abstract：:Cervical cancer is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer death in women. The discrepancy in cervical cancer incidence and mortality between developed and developing nations has become increasingly apparent with 84% of the incidence and 88% of the mortality of cervical cance...

journal_title：Seminars in radiation oncology

authors： Gurram L,Kalra B,Mahantshetty U

更新日期：2020-10-01 00:00:00

abstract：:Definitive reirradiation using a stereotactic technique is an effective local treatment option for both recurrent liver metastases and recurrent primary liver cancers. The tolerance of the liver, bile ducts, and surrounding gastrointestinal luminal organs must be respected to ensure safe retreatment. The risks associa...

journal_title：Seminars in radiation oncology

authors： Owen D,Lukovic J,Hosni A,Crane CH,Hong TS,Dawson LA,Velec M,Lawrence TS

更新日期：2020-07-01 00:00:00

abstract：:Brachytherapy has become an essential pillar in all-stages of localized prostate cancer, where dose escalation has been demonstrated to improve outcome. HDR brachytherapy has evolved over the decades to be administered in 1-2 fractions. As either monotherapy or in combination with external beam, it offers many advanta...

journal_title：Seminars in radiation oncology

authors： Crook J,Marbán M,Batchelar D

更新日期：2020-01-01 00:00:00

abstract：:In oncology, the term "big data" broadly describes the rapid acquisition and generation of massive amounts of information, typically from population cancer registries, electronic health records, or large-scale genetic sequencing studies. The challenge of using big data in cancer research lies in interdisciplinary coll...

journal_title：Seminars in radiation oncology

authors： Tsai CJ,Riaz N,Gomez SL

更新日期：2019-10-01 00:00:00

abstract：:The world is embracing the information age, with real-time data at hand to assist with many decisions. Similarly, in cancer radiotherapy we are inexorably moving toward using information in a smarter and faster fashion, to usher in the age of real-time adaptive radiotherapy. The three critical steps of real-time adapt...

journal_title：Seminars in radiation oncology

authors： Keall P,Poulsen P,Booth JT

更新日期：2019-07-01 00:00:00

abstract：:Oropharyngeal carcinoma associated with the human papillomavirus is increasing in incidence and represents a unique head and neck disease with favorable treatment outcomes. This review evaluates the evolving role of radiotherapy in regional management with an overall goal of treatment de-escalation in the appropriate ...

journal_title：Seminars in radiation oncology

authors： Tam M,Hu K

更新日期：2019-04-01 00:00:00

abstract：:Data from observational studies indicate that both physical activity as well as exercise (ie, structured physical activity) is associated with reductions in the risk of recurrence and cancer mortality after a diagnosis of certain forms of cancer. Emerging evidence from preclinical studies indicates that physical activ...

journal_title：Seminars in radiation oncology

authors： Ashcraft KA,Warner AB,Jones LW,Dewhirst MW

更新日期：2019-01-01 00:00:00

abstract：:Surgical resection or liver transplantation offers the best chance of cure for patients with hepatocellular carcinoma (HCC). Unfortunately, most patients are not good candidates for liver resection due to locally advanced disease or compromised liver function. Moreover, liver transplantation waiting lists are long. Fo...

journal_title：Seminars in radiation oncology

authors： Toesca DAS,Barry A,Sapisochin G,Beecroft R,Dawson L,Owen D,Mouli S,Lewandowski R,Salem R,Chang DT

更新日期：2018-10-01 00:00:00

abstract：:The International Commission on Radiation Units and Measurements (ICRU) volumes are standardized volume definitions used in radiation oncology practice that have evolved over time to account for advancements in technology and radiation planning. The current definitions have strengths but also practical limitations. Th...

journal_title：Seminars in radiation oncology

authors： Shepherd A,James SS,Rengan R

更新日期：2018-06-01 00:00:00

abstract：:Proton radiotherapy confers significant dosimetric advantages in the treatment of malignancies that arise adjacent to critical radiosensitive structures. To date, these advantages have been most prominent in the treatment of pediatric and central nervous system malignancies, although emerging data support the use of p...

journal_title：Seminars in radiation oncology

authors： Braunstein LZ,Cahlon O

更新日期：2018-04-01 00:00:00

abstract：:Immune system dysfunction plays a role in both the development and progression of head and neck squamous cell carcinoma (HNSCC), highlighting the potential role for immunotherapy to improve outcomes in this disease. The application of anti-PD-1 therapies for recurrent or metastatic HNSCC has found promising results. T...

journal_title：Seminars in radiation oncology

authors： Ling DC,Bakkenist CJ,Ferris RL,Clump DA

更新日期：2018-01-01 00:00:00

abstract：:Thoracic malignancies are often a difficult group of tumors to treat definitively as the radiation doses needed to achieve a high probability for tumor control are often associated with high rates of radiation-induced toxicities. The lungs are particularly radiosensitive and are susceptible to radiation pneumonitis in...

journal_title：Seminars in radiation oncology

authors： Simone CB 2nd

更新日期：2017-10-01 00:00:00

abstract：:This review provides an overview of the use of stereotactic ablative body radiotherapy (SABR) for pulmonary metastases. The local control rates after SABR are generally >90%. Whether this also translates into a significant improvement in overall survival is the subject of ongoing studies. New exciting opportunities in...

journal_title：Seminars in radiation oncology

authors： Siva S,Slotman BJ

更新日期：2017-07-01 00:00:00

abstract：:Low socioeconomic and health care access realities of being American Indian/Alaskan Native (AI/AN) in the United States combined with decades of data documenting poor cancer outcomes for this population provide a population nested within the United States that is analogous to the cancer care landscape of low- and midd...

journal_title：Seminars in radiation oncology

authors： Guadagnolo BA,Petereit DG,Coleman CN

更新日期：2017-04-01 00:00:00

abstract：:The past decade has brought an improved ability to precisely target and deliver radiation as well as other focal prostate-directed therapy. Stereotactic body radiotherapy (SBRT), proton beam radiation, high-dose-rate (HDR) brachytherapy, as well as nonradiotherapy treatments such as cryoablation and high-intensity foc...

journal_title：Seminars in radiation oncology

authors： Magnuson WJ,Mahal A,Yu JB

更新日期：2017-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is an aggressive intracranial tumor characterized by local and distant brain relapse despite aggressive therapy. Current standard treatment includes surgical resection followed by radiation with concurrent and adjuvant temozolomide as part of a combined modality approach. In this review, ...

journal_title：Seminars in radiation oncology

authors： Corso CD,Bindra RS

更新日期：2016-10-01 00:00:00

abstract：:Functional imaging is emerging as a valuable contributor to the clinical management of patients with rectal cancer. Techniques such as diffusion-weighted magnetic resonance imaging, perfusion imaging, and positron emission tomography can offer meaningful insights into tissue architecture, vascularity, and metabolism. ...

journal_title：Seminars in radiation oncology

authors： Lambregts DM,Maas M,Stokkel MP,Beets-Tan RG

更新日期：2016-07-01 00:00:00

abstract：:Understanding dose constraints for critical structures in stereotactic body radiation therapy (SBRT) is essential to generate a plan for optimal efficacy and safety. Published dose constraints are derived by a variety of methods, including crude statistics, actuarial analysis, modeling, and simple biologically effecti...

journal_title：Seminars in radiation oncology

authors： Xue J,Kubicek G,Patel A,Goldsmith B,Asbell SO,LaCouture TA

更新日期：2016-04-01 00:00:00

abstract：:When surgery is the first line of breast cancer treatment, numerous randomized clinical trials and meta-analyses have demonstrated that postmastectomy radiation therapy (PMRT) improves locoregional control and survival for many women with axillary lymph node-positive disease. In contrast, there are no randomized data ...

journal_title：Seminars in radiation oncology

authors： Bazan JG,White JR

更新日期：2016-01-01 00:00:00

abstract：:Treatment of newly diagnosed or suspected low-grade glioma (LGG) is one of the most controversial areas in neuro-oncology. The heterogeneity of these tumors, concern regarding morbidity of treatment, and absence of proven overall survival benefit from any known treatment have resulted in a lack of consensus regarding ...

journal_title：Seminars in radiation oncology

authors： Laack NN,Sarkaria JN,Buckner JC

更新日期：2015-07-01 00:00:00

abstract：:Non-small cell lung cancers are now recognized to contain considerable heterogeneity and molecular diversity. Substantial progress has been made regarding molecular determinants of response to targeted agents in advanced lung cancer, and recent findings have revealed subsets of patients with driver mutations that resp...

journal_title：Seminars in radiation oncology

authors： Yom SS,Diehn M,Raben D

更新日期：2015-04-01 00:00:00

abstract：:The immune system has the power to modulate the expression of radiation-induced normal and tumor tissue damage. On the one hand, it can contribute to cancer cure, and on the other hand, it can influence acute and late radiation side effects, which in many ways resemble acute and chronic inflammatory disease states. Th...

journal_title：Seminars in radiation oncology

authors： Schaue D,Micewicz ED,Ratikan JA,Xie MW,Cheng G,McBride WH

更新日期：2015-01-01 00:00:00

abstract：:Standard treatment for Glioblastoma Multiforme (GBM) consists of a combination of chemotherapy and radiation therapy followed by adjuvant chemotherapy. While the optimal dose of radiation therapy has been established, significant variability in volume of tissue irradiated exists. In this article we review the current ...

journal_title：Seminars in radiation oncology

authors： Fogh S,Wahl M,Anwar M,Haas-Kogan D,Clarke JL,Sneed PK

更新日期：2014-10-01 00:00:00

abstract：:The recent development of intensity-modulated radiation therapy (IMRT) and improvements in image-guided radiotherapy (IGRT) have provided considerable advances in the utilization of radiation therapy (RT) for the management of pancreatic cancer. IGRT allows for the reduction of treatment volumes, potentially less chan...

journal_title：Seminars in radiation oncology

authors： Reese AS,Lu W,Regine WF

更新日期：2014-04-01 00:00:00

abstract：:Radiation oncology encompasses a diverse spectrum of treatment modalities, including stereotactic radiosurgery, hypofractionated radiotherapy, and brachytherapy. Though all these modalities generally aim to do the same thing-treat cancer with therapeutic doses of radiation while relatively sparing normal tissue from e...

journal_title：Seminars in radiation oncology

authors： Aneja S,Yu JB

更新日期：2014-01-01 00:00:00

abstract：:Most solid tumors are characterized by unstable perfusion patterns, creating regions of hypoxia that are detrimental to radiotherapy treatment response. Because postsurgical radiotherapy, alone or in combination with other interventions, is a first-line treatment for many malignancies, strategies aimed at homogeneousl...

journal_title：Seminars in radiation oncology

authors： Danhier P,De Saedeleer CJ,Karroum O,De Preter G,Porporato PE,Jordan BF,Gallez B,Sonveaux P

更新日期：2013-10-01 00:00:00

abstract：:Proponents of proton radiotherapy have cited the dose distribution characteristics of proton beams as evidence of its superiority over photon radiotherapy. Outcomes after photon radiotherapy remain suboptimal owing to poor local control and normal-tissue toxicity in many clinical indications. Critics of proton radioth...

journal_title：Seminars in radiation oncology

authors： Miller RC,Lodge M,Murad MH,Jones B

更新日期：2013-04-01 00:00:00

abstract：:Oncological treatment decision-making is a highly complex enterprise integrating multiple patient, tumor, treatment, and professional factors with the available medical evidence. This management complexity can be exacerbated by the interplay of patient age and comorbid non-cancer conditions that can affect patient qua...

journal_title：Seminars in radiation oncology

authors： Rodrigues G,Sanatani M

更新日期：2012-10-01 00:00:00

abstract：:The initial management of thyroid cancer is usually surgery, followed by radioactive iodine in differentiated thyroid cancer. The role of external beam radiotherapy for gross residual or unresected disease is discussed. For both differentiated thyroid cancer and medullary thyroid cancer, the role of external beam radi...

journal_title：Seminars in radiation oncology

authors： Brierley J,Sherman E

更新日期：2012-07-01 00:00:00

abstract：:There has been a gradual change in the demographics of head and neck carcinoma. Although relatively uncommon, the incidence of oropharyngeal carcinoma has been increasing despite declining tobacco consumption and contrary to a diminishing incidence of cancers at other head and neck sites. It is now clear that the inci...

journal_title：Seminars in radiation oncology

authors： Ang KK,Sturgis EM

更新日期：2012-04-01 00:00:00

abstract：:There has been growing emphasis on quality measures and process analysis techniques that may be implemented in the daily practice of radiation oncology to improve the overall quality of patient care. In this work, quality measures are a form of monitoring that should be actionable and specific to guide process improve...

journal_title：Seminars in radiation oncology

authors： Pawlicki T,Chera B,Ning T,Marks LB

更新日期：2012-01-01 00:00:00

abstract：:Most hepatocellular carcinoma (HCC) patients present with locally advanced disease with a risk of development of intrahepatic or extrahepatic metastases. Conformal radiotherapy (RT) can be delivered to focal HCCs with sustained local control in selected HCC patients. However, it is frequently not possible to deliver t...

journal_title：Seminars in radiation oncology

authors： Lee IJ,Seong J

更新日期：2011-10-01 00:00:00

abstract：:Diffusion-weighted MRI (DW-MRI) is able to detect and characterize tissues because it incorporates sensitivity to water content and water movements into the images that are produced. Compared with other imaging modalities used in oncologic assessments, DW-MRI does not expose patients to ionizing radiations, and no inj...

journal_title：Seminars in radiation oncology

authors： Padhani AR

更新日期：2011-04-01 00:00:00

abstract：:Breast-conserving therapy is a reliable, evidenced-based approach for early-stage breast carcinoma. This article reviews the issues and limitations related to simple margin measurements, data supporting the association between the amount of carcinoma near the margin, and ipsilateral breast failure risk. Additional fac...

journal_title：Seminars in radiation oncology

authors： Goldstein SN

更新日期：2011-01-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) induced during clinical radiotherapy are potent inducers of cell death. Poly(ADP-ribose) polymerase (PARP)-1 is a 113-kD nuclear protein that binds to both single- and double-strand DNA breaks and is actively involved in DNA single-strand break repair and base excision repair. Recently,...

journal_title：Seminars in radiation oncology

authors： Chalmers AJ,Lakshman M,Chan N,Bristow RG

更新日期：2010-10-01 00:00:00

abstract：:For medically operable patients with stage I non-small-cell lung cancer (NSCLC), lobectomy or pneumonectomy remains the standard of care. The utility of radiotherapy or chemotherapy after major pulmonary resection remains unproven, though clinical and biological models may identify subgroups most likely to benefit. Li...

journal_title：Seminars in radiation oncology

authors： Robinson CG,Bradley JD

更新日期：2010-07-01 00:00:00

abstract：:Since the breakthrough 10 years ago with concomitant radio-chemotherapy, substantial progress in the treatment of locally advanced cervical cancer has been lacking. Radiotherapy continues to be the cornerstone in the treatment of this disease and now shows much potential for progress, as image guidance of both externa...

journal_title：Seminars in radiation oncology

authors： Tanderup K,Georg D,Pötter R,Kirisits C,Grau C,Lindegaard JC

更新日期：2010-04-01 00:00:00

abstract：:In most cancers, the age of the affected patient has a significant influence on how that cancer is approached. This is less often the case in sarcomas in that both children and adults are treated similarly. However, different types of sarcomas are most typical in these populations, and our understanding of these cance...

journal_title：Seminars in radiation oncology

authors： Wolden SL,Alektiar KM

更新日期：2010-01-01 00:00:00

abstract：:Inflammatory breast cancer (IBC) represents the most virulent form of breast cancer, characterized by involvement of the skin and rapid progression of the disease. Management involves careful coordination of all multidisciplinary modalities, including imaging, systemic chemotherapy, surgery, and radiation therapy. The...

journal_title：Seminars in radiation oncology

authors： Woodward WA,Cristofanilli M

更新日期：2009-10-01 00:00:00

abstract：:Although the addition of concurrent and adjuvant temozolomide (TMZ) to standard-dose radiation (60 Gy) improves survival, the pattern of failure continues to be local. Conventional contrast enhanced T1-weighted and T2-weighted magnetic resonance imaging (MRI) used for radiation planning reflect anatomic rather than mo...

journal_title：Seminars in radiation oncology

authors： Tsien CI,Cao Y,Lawrence TS

更新日期：2009-07-01 00:00:00