The ocular hypotensive effects of demeclocycline, tetracycline and other tetracycline derivatives.

abstract：PURPOSE:We showed previously that single nucleotide polymorphism (SNP) rs662702 in PAX6 may be located in a microRNA-328 binding site that causes susceptibility to high myopia. Our study was done to elucidate the role of PAX6 and its relationship with microRNA-328 in myopia. METHODS:A luciferase assay was used to conf...

journal_title：Investigative ophthalmology & visual science

authors： Chen KC,Hsi E,Hu CY,Chou WW,Liang CL,Juo SH

更新日期：2012-05-31 00:00:00

abstract：PURPOSE:To test the hypothesis that subnormal retinal oxygenation response (DeltaPo2) found at 3 months of experimental diabetes is associated with cellular swelling and increased retinal thickness. METHODS:Two groups of animals were studied: control rats injected intraperitoneally with either 15% body weight of salin...

journal_title：Investigative ophthalmology & visual science

authors： Luan H,Roberts R,Sniegowski M,Goebel DJ,Berkowitz BA

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:To determine some of the mechanisms by which substance P (SP) induces contraction in the isolated rat iris. METHODS:Rings of rat iris were mounted in a 5-ml organ chamber containing Krebs solution at 37 degrees C under basal tension of 75 mg, and isometric tension was recorded. RESULTS:Substance P produced gr...

journal_title：Investigative ophthalmology & visual science

authors： Grumann-Júnior A,Dias MA,Alves RV,Boteon JE,Calixto JB

更新日期：2000-06-01 00:00:00

abstract：:Retinal leukocyte velocity and density were estimated using blue-field entoptic imaging techniques in a controlled double-masked study to determine the relative effects of oxygen and carbon dioxide on perimacular hemodynamics in single eyes of ten normal human subjects. Mild hypoxia (inspiration of 16% O2) did not sig...

journal_title：Investigative ophthalmology & visual science

authors： Sponsel WE,DePaul KL,Zetlan SR

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:To characterize retinal autoantigens in patients with cancer-associated retinopathy (CAR). METHODS:The sera of 4 patients with CAR were examined by western blot analysis, and the proteins specifically probed were partially purified from bovine retinas and identified by Edman sequence analysis of the proteolyti...

journal_title：Investigative ophthalmology & visual science

authors： Ohguro H,Ogawa K,Nakagawa T

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:To compare two spectral domain optical coherence tomography (SD-OCT) devices for the identification of angle structures and the presence of angle closure. METHODS:This was a prospective comparative study. Consecutive patients underwent gonioscopy and anterior segment imaging using two SD-OCT devices (iVue and ...

journal_title：Investigative ophthalmology & visual science

authors： Quek DT,Narayanaswamy AK,Tun TA,Htoon HM,Baskaran M,Perera SA,Aung T

更新日期：2012-08-03 00:00:00

abstract：:Gross correlation coefficient between light-scattering intensity and the optical parameters obtained for 48 sections of eight lenses with nuclear cataracts were evaluated. On the basis of these and other data in the literature, the structural elements, within the lens fiber are identified. These give rise to the optic...

journal_title：Investigative ophthalmology & visual science

authors： Bettelheim FA,Siew EL,Chylack LT Jr

更新日期：1981-03-01 00:00:00

abstract：:Inoculation of the neurotropic coronavirus mouse hepatitis virus strain JHM intravitreally or into the anterior chamber causes acute infection of the retinal pigment epithelium (RPE) and neural retina. Weeks later, many retinas have foci of moderate to severe atrophy. The effect of coronavirus infection (after intravi...

journal_title：Investigative ophthalmology & visual science

authors： Robbins SG,Wiggert B,Kutty G,Chader GJ,Detrick B,Hooks JJ

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Recent studies have suggested the hypothesis that quench-assisted 1/T1 magnetic resonance imaging (MRI) measures free radical production with laminar resolution in vivo without the need of a contrast agent. Here, we test this hypothesis further by examining the spatial and detection sensitivity of quench-assist...

journal_title：Investigative ophthalmology & visual science

authors： Berkowitz BA,Lewin AS,Biswal MR,Bredell BX,Davis C,Roberts R

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in transducing inner retinal neurons after intravitreal injection in several species. However, results in nonprimates may not be predictive of transduction in the human inner retina, because of differences in eye size and the specialized mo...

journal_title：Investigative ophthalmology & visual science

authors： Yin L,Greenberg K,Hunter JJ,Dalkara D,Kolstad KD,Masella BD,Wolfe R,Visel M,Stone D,Libby RT,Diloreto D Jr,Schaffer D,Flannery J,Williams DR,Merigan WH

更新日期：2011-04-25 00:00:00

abstract：:PURPOSE. To investigate the normative data of corneal and anterior segment biometric parameters and their associations in Chinese adults, for use in preoperative assessment for corneal and anterior segment surgery. METHODS. This cross-sectional, population-based study included 750 subjects aged > or =50 years. The sub...

journal_title：Investigative ophthalmology & visual science

authors： Yuen LH,He M,Aung T,Htoon HM,Tan DT,Mehta JS

更新日期：2010-07-01 00:00:00

abstract：:Lenses from young rhesus monkeys were incubated in the presence of H2O2 or oxygen radical generating systems to determine their suitability as a model for investigating lenticular oxidative stress. Additionally, direct comparisons were made between the effects found with the monkey lenses and those observed with cultu...

journal_title：Investigative ophthalmology & visual science

authors： Zigler JS Jr,Lucas VA,Du XY

更新日期：1989-10-01 00:00:00

abstract：PURPOSE:Tests for ocular Chlamydia trachomatis have not been well characterized, because there is no gold standard test. Latent class analysis (LCA) was performed to estimate the sensitivity and specificity of laboratory and clinical tests for trachoma in the absence of a gold standard. METHODS:Individual data from pr...

journal_title：Investigative ophthalmology & visual science

authors： See CW,Alemayehu W,Melese M,Zhou Z,Porco TC,Shiboski S,Gaynor BD,Eng J,Keenan JD,Lietman TM

更新日期：2011-08-03 00:00:00

abstract：PURPOSE:Two noninvasive delivery strategies for VEGF/PDGF receptor tyrosine kinase inhibitors (RTKI) were explored that exploited uveal retention as a means for establishing an ocular drug depot: a single oral "loading" dose and topical administration. METHODS:Melanin binding was confirmed by centrifugation and mass s...

journal_title：Investigative ophthalmology & visual science

authors： Robbie SJ,Lundh von Leithner P,Ju M,Lange CA,King AG,Adamson P,Lee D,Sychterz C,Coffey P,Ng YS,Bainbridge JW,Shima DT

更新日期：2013-02-27 00:00:00

abstract：Purpose:The purpose of this study was to investigate the impact of stanniocalcin-1 (STC-1), a photoreceptor-protective glycoprotein, on the development of choroidal neovascularization (CNV) in relation to VEGF and its main receptor (VEGFR2) expression after laser injury. Methods:In rats, CNV was induced by laser photo...

journal_title：Investigative ophthalmology & visual science

authors： Zhao M,Xie W,Tsai SH,Hein TW,Rocke BA,Kuo L,Rosa RH Jr

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Epidemiologic studies have linked UV-B exposure to development of cortical cataracts, but the underlying molecular mechanism(s) is unresolved. Here, we used a mouse model to examine the nature and distribution of DNA photolesions produced by ocular UV-B irradiation. METHODS:Anesthetized mice, eye globes, or is...

journal_title：Investigative ophthalmology & visual science

authors： Mesa R,Bassnett S

更新日期：2013-10-17 00:00:00

abstract：PURPOSE:To assess the suitability of human donor corneas maintained in long-term organ culture for the isolation and expansion of viable and functional corneal stromal stem cells (CSSCs). These cells display properties similar to mesenchymal stem cells and demonstrate the ability to reproduce an organized matrix in vit...

journal_title：Investigative ophthalmology & visual science

authors： Kureshi AK,Funderburgh JL,Daniels JT

更新日期：2014-10-21 00:00:00

abstract：PURPOSE:Juvenile monkeys being trained on smooth-pursuit tasks exhibit ocular oscillations resembling pendular nystagmus. The purpose of this study was to analyze these oscillations, the effects of gabapentin on them, and responses of cerebellar floccular neurons to understand possible neuronal mechanisms. METHODS:Fou...

journal_title：Investigative ophthalmology & visual science

authors： Shichinohe N,Barnes G,Akao T,Kurkin S,Fukushima J,Kase M,Leigh RJ,Belton T,Fukushima K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:To our knowledge, studies comparing binocular eye movements during reading task in strabismic children are scarce. The goal of our study was to examine binocular coordination of saccades during reading in strabismic children. METHODS:Binocular eye movements were recorded by an infrared system (mobile EBT) in 1...

journal_title：Investigative ophthalmology & visual science

authors： Lions C,Bui-Quoc E,Seassau M,Bucci MP

更新日期：2013-01-21 00:00:00

abstract：Purpose:This study addresses the hypothesis that age-related stresses upregulate Thy-1 in choroidal endothelial cells (CECs) and contribute to CEC activation and migration, processes important in choroidal neovascularization (CNV). Methods:Measurements were made of Thy-1 protein (Western blot) in CECs and Thy-1 mRNA (...

journal_title：Investigative ophthalmology & visual science

authors： Wang H,Han X,Kunz E,Hartnett ME

更新日期：2016-10-01 00:00:00

abstract：:We have investigated suprathreshold contrast sensitivity and binocular interactions in strabismic and anisometropic amblyopes using a reaction time paradigm. For every spatial frequency, reaction time increased as the grating contrast decreased. At all spatial frequencies and contrast values the reaction times using t...

journal_title：Investigative ophthalmology & visual science

authors： Levi DM,Harwerth RS,Manny RE

更新日期：1979-07-01 00:00:00

abstract：:The rhodopsin content of the human retina was determined spectrophotometrically. Retinas were removed completely by using an in vitro technique based on a simulation of retinal detachment. This method provides a total recovery of rod outer segments which contain the rhodopsin visual pigment or its apoprotein, opsin. U...

journal_title：Investigative ophthalmology & visual science

authors： van Kuijk FJ,Lewis JW,Buck P,Parker KR,Kliger DS

更新日期：1991-06-01 00:00:00

abstract：PURPOSE:To assess the impact of zinc finger E-box binding homeobox 1 (ZEB1) gene mutations associated with posterior polymorphous corneal dystrophy 3 (PPCD3) and Fuchs' endothelial corneal dystrophy (FECD). METHODS:Thirteen of the 27 previously reported ZEB1 truncating mutations associated with PPCD3 and the six previ...

journal_title：Investigative ophthalmology & visual science

authors： Chung DW,Frausto RF,Ann LB,Jang MS,Aldave AJ

更新日期：2014-09-04 00:00:00

abstract：PURPOSE:To examine the relationship between short-wavelength-sensitive (SWS) resolution acuity and epidemiologically defined stages of early age-related maculopathy (ARM). METHODS:Subjects consisted of 88 adults aged 51 to 87 years. Psychophysical testing was undertaken in only one eye of each subject (the study eye)....

journal_title：Investigative ophthalmology & visual science

authors： Beirne RO,Hogg RE,Stevenson MR,Zlatkova MB,Chakravarthy U,Anderson RS

更新日期：2006-10-01 00:00:00

abstract：Purpose:Patients with diabetes have a propensity to develop dry eye symptoms (DES), with reduced tear secretion and corneal sensitivity. The underlying pathologic basis of DES was explored in patients with Type 1 diabetes. Methods:Forty-two patients with Type 1 diabetes mellitus (T1DM) (age: 49.21 ± 2.53 years, durati...

journal_title：Investigative ophthalmology & visual science

authors： Ferdousi M,Petropoulos IN,Kalteniece A,Azmi S,Ponirakis G,Efron N,Soran H,Malik RA

更新日期：2018-11-01 00:00:00

abstract：:The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNA...

journal_title：Investigative ophthalmology & visual science

authors： Ambati J

更新日期：2011-04-06 00:00:00

abstract：PURPOSE:Compensatory eye movements (CEM) maintain a stable image on the retina by minimizing retinal slip. The optokinetic reflex (OKR) and vestibulo-ocular reflex (VOR) compensate for low and high velocity stimuli, respectively. The OKR system is known to be highly nonlinear. The VOR is generally modeled as a linear s...

journal_title：Investigative ophthalmology & visual science

authors： Sibindi TM,Holland PJ,van der Geest JN,Donchin O,Frens MA

更新日期：2016-07-01 00:00:00

abstract：:Ocular sympathetic nerves were stimulated chronically in awake rabbits using electrodes unilaterally implanted on the cervical sympathetic trunk. IOP was measured by pneumatonometry and aqueous inflow was measured by fluorophotometry. In each animal, continuous trains of 1 msec pulses were delivered by means of a port...

journal_title：Investigative ophthalmology & visual science

authors： Belmonte C,Bartels SP,Liu JH,Neufeld AH

更新日期：1987-10-01 00:00:00

abstract：PURPOSE:Diabetic complications are associated with hypoglycemia and hyperglycemia. The purpose of this study was to investigate the effect of both glucose deprivation and hyperglycemia on the induction of endoplasmic reticulum (ER) stress and the subsequent activation of the unfolded protein response (UPR) that results...

journal_title：Investigative ophthalmology & visual science

authors： Mulhern ML,Madson CJ,Danford A,Ikesugi K,Kador PF,Shinohara T

更新日期：2006-09-01 00:00:00

abstract：:The laser Doppler technique was used to measure alterations in retinal blood flow in human subjects under dark-adapted conditions compared to light-adapted conditions. Retinal blood flow increased 40 to 70% after the transition from light to dark. We show quantitatively that the measured increases in retinal blood flo...

journal_title：Investigative ophthalmology & visual science

authors： Feke GT,Zuckerman R,Green GJ,Weiter JJ

更新日期：1983-01-01 00:00:00