of the murine IFN-beta ...

journal_title：Investigative ophthalmology & visual science

authors： Alizadeh H,Howard K,Mellon J,Mayhew E,Rusciano D,Niederkorn JY

更新日期：2003-07-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the impact of stanniocalcin-1 (STC-1), a photoreceptor-protective glycoprotein, on the development of choroidal neovascularization (CNV) in relation to VEGF and its main receptor (VEGFR2) expression after laser injury. Methods:In rats, CNV was induced by laser photo...

journal_title：Investigative ophthalmology & visual science

authors： Zhao M,Xie W,Tsai SH,Hein TW,Rocke BA,Kuo L,Rosa RH Jr

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Hormone diseases induce changes in the lacrimal gland (LG) and ocular surface (OS). Thyroid hormone (TH) induces cell proliferation and lipid metabolism through the activation of TH receptors. The aim of the present study was to evaluate the location and comparative expression of TH receptor beta-1 (Thrb) in LG...

journal_title：Investigative ophthalmology & visual science

authors： Dias AC,Módulo CM,Jorge AG,Braz AM,Jordão AA Jr,Filho RB,de Paula JS,Rocha EM

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:To study relationships between glaucoma-sensitive components identified with frequency-domain analysis of global-flash multifocal electroretinogram (mfERG), regional retinal nerve fiber layer thickness (RNFLT), and local visual field sensitivity (VS). METHODS:Eleven macaque monkeys, including four controls and...

journal_title：Investigative ophthalmology & visual science

authors： Luo X,Patel NB,Harwerth RS,Frishman LJ

更新日期：2011-06-01 00:00:00

abstract：:The existence of wide-band, phase-specific channels in the human visual system has been suggested in recent investigations. We used a number of adapting gratings to test for phase-specific adaptation effects. Observers were asked to discriminate between a simple 3 cpd sine-wave grating, (3), and a complex grating comp...

journal_title：Investigative ophthalmology & visual science

authors： Sansbury RV,Distelhorst J,Moore S

更新日期：1978-05-01 00:00:00

abstract：Purpose:IFT81, a core component of the IFT-B complex, involved in the bidirectional transport of ciliary proteins, has been recently implicated in syndromic ciliopathies. However, none of the IFT-B core complex proteins have been associated with nonsyndromic retinal dystrophies. Given the importance of ciliary transpor...

journal_title：Investigative ophthalmology & visual science

authors： Dharmat R,Liu W,Ge Z,Sun Z,Yang L,Li Y,Wang K,Thomas K,Sui R,Chen R

更新日期：2017-05-01 00:00:00

abstract：Purpose:Applying CNGA3 gene augmentation therapy to cure a novel causative mutation underlying achromatopsia (ACHM) in sheep. Methods:Impaired vision that spontaneously appeared in newborn lambs was characterized by behavioral, electroretinographic (ERG), and histologic techniques. Deep-sequencing reads of an affected...

journal_title：Investigative ophthalmology & visual science

authors： Gootwine E,Abu-Siam M,Obolensky A,Rosov A,Honig H,Nitzan T,Shirak A,Ezra-Elia R,Yamin E,Banin E,Averbukh E,Hauswirth WW,Ofri R,Seroussi E

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic. One such ligand, TCDD, was found to exert potent immunosuppressive capacities in mice developing pathogenic autoimmune processes, including EAU, but its toxicity makes it unusable for humans. A recently identified endogenous AHR lig...

journal_title：Investigative ophthalmology & visual science

authors： Nugent LF,Shi G,Vistica BP,Ogbeifun O,Hinshaw SJ,Gery I

更新日期：2013-11-13 00:00:00

abstract：PURPOSE:This study investigated the role of sterile alpha/Armadillo/Toll-Interleukin receptor homology domain 1 protein (SARM1) in Wallerian-like degeneration of retinal ganglion cells (RGCs) and their axons after inducing excitotoxicity. METHODS:To induce excitotoxicity, kainic acid (KA) was injected into the vitreou...

journal_title：Investigative ophthalmology & visual science

authors： Massoll C,Mando W,Chintala SK

更新日期：2013-04-17 00:00:00

abstract：PURPOSE:To define the inductive pathways leading to rat tear IgA antibody responses. METHODS:Fluoresceinated dinitrophenylated bovine serum albumin was encapsulated in poly(lactide-co-glycolide) microparticles and was administered by intranasal, ocular topical, or gastrointestinal routes. Histologic methods were used ...

journal_title：Investigative ophthalmology & visual science

authors： Ridley Lathers DM,Gill RF,Montgomery PC

更新日期：1998-05-01 00:00:00

abstract：PURPOSE:Human adenovirus species D type 19 (HAdV-D19) has been associated with epidemic keratoconjunctivitis (EKC), a highly inflammatory infection of the ocular surface. Confusion exists regarding the origins of HAdV-D19. The prototype virus (HAdV-D19p) does not cause EKC, while a virus identified later with the ident...

journal_title：Investigative ophthalmology & visual science

authors： Zhou X,Robinson CM,Rajaiya J,Dehghan S,Seto D,Jones MS,Dyer DW,Chodosh J

更新日期：2012-05-14 00:00:00

abstract：PURPOSE:High concentrations of unconjugated bilirubin are neurotoxic and cause brain damage in newborn infants. However, the exact level of bilirubin that may be neurotoxic in a given infant is unknown. The aim of this study was to use a quantitative measure of neural activity, the swept parameter visual evoked potenti...

journal_title：Investigative ophthalmology & visual science

authors： Hou C,Norcia AM,Madan A,Good WV

更新日期：2014-09-02 00:00:00

abstract：PURPOSE:To calculate the relative amount of hemoglobin (Hb) in sectors of the optic nerve head (ONH) from stereoscopic color fundus images using the Laguna ONhE method and compare the results with the visual field evaluation and optical coherence tomography (OCT). METHODS:Healthy eyes (n = 87) and glaucoma eyes (n = 7...

journal_title：Investigative ophthalmology & visual science

authors： Pena-Betancor C,Gonzalez-Hernandez M,Fumero-Batista F,Sigut J,Medina-Mesa E,Alayon S,Gonzalez de la Rosa M

更新日期：2015-02-10 00:00:00

abstract：PURPOSE:RPE65 has been shown to be essential for the production of 11-cis retinal by the retinal pigment epithelium. Mutations in RPE65 are known to be associated with severe forms of early-onset retinal dystrophy. This project was designed to determine the amount of regenerable opsin in Rpe65-/- mice during developmen...

journal_title：Investigative ophthalmology & visual science

authors： Rohrer B,Goletz P,Znoiko S,Ablonczy Z,Ma JX,Redmond TM,Crouch RK

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:To learn whether locally expressed and systemic mediators might modulate the cholinergically induced transepithelial Cl(-) fluxes that underlie lacrimal fluid production. METHODS:Reconstituted epithelial monolayers were exposed to a submaximal dose of the muscarinic agonist, carbachol (CCh), or to one of sever...

journal_title：Investigative ophthalmology & visual science

authors： Selvam S,Mircheff AK,Yiu SC

更新日期：2013-04-26 00:00:00

abstract：PURPOSE:Advanced glycation end products (AGEs) form irreversible cross-links with many macromolecules and have been shown to accumulate in tissues at an accelerated rate in diabetes. In the present study, AGE formation in vitreous was examined in patients of various ages and in patients with diabetes. Ex vivo investiga...

journal_title：Investigative ophthalmology & visual science

authors： Stitt AW,Moore JE,Sharkey JA,Murphy G,Simpson DA,Bucala R,Vlassara H,Archer DB

更新日期：1998-12-01 00:00:00

abstract：PURPOSE:To identify cell types and extracellular matrix components in Molteno implant capsules. METHODS:Histologic features including cytology, distribution of apoptotic cells, cytoantigens, collagens, basement membranes, elastic fibers, and glycoproteins were examined by light microscopy. Findings were correlated wit...

journal_title：Investigative ophthalmology & visual science

authors： Molteno AC,Thompson AM,Bevin TH,Dempster AG

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to demonstrate the synthesis and cellular distribution of group II phospholipase A2 and lysozyme in the main and accessory lacrimal glands. METHODS:The authors studied samples of normal main lacrimal glands of seven autopsied subjects and accessory lacrimal glands of eight patients wh...

journal_title：Investigative ophthalmology & visual science

authors： Aho HJ,Saari KM,Kallajoki M,Nevalainen TJ

更新日期：1996-08-01 00:00:00

abstract：:The effect of prostaglandin (PG) F2 alpha-isopropyl ester (IE), PGA2, or PGA2-IE on intraocular pressure (IOP) was tested in eight cynomolgus monkey eyes with argon laser-induced glaucoma. Dose-response testing and baseline IOP measurements were done. For multiple dose testing, 5 micrograms in 25 microliters (0.02%) o...

journal_title：Investigative ophthalmology & visual science

authors： Wang RF,Camras CB,Lee PY,Podos SM,Bito LZ

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:Mutations in the CLN6 gene cause variant late-infantile neuronal ceroid lipofuscinosis, a lysosomal storage disorder clinically characterized by progressive loss of vision, dementia, seizures, and early death. Here, we analyzed the time course of photoreceptor loss and the role of lysosomes in nclf mice, an ani...

journal_title：Investigative ophthalmology & visual science

authors： Bartsch U,Galliciotti G,Jofre GF,Jankowiak W,Hagel C,Braulke T

更新日期：2013-10-23 00:00:00