Radiation and inflammation.


:The immune system has the power to modulate the expression of radiation-induced normal and tumor tissue damage. On the one hand, it can contribute to cancer cure, and on the other hand, it can influence acute and late radiation side effects, which in many ways resemble acute and chronic inflammatory disease states. The way radiation-induced inflammation feeds into adaptive antigen-specific immune responses adds another dimension to the tumor-host cross talk during radiation therapy and to possible radiation-driven autoimmune responses. Understanding how radiation affects inflammation and immunity is therefore critical if we are to effectively manipulate these forces for benefit in radiation oncology treatments.


Semin Radiat Oncol


Schaue D,Micewicz ED,Ratikan JA,Xie MW,Cheng G,McBride WH




Has Abstract


2015-01-01 00:00:00














  • The role of external beam radiation and targeted therapy in thyroid cancer.

    abstract::The initial management of thyroid cancer is usually surgery, followed by radioactive iodine in differentiated thyroid cancer. The role of external beam radiotherapy for gross residual or unresected disease is discussed. For both differentiated thyroid cancer and medullary thyroid cancer, the role of external beam radi...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Brierley J,Sherman E

    更新日期:2012-07-01 00:00:00

  • Validity of Current Stereotactic Body Radiation Therapy Dose Constraints for Aorta and Major Vessels.

    abstract::Understanding dose constraints for critical structures in stereotactic body radiation therapy (SBRT) is essential to generate a plan for optimal efficacy and safety. Published dose constraints are derived by a variety of methods, including crude statistics, actuarial analysis, modeling, and simple biologically effecti...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Xue J,Kubicek G,Patel A,Goldsmith B,Asbell SO,LaCouture TA

    更新日期:2016-04-01 00:00:00

  • Protection of salivary function by intensity-modulated radiation therapy in patients with head and neck cancer.

    abstract::The degree of xerostomia has been reported to depend on the radiation dose and the salivary gland volume irradiated. Sparing salivary function can be achieved by reducing radiation dose to the salivary glands or using a radiation protector, such as amifostine (Ethyol). In this report, the author reviews clinical exper...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章


    authors: Chao KS

    更新日期:2002-01-01 00:00:00

  • Target definition in the thorax and central nervous system.

    abstract::It is the aim of conformal radiotherapy to restrict the high-dose region to the target volume as much as possible, thereby sparing the neighboring healthy tissues. However, to increase the therapeutic range, smaller margins tend to be used. This reduction of safety margins enhances the risk of unsuitable dosage becaus...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Giraud P,Kantor G,Loiseau H,Rosenzweig KE

    更新日期:2005-07-01 00:00:00

  • The Low-Grade Lymphomas.

    abstract::The lymphomas comprise a spectrum of diseases with vast variation in histologic appearance, presentation and natural history, and response to therapy. At one end of the spectrum are the low-grade lymphomas (LGLs), indolent malignancies characterized by paradox. Despite an exceedingly low growth fraction, the LGLs are ...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章


    authors: Mendenhall NP,Lynch JW Jr

    更新日期:1995-10-01 00:00:00

  • The Role of Surgical Staging for Cervical Cancer.

    abstract::Recent trends in gynecologic oncology have favored surgical staging of disease not only to define local extent, but more importantly nodal involvement. For cervical cancer, surgical staging includes intraperitoneal exploration, cytological washings, direct tumor palpation, and para-aortic with or without pelvic lymph ...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章


    authors: Lanciano RM,Corn BW

    更新日期:1994-01-01 00:00:00

  • Utilization of intensity-modulated radiation therapy and image-guided radiation therapy in pancreatic cancer: is it beneficial?

    abstract::The recent development of intensity-modulated radiation therapy (IMRT) and improvements in image-guided radiotherapy (IGRT) have provided considerable advances in the utilization of radiation therapy (RT) for the management of pancreatic cancer. IGRT allows for the reduction of treatment volumes, potentially less chan...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Reese AS,Lu W,Regine WF

    更新日期:2014-04-01 00:00:00

  • Adaptive management of cervical cancer radiotherapy.

    abstract::Since the breakthrough 10 years ago with concomitant radio-chemotherapy, substantial progress in the treatment of locally advanced cervical cancer has been lacking. Radiotherapy continues to be the cornerstone in the treatment of this disease and now shows much potential for progress, as image guidance of both externa...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Tanderup K,Georg D,Pötter R,Kirisits C,Grau C,Lindegaard JC

    更新日期:2010-04-01 00:00:00

  • The Role of Postmastectomy Radiation Therapy in Patients With Breast Cancer Responding to Neoadjuvant Chemotherapy.

    abstract::When surgery is the first line of breast cancer treatment, numerous randomized clinical trials and meta-analyses have demonstrated that postmastectomy radiation therapy (PMRT) improves locoregional control and survival for many women with axillary lymph node-positive disease. In contrast, there are no randomized data ...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Bazan JG,White JR

    更新日期:2016-01-01 00:00:00

  • Potential Morbidity Reduction With Proton Radiation Therapy for Breast Cancer.

    abstract::Proton radiotherapy confers significant dosimetric advantages in the treatment of malignancies that arise adjacent to critical radiosensitive structures. To date, these advantages have been most prominent in the treatment of pediatric and central nervous system malignancies, although emerging data support the use of p...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Braunstein LZ,Cahlon O

    更新日期:2018-04-01 00:00:00

  • Gynecologic brachytherapy I: Proper incorporation of brachytherapy into the current multimodality management of carcinoma of the cervix.

    abstract::The incidence of carcinoma of the cervix has continuously declined over the past decades because of effective screening. The International Federation of Gynecology and Obstetrics (FIGO) clinical staging, though universally used, is considered inadequate either to determine the type of treatment or to predict treatment...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Nori D,Dasari N,Allbright RM

    更新日期:2002-01-01 00:00:00

  • Radiation Therapy Oncology Group 9802: Controversy or Consensus in the Treatment of Newly Diagnosed Low-Grade Glioma?

    abstract::Treatment of newly diagnosed or suspected low-grade glioma (LGG) is one of the most controversial areas in neuro-oncology. The heterogeneity of these tumors, concern regarding morbidity of treatment, and absence of proven overall survival benefit from any known treatment have resulted in a lack of consensus regarding ...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Laack NN,Sarkaria JN,Buckner JC

    更新日期:2015-07-01 00:00:00

  • Cancer Care Access and Outcomes for American Indian Populations in the United States: Challenges and Models for Progress.

    abstract::Low socioeconomic and health care access realities of being American Indian/Alaskan Native (AI/AN) in the United States combined with decades of data documenting poor cancer outcomes for this population provide a population nested within the United States that is analogous to the cancer care landscape of low- and midd...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Guadagnolo BA,Petereit DG,Coleman CN

    更新日期:2017-04-01 00:00:00

  • The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery.

    abstract::The linear-quadratic (LQ) model is widely used to model the effect of total dose and dose per fraction in conventionally fractionated radiotherapy. Much of the data used to generate the model are obtained in vitro at doses well below those used in radiosurgery. Clinically, the LQ model often underestimates tumor contr...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章


    authors: Kirkpatrick JP,Meyer JJ,Marks LB

    更新日期:2008-10-01 00:00:00

  • Inflammatory breast cancer.

    abstract::Inflammatory breast cancer (IBC) represents the most virulent form of breast cancer, characterized by involvement of the skin and rapid progression of the disease. Management involves careful coordination of all multidisciplinary modalities, including imaging, systemic chemotherapy, surgery, and radiation therapy. The...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Woodward WA,Cristofanilli M

    更新日期:2009-10-01 00:00:00

  • Pediatric hodgkin lymphoma: maximizing efficacy and minimizing toxicity.

    abstract::Historically, both adult and childhood Hodgkin lymphoma (HL) were treated with full-dose (35-45 Gy) extended-field radiation therapy (RT). Although this treatment was the first to produce reliable disease control, the resulting late toxicity led pediatric oncologists to pioneer the use of combined chemotherapy and low...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Hodgson DC,Hudson MM,Constine LS

    更新日期:2007-07-01 00:00:00

  • Artifacts in computed tomography scanning of moving objects.

    abstract::Target volumes in the thorax and abdomen are commonly computed tomography (CT) scanned during light respiration. In this article, we analyze the distortions introduced in helical scanning of moving objects. Objects of known geometry are placed on a moving sled and scanned in a multirow helical CT scanner. The motion o...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章


    authors: Chen GT,Kung JH,Beaudette KP

    更新日期:2004-01-01 00:00:00

  • Magnetic resonance imaging and positron-emission tomography imaging in the 21st century as tools for the evaluation and management of patients with invasive cervical carcinoma.

    abstract::For over 4 decades, the delivery of definitive radiotherapy to patients with carcinoma of the cervix has involved both external beam and brachytherapy. Both of these therapeutic modalities have been traditionally linked to 2-dimensional radiographic guidance. Currently, the staging of these tumors still resides in cli...

    journal_title:Seminars in radiation oncology

    pub_type: 历史文章,杂志文章,评审


    authors: Wolfson AH

    更新日期:2006-07-01 00:00:00

  • When X-ray-inducible proteins meet DNA double strand break repair.

    abstract::Cellular responses to ionizing radiation (IR) include (a) activation of signal transduction enzymes; (b) stimulation of DNA repair, most notably DNA double strand break (DSB) repair by homologous or nonhomologous recombinatorial pathways; (c) activation of transcription factors and subsequent IR-inducible transcript a...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Leskov KS,Criswell T,Antonio S,Li J,Yang CR,Kinsella TJ,Boothman DA

    更新日期:2001-10-01 00:00:00

  • Clinical aspects of intensity-modulated radiotherapy in the treatment of breast cancer.

    abstract::In recent years, interest has grown throughout the radiotherapy community in investigation and clinical application of intensity-modulated radiation therapy (IMRT) for adjuvant treatment of breast cancer. IMRT removes the usual reliance on flat (or uniform-intensity) radiation fields, and instead replaces that simple ...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Krueger EA,Fraass BA,Pierce LJ

    更新日期:2002-07-01 00:00:00

  • Meeting the Global Need for Radiation Therapy in Cervical Cancer-An Overview.

    abstract::Cervical cancer is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer death in women. The discrepancy in cervical cancer incidence and mortality between developed and developing nations has become increasingly apparent with 84% of the incidence and 88% of the mortality of cervical cance...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Gurram L,Kalra B,Mahantshetty U

    更新日期:2020-10-01 00:00:00

  • Poly(ADP-ribose) polymerase inhibition as a model for synthetic lethality in developing radiation oncology targets.

    abstract::DNA double-strand breaks (DSBs) induced during clinical radiotherapy are potent inducers of cell death. Poly(ADP-ribose) polymerase (PARP)-1 is a 113-kD nuclear protein that binds to both single- and double-strand DNA breaks and is actively involved in DNA single-strand break repair and base excision repair. Recently,...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Chalmers AJ,Lakshman M,Chan N,Bristow RG

    更新日期:2010-10-01 00:00:00

  • Measuring health-related quality of life consequences from primary treatment for early-stage prostate cancer.

    abstract::Radical prostatectomy, external radiation therapy, and brachytherapy are all mainstay treatment options for clinically localized prostate cancer. Over time, each of these treatments has been modified so as to maximize percent cancer-free survival while minimizing health-related risks such as urinary incontinence, bowe...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Dandapani SV,Sanda MG

    更新日期:2008-01-01 00:00:00

  • Clinical Case Panel: Treatment Alternatives for Inoperable Hepatocellular Carcinoma.

    abstract::Surgical resection or liver transplantation offers the best chance of cure for patients with hepatocellular carcinoma (HCC). Unfortunately, most patients are not good candidates for liver resection due to locally advanced disease or compromised liver function. Moreover, liver transplantation waiting lists are long. Fo...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Toesca DAS,Barry A,Sapisochin G,Beecroft R,Dawson L,Owen D,Mouli S,Lewandowski R,Salem R,Chang DT

    更新日期:2018-10-01 00:00:00

  • Comparative effectiveness research in radiation oncology: stereotactic radiosurgery, hypofractionation, and brachytherapy.

    abstract::Radiation oncology encompasses a diverse spectrum of treatment modalities, including stereotactic radiosurgery, hypofractionated radiotherapy, and brachytherapy. Though all these modalities generally aim to do the same thing-treat cancer with therapeutic doses of radiation while relatively sparing normal tissue from e...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Aneja S,Yu JB

    更新日期:2014-01-01 00:00:00

  • Neural precursor cells and central nervous system radiation sensitivity.

    abstract::The tolerance of normal brain tissues limits the radiation dose that can be delivered safely during cranial radiotherapy, and one of the potential complications that can arise involves cognitive impairment. Extensive laboratory data have appeared recently showing that hippocampal neurogenesis is significantly impacted...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Fike JR,Rosi S,Limoli CL

    更新日期:2009-04-01 00:00:00

  • Measuring Tumor Hypoxia.

    abstract::A variety of techniques for measuring oxygen in normal and tumor tissue has been developed over the years in response to the realization that hypoxia is important in a number of pathophysiological conditions in normal tissues and in the response of tumors to radiation treatment. A review of the techniques for measurin...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章


    authors: Raleigh JA,Dewhirst MW,Thrall DE

    更新日期:1996-01-01 00:00:00

  • Locoregional failure rates in patients with involved axillary nodes after mastectomy and systemic therapy.

    abstract::Published series vary substantially in describing the incidence of locoregional failure after mastectomy among patients with involved axillary lymph nodes who receive systemic therapy. There are few data on such risks with regards to particular patient subsets (such as those defined by combinations of tumor size and n...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Recht A

    更新日期:1999-07-01 00:00:00

  • Age and comorbidity considerations related to radiotherapy and chemotherapy administration.

    abstract::Oncological treatment decision-making is a highly complex enterprise integrating multiple patient, tumor, treatment, and professional factors with the available medical evidence. This management complexity can be exacerbated by the interplay of patient age and comorbid non-cancer conditions that can affect patient qua...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Rodrigues G,Sanatani M

    更新日期:2012-10-01 00:00:00

  • Diffusion magnetic resonance imaging in cancer patient management.

    abstract::Diffusion-weighted MRI (DW-MRI) is able to detect and characterize tissues because it incorporates sensitivity to water content and water movements into the images that are produced. Compared with other imaging modalities used in oncologic assessments, DW-MRI does not expose patients to ionizing radiations, and no inj...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Padhani AR

    更新日期:2011-04-01 00:00:00