Controversies in pathology in early-stage breast cancer.


:Breast-conserving therapy is a reliable, evidenced-based approach for early-stage breast carcinoma. This article reviews the issues and limitations related to simple margin measurements, data supporting the association between the amount of carcinoma near the margin, and ipsilateral breast failure risk. Additional factors pertinent to radiation oncologists include extensive intraductal carcinoma, lymphovascular space invasion, atypical ductal hyperplasia, and molecular clonality of ipsilateral breast failures as they relate to outcome.


Semin Radiat Oncol


Goldstein SN




Has Abstract


2011-01-01 00:00:00














  • Altered fractionation trials in head and neck cancer.

    abstract::Advancement in radiobiological concepts has led to the development of two classes of new fractionation schedules for the treatment of head and neck cancers. These altered fractionation regimens are referred to as hyperfractionation and accelerated fractionation schedules. Hyperfractionation exploits the difference in ...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,meta分析


    authors: Ang KK

    更新日期:1998-10-01 00:00:00

  • Challenges in Reirradiation of Intrahepatic Tumors.

    abstract::Definitive reirradiation using a stereotactic technique is an effective local treatment option for both recurrent liver metastases and recurrent primary liver cancers. The tolerance of the liver, bile ducts, and surrounding gastrointestinal luminal organs must be respected to ensure safe retreatment. The risks associa...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Owen D,Lukovic J,Hosni A,Crane CH,Hong TS,Dawson LA,Velec M,Lawrence TS

    更新日期:2020-07-01 00:00:00

  • Sequential Therapy in the Treatment of Locally Advanced Noninflammatory Breast Cancer.

    abstract::Optimal care of patients with locally advanced breast cancer requires the use and thoughtful integration of all effective modalities of treatment. A number of alternative combinations of surgery, chemotherapy, and radiation have been promoted, each with its own particular advantages and shortcomings. The advantages of...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章


    authors: Strom EA,Dhingra K

    更新日期:1994-10-01 00:00:00

  • The role of external beam radiation and targeted therapy in thyroid cancer.

    abstract::The initial management of thyroid cancer is usually surgery, followed by radioactive iodine in differentiated thyroid cancer. The role of external beam radiotherapy for gross residual or unresected disease is discussed. For both differentiated thyroid cancer and medullary thyroid cancer, the role of external beam radi...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Brierley J,Sherman E

    更新日期:2012-07-01 00:00:00

  • Adaptive management of cervical cancer radiotherapy.

    abstract::Since the breakthrough 10 years ago with concomitant radio-chemotherapy, substantial progress in the treatment of locally advanced cervical cancer has been lacking. Radiotherapy continues to be the cornerstone in the treatment of this disease and now shows much potential for progress, as image guidance of both externa...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Tanderup K,Georg D,Pötter R,Kirisits C,Grau C,Lindegaard JC

    更新日期:2010-04-01 00:00:00

  • Human papillomavirus as a marker of the natural history and response to therapy of head and neck squamous cell carcinoma.

    abstract::There has been a gradual change in the demographics of head and neck carcinoma. Although relatively uncommon, the incidence of oropharyngeal carcinoma has been increasing despite declining tobacco consumption and contrary to a diminishing incidence of cancers at other head and neck sites. It is now clear that the inci...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Ang KK,Sturgis EM

    更新日期:2012-04-01 00:00:00

  • Three-dimensional conformal radiation treatment planning and delivery for low- and intermediate-grade gliomas.

    abstract::Three-Dimensional conformal radiation treatment (3D-CRT) planning and delivery is an external beam radiation therapy modality that has the general goal of conforming the shape of a prescribed dose volume to the shape of a 3-dimensional target volume, simultaneously limiting dose to critical normal structures. 3-Dimens...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Morris DE,Bourland JD,Rosenman JG,Shaw EG

    更新日期:2001-04-01 00:00:00

  • Targeted therapies and radiation for the treatment of head and neck cancer: are we making progress?

    abstract::Targeting specific biological pathways in tumor development has been heralded as a promising approach to the treatment of cancer. Familiar to most investigators are the studies done with epidermal growth factor receptor (EGFR) antagonists, but newer agents currently under development also target angiogenic or cell cyc...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Raben D,Bianco C,Milas L,Ang KK

    更新日期:2004-04-01 00:00:00

  • Diffusion magnetic resonance imaging in cancer patient management.

    abstract::Diffusion-weighted MRI (DW-MRI) is able to detect and characterize tissues because it incorporates sensitivity to water content and water movements into the images that are produced. Compared with other imaging modalities used in oncologic assessments, DW-MRI does not expose patients to ionizing radiations, and no inj...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Padhani AR

    更新日期:2011-04-01 00:00:00

  • Lactate: mirror and motor of tumor malignancy.

    abstract::A number of studies have shown that malignant transformation is associated with an increase in glycolytic flux and in anaerobic and aerobic cellular lactate excretion. Using quantitative bioluminescence imaging in various primary carcinomas in patients (uterine cervix, head and neck, colorectal region) at first diagno...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Walenta S,Mueller-Klieser WF

    更新日期:2004-07-01 00:00:00

  • Measuring health-related quality of life consequences from primary treatment for early-stage prostate cancer.

    abstract::Radical prostatectomy, external radiation therapy, and brachytherapy are all mainstay treatment options for clinically localized prostate cancer. Over time, each of these treatments has been modified so as to maximize percent cancer-free survival while minimizing health-related risks such as urinary incontinence, bowe...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Dandapani SV,Sanda MG

    更新日期:2008-01-01 00:00:00

  • Role of Immunotherapy in Head and Neck Cancer.

    abstract::Immune system dysfunction plays a role in both the development and progression of head and neck squamous cell carcinoma (HNSCC), highlighting the potential role for immunotherapy to improve outcomes in this disease. The application of anti-PD-1 therapies for recurrent or metastatic HNSCC has found promising results. T...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Ling DC,Bakkenist CJ,Ferris RL,Clump DA

    更新日期:2018-01-01 00:00:00

  • Molecular prognostic factors for breast cancer metastasis and survival.

    abstract::The biological characteristics of the tumor are used to estimate prognosis and select appropriate systemic therapy for patients with early-stage breast cancer. Well-established molecular prognostic factors include the estrogen and progesterone receptors, proliferation markers, and the HER2 gene. Novel tumor markers wi...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Esteva FJ,Sahin AA,Cristofanilli M,Arun B,Hortobagyi GN

    更新日期:2002-10-01 00:00:00

  • Magnetic Resonance Imaging and Other Imaging Modalities in Diagnostic and Tumor Response Evaluation.

    abstract::Functional imaging is emerging as a valuable contributor to the clinical management of patients with rectal cancer. Techniques such as diffusion-weighted magnetic resonance imaging, perfusion imaging, and positron emission tomography can offer meaningful insights into tissue architecture, vascularity, and metabolism. ...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Lambregts DM,Maas M,Stokkel MP,Beets-Tan RG

    更新日期:2016-07-01 00:00:00

  • Clinical Case Panel: Treatment Alternatives for Inoperable Hepatocellular Carcinoma.

    abstract::Surgical resection or liver transplantation offers the best chance of cure for patients with hepatocellular carcinoma (HCC). Unfortunately, most patients are not good candidates for liver resection due to locally advanced disease or compromised liver function. Moreover, liver transplantation waiting lists are long. Fo...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Toesca DAS,Barry A,Sapisochin G,Beecroft R,Dawson L,Owen D,Mouli S,Lewandowski R,Salem R,Chang DT

    更新日期:2018-10-01 00:00:00

  • Partial irradiation of the parotid gland.

    abstract::Recent efforts to reduce xerostomia associated with irradiation (RT) of head and neck cancer include the use of conformal and intensity-modulated RT (IMRT) to partly spare the major salivary glands, notably the parotid glands, from a high radiation dose while treating adequately all the targets at risk of disease. Kno...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Eisbruch A,Ship JA,Kim HM,Ten Haken RK

    更新日期:2001-07-01 00:00:00

  • The mechanism of action of radiosensitization of conventional chemotherapeutic agents.

    abstract::It is not an exaggeration to state that most of the advances in curing cancer in the last decade have come from successful combinations of conventional chemotherapeutic agents with radiation therapy. Further improvements in therapy will depend on understanding the mechanisms by which chemotherapy improves the effectiv...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Lawrence TS,Blackstock AW,McGinn C

    更新日期:2003-01-01 00:00:00

  • Epidermal growth factor receptor as a therapeutic target in head and neck cancer.

    abstract::Epidermal growth factor receptor (EGFR) is a cell membrane protein that is overexpressed in almost all head and neck squamous cell carcinomas. Overexpression of EGFR has been associated with a poor prognosis in head and neck tumors as well as many other malignancies. This cell membrane protein has been considered an e...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Bonner JA,De Los Santos J,Waksal HW,Needle MN,Trummel HQ,Raisch KP

    更新日期:2002-07-01 00:00:00

  • Integrating radiation therapy in the curative management of ovarian cancer: current issues and future directions.

    abstract::Although important advances in surgery, chemotherapy (CT), and radiation therapy (RT) have been made, overall survival for patients with ovarian cancer (OC) has not changed significantly. Despite its long history in the treatment of OC and its proven curative role in patients with microscopic or minimal residual disea...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Cardenes H,Randall ME

    更新日期:2000-01-01 00:00:00

  • Comparison of three-dimensional conformal radiation therapy and intensity-modulated radiation therapy systems.

    abstract::The use of three-dimensional conformal radiation therapy (3DCRT) has now become common practice in radiation oncology departments around the world. Using beam's eye viewing of volumes defined on a treatment planning computed tomography scan, beam directions and beam shapes can be selected to conform to the shape of th...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Verhey LJ

    更新日期:1999-01-01 00:00:00

  • Standardization and quality assurance of radiation therapy volumes for adults with high-grade gliomas.

    abstract::Standard treatment for Glioblastoma Multiforme (GBM) consists of a combination of chemotherapy and radiation therapy followed by adjuvant chemotherapy. While the optimal dose of radiation therapy has been established, significant variability in volume of tissue irradiated exists. In this article we review the current ...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Fogh S,Wahl M,Anwar M,Haas-Kogan D,Clarke JL,Sneed PK

    更新日期:2014-10-01 00:00:00

  • Emerging Technologies and Techniques in Radiation Therapy.

    abstract::The past decade has brought an improved ability to precisely target and deliver radiation as well as other focal prostate-directed therapy. Stereotactic body radiotherapy (SBRT), proton beam radiation, high-dose-rate (HDR) brachytherapy, as well as nonradiotherapy treatments such as cryoablation and high-intensity foc...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Magnuson WJ,Mahal A,Yu JB

    更新日期:2017-01-01 00:00:00

  • Clinical aspects of intensity-modulated radiotherapy in the treatment of breast cancer.

    abstract::In recent years, interest has grown throughout the radiotherapy community in investigation and clinical application of intensity-modulated radiation therapy (IMRT) for adjuvant treatment of breast cancer. IMRT removes the usual reliance on flat (or uniform-intensity) radiation fields, and instead replaces that simple ...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Krueger EA,Fraass BA,Pierce LJ

    更新日期:2002-07-01 00:00:00

  • Utilization of intensity-modulated radiation therapy and image-guided radiation therapy in pancreatic cancer: is it beneficial?

    abstract::The recent development of intensity-modulated radiation therapy (IMRT) and improvements in image-guided radiotherapy (IGRT) have provided considerable advances in the utilization of radiation therapy (RT) for the management of pancreatic cancer. IGRT allows for the reduction of treatment volumes, potentially less chan...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Reese AS,Lu W,Regine WF

    更新日期:2014-04-01 00:00:00

  • Radiosensitizers in hepatocellular carcinoma.

    abstract::Most hepatocellular carcinoma (HCC) patients present with locally advanced disease with a risk of development of intrahepatic or extrahepatic metastases. Conformal radiotherapy (RT) can be delivered to focal HCCs with sustained local control in selected HCC patients. However, it is frequently not possible to deliver t...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Lee IJ,Seong J

    更新日期:2011-10-01 00:00:00

  • New Directions in Radionuclide Sources for Brachytherapy.

    abstract::Brachytherapy continues to play an important role in the management of cancers of several sites, including the head and neck, brain, uterine cervix, endometrium, and prostate. The physical advantages of brachytherapy result from a superior localization of dose to the tumor volume. In brachytherapy, as radiation is con...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章


    authors: Nath R

    更新日期:1993-10-01 00:00:00

  • The Practicality of ICRU and Considerations for Future ICRU Definitions.

    abstract::The International Commission on Radiation Units and Measurements (ICRU) volumes are standardized volume definitions used in radiation oncology practice that have evolved over time to account for advancements in technology and radiation planning. The current definitions have strengths but also practical limitations. Th...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Shepherd A,James SS,Rengan R

    更新日期:2018-06-01 00:00:00

  • Pediatric hodgkin lymphoma: maximizing efficacy and minimizing toxicity.

    abstract::Historically, both adult and childhood Hodgkin lymphoma (HL) were treated with full-dose (35-45 Gy) extended-field radiation therapy (RT). Although this treatment was the first to produce reliable disease control, the resulting late toxicity led pediatric oncologists to pioneer the use of combined chemotherapy and low...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: Hodgson DC,Hudson MM,Constine LS

    更新日期:2007-07-01 00:00:00

  • Spinal cord and peripheral nerve injury: current management and investigations.

    abstract::Treatment of patients having malignancy near or within the spinal cord can be more challenging or limited than in patients with brain tumors. This is largely because of the near total lack of noneloquent neural tissue associated with the spinal cord and/or intimately associated peripheral nerves. The adverse effects o...

    journal_title:Seminars in radiation oncology

    pub_type: 杂志文章,评审


    authors: St Clair WH,Arnold SM,Sloan AE,Regine WF

    更新日期:2003-07-01 00:00:00

  • Magnetic resonance imaging and positron-emission tomography imaging in the 21st century as tools for the evaluation and management of patients with invasive cervical carcinoma.

    abstract::For over 4 decades, the delivery of definitive radiotherapy to patients with carcinoma of the cervix has involved both external beam and brachytherapy. Both of these therapeutic modalities have been traditionally linked to 2-dimensional radiographic guidance. Currently, the staging of these tumors still resides in cli...

    journal_title:Seminars in radiation oncology

    pub_type: 历史文章,杂志文章,评审


    authors: Wolfson AH

    更新日期:2006-07-01 00:00:00