Radiation and inflammation.

abstract：:Non-small cell lung cancers are now recognized to contain considerable heterogeneity and molecular diversity. Substantial progress has been made regarding molecular determinants of response to targeted agents in advanced lung cancer, and recent findings have revealed subsets of patients with driver mutations that resp...

journal_title：Seminars in radiation oncology

authors： Yom SS,Diehn M,Raben D

更新日期：2015-04-01 00:00:00

abstract：:As more radionuclide therapies move from laboratory feasibility studies into clinical reality, it becomes increasingly important for the labeling chemistry to produce consistently a stable radiopharmaceutical that remains intact under the challenge of human catabolism. Similarly, once proof of principle is established...

journal_title：Seminars in radiation oncology

authors： Wessels BW,Meares CF

更新日期：2000-04-01 00:00:00

abstract：:Radiation therapy has played a minor role in the conventional management of patients with unresectable primary hepatobiliary malignancies and liver metastases. This can be attributed to normal tissue toxicity, which has limited the dose of radiation that can be safely administered, and imaging limitations, which have ...

journal_title：Seminars in radiation oncology

authors： McGinn CJ,Lawrence TS

更新日期：1997-10-01 00:00:00

abstract：:A dose-response relationship can be established for local control of a variety of malignancies treated with radiation, yet palliation of symptoms oftentimes does not have a clear dose-response relationship. It is important that palliation be achieved with as efficient a fractionation schedule as possible in patients w...

journal_title：Seminars in radiation oncology

authors： Anderson PR,Coia LR

更新日期：2000-07-01 00:00:00

abstract：:In oncology, the term "big data" broadly describes the rapid acquisition and generation of massive amounts of information, typically from population cancer registries, electronic health records, or large-scale genetic sequencing studies. The challenge of using big data in cancer research lies in interdisciplinary coll...

journal_title：Seminars in radiation oncology

authors： Tsai CJ,Riaz N,Gomez SL

更新日期：2019-10-01 00:00:00

abstract：:Immune system dysfunction plays a role in both the development and progression of head and neck squamous cell carcinoma (HNSCC), highlighting the potential role for immunotherapy to improve outcomes in this disease. The application of anti-PD-1 therapies for recurrent or metastatic HNSCC has found promising results. T...

journal_title：Seminars in radiation oncology

authors： Ling DC,Bakkenist CJ,Ferris RL,Clump DA

更新日期：2018-01-01 00:00:00

abstract：:Surgical resection is often the first-line treatment option for primary and select metastatic hepatic malignancies. A minority of patients with hepatocellular carcinoma undergo potentially curative resection. Similarly, patients with liver-only metastasis are candidates for resection less than 15% of the time because ...

journal_title：Seminars in radiation oncology

authors： Gannon CJ,Curley SA

更新日期：2005-10-01 00:00:00

abstract：:Inflammatory breast cancer (IBC) represents the most virulent form of breast cancer, characterized by involvement of the skin and rapid progression of the disease. Management involves careful coordination of all multidisciplinary modalities, including imaging, systemic chemotherapy, surgery, and radiation therapy. The...

journal_title：Seminars in radiation oncology

authors： Woodward WA,Cristofanilli M

更新日期：2009-10-01 00:00:00

abstract：:Radiation therapy (RT) is frequently used to treat patients with tumors in and around the thorax. Clinical radiation pneumonitis is a common side effect, occurring in 5% to 20% of patients. Efforts to identify patients at risk for pneumonitis have focused on physical factors, such as dose and volume. Recently, the und...

journal_title：Seminars in radiation oncology

authors： Vujaskovic Z,Marks LB,Anscher MS

更新日期：2000-10-01 00:00:00

abstract：:For over 4 decades, the delivery of definitive radiotherapy to patients with carcinoma of the cervix has involved both external beam and brachytherapy. Both of these therapeutic modalities have been traditionally linked to 2-dimensional radiographic guidance. Currently, the staging of these tumors still resides in cli...

journal_title：Seminars in radiation oncology

authors： Wolfson AH

更新日期：2006-07-01 00:00:00

abstract：:Low socioeconomic and health care access realities of being American Indian/Alaskan Native (AI/AN) in the United States combined with decades of data documenting poor cancer outcomes for this population provide a population nested within the United States that is analogous to the cancer care landscape of low- and midd...

journal_title：Seminars in radiation oncology

authors： Guadagnolo BA,Petereit DG,Coleman CN

更新日期：2017-04-01 00:00:00

abstract：:Historically, both adult and childhood Hodgkin lymphoma (HL) were treated with full-dose (35-45 Gy) extended-field radiation therapy (RT). Although this treatment was the first to produce reliable disease control, the resulting late toxicity led pediatric oncologists to pioneer the use of combined chemotherapy and low...

journal_title：Seminars in radiation oncology

authors： Hodgson DC,Hudson MM,Constine LS

更新日期：2007-07-01 00:00:00

abstract：:Copyright ...

journal_title：Seminars in radiation oncology

authors： Dewhirst MW,Mitchell JB

更新日期：1998-07-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a cell membrane protein that is overexpressed in almost all head and neck squamous cell carcinomas. Overexpression of EGFR has been associated with a poor prognosis in head and neck tumors as well as many other malignancies. This cell membrane protein has been considered an e...

journal_title：Seminars in radiation oncology

authors： Bonner JA,De Los Santos J,Waksal HW,Needle MN,Trummel HQ,Raisch KP

更新日期：2002-07-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is an aggressive intracranial tumor characterized by local and distant brain relapse despite aggressive therapy. Current standard treatment includes surgical resection followed by radiation with concurrent and adjuvant temozolomide as part of a combined modality approach. In this review, ...

journal_title：Seminars in radiation oncology

authors： Corso CD,Bindra RS

更新日期：2016-10-01 00:00:00

abstract：:There has been growing emphasis on quality measures and process analysis techniques that may be implemented in the daily practice of radiation oncology to improve the overall quality of patient care. In this work, quality measures are a form of monitoring that should be actionable and specific to guide process improve...

journal_title：Seminars in radiation oncology

authors： Pawlicki T,Chera B,Ning T,Marks LB

更新日期：2012-01-01 00:00:00

abstract：:A variety of techniques for measuring oxygen in normal and tumor tissue has been developed over the years in response to the realization that hypoxia is important in a number of pathophysiological conditions in normal tissues and in the response of tumors to radiation treatment. A review of the techniques for measurin...

journal_title：Seminars in radiation oncology

authors： Raleigh JA,Dewhirst MW,Thrall DE

更新日期：1996-01-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) induced during clinical radiotherapy are potent inducers of cell death. Poly(ADP-ribose) polymerase (PARP)-1 is a 113-kD nuclear protein that binds to both single- and double-strand DNA breaks and is actively involved in DNA single-strand break repair and base excision repair. Recently,...

journal_title：Seminars in radiation oncology

authors： Chalmers AJ,Lakshman M,Chan N,Bristow RG

更新日期：2010-10-01 00:00:00

abstract：:Surgical resection or liver transplantation offers the best chance of cure for patients with hepatocellular carcinoma (HCC). Unfortunately, most patients are not good candidates for liver resection due to locally advanced disease or compromised liver function. Moreover, liver transplantation waiting lists are long. Fo...

journal_title：Seminars in radiation oncology

authors： Toesca DAS,Barry A,Sapisochin G,Beecroft R,Dawson L,Owen D,Mouli S,Lewandowski R,Salem R,Chang DT

更新日期：2018-10-01 00:00:00

abstract：:The majority of newly diagnosed patients are expected to survive Hodgkin's disease because of effective therapies established during past 30 years. Long-term observations from large populations of treated patients have disclosed a variety of late effects of the disease and its therapy have contributed morbidity and ex...

journal_title：Seminars in radiation oncology

authors： Hancock SL,Hoppe RT

更新日期：1996-07-01 00:00:00

abstract：:Three-Dimensional conformal radiation treatment (3D-CRT) planning and delivery is an external beam radiation therapy modality that has the general goal of conforming the shape of a prescribed dose volume to the shape of a 3-dimensional target volume, simultaneously limiting dose to critical normal structures. 3-Dimens...

journal_title：Seminars in radiation oncology

authors： Morris DE,Bourland JD,Rosenman JG,Shaw EG

更新日期：2001-04-01 00:00:00

abstract：:This review provides an overview of the use of stereotactic ablative body radiotherapy (SABR) for pulmonary metastases. The local control rates after SABR are generally >90%. Whether this also translates into a significant improvement in overall survival is the subject of ongoing studies. New exciting opportunities in...

journal_title：Seminars in radiation oncology

authors： Siva S,Slotman BJ

更新日期：2017-07-01 00:00:00

abstract：:Definitive reirradiation using a stereotactic technique is an effective local treatment option for both recurrent liver metastases and recurrent primary liver cancers. The tolerance of the liver, bile ducts, and surrounding gastrointestinal luminal organs must be respected to ensure safe retreatment. The risks associa...

journal_title：Seminars in radiation oncology

authors： Owen D,Lukovic J,Hosni A,Crane CH,Hong TS,Dawson LA,Velec M,Lawrence TS

更新日期：2020-07-01 00:00:00

abstract：:The degree of xerostomia has been reported to depend on the radiation dose and the salivary gland volume irradiated. Sparing salivary function can be achieved by reducing radiation dose to the salivary glands or using a radiation protector, such as amifostine (Ethyol). In this report, the author reviews clinical exper...

journal_title：Seminars in radiation oncology

authors： Chao KS

更新日期：2002-01-01 00:00:00

abstract：:Targeting specific biological pathways in tumor development has been heralded as a promising approach to the treatment of cancer. Familiar to most investigators are the studies done with epidermal growth factor receptor (EGFR) antagonists, but newer agents currently under development also target angiogenic or cell cyc...

journal_title：Seminars in radiation oncology

authors： Raben D,Bianco C,Milas L,Ang KK

更新日期：2004-04-01 00:00:00

abstract：:Target volumes in the thorax and abdomen are commonly computed tomography (CT) scanned during light respiration. In this article, we analyze the distortions introduced in helical scanning of moving objects. Objects of known geometry are placed on a moving sled and scanned in a multirow helical CT scanner. The motion o...

journal_title：Seminars in radiation oncology

authors： Chen GT,Kung JH,Beaudette KP

更新日期：2004-01-01 00:00:00

abstract：:Optimal care of patients with locally advanced breast cancer requires the use and thoughtful integration of all effective modalities of treatment. A number of alternative combinations of surgery, chemotherapy, and radiation have been promoted, each with its own particular advantages and shortcomings. The advantages of...

journal_title：Seminars in radiation oncology

authors： Strom EA,Dhingra K

更新日期：1994-10-01 00:00:00

abstract：:Although important advances in surgery, chemotherapy (CT), and radiation therapy (RT) have been made, overall survival for patients with ovarian cancer (OC) has not changed significantly. Despite its long history in the treatment of OC and its proven curative role in patients with microscopic or minimal residual disea...

journal_title：Seminars in radiation oncology

authors： Cardenes H,Randall ME

更新日期：2000-01-01 00:00:00

abstract：:Radiation-induced fibrosis (RIF) and radionecrosis (RN) are late complications that are usually considered irreversible. Usual management strategy includes eliminating local and general aggravating factors and controlling acute and chronic inflammation with steroids. Thanks to progress in understanding the pathophysio...

journal_title：Seminars in radiation oncology

authors： Delanian S,Lefaix JL

更新日期：2007-04-01 00:00:00

abstract：:Recent efforts to reduce xerostomia associated with irradiation (RT) of head and neck cancer include the use of conformal and intensity-modulated RT (IMRT) to partly spare the major salivary glands, notably the parotid glands, from a high radiation dose while treating adequately all the targets at risk of disease. Kno...

journal_title：Seminars in radiation oncology

authors： Eisbruch A,Ship JA,Kim HM,Ten Haken RK

更新日期：2001-07-01 00:00:00