Autoregulation of blood flow in the capillaries of the human macula.

abstract：PURPOSE:MRL/Mp-lpr/lpr mice (MRL/lpr) spontaneously develop lacrimal gland inflammatory lesions and are a model for the human disease Sjögren's syndrome. Therapy with monoclonal antibodies (mAb) to CD4 ameliorates the autoimmune renal, vasculitic, and intraocular inflammatory lesions in MRL/lpr mice. The effect of anti...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Burns WH,Prendergast RA

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. METHODS:72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related ac...

journal_title：Investigative ophthalmology & visual science

authors： Balaskas K,Ballabeni P,Guex-Crosier Y

更新日期：2012-09-14 00:00:00

abstract：PURPOSE:Retinal pigment epithelial (RPE) cells are known to play important roles in maintaining the homeostasis of the retina and in controlling choroidal neovascularization. The purpose of this study was to identify a factor or factors that would stimulate RPE cells to proliferate. METHODS:To isolate such a factor, 1...

journal_title：Investigative ophthalmology & visual science

authors： Tanaka Y,Utsumi J,Matsui M,Sudo T,Nakamura N,Mutoh M,Kajita A,Sone S,Kigasawa K,Shibuya M,Reddy VN,Zhang Q,Iwata T

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To compare self-assessed driving habits and skills of licensed drivers with central visual loss who use bioptic telescopes to those of age-matched normally sighted drivers, and to examine the association between bioptic drivers' impressions of the quality of their driving and ratings by a "backseat" evaluator. ...

journal_title：Investigative ophthalmology & visual science

authors： Owsley C,McGwin G Jr,Elgin J,Wood JM

更新日期：2014-01-15 00:00:00

abstract：PURPOSE:To evaluate interictal visual dysfunction in persons with migraine in terms of spatiotemporal selectivity and location within the visual pathways. METHODS:The vision of a group of 15 persons who had experienced migraine with aura was compared with that of 15 normal age-matched control subjects. A range of thre...

journal_title：Investigative ophthalmology & visual science

authors： McKendrick AM,Vingrys AJ,Badcock DR,Heywood JT

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:To evaluate the performance and potential clinical role of three-dimensional (3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality. METHODS:...

journal_title：Investigative ophthalmology & visual science

authors： Esmaeelpour M,Povazay B,Hermann B,Hofer B,Kajic V,Kapoor K,Sheen NJ,North RV,Drexler W

更新日期：2010-10-01 00:00:00

abstract：:A sensitive fluorometric assay for measuring permeability of liposomes containing bovine lens MIP26 has been developed and characterized. Lens membrane proteins were isolated and incorporated into artificial membranes composed of bovine brain phospholipids, sphingomyelin and the fluorescent probe, N-4-nitrobenzo-2-oxa...

journal_title：Investigative ophthalmology & visual science

authors： Scaglione BA,Rintoul DA

更新日期：1989-05-01 00:00:00

abstract：PURPOSE:To assess whether saccadic eye movements show distinct changes in patients with early active Graves' ophthalmopathy (GO), which could serve as a diagnostic tool for early detection and treatment. METHODS:Each of two prospective studies included 10 patients with early acute GO and 10 age- and sex-matched contro...

journal_title：Investigative ophthalmology & visual science

authors： Schworm HD,Heufelder AE,Kunze A,Welge E,Boergen KP

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:Best disease is a monogenic macular degeneration caused mainly by heterozygous mutations in the BEST1 gene. The objective was to characterize the molecular and clinical features of patients with the classical form of Best disease that is inherited in an autosomal recessive mode. METHODS:Clinical evaluation inc...

journal_title：Investigative ophthalmology & visual science

authors： Bitner H,Mizrahi-Meissonnier L,Griefner G,Erdinest I,Sharon D,Banin E

更新日期：2011-07-18 00:00:00

abstract：Purpose:To accelerate the development of new therapies, an inherited retinal degeneration model in a nonhuman primate would be useful to confirm the efficacy in preclinical studies. In this study, we describe the discovery of retinitis pigmentosa in a cynomolgus monkey (Macaca fascicularis) pedigree. Methods:First, sc...

journal_title：Investigative ophthalmology & visual science

authors： Ikeda Y,Nishiguchi KM,Miya F,Shimozawa N,Funatsu J,Nakatake S,Fujiwara K,Tachibana T,Murakami Y,Hisatomi T,Yoshida S,Yasutomi Y,Tsunoda T,Nakazawa T,Ishibashi T,Sonoda KH

更新日期：2018-02-01 00:00:00

abstract：Purposes:Trabeculectomy is a surgical procedure for lowering intraocular pressure in glaucoma patients, in which excessive scarring leading to failure of the filtering bleb adversely affects the surgical outcome. Heightened Tenon's capsule fibroblast (TCF) proliferation and extracellular matrix (ECM) deposition are imp...

journal_title：Investigative ophthalmology & visual science

authors： Lei D,Dong C,Wu WK,Dong A,Li T,Chan MT,Zhou X,Yuan H

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To evaluate the rate and location of visual field (VF) progression before and after detection of disc hemorrhage (DH). METHODS:Disc photographs of consecutive patients with glaucoma with >or=5 SITA-Standard 24-2 VF in either eye were evaluated for the presence and location of DH. Exclusion criteria included di...

journal_title：Investigative ophthalmology & visual science

authors： De Moraes CG,Prata TS,Liebmann CA,Tello C,Ritch R,Liebmann JM

更新日期：2009-10-01 00:00:00

abstract：:The uveal absorption of aqueous humor at two different intraocular pressures was measured in rhesus monkeys by sampling vortex vein blood during anterior chamber perfusion of Ringer's solution containing both fluorescein and 125I albumin. At 20 mm. Hg, an excess of fluorescein equivalent in amount to 0.45 microliter/m...

journal_title：Investigative ophthalmology & visual science

authors： Pederson JE,Gaasterland DE,MacLellan HM

更新日期：1977-11-01 00:00:00

abstract：PURPOSE:To evaluate the longitudinal variability of optic disc and retinal nerve fiber layer (RNFL) measurements obtained from optical coherence tomography (OCT), scanning laser polarimetry (SLP), and confocal scanning laser ophthalmoscopy (CSLO). METHODS:Forty-five normal and 43 glaucomatous eyes of 88 subjects were ...

journal_title：Investigative ophthalmology & visual science

authors： Leung CK,Cheung CY,Lin D,Pang CP,Lam DS,Weinreb RN

更新日期：2008-11-01 00:00:00

abstract：PURPOSE:To investigate in vitro the cell toxicity and antioxidant effects of two major tear substitutes, hyaluronic acid and a widely used carbomer, with and without preservative. METHODS:Chang conjunctival cells were treated with different concentrations of unpreserved or preserved carbomer 934P (0.03% and 0.3%), unp...

journal_title：Investigative ophthalmology & visual science

authors： Debbasch C,De La Salle SB,Brignole F,Rat P,Warnet JM,Baudouin C

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:To study reading acuity in children and assess the reliability of its measurement using the Italian version of the MNREAD reading chart. METHODS:One hundred sixteen children from grades 3 to 8 with normal near vision were tested at a pediatric eye care institution in northeastern Italy. Visual acuity was evalu...

journal_title：Investigative ophthalmology & visual science

authors： Virgili G,Cordaro C,Bigoni A,Crovato S,Cecchini P,Menchini U

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:Optical coherence tomography (OCT) has been used to investigate papilledema in single-site, mostly retrospective studies. We investigated whether spectral-domain OCT (SD-OCT), which provides thickness and volume measurements of the optic nerve head and retina, could reliably demonstrate structural changes due t...

journal_title：Investigative ophthalmology & visual science

authors： OCT Sub-Study Committee for NORDIC Idiopathic Intracranial Hypertension Study Group.,Auinger P,Durbin M,Feldon S,Garvin M,Kardon R,Keltner J,Kupersmith M,Sibony P,Plumb K,Wang JK,Werner JS

更新日期：2014-11-04 00:00:00

abstract：PURPOSE:To characterize the thickness profile of the corneal epithelium and the Bowman's layer across the horizontal meridian. METHODS:Forty-four eyes of 22 healthy subjects were investigated in this study. Ultra-high resolution anterior segment spectral domain-optical coherence tomography (SD-OCT) was used to assess ...

journal_title：Investigative ophthalmology & visual science

authors： Tao A,Wang J,Chen Q,Shen M,Lu F,Dubovy SR,Shousha MA

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:Recent studies suggest that photoreceptor cells regulate local inflammation in the retina in diabetes. The purpose of this study was to determine if photoreceptor cells themselves produce inflammatory proteins in diabetes and if soluble factors released by photoreceptors in elevated glucose induce inflammatory ...

journal_title：Investigative ophthalmology & visual science

authors： Tonade D,Liu H,Kern TS

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To compare structural properties from spectral-domain optical coherence tomography (SDOCT) and psychophysical measures from a subset of patients enrolled in a larger multicenter natural history study of X-linked retinoschisis (XLRS). METHODS:A subset of males (n = 24) participating in a larger natural history ...

journal_title：Investigative ophthalmology & visual science

authors： Bennett LD,Wang YZ,Klein M,Pennesi ME,Jayasundera T,Birch DG

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:To characterize the outward chloride currents (Cl(OR)) in single acinar cells isolated from the rabbit superior lacrimal gland (RSLG) to investigate the hypothesis that Cl(OR) may have a role in regulating the volume of RSLG acini. METHODS:Cl(OR) was characterized by using patch-clamp electrophysiology. Confoc...

journal_title：Investigative ophthalmology & visual science

authors： Herok GH,Millar TJ,Anderton PJ,Martin DK

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To evaluate the expression of lumican and decorin, the major proteoglycans of the adult corneal stroma, during the acquisition of corneal transparency in developing chick embryos. METHODS:mRNA levels of decorin and lumican were measured in total RNA extracted from corneas of days 9 to 18 of development by Nort...

journal_title：Investigative ophthalmology & visual science

authors： Cornuet PK,Blochberger TC,Hassell JR

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:To compare confocal scanning laser tomography (CSLT) to optic disc photography for detecting progressive glaucomatous disc changes. METHODS:Four expert observers first examined a training set of 40 pairs of monoscopic disc photographs to help set a criterion for change. They then classified 44 pairs of monosco...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Hutchison DM,Artes PH,Caprioli J,Jonas JB,LeBlanc RP,Nicolela MT

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Severe ocular allergic diseases are characterized by pronounced conjunctival inflammation triggered by T helper 2 (Th2) cells and corneal epithelial damage induced by eosinophils. To examine the role of alarmins released by damaged corneal epithelial cells in tissue eosinophilia, we investigated the effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Fukuda K,Ishida W,Tanaka H,Harada Y,Matsuda A,Ebihara N,Fukushima A

更新日期：2013-08-27 00:00:00

abstract：PURPOSE:We investigated the mechanism of tamoxifen (TAM) retinotoxicity using human retinal pigment epithelial (RPE)-derived (ARPE-19) and photoreceptor-derived (661W) cells. METHODS:Cultured ARPE-19 and 661W cells were treated with 5 to 10 μM TAM, and the resultant cell death was quantified using lactate dehydrogenas...

journal_title：Investigative ophthalmology & visual science

authors： Cho KS,Yoon YH,Choi JA,Lee SJ,Koh JY

更新日期：2012-08-09 00:00:00

abstract：:The histological distribution of R-cognin in chick retinas was determined from embryonic day 8 through 13 wk post-hatching by indirect immunofluorescence using polyclonal anticognin. On embryonic day 8, at a developmental stage without distinct retina layers, most of the cells within the tissue exhibited fluorescence....

journal_title：Investigative ophthalmology & visual science

authors： Dobi ET,Troccoli NM,Hausman RE

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:Hypoxia and growth factors are postulated to be involved in the development of retinal neovascularization through the regulation of extracellular proteinase production. It has been shown that matrix metalloproteinases (MMPs) are elevated in the retina during the neovascularization process. However, the factors ...

journal_title：Investigative ophthalmology & visual science

authors： Majka S,McGuire PG,Das A

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Strabismic amblyopia is typically associated with several visual deficits, including loss of contrast sensitivity in the amblyopic eye and abnormal binocular vision. Binocular summation ratios (BSRs) are usually assessed by comparing contrast sensitivity for binocular stimuli (sens(BIN)) with that measured in t...

journal_title：Investigative ophthalmology & visual science

authors： Baker DH,Meese TS,Mansouri B,Hess RF

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To investigate the interobserver agreement for the detection of optical coherence tomography (OCT) features of disease activity in patients with neovascular age-related macular degeneration (nAMD). METHODS:This was a cross-sectional agreement study in which grading of OCT line scans from patients with nAMD was...

journal_title：Investigative ophthalmology & visual science

authors： Patel PJ,Browning AC,Chen FK,Da Cruz L,Tufail A

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:The goal of this study was to determine the changes in the organization of the retinal cytoskeleton after experimental retinal detachment. METHODS:Cat retinas were detached from the retinal pigment epithelium and then processed for Western blot analysis and fluorescence microscopy. Proteins examined included g...

journal_title：Investigative ophthalmology & visual science

authors： Lewis GP,Matsumoto B,Fisher SK

更新日期：1995-11-01 00:00:00