Controversies in pathology in early-stage breast cancer.

abstract：:Over the past year we have developed two similar questionnaires on three-dimensional radiotherapy treatment planning (3DRTP) systems and used them to conduct a study of the function and features of commercially available 3DRTP systems. The issues which we reviewed to develop these questionnaires are important to all c...

journal_title：Seminars in radiation oncology

authors： Harms WB Sr,Purdy JA

更新日期：1997-01-01 00:00:00

abstract：:A dose-response relationship can be established for local control of a variety of malignancies treated with radiation, yet palliation of symptoms oftentimes does not have a clear dose-response relationship. It is important that palliation be achieved with as efficient a fractionation schedule as possible in patients w...

journal_title：Seminars in radiation oncology

authors： Anderson PR,Coia LR

更新日期：2000-07-01 00:00:00

abstract：:Recent trends in gynecologic oncology have favored surgical staging of disease not only to define local extent, but more importantly nodal involvement. For cervical cancer, surgical staging includes intraperitoneal exploration, cytological washings, direct tumor palpation, and para-aortic with or without pelvic lymph ...

journal_title：Seminars in radiation oncology

authors： Lanciano RM,Corn BW

更新日期：1994-01-01 00:00:00

abstract：:Most solid tumors are characterized by unstable perfusion patterns, creating regions of hypoxia that are detrimental to radiotherapy treatment response. Because postsurgical radiotherapy, alone or in combination with other interventions, is a first-line treatment for many malignancies, strategies aimed at homogeneousl...

journal_title：Seminars in radiation oncology

authors： Danhier P,De Saedeleer CJ,Karroum O,De Preter G,Porporato PE,Jordan BF,Gallez B,Sonveaux P

更新日期：2013-10-01 00:00:00

abstract：:Immune system dysfunction plays a role in both the development and progression of head and neck squamous cell carcinoma (HNSCC), highlighting the potential role for immunotherapy to improve outcomes in this disease. The application of anti-PD-1 therapies for recurrent or metastatic HNSCC has found promising results. T...

journal_title：Seminars in radiation oncology

authors： Ling DC,Bakkenist CJ,Ferris RL,Clump DA

更新日期：2018-01-01 00:00:00

abstract：:Proton radiotherapy confers significant dosimetric advantages in the treatment of malignancies that arise adjacent to critical radiosensitive structures. To date, these advantages have been most prominent in the treatment of pediatric and central nervous system malignancies, although emerging data support the use of p...

journal_title：Seminars in radiation oncology

authors： Braunstein LZ,Cahlon O

更新日期：2018-04-01 00:00:00

abstract：:Radiation therapy will be used much more commonly in the treatment of adenocarcinoma of the stomach because of the results of the Intergroup Trial demonstrating an advantage to adjuvant postoperative chemoradiation therapy. Previous descriptions of radiation fields have not emphasized the variation in local spread pat...

journal_title：Seminars in radiation oncology

authors： Tepper JE,Gunderson LL

更新日期：2002-04-01 00:00:00

abstract：:The intensification of radiation, induction chemotherapy, and concomitant chemoradiotherapy has been extensively investigated over the past 2 decades for the nonsurgical management of locally advanced, nonmetastatic squamous cell head and neck cancer (HNC). Concurrent chemoradiation has emerged as the standard of care...

journal_title：Seminars in radiation oncology

authors： Brizel DM,Vokes EE

更新日期：2009-01-01 00:00:00

abstract：:Non-small cell lung cancers are now recognized to contain considerable heterogeneity and molecular diversity. Substantial progress has been made regarding molecular determinants of response to targeted agents in advanced lung cancer, and recent findings have revealed subsets of patients with driver mutations that resp...

journal_title：Seminars in radiation oncology

authors： Yom SS,Diehn M,Raben D

更新日期：2015-04-01 00:00:00

abstract：:Historically, both adult and childhood Hodgkin lymphoma (HL) were treated with full-dose (35-45 Gy) extended-field radiation therapy (RT). Although this treatment was the first to produce reliable disease control, the resulting late toxicity led pediatric oncologists to pioneer the use of combined chemotherapy and low...

journal_title：Seminars in radiation oncology

authors： Hodgson DC,Hudson MM,Constine LS

更新日期：2007-07-01 00:00:00

abstract：:The past decade has brought an improved ability to precisely target and deliver radiation as well as other focal prostate-directed therapy. Stereotactic body radiotherapy (SBRT), proton beam radiation, high-dose-rate (HDR) brachytherapy, as well as nonradiotherapy treatments such as cryoablation and high-intensity foc...

journal_title：Seminars in radiation oncology

authors： Magnuson WJ,Mahal A,Yu JB

更新日期：2017-01-01 00:00:00

abstract：:The International Commission on Radiation Units and Measurements (ICRU) volumes are standardized volume definitions used in radiation oncology practice that have evolved over time to account for advancements in technology and radiation planning. The current definitions have strengths but also practical limitations. Th...

journal_title：Seminars in radiation oncology

authors： Shepherd A,James SS,Rengan R

更新日期：2018-06-01 00:00:00

abstract：:Clinician-based rating scales and quantitative instruments used to quantify the severity of soft-tissue fibrosis were reviewed to determine if they were reliable and valid measures for clinical and research use. Existing clinician-based measures, the Medical Research Council (MRC) and European Organization for Researc...

journal_title：Seminars in radiation oncology

authors： Davis AM,Dische S,Gerber L,Saunders M,Leung SF,O'Sullivan B

更新日期：2003-07-01 00:00:00

abstract：:There has been a gradual change in the demographics of head and neck carcinoma. Although relatively uncommon, the incidence of oropharyngeal carcinoma has been increasing despite declining tobacco consumption and contrary to a diminishing incidence of cancers at other head and neck sites. It is now clear that the inci...

journal_title：Seminars in radiation oncology

authors： Ang KK,Sturgis EM

更新日期：2012-04-01 00:00:00

abstract：:We have assessed radiation therapy physics quality assurance (QA) elements in the United States and compared the results with the Patterns of Care Study (PCS) Consensus Guidelines for Treatment Planning and the American College of Radiology (ACR) Standard for Radiation Oncology Physics for External Beam Therapy. Data ...

journal_title：Seminars in radiation oncology

authors： Smith AR,Gerber RL,Hughes B,Kline RW,Kutcher G,Ling C,Hanlon A,Owen JB,Hanks GE

更新日期：1997-04-01 00:00:00

abstract：:In recent years, interest has grown throughout the radiotherapy community in investigation and clinical application of intensity-modulated radiation therapy (IMRT) for adjuvant treatment of breast cancer. IMRT removes the usual reliance on flat (or uniform-intensity) radiation fields, and instead replaces that simple ...

journal_title：Seminars in radiation oncology

authors： Krueger EA,Fraass BA,Pierce LJ

更新日期：2002-07-01 00:00:00

abstract：:Inflammatory breast cancer (IBC) represents the most virulent form of breast cancer, characterized by involvement of the skin and rapid progression of the disease. Management involves careful coordination of all multidisciplinary modalities, including imaging, systemic chemotherapy, surgery, and radiation therapy. The...

journal_title：Seminars in radiation oncology

authors： Woodward WA,Cristofanilli M

更新日期：2009-10-01 00:00:00

abstract：:Although the addition of concurrent and adjuvant temozolomide (TMZ) to standard-dose radiation (60 Gy) improves survival, the pattern of failure continues to be local. Conventional contrast enhanced T1-weighted and T2-weighted magnetic resonance imaging (MRI) used for radiation planning reflect anatomic rather than mo...

journal_title：Seminars in radiation oncology

authors： Tsien CI,Cao Y,Lawrence TS

更新日期：2009-07-01 00:00:00

abstract：:Targeting specific biological pathways in tumor development has been heralded as a promising approach to the treatment of cancer. Familiar to most investigators are the studies done with epidermal growth factor receptor (EGFR) antagonists, but newer agents currently under development also target angiogenic or cell cyc...

journal_title：Seminars in radiation oncology

authors： Raben D,Bianco C,Milas L,Ang KK

更新日期：2004-04-01 00:00:00

abstract：:Data from observational studies indicate that both physical activity as well as exercise (ie, structured physical activity) is associated with reductions in the risk of recurrence and cancer mortality after a diagnosis of certain forms of cancer. Emerging evidence from preclinical studies indicates that physical activ...

journal_title：Seminars in radiation oncology

authors： Ashcraft KA,Warner AB,Jones LW,Dewhirst MW

更新日期：2019-01-01 00:00:00

abstract：:Radiation therapy (RT) is frequently used to treat patients with tumors in and around the thorax. Clinical radiation pneumonitis is a common side effect, occurring in 5% to 20% of patients. Efforts to identify patients at risk for pneumonitis have focused on physical factors, such as dose and volume. Recently, the und...

journal_title：Seminars in radiation oncology

authors： Vujaskovic Z,Marks LB,Anscher MS

更新日期：2000-10-01 00:00:00

abstract：:A number of studies have shown that malignant transformation is associated with an increase in glycolytic flux and in anaerobic and aerobic cellular lactate excretion. Using quantitative bioluminescence imaging in various primary carcinomas in patients (uterine cervix, head and neck, colorectal region) at first diagno...

journal_title：Seminars in radiation oncology

authors： Walenta S,Mueller-Klieser WF

更新日期：2004-07-01 00:00:00

abstract：:For over 4 decades, the delivery of definitive radiotherapy to patients with carcinoma of the cervix has involved both external beam and brachytherapy. Both of these therapeutic modalities have been traditionally linked to 2-dimensional radiographic guidance. Currently, the staging of these tumors still resides in cli...

journal_title：Seminars in radiation oncology

authors： Wolfson AH

更新日期：2006-07-01 00:00:00

abstract：:Target volumes in the thorax and abdomen are commonly computed tomography (CT) scanned during light respiration. In this article, we analyze the distortions introduced in helical scanning of moving objects. Objects of known geometry are placed on a moving sled and scanned in a multirow helical CT scanner. The motion o...

journal_title：Seminars in radiation oncology

authors： Chen GT,Kung JH,Beaudette KP

更新日期：2004-01-01 00:00:00

abstract：:Functional imaging techniques are gaining significant interest from radiation oncologists. Many now claim the need for physical and physiological information during both treatment planning and in the study of normal tissue injury. Toward this goal, the nuclear medicine functional imaging modalities, single-photon emis...

journal_title：Seminars in radiation oncology

authors： Munley MT,Marks LB,Hardenbergh PH,Bentel GC

更新日期：2001-01-01 00:00:00

abstract：:The world is embracing the information age, with real-time data at hand to assist with many decisions. Similarly, in cancer radiotherapy we are inexorably moving toward using information in a smarter and faster fashion, to usher in the age of real-time adaptive radiotherapy. The three critical steps of real-time adapt...

journal_title：Seminars in radiation oncology

authors： Keall P,Poulsen P,Booth JT

更新日期：2019-07-01 00:00:00

abstract：:The tolerance of normal brain tissues limits the radiation dose that can be delivered safely during cranial radiotherapy, and one of the potential complications that can arise involves cognitive impairment. Extensive laboratory data have appeared recently showing that hippocampal neurogenesis is significantly impacted...

journal_title：Seminars in radiation oncology

authors： Fike JR,Rosi S,Limoli CL

更新日期：2009-04-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is an aggressive intracranial tumor characterized by local and distant brain relapse despite aggressive therapy. Current standard treatment includes surgical resection followed by radiation with concurrent and adjuvant temozolomide as part of a combined modality approach. In this review, ...

journal_title：Seminars in radiation oncology

authors： Corso CD,Bindra RS

更新日期：2016-10-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) induced during clinical radiotherapy are potent inducers of cell death. Poly(ADP-ribose) polymerase (PARP)-1 is a 113-kD nuclear protein that binds to both single- and double-strand DNA breaks and is actively involved in DNA single-strand break repair and base excision repair. Recently,...

journal_title：Seminars in radiation oncology

authors： Chalmers AJ,Lakshman M,Chan N,Bristow RG

更新日期：2010-10-01 00:00:00

abstract：:This review provides an overview of the use of stereotactic ablative body radiotherapy (SABR) for pulmonary metastases. The local control rates after SABR are generally >90%. Whether this also translates into a significant improvement in overall survival is the subject of ongoing studies. New exciting opportunities in...

journal_title：Seminars in radiation oncology

authors： Siva S,Slotman BJ

更新日期：2017-07-01 00:00:00